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Treatment of Depression — Pharmacokinetic and Pharmacogenetic Considerations

  • Gunnar Alván
  • Folke Sjöqvist

Abstract

In spite of rapid progress in neurobiology, the brain remains the least explored organ in clinical pharmacology and its responses to drugs are notoriously difficult to assess in a reproducible way. In the mid-′60s, we began to study the mechanisms behind interindividual differences in response to tricyclic antidepressant drugs (TCA) using a pharmacokinetic research strategy. This paper summarizes some of the results obtained and the methodological problems encountered in this work.

Keywords

Depressed Patient Plasma Protein Binding Metabolic Ratio Endogenous Depression Monoamine Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Gunnar Alván
    • 1
  • Folke Sjöqvist
    • 1
  1. 1.Department of Clinical Pharmacology Karolinska InstituteHuddinge University HospitalHuddingeSweden

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