Integral Procedures in Pharmacokinetics and their Application to the Parameter Determination of Appearing Metabolites
The pharmacokinetics of a substance are studied best by the simultaneous measurement of the drug and all of its possible metabolites, especially if they possess similar pharmacological activities, in all monitorable tissues of the animal (1,2). The mathematical delineation of the plasma concentration-time course of the administered drug yields only an equation. Thus, it is difficult to predict the time course of drug and metabolites in plasma and urine under selected conditions of dose and administration. An integrated model, that quantitatively describes the tissue concentrations, interconversions, transformations, and excretory patterns of the drug and its metabolites as functions of the dose, may permit correlations with pharmacodynamic activities and give insight into the mechanisms of action.
KeywordsPharmacokinetic Parameter Cumulative Amount Metabolic Clearance Enterohepatic Circulation Integral Procedure
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