Skip to main content

Unusual Pharmacokinetics

  • Chapter
Pharmacokinetics

Abstract

This chapter covers several items which are related only in that they are unusual; that explains the title. Two of these involve absorption kinetics, while the others involve disposition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.F. Bergstrom, D.R. Kay and J.G. Wagner, High-performance liquid chromatographic determination of penicillamine in whole blood, plasma and urine, J. Chromatogr. 222: 445–452 (1981).

    Article  PubMed  CAS  Google Scholar 

  2. R.F. Bergstrom, D.R. Kay and J.G. Wagner, Thein vitroloss of penicillamine in plasma, albumin solutions, and whole blood: Implications for pharmacokinetic studies of penicillamine, Life Sci. 27: 189–198 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. R.F. Bergstrom, D.R. Kay, T.M. Harkcom and J.G. Wagner, Penicillamine kinetics in normal subjects, Clin. Pharmacol. Ther. 30: 404–413 (1981).

    Article  PubMed  CAS  Google Scholar 

  4. M. Weinberger, L. Hendeles and L. Bighley, The relation of product formulation to absorption of oral theophylline, N. Engl. J. Med. 299: 852–857 (1978).

    Article  PubMed  CAS  Google Scholar 

  5. J.G. Wagner and E. Nelson, Percent absorbed time plots derived from blood level and/or urinary excretion data, J. Pharm. Sci. 52: 610–611 (1963).

    Article  PubMed  CAS  Google Scholar 

  6. J.G. Wagner, Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data, J. Pharmacokin. Biopharm. 4: 443–467 (1976).

    Article  CAS  Google Scholar 

  7. J.G. Wagner, K.D. Popat, S.K. Das, E. Sakmar and H. Movahhed, Evidence of nonlinearity in digoxin pharmacokinetics, J. Pharmacokin. Biopharm. 9: 147–166 (1981).

    Article  CAS  Google Scholar 

  8. J.G. Wagner, M.R. Hallmark, E. Sakmar and J.W. Ayres, Sensitive radioimmunoassay for digoxin in plasma and urine, Steroids 29: 787–807 (1977).

    Article  PubMed  CAS  Google Scholar 

  9. J.A. Morais, R.A. Zlotecki, E.Sakmar, P.L. Stetson and J.G. Wagner, Specific and sensitive assays for digoxin in plasma, urine and heart tissue, Res. Commun. Chem. Path. Pharmacol. 31: 285–298 (1981).

    CAS  Google Scholar 

  10. D.J. Weidler, N.S. Jallad, K.L. Black and J.G. Wagner, Alteration of pharmacokinetic parameters for pentobarbital by ischemic stroke and reversion to normal by dexamethasone treatment, J. Clin. Pharmacol. 20: 543–551 (1980).

    PubMed  CAS  Google Scholar 

  11. J.L. Anderson, E. Patterson, J.G. Wagner, J.R. Stewart, H.L. Behm and B.R. Lucchesi, Oral and intravenous bretylium disposition, Clin. Pharmacol. Ther. 28: 408–478 (1980).

    Article  Google Scholar 

  12. . J.L. Anderson, E. Patterson, J.G. Wagner, T.A. Johnson, B.R. Lucchesi and B. Pitt, Clinical pharmacokinetics of intravenous and oral bretylium tosylate in survivors of ventricular tachycardia or fibrillation: Clinical application of a new assay for bretylium, J. Cardiovasc. Pharmacol. 3: 485–499 (1981).

    Article  PubMed  CAS  Google Scholar 

  13. K.C. Kwan and A.E. Till, Novel method for bioavailability assessment, J. Pharm. Sci. 62: 1494–1497 (1973).

    Article  PubMed  CAS  Google Scholar 

  14. J.G. Wagner, A.R. DiSanto, W.R. Gillespie and K.S. Albert, Reversible metabolism and pharmacokinetics: Application to prednisone-prednisolone, Res. Commun. Chem. Path. Pharmacol. 32: 387–406 (1981).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Wagner, J.G. (1984). Unusual Pharmacokinetics. In: Benet, L.Z., Levy, G., Ferraiolo, B.L. (eds) Pharmacokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2799-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2799-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9725-3

  • Online ISBN: 978-1-4613-2799-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics