Abstract
The amount of drug absorbed from the gastrointestinal (GI) tract into the systemic circulation with conventional tablet and capsule dosage forms is dependent on the quantity and type of food in the stomach, GI motility and GI microbial flora. Furthermore, for drugs with a high hepatic extraction ratio, the drug may be largely deactivated by first-pass metabolism before reaching the systemic circulation. Drug absorption from the GI tract can, therefore, result in variable and/or unpredictable plasma concentrations. Some of this variability can be minimized by administering controlled release tablet and capsule formulations. However, these dosage forms cannot eliminate the inherent variability associated with first-pass metabolism.
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© 1984 Plenum Press, New York
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Azarnoff, D.L., Karim, A., Lambert, H., Boylan, J., Schoenhardt, G. (1984). Transdermal Absorption: A Unique Opportunity for Drug Delivery. In: Benet, L.Z., Levy, G., Ferraiolo, B.L. (eds) Pharmacokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2799-8_10
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DOI: https://doi.org/10.1007/978-1-4613-2799-8_10
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