In vivo and in vitro regulation of albumin synthesis

  • M. A. Rothschild
  • M. Oratz
  • S. S. Schreiber


The regulation of albumin synthesis and the factors that influence its rate of production have been of particular interest to our laboratory for many years. This chapter will review the factors which influence albumin metabolism, the current concepts concerning protein synthesis and the effects of disease, particularly cirrhosis and alcohol ingestion, on the synthesis of serum albumin.


Albumin Concentration Serum Albumin Level Urea Cycle Ethanol Metabolism Oncotic Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schreier, M. H., Erni, B. and Staehelin, T. (1977). J. Moh Biol, 116, 727.CrossRefGoogle Scholar
  2. 2.
    Trachsel, H., Erni, B., Schreier, M. H. and Staehelin, T. (1977). J. Mol. Biol, 116, 755.PubMedCrossRefGoogle Scholar
  3. 3.
    Thomas, A. A. M., Benne, R. and Voorma, H. O. (1981). FEBS Lett., 128, 177.PubMedCrossRefGoogle Scholar
  4. 4.
    Blobel, G. and Dobberstein, B. (1975). J. Cell Biol, 67, 835.PubMedCrossRefGoogle Scholar
  5. 5.
    Quinn, P. S., Gamble, M. and Judah, J D. (1975). Biochem. J, 146, 389.PubMedGoogle Scholar
  6. 6.
    Urban, J., Chelladurai, M., Milleship, A. and Schreiber, G. (. 1976 ). Eur. J. Biochem, 67, 477.PubMedCrossRefGoogle Scholar
  7. 7.
    Strauss, A. W., Donohue, A. M., Bennett, C. D., Rodkey, J. A. and Alberts, A. W. (1977). Proc. Natl Acad. Sci. U.S.A, 74, 1358.PubMedCrossRefGoogle Scholar
  8. 8: Strauss, A. W., Bennett, C. D., Donohue, A. M., Rodkey, J. A. and Alberts, A. W. (1977). J. Biol. Chem., 252, 6846Google Scholar
  9. 9.
    Walter, P., Ibrahimi, I. and Blobel, G. (1981). J.Cell Biol, 91, 545.PubMedCrossRefGoogle Scholar
  10. 10.
    Yap, S. H., Strair, R. K. and Shafritz, D. A. (1978). Biochem. Biophys. Res. Commun, 83, 427PubMedCrossRefGoogle Scholar
  11. 11.
    Shafritz, S. H., Yap, S. H. and Strair, R. K. (1979). Molec. Biol. Rep, 5, 71CrossRefGoogle Scholar
  12. 12.
    Rothman, J. E. (1981). Science, N. Y, 213, 1212 (1981).CrossRefGoogle Scholar
  13. 13.
    Rothschild, M. A., Schreiber, S. S., Oratz, M. and McGee, H. L. (195 8). J. Clin. Invest., 37, 1229Google Scholar
  14. 14.
    Tata, J. R. and Widnell, C. C. (1966). Biochem. J., 98, 604Google Scholar
  15. 15.
    Kernoff, L. M., Primstone, B. L., Solomon, J. and Brock, J. F. (1971). Biochem. J, 124, 529.PubMedGoogle Scholar
  16. 16.
    Tolman, E. L., Schworer, C. M. and Jefferson, L. S. (1973). J. Biol. Chem, 248, 4552.PubMedGoogle Scholar
  17. 17.
    Jefferson, L. S., Schworer, C. M. and Tolman, E. L. (1975.). J. Biol. Chem., 250,197.Google Scholar
  18. 18.
    Peavy, D. E., Taylor, J. M. and Jefferson, L. S. (1978). Proc. Natl Acad. Sci. U.S.A, 75, 5879.PubMedCrossRefGoogle Scholar
  19. 19.
    Keller, G. H. and Taylor, J. M. (1979). J. Biol. Chem, 254, 276.PubMedGoogle Scholar
  20. 20.
    Peavy, D. E., Taylor, J. M. and Jefferson, L. S. (1981). Biochem. J, 198, 289.PubMedGoogle Scholar
  21. 21.
    Oratz, M., Rothschild, M. A. and Schreiber, S. S. (1977). In Albumin Structure, Function and Uses(V. M. Rosenoer, M. Oratz and M. A. Rothschild; Eds.), Pergamon Press, New York, p. 275.Google Scholar
  22. 22.
    Cohen, S. and Hansen, J. D. L. (1-962). Clin. Sci., 23,3 51.Google Scholar
  23. 23.
    Rothschild, M. A., Oratz, M., Mongelli, J. and Schreiber, S. S. (1968). J. Clin. Invest, 47, 2591.PubMedCrossRefGoogle Scholar
  24. 24.
    Enwonwu, C. O. and Munro, H. N. (1970). Arch. Biochem, Biophys., 1;38, 532.Google Scholar
  25. 25.
    Rothschild, M. A., Oratz, M., Mongelli, J., Fishman, L. and Schreiber, S. S. (1969). J. Nutr, 98, 395.PubMedGoogle Scholar
  26. 26.
    Sidransky, H., Sarma, D. S. R., Bongiorno, M. and Verney, E. (1968). J. Biol. Chem, 243, 1123.PubMedGoogle Scholar
  27. 27.
    Staehelin, T., Verney, E. and Sidransky., H. (1967). Biochem. Biophys. Acta, 145, 105.PubMedGoogle Scholar
  28. 28.
    Baliga, B. S., Pronczuk, A. W and Munro, H. N. (1968). J. Molec. Biol, 34, 199.PubMedCrossRefGoogle Scholar
  29. 29.
    Post, J. and Patek, A J. (1942). Arch. Int. Med, 69, 67.Google Scholar
  30. 30.
    Levin, A. S. and Jeffay, H. (1964). J. Lab. Clin Med, 63, 776.PubMedGoogle Scholar
  31. 31.
    Rothschild, M. A., Oratz, M., Zimmon, D., Schreiber, S. S., Weiner, I. and Van Caneghen, A. (1969). J. Clin. Invest, 48, 344.PubMedCrossRefGoogle Scholar
  32. 32.
    Reeve, E. B., Pearson, J. B. and Martz, D. C. (1963). Science, N. Y, 139, 914.CrossRefGoogle Scholar
  33. 33.
    McFarlane, A. S. (1963). Biochem. J, 89, 277.PubMedGoogle Scholar
  34. 34.
    Rothschild, M. A., Oratz, M. and Schreiber, S. S. (1974). Gastroenterology, 67, 1200.PubMedGoogle Scholar
  35. 35.
    Oratz; M., Rothschild, M. A. and Schreiber, S. S. (1978). Gastroenterology, 74)672.Google Scholar
  36. 36.
    Peters, T. (1977). In Albumin Structure, Function and Uses(V. Rosenoer, M. Oratz and M. A. Rothschild, Eds.), Pergamon Press, New York, p. 305.Google Scholar
  37. 37.
    Redman, C. M., Banerjee, D., Manning, C., Huang, C. Y. and Green, K. (1978). J. Cell Biol, 77, 400.PubMedCrossRefGoogle Scholar
  38. 38.
    Baraona, E., Leo, M. A., Borowsky, S.. and Lieber, C. S. (1977). J. Clin. Invest, 60, 546.PubMedCrossRefGoogle Scholar
  39. 39.
    Sorrell, M. F. and Tuma, D. J. (1978). Gastroenterology, 75, 200.PubMedGoogle Scholar
  40. 40.
    Algranati, 1. D. and Sabatini, D. D. (1979). Biochem. Biophys. Res. Commun, 90, 220.CrossRefGoogle Scholar
  41. 41.
    Brennan, S. O. and Carrell, R. W (1978). Nature, Lond., 274, 908.CrossRefGoogle Scholar
  42. 42.
    Rothschild, M. A., Kreek, M. J., Oratz, M., Schreiber, S. S. and Mongelli, J. G. (1976). Gastroenterology, 71, 214Google Scholar
  43. 43.
    Morland, J., Rothschild, M. A., Oratz, M., Mongelli, J., Donor, D. and Schreiber, S. S. (. 1981 ). Gastroenterology, 80, 159.PubMedGoogle Scholar
  44. 44.
    Baraona, E., Pikkarainen, P., Salispuro, M., Finkelman, F. and Lieber, C. S. (1980). Gastroenterology, 79, 104.PubMedGoogle Scholar
  45. 45.
    Tabor, C. W. and Tabor, H. A. (1976). Ann. Rev. Biochem, 45, 285.PubMedCrossRefGoogle Scholar
  46. 46.
    Poso, L., Poso, H. and Raina, A. (1978). Biochem. Biophys. Acta, 473, 241.PubMedGoogle Scholar
  47. 47.
    Khawaja, J. A. (1971). Biochem. Biophys. Acta, 254, 117.PubMedGoogle Scholar
  48. 48.
    Oratz, M., Rothschild, M. A. and Schreiber, S S. (1976). Gastroenterology, 71,123Google Scholar
  49. 49.
    Oratz, M., Rothschild, M. A:.,. Schreiber, S. S. and Lane, B. P. (1980). Gastroenterology, 77, 1165.Google Scholar
  50. 50.
    Metcalf, B. W., Bey, P., Danzin, C., Jung, M. S., Casara, P. and Vervet, J. P.-(1978). J. Am. Chem. Soc, 100, 2551.Google Scholar
  51. 51.
    Adelman, M. R., Sabatini, D. C. and Blobel, G. (1973). J. Cell Biol, 56, 206.PubMedCrossRefGoogle Scholar
  52. 52.
    Harrison, T. M., Brownlee, G.. and Milstein, C. (1974). Eur. J. Biochem, 47, 613.PubMedCrossRefGoogle Scholar

Copyright information

© The Contributors 1984

Authors and Affiliations

  • M. A. Rothschild
  • M. Oratz
  • S. S. Schreiber

There are no affiliations available

Personalised recommendations