Abstract
In a population study of leukocytes from 140 human subjects, far UV-induced unscheduled DNA synthesis (UDS) variation correlated with at least three demographic factors — smoking tobacco, season of sample obtainment and “street opiate” addiction. The ability to correlate UDS variability with these factors demonstrates the importance of environmental influences in control of DNA repair processes and the need to include the effect of demographics in genetic risk assessment models. In addition, mutagen-induced UDS patterns for mononuclear leukocytes from a single subject did not match the UDS pattern for fibroblasts grown from a forearm skin biopsy from the same individual which suggests that UDS may be tissue specific.
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J. J. Madden, A. Falek, D. A. Shafer, and J. H. Glick, Effects of opiates and demographic factors on DNA repair synthesis in human leukocytes, Proc. Natl. Acad. Sci., U.S.A., 76:5769–5773 (1979).
B. Lambert, U. Ringborg, and L. Skoog, Age-related decrease in UV light-induced DNA repair synthesis in human peripheral leukocytes, Cancer Res., 39:2792–2795 (1979).
B. Lambert, K. Hansson, T. H. Bui, F. Funes-Cravioto, J. Lindsten, M. Holmberg, and R. Strausmanis, DNA repair and frequency of x-ray and UV-induced chromosome aberrations in leukocytes from patients with Down’s Syndrome, Ann. Hum. Genet., London, 39:293–303 (1976).
M. Frey-Wettstein, R. Longmire, and C. G. Craddock, Deoxyribonucleic acid (DNA) repair replication of ultraviolet (UV) irradiated normal and leukemic leukocytes, J. Lab. Clin. Med., 74:109–118 (1972).
F. H. Yew and R. T. Johnson, Human B and T lymphocytes differ in UV-induced repair capacity, Exp. Cell Res., 113:227–231 (1978).
F.-H. Yew and R. T. Johnson, Ultraviolet-induced DNA excision repair in human B and T lymphocytes. III. Repair in lymphocytes from chronic lymphocytic leukaemia, J. Cell Sci., 39:329–337 (1979).
R. W. Pero and H. 0. Sjogren, The influence of monocyte (adherent cell) content in human mononuclear blood cell populations on the estimation of individual levels of N-acetoxy-2-acetylaminofluorene induced unscheduled DNA synthesis, Carcinogenesis, 3:39–43 (1982).
T. J. Lampidis and J. B. Little, Enhancement of UV-induced unscheduled DNA synthesis by hydroxyurea, Exp. Cell Res., 110:41–46 (1977).
R. W. Pero and C. Vopat, A human platelet-derived inhibitor of unscheduled DNA synthesis in resting lymphocytes, Carcinogenesis, 2:1103–10 (1981).
A. R. S. Collins, S. L. Schor, and R. T. Johnson, The inhibition of repair in UV irradiated human cells, Mutat. Res., 42:413–432 (1977).
K. Erixon and G. Ahnstrom, Single strand breaks in DNA during repair of UV-induced damage in normal human and xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatography. Effects of hydroxyurea, 5-fluoro-deoxyuridine and 1-3-D-arabinofuranosylcytosine on the kinetics of repair, Mutat. Res., 59:257–271 (1979).
R. W. Pero and C. Ostlund, Direct comparison, in human resting lymphocytes, of the interindividual variations in U.D.S. induced by N-acetoxy-2-acetylaminofluorene and UV irradiation, Mutat. Res., 73:349–61 (1980).
N. Prashad and R. Cutler, Percent satellite DNA as a function of tissue and age of mice, Biochem. Biophys. Act., 418:1–23 (1976).
K. W. Giles and A. Myers, An improved diphenylamine method for the estimation of DNA, Nature, 4979:93 (1965).
R. W. Pero and F. Mitelman, Another approach to in vivo estimation of genetic damage in humans, Proc. Natl. Acad. Sci., U.S.A., 76:462–3 (1979).
B. Paigen, E. Ward, A. Reilly, L. Horton, H. L. Gurtoo, J. Minowada, K. Steenland, M. B. Havens, and P. Sartori, Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes, Cancer Res., 41:2757–2761 (1981).
E. W. Van Carter, E. Virasoro, R. Le Clercq, and G. Copinschi, Seasonal, circadian, and episodic variations of human immunereactive β-MSH, ACTH, and Cortisol, Int. J. Pept. Protein Res., 17:3–13 (1981).
P. B. Curtis-Prior, Seasonal variation in the responses of adipose tissue to a serum fat-mobilizing factor may be explained in terms of reduced availability of fat cell receptors, Horm. Metab. Res., 13:686–688 (1981).
E. E. Codd and W. L. Byrne, Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists, Life Sci., 28:2577–2583 (1981).
R. J. McDonough, J. J. Madden, A. Falek, D. A. Shafer, M. Pline, D. Gordon, P. Bokos, J. C. Kuehnle, and J. Mendelson, Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts:in vivo evidence for opiate receptor sites on T lymphocytes, J. Immunol., 125:2539–2543 (1980).
A. Melander, E. Nordenskjold, B. Lundh, J. Thorell, Influence of smoking on thyroid activity, Acata Med. Scan., 209 (1–2):41–43 (1981).
A. Beaumont and J. Hughes, Biology of opioid peptides, Ann. Ref. Pharmacol. Toxicol., 19:245–267 (1979).
N. A. Berger, G. W. Sikorski, S. J. Petzold, and K. K. Kurohara, Defective poly (adenosine diphosphoribose) synthesis in xeroderma pigmentosum, Biochem., 19:289–293 (1980).
H. Juarez-Salinas, J. L. Sims, and M. K. Jacobson, Poly(ADP-ribose) levels in carcinogen-treated cells, Nature, 282:740–1 (1979).
B. W. Durkacz, O. Omidiji, D. A. Gray, and S. Shall, (ADP- ribose)n participates in DNA excision repair, Nature, 283:593– 596 (1980).
J. D. Roberts and M. W. Lieberman, Deoxyribonucleic acid repair synthesis in permeable human fibroblasts exposed to ultraviolet radiation and N-acetoxy-2-(acetylamino) florene, Biochem., 18:4499–4505 (1979).
P. P. W. Van Buul, Absence of correlation between the chromosomal radiosensitivity of peripheral blood lymphocytes and stem-cell spermatogonia in mammals, Mutat. Res., 95:69–77 (1982).
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© 1985 Plenum Press, New York
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Madden, J.J. et al. (1985). Influence of Demographic Factors on Scheduled DNA Synthesis as Measured in Human Peripheral Leukocytes and Fibroblasts. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_23
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DOI: https://doi.org/10.1007/978-1-4613-2765-3_23
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