Abstract
The evidence is strong now that metabolic parameters and DNA repair competence are probably the most important factors determining cancer incidence. It has been estimated that most human cancers are caused from exposures to genotoxic agents in our environment [1]. Furthermore, most environmental mutagens are not active as DNA damaging agents until they have been metabolized by the mixed function oxygenases (MFO). The MFO system are inducible enzymes [2] and this form of altered metabolism may relate to high affinity absorption of xenobiotics [3]. Clearly, any effective human assay system for assessing risk from hazardous environmental exposures must take into account the cellular mechanisms governing uptake, transport, activation and degradation of potentially genotoxic agents.
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© 1984 Plenum Press, New York
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Pero, R.W. (1984). Unscheduled DNA Synthesis Induced by N-Acetoxy-2-Acetylaminoflourine as an Indicator of Risk from Genotoxic Exposures. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_21
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DOI: https://doi.org/10.1007/978-1-4613-2765-3_21
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