Abstract
The most difficult wound to treat is one characterized by the presence of infection, devitalized tissue, and foreign-body contaminants. In efforts to improve methods of treating these wounds and to prevent infection, antibiotics microencapsulated in poly(DL-lactide-co-glycolide) (DL-PLG) have been formulated to release drug at a controlled rate over an extended period. The microcapsules are applied topically to open contaminated wounds so that the antibiotics are released from multiple sites within the tissue where they are concentrated in the area of need.
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© 1984 Springer-Verlag US
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Setterstrom, J.A., Tice, T.R., Myers, W.E. (1984). Development of Encapsulated Antibiotics for Topical Administration to Wounds. In: Anderson, J.M., Kim, S.W. (eds) Recent Advances in Drug Delivery Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2745-5_12
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DOI: https://doi.org/10.1007/978-1-4613-2745-5_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9700-0
Online ISBN: 978-1-4613-2745-5
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