Abstract
Chagas’ disease is caused by infection with Trypanosoma cruzi, a flagellate parasite discovered in Brazil by Carlos Chagas (1909), who described (1911) the clinical, pathological and epidemiological features of the disease that was to bear his name. The T. cruzi life cycle is a complex one, with several stages of development in vertebrate and invertebrate hosts. In the vertebrates, T. cruzi undergoes intracellular multiplication (amastigote). The emerging nonmultiply- ing trypomastigotes are found in the bloodstream of the infected vertebrates. In the invertebrate (insect) host, the life of T. cruzi is characterized by mor-phological transformations that take place along the digestive tract. Different strains of T. cruzi show differences in morphology during their life cycles (Brener, 1971). The most usual mode of transmission is by means of the invertebrate (hematophagus) intermediary host (Hoare, 1972). After feeding on the infected vertebrates, bloodstream trypomastigotes differentiate in the digestive tracts of the Triatoma bugs. Metacyclic forms of the parasite, eliminated in the insect feces, are considered responsible for infection in the vertebrate host (Zeledon, 1977).
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References
Abrahamsohn, I. A., and Dias Da Silva, W., 1977, Antibody-dependent cell mediated cytotoxicity against Trypanosoma cruzi, J. Parasitol. 60: 1037–1038.
Abrahamsohn, I. A., Blotta, M. H. S. L., and Curotto, M. A., 1981, Enhancement of delayed type hypersensitivity to Trypanosoma cruzi in mice treated with mycobacterium bovis B.C.G. and cyclophosphamide, Infect. Immun. 31: 1145–1151.
Afchain, D., Fruit, J., Yarzabal, L., and Capron, A., 1978, Purification of a specific antigen of Trypanosoma cruzi for culture forms, Am. J. Trop. Med. Hyg. 27: 478–482.
Afchain, D., Le Ray, D., Fruit, J., and Capron, A., 1979, Antigenic make-up of Trypanosoma cruzi culture forma: Identification of a specific component, J. Parasitol. 65: 507–514.
Albright, J. W., and Albright, J. F., 1981, Inhibition of murine humoral immune response by substances derived from trypanosomes. J. Immunol. 126: 300–303.
Alcantara, F. G., 1961, Sistema neurovegetative do coracao na molestia de Chagas experimental, Rev. Goiana Med. 7: 111–115.
Alcantara, H., and Brener, Z., 1978, The in vitro interaction of Trypanosoma cruzi blood stream forms and mouse peritoneal macrophages, Acta Trop. 35: 209–219.
Amato-Neto, V., Magaldi, C., and Pessoa, S. B., 1964, Intradermorreacao para o diagnostico da doenca de Chagas’ con antigeno de Trypanosoma cruzi obtenido de cultura de tecido, Rev. GioanaMed. 10: 121–126.
Amorin, D. S., Mango, J. C., Gallo, L., and Neto J. A. M., 1979, Forma crónica cardiaca, in: Trypanosoma cruzi e doenca de Chagas ( Z. Brener and Z. A. Andrade eds.), R. Guana Bara Koogan, Rio de Janeiro.
Aune, T. M., and Pierce, C. W., 1981, Monoclonal soluble immune response suppressor derived from T cell hybridomas, in: Monoclonal Antibodies and T Cell Hybridomas ( G. J. Nammerling and J. Kearney, eds.), Elsevier, New York, pp. 516–530.
Aune, T. M., and Pierce C. W., 1982, Activation of a suppressor T cell pathway by interferon, Proc. Nat. Acad. Sei. U.S.A. 79: 3808–3812.
Badinez, O. S., 1945, Contribución a la anatomía patológica de la enfermedad de Chagas, Biología 3: 3–52.
Barreto, M. P., 1979, Trypanosoma cruzi e doenca de Chagas, in: Epidemiología (Z. Brener and Z. Andrade, eds.), Editora Guanabara, Rio de Janeiro, Brazil.
Behbehani, M. K., 1971, Trypanosoma (Schizotrypanum) cruzi infections in x-irradiated and in thymectomized mice, Trans. Roy. Soc. Trop. Med. Hyg. 65: 265.
Bittencourt, A. L., 1976, Congenital Chagas’ disease, Am. J. Dis. Child. 130: 97–103.
Brener, Z., 1971, Life cycle of Trypanosoma cruzi, Rev. Inst. Med. Trop. Sao Paulo 13: 171–178.
Brener, Z., 1973, Biology of Trypanosoma cruzi, Annu. Rev. Microbiol. 27: 347–383.
Brener, Z., 1980, Immunity to Trypanosoma cruzi. Adv. Parasitol. 18: 247–298.
Brener, A., and Cardozo, J. E., 1976, Nonspecific resistance against Trypanosoma cruzi enhanced by Corynebacterium parvum, J. Parasitol. 62: 645–646.
Brener, Z., and Chiari, E., 1971, The effects of some immunosuppressive agents in experimental Chagas’ disease, Trans. Roy. Soc. Trop. Med. Hyg. 65: 629–636.
Budzko, D. B., Pizzimenti, M. C., and Kierszenbaum, F., 1975, Effects of complement depletion in experimental Chagas’ disease: Immunoanalysis of virulent blood forms of Trypanosoma cruzi, Infect. Immun. 11: 86–91.
Burgess, D. E., and Hanson, W., 1979, Adoptive transfer of protection against Trypanosoma cruzi with lymphocytes and macrophages, Infect. Immun. 25: 838–843.
Burgess, D. E., and Hanson, W. L., 1980, Trypanosoma cruzi: The T-cell dependence of the primary immune response and the effects of depletion of T cells and Ig-bearing cells on immunological memory, Cell. Immunol. 52: 176–186.
Castro, A. C. L., and Ribeiro Dos Santos, R., 1977, Immunopatologia do rim na forma cronica da molestia de Chagas experimental. Rev. Goiana Med. 23: 1–13.
Cerisola, J. A., 1970, Immunodiagnosis of Chagas’ disease: Hemagglutination and immunofluorescence test, J. Parasitol. 56: 409–410.
Chagas, C., 1909, Neve Trypanosomen, Arch. Schiff Tropenhyg. 13: 120–122.
Chagas, C., 1911, Nova entidade morbida do homen resumo feral do Estudos etiologicos e clinicos, Memorias do Instituto Oswaldo do Cruz 3: 219–275.
Clayton, C. E., Sacks, D. L., Ogilvie, B. M., and Askonas, B. A., 1979, Membrane fractions of trypanosomas mimic the immunosuppressive and mitogenic effects of living parasites on the host, Parasitol. Immunol. 1: 241–249.
Clinton, B. A., Ortiz-Ortiz, L., Garcia, W., Martinez, T., and Capin, R., 1975, Trypanosoma cruzi: Early immune response in infected mice, Exp. Parasitol. 37: 417–425.
Corsini, A. C., Costa, M. G., Oliveira, O. L. P., Camargo, I. I. B., and Rangel, H. A., 1980, A fraction (F.A. d.) from Trypanosoma cruzi epimastigotes depresses the immunoresponse in mice, Immunology 40: 505–511.
Cossio, P. M., Diaz, C., Szarfman, A., Krentzen, E., Candiolo, B., and Arana, R. M., 1974, Chagasic cardiopathy, demonstration of a serum gamma globulin factor which reacts with endocardium in vascular structures, Circulation 49: 13–21.
Cross, G. A. M., Holder, A. A., Gleen, G., and Boothroyd, J. C., 1980, An introduction to antigenic variation in trypanosomes, Am. J. Trop. Med. Hyg. 29: 1027–1032.
Culbertson, J. T., and Kessler, W. R., 1941, Age resistance of mice to Trypanosoma cruzi, J. Parasitol. 28: 155–158.
Cunningham, D. S., and Kuhn, R. E., 1980a, Trypanosoma cruzi induced suppressor substance: I. Cellular involvement and partial characterization, J. Immunol. 124: 2122–2129.
Cunningham, D. S., and Kuhn, R. E., 1980b, Trypanosoma cruzi induced suppressor substance: II. Regulatory activity, Immunogenetics 10: 557–571.
Cunningham, D. S., Kuhn, R. E., and Rowland, E. C., 1978, Suppression of humoral response during Trypanosoma cruzi infections in mice, Infect. Immun. 22: 155–160.
Dennert, G., 1976, Thymus derived killer cells: Specificity of function and antigen recognition. Transplant. Rev. 29: 59–124.
Dias, E., 1944, Nao receptividade do pombo domestico a infeccao por Schiotrypanum, Memorias do Instituto Oswaldo Cruz 40: 191–193.
Doherty, P. C., Zinkernagel, R. M., and Ramshaw, I. A., 1974, Specificity and development of cytotoxic thymus–derived lymphocytes in lymphocytic choriomeningitis, J. Immunol. 112: 1548–1552.
Dzbenski, T. H., 1974, Exoantigens of Trypanosoma cruzi in vivo, Tropenmed. Parasitol. 25: 485–491.
Fayer, R., and Baron, S., 1971, Activity of interferon and inducer against development of Eimeri tenella, J. Protozool. 18: 12–17.
Goble, F. C., 1970, South American trypanosomisis, in: Immunity to Parasitic Animals ( G. J. Jackson, R. Herman, and I. Singer, eds.), Appleton-Century-Crofts, New York, pp. 597–689.
Goble, F. C., and Boyd, J. L., 1962, Reticuloendothelial blockade in experimental Chagas’ disease, J. Parasitol. 48: 223–228.
González-Cappa, S. M., Schmunis, G. A., Traversa, O. C., Yousky, J. F., and Parodi, A. S., 1968, Complement fixation tests, skin tests and experimental immunization with antigens of Trypanosoma cruzi prepared under pressure, Am. J. Trop. Med. Hyg. 17: 709–715.
Gottlieb, M., 1977, A carbohydrate-containing antigen from Trypanosoma cruzi and its detection in the Circulation of infected mice, J. Immunol. 119: 465–470.
Gottlieb, M., 1978, Trypanosoma cruzi: Identification of a cell surface polysaccharide, Exp. Parasitol. 45: 183–189.
Gray, A. R., and Luckins, A. G., 1976, Antigenic variation in salivarían trypanosomes, in: Biology of the Kinetoplastida ( W. A. R. Lumsden and D. A. Evans, eds.), Academic Press, London, pp. 493–542.
Greenwood, B. M., 1974, Immunosuppression in malaria and trypanosomiasis, in: Parasites in the Immunized Host: Mechanisms of Survival, Ciba Foundation Symposium (new series) 25.
Guerreiro, C., and Machado, A., 1913, Da reacao de Bordet e Gengouna molestia de Carlos Chagas como elemento de diagnostico, Brasil Medico 27: 225–226.
Hanson, W. L., 1977, Immune response and mechanisms of resistance in Trypanosoma cruzi, Pan Am. Health Org. Sei. Pub. 347: 22–34.
Hanson, W. L., Devli, R. F., and Robertson, E. L., 1974, Immunoglobulin levels in a laboratory acquired case of human Chagas’ disease, J. Parasitol. 60: 532–533.
Hatcher, F. M., and Kuhn, R. E., 1982, Destruction of Trypanosoma cruzi by natural killer cells, Science 218: 295–296.
Hauschka, T. S., 1947, Sex of host as a factor in Chagas’ disease, J. Parasitol. 33: 339–404.
Herberman, R. B., and Holden, T. H., 1978, Natural cell-mediated immunity, in: Advances in Cancer Research, Vol. 27 ( G. Klein and S. Weinhouse, eds.), Academic Press, New York, pp. 305–377.
Herberman, R. B., Timonen, T., Reynolds, C., and Ortaldo, J. R., 1980, in: Natural Cell-Mediated Immunity against Tumors (R. B. Herberman, ed.), Academic Press, New York.
Hoare, G. A., 1972, The Trypanosomes of Mammals: A Zoological Monograph, Blackwell Scientific Publications, Oxford, England.
Hoff, B., 1975, Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG and absence of cross-immunity on challenge in vivo, J. Exp. Med. 142: 299–311.
Jachiel, R. I., Nussenzweigh, R., Vilcek, J., and Vanderberg, J., 1968, Protective effect of interferon inducers on Plasmodium berghei malaria, Am. J. Trop. Med. Hyg. 18: 823–835.
Kagan, I. G., 1974, Advances in the immunodiagnosis of parasitic infections, Z. Parasitenkd. 45: 163–195.
Khoury, E. L., Ritacco, V., Cossio, P. M., Laguens, R. P., Szarfman, A., Dez, C., and Arana, R. M., 1979, Circulating antibodies to peripheral nerve in American trypanosomiasis (Chagas’ disease), Clin. Exp. Immunol. 36: 8–15.
Kierszenbaum, F., 1976, Cross-reactivity of lytic antibodies against blood forms of Trypanosoma cruzi, J. Parasitol. 62: 134–135.
Kierszenbaum, F., 1979, Antibody-dependent killing of blood stream forms of Trypanosoma cruzi by human blood leukocytes, Am. J. Trop. Med. Hyg. 28: 968–973.
Kierszenbaum, F., 1980, Protection of congenitally athymic mice against Trypanosoma cruzi infection by passive antibody transfer, J. Parasitol. 66: 673–675.
Kierszenbaum, F., and Ferraresi, R. W., 1979, Enhancement of host resistance against Trypanosoma cruzi infection by the immunoregulatory agent muramyl dipeptide. Infect. Immun. 25: 273–278.
Kierszenbaum, F., and Hayes, M. M., 1980, Evaluation of lymphocyte responsiveness to polyclonal activators during acute and chronic experimental Trypanosoma cruzi infection, Am. J. Trop. Med. Hyg. 29: 708–710.
Kierszenbaum, F., and Howard, J. G., 1976, Mechanisms of resistance against experimental Trypanosoma cruzi infection: The importance of antibodies and antibody forming capacity in the Biozzi high and low response mice, J. Immunol. 116: 1208–1211.
Kierszenbaum, F., and Pienkowski, M. M. 1979, Thymus-dependent control to the host defense mechanism against Trypanosoma cruzi infection, Infect. Immun. 24: 117–120.
Kierszenbaum, F., and Sonnenfeld, G., 1982, Characterization of the antiviral activity produced during Trypanosoma cruzi infection and protective effects of exogenous interferon against experimental Chagas’ disease, J. Parasitol. 68: 194–198.
Kierszenbaum, F., Ivann, J., and Budzco, D. B., 1976, Mechanisms of natural resistance to try-panosomal infection: Role of complement in avian resistance to Trypanosoma cruzi infection, Immunology 30: 1–6.
Kumar, R., Worthington, M., Tilles, J. G., and Abelmann, W. A., 1971, Effect of the interferon inducer polynosinic-polycytidylic acid on experimental Trypanosoma cruzi infection, Proc. Soc. Exp. Biol. Med. 137: 884–888.
Koberle, F., 1961, Patología y anatomía patológica de la enfermedad de Chagas, Boletín de la Oficina Sanitaria Panamericana 51: 404–428.
Koberle, F., 1974, Pathogenesis of Chagas’ disease, in: Trypanosomiasis and Leishmaniasis with Special Reference to Chagas’ Disease, Ciba Foundation Symposium (new series) 20.
Koberle, F., and Alcantara, F. G., 1960, Mecanismo da destruiao neuronal do sistema nervoso periférico na moslestia de Chagas, Hospital (Rio de Janeiro) 57: 1057–1062.
Kohl, S., Pickering, L. K., Frankel, L. S., and Yagar, R. G., 1982, Reactivation of Chagas’ disease during therapy of acute lymphocytic leukemia, Cancer 50: 827–828.
Krettli, A. U., and Brener, Z., 1976, Protective effects of specific antibodies in Trypanosoma cruzi infections, J. Immunol. 116: 755–760.
Kuhn, R. E., and Murnane, J. E., 1977, Trypanosoma cruzi: Immune destruction of parasited mouse fibroblasts in vivo, Exp. Parasitol. 41: 66–73.
Lelchuck, R., Dalmasso, A. P., Inglesini, C. L., Alvarez, M., and Cerisola, J. A., 1970, Immunoglobulin studies of patients with American trypanosomiasis (Chagas’ disease), Clin. Exp. Immunol. 6: 547–555.
Lelchuck, R., Patrucco, A., and Manni, J. A., 1974, Studies of cellular immunity in Chagas’ disease: Effect of glutaraldehyde-treated specific antigen on inhibition of leukocyte migration, J. Immunol. 112: 1578–1581.
Lelchuck, R., Cardoni, R. L.\ and Fuks, A. S., 1977, Cell-mediated immunity in Chagas’ disease: Alterations induced by treatment with a trypanocidal drug (nifurtimox), Clin. Exp. Immunol. 110: 959–967.
Liacopapoulos-Briot, M., Biouthillier, Y., Mouton, D., Decreuscfond, C., Lambert, F., Stiffel, C., and Biozzi, G., 1972, Comparison of skin allograft rejection and cytotoxic antibody production in two lines of mice genetically selected for high and low humoral antibody synthesis, Transplantation 14: 590–596.
Luini, W., Boraschi, D., Alberti, S., Aleotti, A., and Tagliaboe, A., 1981, Morphological characterization of a cell population responsible for natural killer activity, Immunology 43: 663–668.
Martínez-Silva, R., López, V. A., and Chiriboga, J., 1970, Effect of poly I-C on the course of infection with Trypanosoma cruzi, Proc. Soc. Exp. Biol. Med. 134: 885–888.
Montufar, O. M. B., Musatti, C. C., Mendes, E., and Mendes, N. F., 1977, Cellular immunity in chronic Chagas’ disease, J. Clin. Microbiol. 5: 401–404.
Mosca, W., and Plaja, J., 1981, Delayed hypersensitivity to heart antigens in Chagas’ disease as measured by in vitro lymphocyte stimulation, J. Clin. Microbiol. 14: 1–5.
Muniz, J., and Freitas, G., 1944, Contribucao para o diagnostico da doenca de Chagas pelas reacoes de imunidade: I. Estudio comparativo entre as recoes de aglutinacao e de fixacao de complemen- to, Memorias do Instituto Oswaldo Cruz 41: 303–333.
Nogeira, N., and Cohn, Z., 1977, Trypanosoma cruzi: Modification of macrophage functions during infection, J. Exp. Med. 146: 157–170.
Nogeira, N., Ellis, J., Chaplan, S., and Cohn, Z., 1980, Trypanosoma cruzi: In vivo and in vitro correlation between T-cell activation and susceptibility in inbred strains of mice. Exp. Parasitol. 51: 325–334.
Nussenzweig, V., Deane, L. M., and Loetzel, J., 1963, Differences in antigenic constitution of strains of Trypanosoma cruzi, Exp. Parasitol. 14: 221–232.
Nussenzweig, V., and Goble, F. C., 1966, Further studies on the antigenic constitution of strains of Trypanosoma (Schizotrypanum) cruzi, Exp. Parasitol. 18: 224–230.
Nussenzweig, V., and Goble, F. C., 1966, Further studies on the antigenic constitution of strains of Trypanosoma (Schizotrypanum) cruzi, Exp. Parasitol. 18: 224–230.
Ogilve, B. M., and Wilson, R. J. M., 1976, Evasion of the immune response by parasites, Br. Med. Bull. 32: 177–184.
Pearson, T. W., Roelands, G. E., Lundin, L. B., and Mayor-Withey, K. S., 1978, Immune depression in Trypanosome-infected mice: I. Depressed T. lymphocyte responses, Eur. J. Immunol. 8: 723–727.
Pecora, I. L., and Barcinski, M. A., 1979, Genetic control of the mechanisms of resistance against experimental Trypanosoma cruzi Infection: I. role of the macrophages in resistance and susceptible strains of mice, Rev. Brasil Biol. 39: 445–450.
Ramos, C., Lomoyi, E., Feoli, M., Rodriguez, M., Perez, M., and Ortiz-Ortiz, L., 1978, Trypanosoma cruzi: Immunosuppressed response to different antigens in the infected mouse, Exp. Parasitol. 45: 190–199.
Ramos, C. I., Schadtler-Siwon, I., and Ortiz-Ortiz, L., 1979, Suppressor cells present in the spleens of Trypanosoma cruzi infected mice, J. Immunol. 122: 1243–1247.
Reed, S. G., Larson, C. L., and Speer, C. A., 1977, Suppression of cell mediated immunity in experimental Chagas’ disease, Z. Parasitend. 52: 11–17.
Reed, S. G., Douglas, T. G., and Speer, C. A., 1982, Surface interactions between macrophages and Trypanosoma cruzi, Am. J. Trop. Med. Hyg. 31: 723–729.
Remington, J. S., and Meringan, T. C., 1968, Interferon: Protection of cells infected with an intracellular protozoan (Toxoplasma gondi). Science 161: 804–806.
Repka, D., Camargo, I. J. B., Santana, E. M., Cunha, W. M., De Souza, O. C., Sakurada, J. K., and Rangel, H. A., 1980, Surface antigenic determinant of epimastigote forms common to trypomastigote and amastigote forms of different strains of Trypanosoma cruzi. Tropenmed. Parasitol. 31: 239–246.
Ribeiro Dos Santos, R., and Hudson, L., 1980a, Trypanosoma cruzi: Immunological consequences of parasite modification of host cells, Clin. Exp. Immunol. 40: 36–42.
Ribeiro Dos Santos, R., and Hudson, L., 1980b, Trypanosoma cruzi: Binding of parasite antigen to mammalian cells in culture. Parasit. Immunol. 2: 1–7.
Ribeiro Dos Santos, R., and Hudson, L., 1981, Denervation and the immune response in mice infected with Trypanosoma cruzi. Clin. Exp. Immunol. 44: 349–354.
Rimaldi, M. T., Olabuenga, S. E., and Bracco, M. M. De E., 1981, Phagocytosis of Trypanosoma cruzi by human polymorphonuclear leukocytes. J. Protozool. 28: 351–354.
Robertson, E. L., Hanson, W. L., and Chapman, W. L., 1973, Trypanosoma cruzi: Effects of antithymocyte serum in mice and neonatal thymectomy in rats, Exp. Parasitol. 34: 168–180.
Rowland, E. C., and Kunn, R. E., 1978, Suppression of anamnestic cellular response during experimental American trypanosomiasis, J. Parasitol. 64: 741–742.
Rytel, M. W., and Marsden, P. D., 1970, Induction of an interferon-like inhibitor by Trypanosoma cruzi infection in mice, Am. J. Trop. Med. Hyg. 19: 929–931.
Sanderson, C. J., and De Souza, W., 1979, A morphological study of the interaction between Trypanosoma cruzi and rat eosinophils, neutrophils and macrophages in vitro, J. Cell. Sci. 37: 275–286.
Sanderson, C. J., Lopez, A. F., and Moreno, M. M. B., 1977, Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigote, Nature 268: 340–341.
Santos-Buch, C. A., and Texeira, A. R. L., 1974, The Immunology of experimental Chagas’ disease: III. Rejection of allogeneic heart cells in vitro, J. Exp. Med. 140: 38–53.
Schmunis, G. A., Gonzalez-Cappra, S. M., Traversa, O. C., and Janousky, J. F., 1971, The effect of immune-depression due to neonatal thymectomy on infections. Trans. Roy. Soc. Trop. Med. Hyg. 68: 338–342.
Schmunis, G. A., Vattuone, H., Szarfman, A., and Pesce, U. J., 1973, Cell mediated immunity in mice inoculated with epimastigote or trypomastigote of Trypanosoma cruzi, Tropenmed. Parasitol. 24: 81–85.
Schmunis, G. A., Baron, S., Gonzalez-Cappa, S., and Weissenbacher, M. C., 1977, El try- panosoma cruzi como inductor de interferon, Medicina 37: 429–430.
Schmunis, G. A., Szarfman, A., Coanasa, L., and Vainstok, C., 1978, Immunoglobulin concentration in treated human acute Chagas’ disease, Ann. J. Trop. Med. Hyg. 27: 473–477.
Seah, S., 1970, Delayed hypersensitivity in Trypanosoma cruzi infection, Nature 225: 1256–1257.
Seah, S., Marsden, P. V., Voller, A., and Pettit, L. E., 1974, Experimental Trypanosoma cruzi infection in rhesus monkeys—the acute phase, Trans. Roy. Soc. Trop. Med. Hyg. 27: 473–477.
Sonnenfeld, G., and Kierszenbaum, F., 1981, Increased serum levels of an interferon–like activity during the acute period of experimental infection with different strains of Trypanosoma cruzi, Am. J. Trop. Med. Hyg. 30: 1189–1191.
Spina-Franca, A., and Mattosinho-Franca, L. C., 1978, American trypanosomiasis (Chagas’ disease), in: Handbook of Clinical Neurology ( P. Virken and J. Bruyn eds.), Elsevier North Holland, Amsterdam.
Splitter, G. A., McGuire, T. C., and Davis, W. C., 1977, The differentiation of bone marrow cells to functional T-lymphocytes following implantation of thymus graft and thymic stroma in nude and AT x BM mice, Cell. Immunol. 34: 93–103.
Szarfman, A., Cossio, P. M., Arana, R. M., Urman, J., Kreutzer, E., Laguens, R. P., Segal, A., and Coarasa, L., 1975, Immunologic and immunopathological studies in congenital Chagas’ disease, Clin. Immunol. Immunopathol. 4: 489–499.
Szarfman, A., Cossio, P. M., Schmunis, G. A., and Arana, R. M., 1977, The EVI antibody in acute Chagas’ disease, J. Parasitol. 63: 149–151.
Tafuri, W. L., 1979, Pathogenesis of Trypanosoma cruzi infections, in: Biology of the Kinetoplastida ( W. H. R. Lumsden and D. A. Evans, eds.), Academic Press, London.
Taliaferro, W. H., and Pizzi, T., 1955, Connective tissue reactions in normal and immunized mice to a reticulotropic strain of Trypanosoma cruzi, J. Infect. Dis. 96: 199–226.
Tanowitz, H. B., Rager-Zisman, B., and Wittner, M., 1980, The effect of silica on resistance to the “Brazil” strain of Trypanosoma cruzi in C57BL/6 (B10) mice, Trans. Roy. Soc. Trop. Med. Hyg. 74: 820–822.
Teixeira, A. R. L., Teixeira, M. L., and Santos-Buch, C. A., 1975, The Immunology of experimental Chagas’ disease: IV. Production of lesions in rabbits similar to those of chronic Chagas’ disease in man, Am. J. Pathol. 80: 163–168.
Teixeira, A. R. L., Teixeira, G., Macedo, V., and Prata, A., 1978, Trypanosoma cruzi-sensitized T- lymphocyte mediated 51Cr release from human heart cells in Chagas’ disease, Am. J. Trop. Med. Hyg. 27: 1097–1108.
Timonen, T., Saksela, E., Ranki, A., and Hayri, P., 1979, Fractionation morphological and functional characterization of effector cells responsible for human natural killer activity against cell– line targets, Cell. Immunol. 48: 133–148.
Trischman, T. M., and Bloom, B. R., 1980, Trypanosoma cruzi: Ability of T-cell-enriched and -depleted lymphocyte populations to passively protect mice, Exp. Parasitol. 49: 225–232.
Trischmann, T., Tanowitz, H., Wittner, M., and Bloom, B., 1978, Trypanosoma cruzi: Role of the immune response in the natural resistance of inbred strains of mice, Exp. Parasitol. 45: 160–168.
Tschudi, E. I., Anziano, D. F., and Dalmasso, A. P., 1972, Lymphocyte transformation in Chagas’ disease, Infect. Immun. 6: 905–908.
Vattuone, N. H., Szarfman, A., and González-Cappa, S. M., 1973, Antibody response and immunoglobulin levels in humans with acute or chronic Trypanosoma cruzi infections (Chagas’ disease), Am. J. Trop. Med. Hyg. 76: 45–47.
Vickerman, K., 1978, Antigenic variation in trypanosomes, Nature 273: 613–617.
Voller, A., Draper, C. C., Bidwell, D. E., and Bartlett, A., 1975, Microplate enzyme-linked immunoabsorbent assay for Chagas’ disease, Lancet 1: 426–428.
Wood, J. N., Hudson, L., Jessell, T. M., and Yamamoto, M., 1982, A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites, Nature 296: 34–37.
Yanofsky, J. F., and Albado, E., 1972, Humoral and cellular responses to Trypanosoma cruzi, Infect. Immunol. 109: 1159–1161.
Zeledon, R., 1977, Epidemiology, modes of transmission and reservoir host of Chagas’ disease, in: Trypanosomiasis and Leishmaniasis with Special Reference to Chagas’ Disease, Vol. 20, Ciba Foundation Associated Scientific Publishers, Basel, pp. 51–62.
Zeledon, N., and Ponce, C., 1974, A skin test for diagnosis of Chagas’ disease, Trans. Roy. Soc. Trop. Med. Hyg. 68: 414–415.
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O’Daly, J.A., Azocar, J. (1984). Immunological Alterations in Chagas’ Disease. In: Chandra, R.K. (eds) Critical Reviews in Tropical Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2723-3_7
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DOI: https://doi.org/10.1007/978-1-4613-2723-3_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9689-8
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