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Emergence of Neuronal and Glial Cell Lineages in Primate Brain

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Cellular and Molecular Biology of Neuronal Development

Abstract

It has become increasingly evident that the interaction between glial and neuronal cells in the developing mammalian brain plays an important role in the migration and compartmentalization of young neurons and, later, in their maintenance and the regulation of their environment. Furthermore, it appears that genetically or environmentally induced disturbances of neuronal—glial interactions during development may lead to structural, biochemical, and functional abnormalities of the brain (e.g., Rakic, 1975a; Caviness and Rakic, 1978; Volpe, 1981). Since the majority of cells in the mammalian brain are of glial lineages, it is safe to say that each neuron is likely to be in direct contact with at least one glial cell, but probably with several glial cells. However, although it is well established that both neuronal and glial cells derive from the neuroepithelium of the primitive neural tube, it has proved difficult to determine the exact timing and cellular mechanisms that lead to divergence of these two cell lines.

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Authors and Affiliations

  1. Section of Neuroanatomy, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Pasko Rakic

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  1. Pasko Rakic
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  1. Cornell University Medical College, New York, New York, USA

    Ira B. Black

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© 1984 Plenum Press, New York

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Rakic, P. (1984). Emergence of Neuronal and Glial Cell Lineages in Primate Brain. In: Black, I.B. (eds) Cellular and Molecular Biology of Neuronal Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2717-2_2

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  • DOI: https://doi.org/10.1007/978-1-4613-2717-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9686-7

  • Online ISBN: 978-1-4613-2717-2

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