Formation of Carbocyclic Compounds
Numerous general methods exist in organic chemistry for the synthesis of cyclic compounds.1 The catalytic hydrogenation of a benzenoid substrate, for example, provides a convenient route to cyclohexane derivatives (Section 7.4). Generally, though, ring synthesis is achieved by intramolecular cyclization of a difunctional substrate. Typical is the synthesis of cycloalkanones, which is readily achieved by a number of methods (Table 3.1). These methods require that two functional groups in the same molecule react together, i.e., intramolecularly rather than intermolecularly; therefore high dilution and small-to-medium ring sizes are preferred.
KeywordsCyclopropane Triphenylphosphine Celite Pyrazolines Dibromide
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