Skip to main content

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrially Important Monomers

  • Chapter
Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Abstract

Owing to their widespread use and occurrence in the environment, and their toxicological hazards, the group vinyl chloride (VCM), vinylidene chloride (VDC), acrylonitrile (ACN), styrene (STY), butadiene (BUT), and chlorobutadiene (CBD) form an important category of industrial chemicals. These so-called monomers are extensively used in the production of homo- and copolymeric materials utilized in the manufacture of many and various products, such as food packaging (VCM, VDC, STY), synthetic textile fibers (ACN, VDC), synthetic rubber goods (CBD, BUT), resins, and elastomers (VCM, VDC, BUT, etc.) and, according to published reports, world annual production varies from 7000 million kg for STY to 300 million kg for chlorobutadiene. All of them are gaseous or volatile and are generally poorly soluble in water.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abreu, M. E., and Ahmed, A. E., 1980, Metabolism of acrylonitrile to cyanide, Drug Met. and Disp. 8: 3762–379.

    Google Scholar 

  • Agakhanyan, A. G., Fridenshtein, A. Y., Allverdyan, A. G., 1973, Immunomorphology of chloroprene toxicosis, Zh. Eksp. Klin. Med.: 13: 3–7.

    CAS  Google Scholar 

  • American Conference of Governmental Industrial Hygienists, 1976, TLVsR, Threshold limit values for chemical substances in workroom air adopted by ACGIH for 1976, Cincinnati, Ohio, p. 30.

    Google Scholar 

  • Andersen, M. E., Jones, R. A. and Jenkins, L., 1978, The acute toxicity of vinyle, oral doses of 1,1 -dichloroethylene in the fasted, male rat: Effect of induction and inhibition of microsomal enzyme activities on mortality, Toxicol. Appl. Pharmacol. 46: 227–234.

    PubMed  CAS  Google Scholar 

  • Andersen, M. E., Gargas, M. L., Jones, R. A. and Jenkins, L. J., 1979a, The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism, Toxicol. Appl. Pharmacol. 47: 395–409.

    PubMed  CAS  Google Scholar 

  • Andersen, M. E., French, J. E., Gargas, M. L., Jones, R. A., and Jenkins, L. J., 1979b, Saturable metabolism and acute toxicity of 1,1-dichloroethylene, Toxicol. Appl. Pharmacol. 47: 385–393.

    PubMed  CAS  Google Scholar 

  • Andersen, M. E., Thomas, O. E., Gargas, M. L., Jones, R. A. and Jenkins, L. J., 1980, The significance of multiple detoxification pathways for reactive metabolites in the toxicity of 1,1-dichloroethylene, Toxicol. Appl. Pharmacol. 52: 422–432.

    PubMed  CAS  Google Scholar 

  • Anderson, D., Hodge, M. C. E. and Purchase, I. F. H., 1977, Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-I mice, Environ. Health Persp. 21: 71–78.

    CAS  Google Scholar 

  • Anderson, D., Hodge, M. C. E. & Purchase, I. F. H., 1976, Vinyl chloride: Dominant lethal studies in male CD-I mice, Mutat. Res. 40: 359–370.

    PubMed  CAS  Google Scholar 

  • Andrews, A. W., Zawistowski, E. S., and Valentine, C. R., 1976, A comparison of the mutagenic properties of vinyl chloride and methyl chloride, Mutat. Res. 40: 273–276.

    PubMed  CAS  Google Scholar 

  • Anonymous, 1980, ACN testing shows tumors at all levels, Food and Drug Packaging, March 20, 1980, 43–44.

    Google Scholar 

  • Antweiler, H., 1976, Studies on the metabolism of vinyl chloride, Environ. Health Perspect. 17: 217–219.

    PubMed  CAS  Google Scholar 

  • Baggett, M. S., Morie, G. P., Simmons, M. W. and Lewis, J. S., 1974, Quantitative determination of semivolatile compounds in cigarette smoke, J. Chromatogr. 97: 79–82.

    PubMed  CAS  Google Scholar 

  • Bakke, O. N., and Sheline, R. R., 1970, Hydroxylation of aromatic hydrocarbons in the rat, Toxicol. Appl. Pharmacol. 16: 691–700.

    PubMed  CAS  Google Scholar 

  • Barbin, A., Bresil, H., Croisy, A., Jacquignon, P., Malaveille, C., Montesano, R., and Bartsch, H., 1975, Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride, Biochem. Biophys. Res. Commun., 67: 596–603.

    PubMed  CAS  Google Scholar 

  • Bardodej, Z., and Bardodejova, E., 1970, Biotransformation of ethylbenzene, styrene, and alpha-methylstyrene in man, Am. Ind. Hyg. Assoc. J. 31: 206–209.

    PubMed  CAS  Google Scholar 

  • Barrio, J. R., Secrist, J. A., and Leonard, N. J., 1972, Fluorescent adenosine and cytidine derivatives, Biochem. Biophys. Res. Commun. 46: 597–604.

    PubMed  CAS  Google Scholar 

  • Bartsch, H., and Montesano, R., 1975, Mutagenic and carcinogenic effects of vinyl chloride, Mutat. Res. 32: 93–114.

    PubMed  CAS  Google Scholar 

  • Bartsch, H., Malaveille, C., Montesano, R., 1975a, Human rat and mouse liver-mediated mutagenicity of vinyl chloride in S. tvphimurium strains, Int..J. Cancer 15: 429–437.

    CAS  Google Scholar 

  • Bartsch, H., Malaveille, C., Montesano, R. and Tomatis, L., 1975b ), Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella tvphimurium, Nature 255: 641–643.

    CAS  Google Scholar 

  • Bartsch, H., Malaveille, C., Barbin, A., Bresil, H., Tomatis, L., and Montesano, R., 1976, Mutagenicity and metabolism of vinyl chloride and related compounds, Environ. Health Perspect. 17: 193–198.

    PubMed  CAS  Google Scholar 

  • Bartsch, H., Malaveille, C., Barbin, A. and Planche, G., 1979, Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono- oxygenases, Arch. Toxicol. 41: 249–277.

    PubMed  CAS  Google Scholar 

  • Basler, A., and Rohrborn, G., 1980, Vinyl chloride: An example for evaluating mutagenic effects in mammals in vivo after exposure to inhalation, Arch. Toxicol. 45: 1–7.

    PubMed  CAS  Google Scholar 

  • Bauer, C., Leporini, C., Bronzetti, G., Corsi, C., Nieri, R., Del Carratore, R., Tonarelli, S., 1980, The problem of negative results for styrene in the in vitro mutagenesis test with metabolic activation, Boll. Soc. It. Biol. Sper. 56: 203–207.

    CAS  Google Scholar 

  • Baxter, P. J., Anthony, P. P., McSween, R. N. M., and Scheuer, P. J., 1977, Angiosarcoma of the liver in Great Britain, 1963–1973. Brit. Med. J.: 919–921.

    Google Scholar 

  • Belvedere, G., Cantoni, L., Tacchinetti, T., and Salmona, M., 1977, Kinetic behaviour of microsomal styrene monooxygenase and styrene epoxide hydratase in different animal species, Experientia 33: 708–709.

    PubMed  CAS  Google Scholar 

  • Biersack, H. J., Sanluis, T. Jr., Lange, C. E., Thelen, M., Veltman, G., Winkler, C., 1977, Scintigraphy of liver and spleen in vinyl chloride workers, Acta Hepato-Gastroenterol. 24: 357–361.

    CAS  Google Scholar 

  • Binns, C. H. B., 1979, Vinyl chloride: a review, J. Soc. Occup. Med. 29: 134–141.

    PubMed  CAS  Google Scholar 

  • Block, J. B., 1974, Angiosarcoma of the liver following vinyl chloride exposure, J. Am. Med. Assoc. 229: 53–54.

    CAS  Google Scholar 

  • Bolt, H. M., Kappus, H., Buchter, A., and Bolt, W., 1976, Disposition of (1,2-14C) vinyl chloride in the rat, Arch. Toxicol., 35: 153–162.

    PubMed  CAS  Google Scholar 

  • Bolt, H. M., and Filser, J. G., 1977, Irreversible binding of chlorinated ethylenes to macromolecules, Environ. Health Perspect. 21: 107–112.

    PubMed  CAS  Google Scholar 

  • Bonatti, S., Abbondandolo, A., Corti, G., Fiorio, R., and Mazzaccaro, A., 1978, The expression curve of mutants induced by styrene oxide at the HGPRT locus in V 79 cells, Mutation Res. 52: 295–300.

    PubMed  CAS  Google Scholar 

  • Border, E. A., and Webster, I., 1977, The effect of vinyl chloride monomer, chloroethylene oxide and chloroacetaldehyde on DNA synthesis in regenerating rat liver, Chem. Biol. Interact. 17: 239–247.

    PubMed  CAS  Google Scholar 

  • Bos, R., Guicherit, R. and Hoogeveen, A., 1977, Distribution of some hydrocarbons in ambient air near Delft and the influence of the formation of secondary air pollutants, Sci. Total Environ. 7: 269–281.

    PubMed  CAS  Google Scholar 

  • Boyland, E., and Williams, K., 1965, An enzyme catalysing the conjugation of epoxides with glutathione, Biochem. J. 94: 190–197.

    PubMed  CAS  Google Scholar 

  • Brady, J, Liberatore, F., Harper, Ph., Greenwald, P., Burnett, W., Davies, J. N. P., Bishop, M., Polan, A., and Vianna, N., 1977, Angiosarcoma of the liver: an epidemiologic study,J Nat’l Cancer Inst. 59: 1383–1385.

    CAS  Google Scholar 

  • Brand, K. G., Buoen, L. C., and Brand, I., 1975, Foreign-body tumorigenesis by vinyl chloride vinyl acetate copolymer: No evidence for chemical cocarcinogenesis, J. Nat’l Cancer Inst. 54: 1259–1262.

    CAS  Google Scholar 

  • Buffler, P. A., Wood, S., Eifler, C., Suarez, L., Kilian, D. J., 1979, Mortality experience of workers in a vinyl chloride monomer production plant, J. Occup. Medicine 21: 195–203.

    CAS  Google Scholar 

  • Busk, L., 1979, Mutagenic effects of styrene and styrene oxide, Mutat. Res. 67: 201–208.

    CAS  Google Scholar 

  • Byrén, D., and Holmberg, B., 1975, Two possible cases of angiosarcoma of the liver in a group of Swedish vinyl chloride-polyvinyl chloride workers, Ann. N. Y. Acad. Sci. 246: 249–250.

    PubMed  Google Scholar 

  • Byrén, D., Engholm, G., Englund, A., and Westerholm, P., 1976, Mortality and cancer morbidity in a group of Swedish VCM and PVC production workers, Environ. Health Perspect. 17: 167–170.

    PubMed  Google Scholar 

  • Cantoni, L., Salmona, M. Facchinetti, T., Pantarotto, C., and Belvedere, G., 1978, Hepatic and extrahepatic formation and hydration of styrene oxide in vitro, in animals of different species and sexes, Tox. Letters 2: 179–186.

    CAS  Google Scholar 

  • Caperos, J. R., Humbert, B. and Droz, P. O., 1979, Exposition au Styrène. II. Bilan de l’absorption, de l’excrétion et du métabolisme sur des sujets humains, Int. Arch. Occup. Environ. Health 42: 223–230.

    PubMed  CAS  Google Scholar 

  • Caputo, A., Viola, P. L., and Bigotti, A., 1974, Oncogenicity of vinyl chloride at low concentrations in rats and rabbits, Int. Res. Commun. 2: 1582.

    CAS  Google Scholar 

  • Chiazze, L., Jr., Nichols, W. E., and Wong, O., 1977, Mortality among employees of PVC fibricators, J. Occup. Med. 19: 623–628.

    PubMed  Google Scholar 

  • Chmielewski, J., and Renke, W., 1976, Clinical and experimental research into the pathogenesis of toxic effect of styrene, Bull. Inst. Mar. Trop. Med. Gdynia 27: 63–68.

    CAS  Google Scholar 

  • Chmielewski, J., and Hac, E., 1976, Clinical and experimental research into the pathogenesis of toxic effects of styrene. IV. Estimation of liver functions in persons exposed to the action of styrene during their work, Bull. Inst. Mar. Trop. Med. Gdynia 27: 69–74.

    CAS  Google Scholar 

  • Chmielewski, J., 1976, Clinical and experimental research into the pathogenesis of toxic effects of styrene. V. Impact of styrene on carbohydrate balance in people in the course of their work, Bull. Inst. Mar. Trop. Med. Gdynia 27: 177–184.

    CAS  Google Scholar 

  • Clarke, C. H., and Loprieno, N., 1965, The influence of genetic background on the induction of methionine reversions by diepoxybutane in Schizosaccharomyces pombe, Microb. Genet. Bull. 22: 11–12.

    Google Scholar 

  • Clary, J. J., Feron, V. J., and Reuzel, P. G. J., 1978, Toxicity of β-chloroprene (2- chlorobutadiene-1,3): Acute and subacute toxicity, Toxicol. Appl. Pharmacol. 46: 375–384.

    PubMed  CAS  Google Scholar 

  • Conner, M. K., Alarie, Y. and Dombroske, R. L., 1979, Sister chromatid exchange in regenerating liver and bone marrow cells of mice exposed to styrene, Toxicol. Appl. Pharmacol. 50: 365–367.

    PubMed  CAS  Google Scholar 

  • Conner, M. K., Alarie, Y., and Dombroske, R. L., 1980, Sister chromatid exchange in murine alveolar macrophages, bone marrow and regenerating liver cells induced by styrene inhalation, Toxicol. Appl. Pharmacol. 55: 37–42.

    PubMed  CAS  Google Scholar 

  • Conolly, R. B., Jaeger, R. J., and Szabo, S., 1978, Acute hepatotoxicity of ethylene, vinyl fluoride, vinyl chloride and vinyl bromide after Aroclor 1254 pretreatment, Exper. Molec. Pathol. 28: 25–33.

    CAS  Google Scholar 

  • Conolly, R. B., and Jaeger, R. J., 1979, Acute hepatotoxicity of vinyl chloride and ethylene: Modification by trichfloropropene oxide, diethylmaleate, and cysteine, Toxicol. Appl. Pharmacol. 50: 523–531.

    PubMed  CAS  Google Scholar 

  • Couderc, P., Panh, M.-H., Pasquier, B., Pasquier, D., N’Golet, A., and Faure, H., 1976, Angiosarcoma of the bone indicating a hepatic tumor in a worker exposed to vinyl chloride (Fr.), Semin. Hop. Paris 52: 1721–1722.

    CAS  Google Scholar 

  • Creech, J. L., Jr., and Johnson, M. N., 1974, Angiosarcoma of liver in the manufacture of polyvinyl chloride, J. occup. Med. 16: 150–151.

    PubMed  Google Scholar 

  • Crouch, C. N., Pullinger, D. H., and Gaunt, J. F., 1979, Inhalation toxicity studies with l,3-butadiene-2. 3 month toxicity study in rats, Am. Ind. Hvg. Assoc. J. 40: 796–802.

    CAS  Google Scholar 

  • Culik, R., Kelly, D. P., and Clary, J. J., 1978, Inhalation studies to evaluate the teratogenic and embryotoxic potential of /3-chloroprene(2-chlorobutadiene-1,3), Toxicol. Appl. Pharmacol. 44: 81–88.

    PubMed  CAS  Google Scholar 

  • Danishefsky, I., and Willhite, M., 1954, The metabolism of styrene in the rat, J. Biol. Chem. 211: 549–553.

    PubMed  CAS  Google Scholar 

  • Delorme, F., and I heriault, G., 1978, Ten cases of angiosarcoma of the liver in Shawinigan, Quebec, J. Occup. Med. 20: 338–340.

    PubMed  CAS  Google Scholar 

  • Delorme, F., 1978, Association d’un angiosarcome du foie et d’un hepatome chez un ouvrier du chlorure de vinyle, Ann. Anat. Pathol. 23: 105–114.

    CAS  Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M., Rondelet, J., and Mercier, M., 1977, Mutagenicity of styrene and styrene oxide, Mutat. Res. 56: 147–152.

    Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M., Mercier, M., 1978a, Mutagenicity of acrylonitrile, Toxicology 11 (1): 19–27.

    PubMed  Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1978b, Etude de Tactivite mutagene du butadiene, de l’acrylonitrile de du styrene. Presented at the National Congres of the Belgian Society for Pharmaceutical Science. Liege, Belgium, March 16-17, Abst., p. 47.

    Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1978c, Impact of microsomal enzymes on the mutagenicity of acrylonitrile, butadiene and styrene. Presented at the Eighth Annual Meeting of the European Environmental Mutagen Society. Dublin, July 11-13, Abst. p. 63.

    Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M.,and Mercier, M., 1978d. Mutagenicity of butadiene and butadiene monoxide, Biochem. Biophys. Res. Commun. 80: 298–305.

    Google Scholar 

  • de Meester, C., Duverger-van Bogaert, M., Lambotte-Vandepaer, M., Roberfroid M., Poncelet, F., Mercier, M., 1979a, Liver extract mediated mutagenicity of acrylonitrile, Toxicology 13 (1): 7–15.

    PubMed  Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1979b, Mutagenic activity of butadiene and related compounds. Presented at the Ninth Annual Meeting of the European Environmental Mutagen Society. Makarska, September 30-0ctober 5, 1979, Abst. p. 94.

    Google Scholar 

  • de Meester, C., Duverger-van Bogaert, M., Lambotte-Vandepar, M., Roberfroid, M., Poncelet, F., and Mercier, M., 1980a, Mutagenicity of vinyl chloride in the Ames test: Possible artifacts related to experimental conditions, Mutat. Res. 77: 175–179.

    PubMed  Google Scholar 

  • de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1980b, The mutagenicity of buradiene towards Salmonella typhimurium. Tox. Letters 6: 125–130.

    Google Scholar 

  • de Meester, C., Duverger-van Bogaert, M., Lombotte-Vandepaer, M., Mercier, M., and Poncelet, F., 1981, Mutagenicity of styrene in the Salmonella typhimurium test system, Mutat. Res., 90: 443–450.

    PubMed  Google Scholar 

  • de Meester, C., Mercier, M., and Poncelet, F., Mutagenic activity of butadiene, hexachlorobutadiene, and isoprene (to be published)

    Google Scholar 

  • de Raat, W. K., 1978, Induction of sister chromatic exchanges by styrene and its presumed metabolite styrene oxide in the presence of rat liver homogenate, Chem.-biol. Interact. 20: 163–170.

    PubMed  Google Scholar 

  • Dinu, V., 1975, Activity of GSH peroxidase and catalase and the concentration of lipid peroxides in acute intoxication with Acrylonitrile, Rev. Roum. Biochim. 12(1): 11–14.

    CAS  Google Scholar 

  • Dinu, V., and Klein, R., 1976, Activite catalasique et concentration de glutathion et d’acide lactique dans l’intoxication aigue par l’acrylonitrile chez le rat, J. Pharmacol. (Paris) 7: 2, 223–226.

    CAS  Google Scholar 

  • Dmitrienko, V. D., and Vasilos, A. F., 1972, Kidney damage during the experimental acute poisoning with hexachlorobutadiene, Zdravookhranenie (Kishinev) 15:11–12. Abstracted in Chem. Abstr. 77, 44061.

    Google Scholar 

  • Dolmierski, R., Kwaiktowski, S. R., and Nitka, J., 1976, Clinical and experimental research into the pathogenesis of toxic effects of styrene: VII. Appraisal of the nervous system in the workers exposed to styrene. Bull. Inst. Mar. Trop. Med. Gdynia 27: 193–196.

    CAS  Google Scholar 

  • Donner, M., Sorsa, M., and Vainio, H., 1979, Recessive lethals induced by styrene and styrene oxide in Drosophila melanogaster. Mutat. Res. 67: 373–376.

    PubMed  CAS  Google Scholar 

  • Drevon, C., and Kuroki, T., 1979, Mutagenicity of vinyl chloride, vinylidene chloride, and chloroprene in V 79 Chinese hamster cells, Mutat. Res. 67: 173–182.

    PubMed  CAS  Google Scholar 

  • Drew, R. T., Harper, C., Gupta, B. N., Talley, F. A., 1975, Effects of vinyl chloride exposures to rats pretreated with phenobarbital. Environ. Health Persp. 11: 235–242.

    CAS  Google Scholar 

  • Drozdowicz, B. Z., and Huang, P. C., 1977, Lack of mutagenicity of vinyl chloride in two strains of Neurospora crassa, Mutat. Res. 48: 43–50.

    PubMed  CAS  Google Scholar 

  • Du, J. T., Sandoz, J. P., Tseng, M. T., and Tamburro, C. H., 1979, Biochemical alterations in livers of rats exposed to vinyl chloride, J. Toxicol. Environm. Health 5: 1119–1132.

    CAS  Google Scholar 

  • Ducatman, A., Hirschhorn, K., and Selikoff, I. J., 1975, Vinyl chloride exposure and human chromsome aberrations, Mutat. Res. 31: 163–168.

    PubMed  CAS  Google Scholar 

  • Duck, B. W., and Carter, J. T., 1976, Vinyl chloride and mortality? Lancet ii:195.

    Google Scholar 

  • Duprat, P., and Gradiski, O., 1978, Percutaneous toxicity of hexachlorobutadiene, Acta Pharmacol. Toxicol. 43: 346–353.

    CAS  Google Scholar 

  • Duverger-van Bogaert, M., Lambotte-Vandepaer, M., Noel, G., Roberfroid, M., and Mercier, M., 1978a, Biochemical effects of acrylonitrile on the rat liver, as influenced by various pretreatments of the animals, Biochem. Biophvs. Res. Commun. 83: 3, 1117–1124.

    CAS  Google Scholar 

  • Duverger-van Bogaert, M., Noel, G., Rollmann, B., Cumps, J., Roberfroid, M., and Mercier, M., 1978b, Determination of oxide synthetase and hydratase activities by a new highly sensitive gas chromatographic method using styrene and styrene oxide as substrates, Biochim. Biophvs. Acta 526: 77–84.

    CAS  Google Scholar 

  • Duverger-van Bogaert, M., Noel, G., Rollmann, B., Cumps, J., Roberfroid, M., and Mercier, M., 1978b, Determination of oxide synthetase and hydratase activities by a new highly sensitive gas chromatographic method using styrene and styrene oxide as substrates, Biochim. Biophvs. Acta 526: 77–84.

    CAS  Google Scholar 

  • Duverger-van Bogaert, M., Lambotte-Vandepaer, M., de Meester, C., Rollmann, b., Poncelet, F., and Mercier, M., 1981b, Effect of several factors on the liver extract mediated mutagenicity of acrylonitrile and identification of four new in vitro metabolites. Tox. Lett. 7: 311–318.

    CAS  Google Scholar 

  • Edmonds, L. D., Anderson, C. E., Flynt, J. W., Jr., and James, L. M., 1978, Congenital central nervous system malformations and vinyl chloride monomer exposure: A community study, Teratology 17: 137–142.

    PubMed  CAS  Google Scholar 

  • El Masri, A. M., Smith, J. N., and Williams, R. T., 1958, Studies in detoxications 73. The metabolism of alkylbenzenes: phenyl acetylene and phenylethylene, Biochem. J. 68: 199–204.

    Google Scholar 

  • Elmore, J. D., Wong, J. L., Laumback, A. D., and Streips, U. N., 1976, Vinyl chloride mutagenicity via the metabolites chlorooxirane and chloroacetaldehyde monomer hydrate, Biochim. Biophvs. Acta 442: 405–419.

    CAS  Google Scholar 

  • Engström, J., Bjurström, R., Astrand, I., and Övrum, B., 1978, Uptake, distribution and elimination of styrene in man, Scand. J. Work. Environ. Health 4: 315–323.

    Google Scholar 

  • Eurocop-Cost, 1976, A comprehensive list of polluting substances which have been identified in various fresh waters, effluent discharges, aquatic animals and plants, and bottom sediments, EUCO/MDU 73 76, XII 476 76. 2nd ed., Luxembourg, Commission of the European Communities, p. 19.

    Google Scholar 

  • Fabry, L., Leonard, A. and Roberfroid, M., 1978, Mutagenicity tests with styrene oxide in mammals, Mutat. Res. 51: 377–381.

    PubMed  CAS  Google Scholar 

  • Falk, H., Creech, J. L., Jr., Heath, C. W., Jr., Johnson, M. N., & Key, M. M., 1974, Hepatic disease among workers at a vinyl chloride polymerization plant, J. Am. Med. Assoc. 230: 59–63.

    CAS  Google Scholar 

  • Fasset, D. W., 1963, Cyanides and nitriles, in Industrial Hygiene and Toxicology (edited by F. A. Patty) 2nd Revised edition, New York, Interscience, Vol. II, pp. 2009 - 2012.

    Google Scholar 

  • Feron, V. J., Kruysse, A., and Til, H. P., 1979a, One-year time sequence inhalation toxicity study of vinyl chloride in rats. I. Growth, mortality, haematology, clinical chemistry and organ weights. Toxicology 13: 25–28.

    PubMed  CAS  Google Scholar 

  • Feron, V. J., Spit, B. J., Immel, H. R., and Kross, R., 1979b, One year time sequence inhalation toxicity study of vinyl chloride in rats. III. Morphological changes in the liver. Toxicology 13: 143–154.

    PubMed  CAS  Google Scholar 

  • Filatova, V. S., and Gronsberg, E. S., 1957, Sanitary-hygienic conditions of work in the production of polychlorvinylic tar and measures of improvement (Russ.) Gig. i Sanit. 22: 38–42.

    CAS  Google Scholar 

  • Fishbein, L., 1979, Potential Industrial Carcinogens and Mutagens, Elsevier, Amsterdam, pp. 165, 178, 189, 193-194, 495.

    Google Scholar 

  • Fleig, L, and Thiess, A. M., 1978, Mutagenicity of vinyl chloride. External chromosome studies on persons with and without illness and on VC exposed animals. J. Occup. Med. 20: 557–560.

    PubMed  CAS  Google Scholar 

  • Fox, A. J., and Collier, P. F., 1976, Low mortality rates in industrial cohort studies due to selection for work and survival in the industry, Br. J. Prev. Soc. Med. 30: 225–230.

    PubMed  CAS  Google Scholar 

  • Fox, A. J., and Collier, P. F., 1977, Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain, Br. J. Ind. Med. 34: 1–10.

    PubMed  CAS  Google Scholar 

  • Fuchs, G., Gawell, B. M., Albanus, L., and Slorach, S., 1975, Vinyl chloride monomer levels in edible fats (Swed.), Var Foeda 27:134–145. Chem. Abstr. 83:14587Og.

    CAS  Google Scholar 

  • Funes-Cravioto, F., Lambert, B., Lindsten, J., Ehrenberg, L., Natarajan, A. L, and Osterman- Golkar, S., 1975, Chromsome aberrations in workers exposed to vinyl chloride, Lancet i:459.

    Google Scholar 

  • Gadzhiev, F. M., and Aliev, T. V., 1974, New method of studying free amino acids and their metabolism in brain tissues under the prolonged effects of gasoline and styrene vapors, Izv. Akad. Nauk. Az. SSR Ser. Biol. Nauk. 4: 112–118.

    Google Scholar 

  • Garro, A. J., Guttenplan, J. B., and Milvy, P., 1976, Vinyl chloride dependent mutagenesis: Effects of liver extracts and free radicals, Mutat. Res. 38: 81–88.

    PubMed  CAS  Google Scholar 

  • Gazzotti, G., Garatti, E., and Salmona, M., 1980, Nuclear metabolism. I. Determination of styrene monooxygenase activity in rat liver nuclei, Chem.-Biol. Interact. 29: 189–195.

    PubMed  CAS  Google Scholar 

  • Gehring, P. J., Watanabe, P. G., and Park, C. N., 1978, Resolution of dose-response toxicity data for chemicals requiring metabolic activation: example—Vinyl chloride, Toxicol. Appl. Pharmacol. 44: 581–591.

    PubMed  CAS  Google Scholar 

  • Glover, S. W., 1956, A comparative study of induced reversions in Escherichia coli, in Genetic studies with bacteria, Carnegie Institution of Washington, Publication GI2, Washington D.C., p. 121–136.

    Google Scholar 

  • Gotell, P., Axelson, O., and Lindelof, B., 1972, Field studies on human styrene exposure, Work Environ. Health 9: 76–83.

    CAS  Google Scholar 

  • Göthe, R., Calleman, C. J., Ehrenberg, L., and Wachtmeister, C. A., 1974, Trapping with 3,4-dichlorobenzenethiol of reactive metabolites formed in vitro from the carcinogen vinyl chloride, Ambio 3: 234–236.

    Google Scholar 

  • Gradiski, D., Duprat, P., Magadur, J. L., Fayein, E., 1975, Etude toxicologique experimental de Thexachlorobutadiène, Eur. J. Toxicol. 8: 180–187.

    CAS  Google Scholar 

  • Green, T., and Hathway, D. E., 1975, The biological fate in rats of vinyl chloride in relation to its oncogenicity, Chem. Biol. Interact. 11: 545–562.

    PubMed  CAS  Google Scholar 

  • Green, T., and Hathway, D. E., 1977, The chemistry and biogenesis of the S-containing metabolites of vinyl chloride in rats, Chem. Biol. Interact. 17: 137–150.

    PubMed  CAS  Google Scholar 

  • Green, T., and Hathway, D. E., 1978, Interactions of vinyl chloride with rat liver DNA in vivo, Chem. Biol. Interact. 22: 211–224.

    PubMed  CAS  Google Scholar 

  • Greim, H., Bonse, G., Radwan, Z., Reichert, D., and Henschler, D., 1975, Mutagenicity w vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation, Biochem. Pharmacol. 24: 2013–2017.

    PubMed  CAS  Google Scholar 

  • Grigorescu, I., and Toba, G., 1966, Chlorura di vino. Aspects de toxicologic industrielle, Rev. Chim. Rom. 17: 499–501.

    CAS  Google Scholar 

  • Gross, H., and Freiberg, J. 1969, Ziir existenz von chloroathylenoxid, J. Prak. Chem. 311: 506–510.

    CAS  Google Scholar 

  • Gudumak, V. S., 1968, The change in activity of the oxidative enzymes in the organs of white rats given hexachlorobutadiene in acute experiments, Zdravookvr (Kishinev) 3:47–50. Abstracted in Ref. Zh. Old. Vyp. Farmakol. Khimioter. Sredstva. Toksikol. 4. 54. 828 (1969).

    Google Scholar 

  • Guengerich, F. P., Grawford, W. M., Watanabe, P. G., Jr., 1979, Activation of vinyl chloride to covalently bound metabolites: Roles of 2-chloroethylene oxide and 2-chloroacetaldehyde, Biochemistry 18: 5177–5182.

    PubMed  CAS  Google Scholar 

  • Guerin, M. R., Olerich, G., and Horton, A. D., 1974, Routine gas chromatographic component profiling of cigarette smoke for the identification of biologically significant constituents, J. Chromatogr. Sci. 12: 385–391.

    PubMed  CAS  Google Scholar 

  • Guillemin, M. P., and Bauer, D., 1979, Human exposure to styrene. Elimination kinetic of urinary mandelic and phenylglyoxylic acids after single experimental exposures, Int. Arch. Occup. Environ. Health 44: 249–263.

    PubMed  CAS  Google Scholar 

  • Gut, I., Nerudova, J., Kopecky, J., and Holecek, V., 1975, Acrylonitrile biotransformation in rats, mice and Chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol or thiosulfate, Arch. Toxico. 33: 151–161.

    CAS  Google Scholar 

  • Gut, I., Kopecky, J., and Filip, J., 1981, Acrylonitrile 14C metabolism in rats: Effect of the route of administration on the elimination of thiocyanate and other radioactive metabolites in urine and faeces, J. Hvg. Epid. Microbiol, and Immunol. 25: 12–16.

    CAS  Google Scholar 

  • Haley, T. J., 1975a, Vinyl chloride: How many unknown problems, J. Toxicol. Environm. Health 1: 47–73.

    CAS  Google Scholar 

  • Haley, T. J., 1975b, Vinylidene chloride: A review of the literature, Clin. Toxicol. 8: 633–643.

    PubMed  CAS  Google Scholar 

  • Haley, T. J., 1978, Chloroprene (2-chloro-l,3-butadiene). What is the evidence for its carcinogenicity? Clin. Toxicol. 13: 153–170.

    PubMed  CAS  Google Scholar 

  • Hansteen, I. L., Hillestad, L., Thiis-Evensen, E., and Heldaas, S. S., 1978, Effects of vinyl chloride in man, a cytogenetic follow up study, Mutat. Res. 51: 271–278.

    PubMed  CAS  Google Scholar 

  • Harleman, J. H., and Seinen, W., 1979, Short-term toxicity and reproduction studies in rats with hexachloro-(l,3)-butadiene, Toxicol. Appl. Pharmacol. 47: 1–14.

    PubMed  CAS  Google Scholar 

  • Härkönen, H., 1978, Styrene: Its experimental and clinical toxicology, Scand. J. Work Environ. Health 4 (2): 104–113.

    PubMed  Google Scholar 

  • Härkönen, H., Lindstrom, H., Sepalainen, A. M., Asp. S., and Hernberg, S., 1978, Exposure relationship between styrene exposure and central nervous functions, Scand. J. Work. Environ. Health 4 (2): 53–59.

    Google Scholar 

  • Hashimoto, K., and Kanai, R., 1965, Studies on the toxicology of acrylonitrile. Metabolism, mode of action and therapy, Ind. Health 3: 30–46.

    CAS  Google Scholar 

  • Hashimoto, K., and Kanai, R., 1972, Effect of acrylonitrile on sulfhydryls and pyruvate metabolism in tissues, Biochem. Pharmacol. 21: 635–640.

    PubMed  Google Scholar 

  • Hathway, D. E., 1977, Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential, Environ. Health Persp. 21: 55–59.

    CAS  Google Scholar 

  • Hawley, G. G., Ed., 1971, The Condensed Chemical Dictionary, 8th ed., Van Nostrand- Reinhold, New York, p. 206.

    Google Scholar 

  • Heath, C. W., Jr., Dumont, C. R., Gamble, J., and Waxweiler, R. J., 1977, Chromosomal damage in men occupationally exposed to vinyl chloride monomer and other chemicals, Environ. Res. 14: 68–72.

    PubMed  CAS  Google Scholar 

  • Hedley, W. H., Cheng, J. T., McCormick, R. J., and Lewis, W. A., 1976, Sampling of automobile interiors for vinyl chloride monomer, EPA-600/2-76-124, Springfield, Va., National Technical Information Service.

    Google Scholar 

  • Hefner, R. E., Jr., Watanabe, P. G., and Gehring, P. J., 1975, Preliminary studies on the fate of inhaled vinyl chloride monomer (VCM) in rats, Environ. Health Perspect. 11: 85–95.

    PubMed  CAS  Google Scholar 

  • Heineman, B., and Howard, A. J., 1964, Induction of lambda-bacteriophage in Escherichia coli as a screening test for potential antitumor agents, Appl. Microbiol. 12: 234–239.

    Google Scholar 

  • Hoffmann, D., Patrianakos, C., Brunnemann, K. D., and Gori, G. B., 1976, Chromatographic determination of vinyl chloride in tobacco smoke, Anal. Chem. 48: 47–50.

    PubMed  CAS  Google Scholar 

  • Holmberg, B., Kronevi, T., and Winell, M., 1976, The pathology of vinyl chloride exposed mice, Acta Vet. Scand. 17: 328–342.

    PubMed  CAS  Google Scholar 

  • Holmberg, P. C., 1977, Central nervous defects in two children of mothers exposed to chemicals in the reinforced plastic industry: Chance or a causal relation? Scand. J. Work Environ. Health 3: 212–214.

    PubMed  CAS  Google Scholar 

  • Hopkins, J., 1980, Vinyl chloride. V. Mutagenicity in man, Food Cosmet. Toxicol. 18: 200–201.

    CAS  Google Scholar 

  • Huberman, E., Bartsch, H., and Sachs, L., 1975, Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde, Int. J. Cancer 16: 639–644.

    PubMed  CAS  Google Scholar 

  • Hushon, J., and Kornreich, M., 1976, Air pollution assessment of vinylidene chloride, Springfield, Va., U.S. National Technical Information Service, PB 256, 738, p. 40.

    Google Scholar 

  • IARC, 1979, IARC monographs on the evaluation of the carcinogenic risk of chemicals to human, 19, some monomers, plastics and synthetic elastomers and acrolein, pp. 73–86; pp. 131–156; pp. 231–244; pp. 377–401; pp. 439–459.

    Google Scholar 

  • Ikeda, M., Ohtsuji, H., and Imamura, I., 1972, In vivo suppression of benzene and styrene oxidation by co-administration of toluene in rats and effects of phenobarbital, Xenobiotica 2: 101–106.

    PubMed  CAS  Google Scholar 

  • Infante, P. F., Wagoner, J. K., and Waxweiller, R. J., 1976, Carcinogenic, mutagenic and teratogenic risks associated with vinyl chloride, Mutat. Res. 41: 131–142.

    PubMed  CAS  Google Scholar 

  • Infante, P. F., Wagoner, J. K., and Young, R. J., 1977, Chloroprene: Observations of carcinogenesis and mutagenesis, in Origins of Human Cancer, Book A, (edited by H. H. Hiatt, J. D. Watson, and J. A. Winsten ), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 205 - 217.

    Google Scholar 

  • Ivanov, V. V., Kutznetsova, G. P., Archakov, A. I., 1978, Stimulation of lipid peroxidation by acrylonitrile in rat liver tissue, Vopr. Med. Khim. 24 (6): 816–818.

    PubMed  CAS  Google Scholar 

  • Ivanetich, K.M., Aronson, I., and Katz, I. D., 1977, The interaction of vinyl chloride with rat hepatic microsomal cytochrome P450 in vitro, Biochem. Biophys. Res. Comm. 74: 1411–1418.

    CAS  Google Scholar 

  • Jacobs, A., Blangetti, M., and Hellmond, F., 1974, Accumulation of noxious chlorinated substances from Rhine River water in the fatty tissue of rats, Vom. Wasser 43:259–274, Abstracted in Chem. Abstr. 82: 165547.

    CAS  Google Scholar 

  • Jaeger, R. J., Trabulus, M. J., and Murphy, S. D., 1973a, The interaction of adrenalectomy partial adrenal replacement therapy, and starvation with hepatotoxicity and lethality of 1,1-dichloroethylene intoxication, Toxicol. Appl. Pharmacol. 25: 491.

    Google Scholar 

  • Jaeger, R. J., Trabulus, M. J., and Murphy, S. D., 1973b, Biochemical effects of 1,1- dichloroethylene in rats: Dissociation of its hepatotoxicity from a lipoperoxidative mechanism, Toxicol. Appl. Pharmacol. 24: 457–467.

    PubMed  CAS  Google Scholar 

  • Jaeger, R. J., Reynolds, E. S., Conolly, R. B., Moslen, M. T., Szabo, S., and Murphy, S. D., 1974, Acute hepatic injury by vinyl chloride in rats pretreated with phenobarbital, Nature 252: 724–725.

    PubMed  CAS  Google Scholar 

  • Jaeger, R. J., Conolly, R. B., Reynolds, E. S., and Murphy, S. D., 1975a, Biochemical toxicology of unsaturated halogenated monomers, Environ. Health Persp. 11: 121–128.

    CAS  Google Scholar 

  • Jaeger, R. J., Conolly, R. B., and Murphy, S. D., 1975b, Short-term inhalation toxicity of halogenated hydrocarbons, Arch. Environm. Health. 30: 26–31.

    CAS  Google Scholar 

  • Jaeger, R. J., 1975, Vinyl chloride monomer: Comments on its hepatotoxicity and interaction with 1,1-dichloroethylene, Ann. N.Y. Acad. Sci. 246: 150–151.

    PubMed  CAS  Google Scholar 

  • Jaeger, R. J., Murphy, S. D., Reynolds, E. S., Szabo, S., and Moslen, M. T., 1977, Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats, Toxicol. Appl. Pharmacol. 41: 597–607.

    PubMed  CAS  Google Scholar 

  • James, S. P., and White, D. A., 1967, The metabolism of phenethyl bromide, styrene, and styrene oxide in the rabbit and rat, Biochem. J. 104: 914–921.

    PubMed  CAS  Google Scholar 

  • James, M. O., Fouts, J. R., and Bend, J. R., 1975, Hepatic and extrahepatic metabolism in vitro of an epoxide (8-14C styrene oxide) in the rabbit, Biochem. Pharmacol. 25: 187–193.

    Google Scholar 

  • John, J. A., Smith, F. A., Leong, B. K. J., and Schwetz, B. A., 1977, The effects of maternally inhaled vinyl chloride on embryonal and foetal development in mice, rats and rabbits, Toxicol. Appl. Pharmacol. 39: 497–513.

    PubMed  CAS  Google Scholar 

  • Jones, B. K., and Hathway, D. E., 1978a, Differences in metabolism of vinylidene chloride between mice and rats, Br. J. Cancer 37: 411–417.

    PubMed  CAS  Google Scholar 

  • Jones, B. K., and Hathway, D. E., 1978b, The biological fate of vinylidene chloride in rats, Chem. Biol. Interact. 20: 27–41.

    PubMed  CAS  Google Scholar 

  • Jones, B. K., and Hathway, D. E., 1978c, Tissue-mediated mutagenicity of vinylidene chloride in Salmonella tvphimurium TA 1535. Cancer Lett. 5: 1–6.

    PubMed  CAS  Google Scholar 

  • Kankaanpää, J., Elovaara, E., Hemminki, K., and Vainio, H., 1979a, Embryotoxicity of acrolein, acrylonitrile and acrylamide, in developing chick embryos, Tox. Lett. 4: 93–96.

    Google Scholar 

  • Kankaanpää, J. T., Hemminki, K., and Vainio, H., 1979b, Embryotoxicity and teratogenicity of styrene and styrene oxide on chick embryos enhanced by trichloropropene oxide, Acta Pharmacol. Toxicol. 45: 399–402.

    Google Scholar 

  • Kankaanpää, J. T., Elovaara, E., Hemminki, K., and Vainio, H., 1980, The effects of maternally inhaled styrene on embryonal and foetal development in mice and Chinese hamsters, Acta Pharmacol. Toxicol. 47: 127–129.

    Google Scholar 

  • Kappus, H., Bolt, H. M., Buchter, A., and Bolt, W., 1976, Liver microsomal uptake of 14C vinyl chloride and transformation to protein alkylating metabolites in vitro, Toxicol. Appl. Pharmacol. 37: 461–471.

    PubMed  CAS  Google Scholar 

  • Keplinger, M. L., Goode, J. W., Gordon, D. E., and Calandra, J. C., 1975, Interim results of exposure of rats, hamsters, and mice to vinyl chloride, Ann. N. Y. Acad. Sci. 246: 219–224.

    PubMed  CAS  Google Scholar 

  • Khachatryan, E. A., 1972, The occurrence of lung cancer among people working with chloroprene, Probl. Oncol. 18: 85.

    Google Scholar 

  • Klimkova-Deutschova, E., Jandova, D., Salcmanova, Z., Schwartzova, K., and Titman, O., 1973, Recent advances concerning the clinical picture of professional styrene exposure (Czech.), Cesk. Neurol. Neurochir. 36: 20–25.

    CAS  Google Scholar 

  • Kociba, R. J., Keyes, D. G., Jersey, G. C., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, C. E., Humiston, C. G., and Schwetz, B. A., 1977, Results of a two year chronic toxicity study with hexachlorobutadiene in rats, Ann. Ind. Hyg. Assoc. J. 38: 589–602.

    CAS  Google Scholar 

  • Kølmark, G., and Westergaard, M.,1953, Further studies on chemically induced reversions at the adenine locus of Neurospora Hereditas 39: 209–224.

    Google Scholar 

  • Kopecky, J., Gut, I., Nerudova, J., Zachardova, D., Holecek, V., Filip, J., 1980, Acrylonitrile metabolism in the rat, Arch. Toxicol. Suppl. 4: 322–324.

    PubMed  CAS  Google Scholar 

  • Kopecky, J., Gut, I., Nerudova, J., Zachardova, D., Holecek, V. 1980a, Two routes of acrylonitrile metabolism, J. Hvg. Epid. Microbiol. Immunol. 24: 356–362.

    CAS  Google Scholar 

  • Kramer, C. G., and Mutchler, J. E., 1972, The correlation of clinical and environmental measurements for workers exposed to vinyl chloride, Am. Ind. Hyg. Assoc. J. 33: 19–30.

    PubMed  CAS  Google Scholar 

  • Krasmyuk, E. P., Zaritskaya, L. A., Bioko, V. G., Viotenko, G. A., and Matokhmyuk, L. A., 1969, Health of vineyard workers having contact with the fumigants hexachlorobutadiene and polychlorobutane, 80, Vrach. Delo. 7: 111–115.

    Google Scholar 

  • Kucerova, M., Polivkova, Z., and Batora, J., 1979, Comparative evaluations of the frequency of chromosomal aberrations and the SCE numbers in peripheral lymphocytes of workers occupationally exposed to vinyl chloride monomer, Mutat. Res. 67: 97–100.

    PubMed  CAS  Google Scholar 

  • Laib, R. J., and Bolt, H. M., 1978, Formation of 3, N4-ethenocytidine moietis in RNA by vinyl chloride metabolites in vitro and in vivo, Arch. Toxicol. 39: 235–240.

    PubMed  CAS  Google Scholar 

  • Lambotte-Vandepaer, M., Duverger-van Bogaert, M., de’Meester, C., Noel, G., Poncelet, F., Roberfroid, M., and Mercier, M., 1979, Styrene induced modification of some rat liver enzymes involved in the activation and inactivation of xenobiotics, Biochem. Pharmacol. 28: 1653–1659.

    PubMed  CAS  Google Scholar 

  • Lambotte-Vandepaer, M., Duverger-van Bogaert, M., de Meester, C., Poncelet, F., and Mercier, M., 1980, Mutagenicity of urine from rats and mice treated with Acrylonitrile, Toxiciology 16: 67–71.

    CAS  Google Scholar 

  • Lambotte-Vandepaer, M., Duverger-van Bogaert, M., de Meester, C., Rollmann, B., Poncelet, F., and Mercier, M., 1981, Identification of two urinary metabolites of rats treated with acrylonitrile: Influence of several inhibitors on the mutagenicity of those urine, Tox. Lett. 7: 321–328.

    CAS  Google Scholar 

  • Lange, C. E., Juhe, S., Stein, G., and Veltman, G. 1975, Further results in polyvinyl chloride production workers, Ann. N. Y. Acad. Sci. 246: 18–21.

    PubMed  CAS  Google Scholar 

  • Langvardt, P. W., Putzig, C. L., Braun, W. H., and Young, J. D., 1980, Identification of the major urinary metabolites of acrylonitrile in the rat, J. Toxicol. Environ. Health 6: 273–282.

    PubMed  CAS  Google Scholar 

  • Laska, A. L., Bartell, C. K., Condie, D. B., Brown, J. W., Evans, R. L., and Laseter, J. L., 1978, Acute and chronic effects of hexachlorobenzene and hexachlorobutadiene in red swamp crayfish (Procambarus clarki) and selected fish species, Toxicol. Appl. Pharmacol. 43: 1–12.

    PubMed  CAS  Google Scholar 

  • Lee, F. I., and Harry, D. S., 1974, Angiosarcoma of the liver in a vinyl chloride worker, Lancet. i:1316–1318.

    Google Scholar 

  • Lee, C. C., Bhandari, J. C., Winston, J. M., House, W. B., Peters, P. J., Dixon, R. L., and Woods, J. S., 1977, Inhalation toxicity of vinyl chloride and vinylidene chloride, Environ. Health Perspect. 21: 25–32.

    PubMed  CAS  Google Scholar 

  • Lee, C. C., Bhandari, J. C., Winston, J. M., House, W. B., Dixon, R. L., and Woods, J. S., 1978, Carcinogenicity of vinyl chloride and vinylidene chloride, J. Toxicol. Environ. Health 4: 15–30.

    PubMed  CAS  Google Scholar 

  • Leibman, K. C., and Ortiz, E., 1969, Oxidation of styrene in liver microsome, Biochem. Pharmacol. 18: 552–554.

    PubMed  CAS  Google Scholar 

  • Leibman, K. C., 1975, Metabolism and toxicity of styrene, Environ. Health Perspect. 11: 115–119.

    PubMed  CAS  Google Scholar 

  • Léonard, A., Decat, G., Leonard, E. D., Lefevre, M. J., Decuyper, I. I., and Nicaise, C., 1977, Cytogenetic investigations on lymphocytes from workers exposed to vinyl chloride, J. Toxicol. Environ. Health 2: 1135–1141.

    PubMed  Google Scholar 

  • Léonard, A., Garny, V., Poncelet, F., and Mercier, M., 1981, Mutagenicity of acrylonitrile in mouse, Tox. Lett. 7: 329–334.

    Google Scholar 

  • Lilis, R., and Nicholson, W. J., 1976, Cancer experience among workers in a chemical plant producing styrene monomers, in Proceedings of NIOSH Styrene-Butadiene briefing, Covington, Kentucky, 1976, (edited by L. Ede), HEW Publ. No. (NIOSH) 77-129, Cincinnati, Ohio, U.S. Department of Health, Education, and Welfare, pp. 22 - 27.

    Google Scholar 

  • Lilis, R., Lorimer, W. V., Diamond, S., and Selikoff, I. J., 1978, Neurotoxicity of styrene in production and polymerization workers, Environ. Res. 15: 133–138.

    PubMed  CAS  Google Scholar 

  • Lindström, K., Härkönen, H., and Hernberg, S., 1976, Disturbances in psychological functions of workers occupationally exposed to styrene, Scand. J. Work. Environ. Health 3: 129–139.

    Google Scholar 

  • Lingeman, C. H., 1976, The vinyl chloride story, The Bulletin of SPEP IV: 9–15.

    Google Scholar 

  • Linnainmaa, K., Meretoja, T., Sorsa, M., and Vainio, H., 1978, Cytogenetic effects of styrene and styrene oxide on human lymphocytes and “Allium Cepa.” Scand. J. Work. Environ. Health 4 (2): 156–162.

    PubMed  CAS  Google Scholar 

  • Lloyd, J. W., 1975, Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers, J. Occup. Med. 17: 333–334.

    PubMed  CAS  Google Scholar 

  • Lloyd, J. W., Decoufle, P., Moore, R. M., 1975, Background information on chloroprene, J. Occup. Med. 17: 263–264.

    PubMed  CAS  Google Scholar 

  • Lock, E. A., and Ishmael, J., 1979, The acute toxic effects of hexachloro-1,3-butadiene on the rat kidney, Arch. Toxicol. 43: 47–57.

    PubMed  CAS  Google Scholar 

  • Locker, G. Y., Doroshow, J. H., Zwelling, L. A., and Chabner, B. A., 1979, The clinical features of hepatic angiosarcomas. A report of four cases and a review of the English literature, Medicine 58: 48–64.

    PubMed  CAS  Google Scholar 

  • Loprieno, N., Barale, R., Baroncelli, S., Bauer, C., Bronzetti, G., Cammellini, A., Cercignani, G., Corsi, C., Gervasi, G., Leporini, C., Nieri, R., Rossi, A. M., Stretti, G., and Turchi. G., 1976a, Evaluation of the genetic effects induced by vinyl chloride monomer (VCM) under mammalian metabolic activation: Studies in vitro and in vivo, Mutat. Res. 40: 85–96.

    PubMed  CAS  Google Scholar 

  • Loprieno, N., Abbondandolo, A., Barale, R., Baroncelli, S., Bonatti, S., Bronzetti, G., Cammellini, A., Corsi, C, Corti, G., Frezza, D., Leporini, C., Mazzaccaro, A., Nieri, R., Rosellini, D., and Rossi, A. M., 1976b, Mutagenicity of industrial compounds; Styrene and its possible metabolite styrene oxide, Mutat. Res. 40: 317–324.

    PubMed  CAS  Google Scholar 

  • Loprieno, N., Barale, R., Baroncelli, S., Bartsch, H., Bronzetti, G., Cammellini, A., Corsi, C., Frozza, D., Nieri, R., Leporini, C., Rosellini, D., and Rossi, A. M., 1977, Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast, Cancer Res. 36: 253–257.

    Google Scholar 

  • Loprieno, N., Presciuttini, S., Sbrana, I., Stretti, G., Zaccaro, L., Abbondandolo, A., Bonatti, S., Fiorio, R., and Mazzaccaro, A., 1978, Mutagenicity of industrial compounds VII: Styrene and styrene oxide. II. Point mutations, chromosome aberrations and DNA repair induction analyses, Scand. J. Work. Environ. Health. 4: (suppl. 2): 169–178.

    PubMed  CAS  Google Scholar 

  • Lorimer, W. V., Lilis, R., Nicholson, W. J., Anderson, H., Fischbein, A., Daum, S., Rom, W., Rice, C., and Selikoff, I. J., 1976, Clinical studies of styrene workers: Initial findings, Environ. Health Perspect. 17: 171–181.

    PubMed  CAS  Google Scholar 

  • Lukoshkima, L. P., and Alekperov, I. I., 1973, Lipid protein metabolism in workers handling divinylbenzene and styrene, Gig. Tr. Prof. Zahol. 17: 42–44.

    Google Scholar 

  • Magnusson, J., and Ramel, C., 1978, Mutagenic effect of vinyl chloride on Drosophila melanogaster with and without pretreatment with sodium phenobarbitone, Mutat. Res. 57: 307–312.

    PubMed  CAS  Google Scholar 

  • Magnusson, J., Hallstrom, I., and Ramel, C., 1979, Studies on metabolic activation of vinyl chloride in Drosophila melanogaster after pretreatment with phenobarbital and poly- chlorinated biphenyls, Chem. Biol. Interact. 24: 287–298.

    PubMed  CAS  Google Scholar 

  • Magos, L., 1962, A study of acrylonitrile poisoning in relation to methaemoglobin-CN complex formation, Brit. J. Ind. Med. 19: 283–286.

    CAS  Google Scholar 

  • Makk, L., Creech, J. L., Whelan, J. G., Jr., and Johnson, M. N., 1974, Liver damage and angiosarcoma in vinyl chloride workers. A systematic detection program, J. Am. Med. Assoc. 230: 64–68.

    CAS  Google Scholar 

  • Malaveille, C., Bartsch, H., Barbin, A., Camus, A. M., Montesano, R., Croisy, A., and Jacquignon, P., 1975, Mutagenicity of vinyl chloride, chloroethyleneoxide, chloro- acetaldehyde, and chloroethanol, Biochem. Biophys. Res. Commun. 63: 363–370.

    PubMed  CAS  Google Scholar 

  • Malaveille, C., Planche, G., and Bartsch, H., 1977, Factors for efficiency of the Salmonella I microsome mutagenicity assay, Chem. Biol. Interact. 17: 129–136.

    PubMed  CAS  Google Scholar 

  • Maltoni, C., 1974, Angiosarcoma of the liver in workers exposed to vinyl chloride. First two cases found in Italy (Ital.), Med. Lav. 65: 445–450.

    PubMed  CAS  Google Scholar 

  • Maltoni, C., Lefemine, G., Chicco, P., and Carreti, D., 1974, Vinyl chloride carcinogenesis: Current results and perspectives, Med. Lav. 65: 421–444.

    PubMed  CAS  Google Scholar 

  • Maltoni, C., 1976a, Vinyl chloride pathology, Med. Biol. Environ. 4: 267–278.

    CAS  Google Scholar 

  • Maltoni, C., 1976b, Occupational chemical carcinogenesis New facts, priorities and perspectives, Colloq. Inst. Natl. Scint. Rech. Med. 52: 127–150.

    CAS  Google Scholar 

  • Maltoni, C., 1977a, Vinyl chloride carcinogenecity: An experimental model for carcinogenesis studies, in Origins of Human Cancer, (edited by H. H. Hiatt, J. D. Watson, and J. A. Winsten ), Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp. 119–146.

    Google Scholar 

  • Maltoni, C., Ciliberti, A., and DiMaio, V., 1977b, Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion, Med. Lav. 68: 401–411.

    PubMed  CAS  Google Scholar 

  • Maltoni, C., Cotti, G., Morisi, L., and Chieco, P. 1977c, Carcinogenicity bioassays of vinylidene chloride, Research plan and early results, Med. Lav. 68: 241–262.

    PubMed  CAS  Google Scholar 

  • Maltoni, C., Failla, G., and Kassapidis, G., 1979, First experimental demonstration of the carcinogenic effects of styrene oxide, Med. Lav. 5: 358–362.

    Google Scholar 

  • Malvoisin, E., Lhoest, G., Poncelet, F., Roberfroid, M., and Mercier, M., 1979, Identification and quantitation of l,2-epoxybutene-3 as the primary metabolite of 1,3-butadiene. J. Chrom. 178: 419–425.

    CAS  Google Scholar 

  • Maricq, H. R., Johnson, M. N., Whetstone, C. L., and Carwille, E., 1976, Capillary abnormalities in polyvinyl chloride production workers. Examination by in vivo microscopy, Jama 236: 1368–1371.

    PubMed  CAS  Google Scholar 

  • Marniemi, J., Suolinna, E. M., Kaartinen, N., and Vainio, H., 1976, Covalent binding of styrene oxide to rat liver macromolecules in vivo and in vitro. Hoppe Seyler’s, Z. Physiol. Chem. 357: 140.

    Google Scholar 

  • Martynenko, D. N., 1973, Hygienic characteristics of working conditions during production of articles from polymeric materials used in machine construction (Russ.), Cig. Tr. 9:57–61. Chem. Abstr. 85:14832If.

    Google Scholar 

  • Mattern, I. E., Van der Zwaan, W. B., and Willems, M. J., 1977, Mutagenicity testing of urine from vinyl chloride treated rats using the Salmonella test system, Mutat. Res. 46: 230–231.

    Google Scholar 

  • McCann, J., Simmon, V., Streitwieser, D., and Ames, B. N., 1975a, Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide, Proc. Natl. Acad. Sci. (Wash.) 72: 3190–3193.

    CAS  Google Scholar 

  • McCann, J., Choi, E., Yamasaki, E., and Ames, B. N., 1975b, Detection of carcinogens as mutagens in the Salmonella I microsome test: Assay of 300 chemicals, Proc. Natl. Acad. Sci. U.S.A. 72: 5135–5139.

    PubMed  CAS  Google Scholar 

  • McKenna, M. J., Watanabe, P. G., and Gehring, P. J., 1977, Pharmacokinetics of vinylidene chloride in the rat, Environm. Health Perspect. 21: 99–105.

    CAS  Google Scholar 

  • McKenna, M. J., Zempel, J. A., Madrid, E. O., Braun, W. H., and Gehring, P. J., 1978a, Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration, Toxicol. Appl. Pharmacol. 45: 821–835.

    PubMed  CAS  Google Scholar 

  • McKenna, M. J., Zempel, J. A., Madrid, E. O., and Gehring, P. J., 1978b, The pharmacokinetics of 14C vinylidene chloride in rats following inhalation exposure, Toxicol. Appl. Pharmacol. 45: 599–610.

    PubMed  CAS  Google Scholar 

  • McLaughlin, J., Jr., Marliac, J.-P., Verrett, M. J., Mutchler, M. K., and Fitzhugh, O. G., 1964, Toxicity of fourteen volatile chemicals as measured by the chick embryo method, Am. Ind. Hyg. Assoc. J. 25: 282–284.

    PubMed  Google Scholar 

  • Menezes, S., Papadopoulo, D., Levry, S., and Markovits, P., 1979, Transformation in vitro de cellules de poumons de jeunes hamsters par le chloro-2-butadiene, C. R. Acad. Sci. Paris 288: 923–926.

    CAS  Google Scholar 

  • Meretoja, T., Vainio, H., Sorsa, M., and Härkönen, H., 1977, Occupational styrene exposure and chromosomal aberrations, Mutat. Res. 56: 193–197.

    CAS  Google Scholar 

  • Meretoja, T., Vainio, H., and Jarventaus, H., 1978, Clastogenic effects of styrene exposure on bone marrow cells of rats, Tox. Lett. 1: 315–318.

    CAS  Google Scholar 

  • Miller, A., Teirstein, A. S., Chuang, M., and Selikoff, I. J., 1975, Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride, Ann. N. Y. Acad. Sci. 246: 42–52.

    PubMed  CAS  Google Scholar 

  • Milvy, P., and Garro, A. J., 1976, Mutagenic activity of styrene oxide (1,2-epoxyethylbenzene), a presumed styrene metabolite, Mutat. Res. 40: 15–18.

    PubMed  CAS  Google Scholar 

  • Milvy, P., and Wolff, M., 1977, Mutagenic studies with acrylonitrile, Mutat. Res. 48 (3-4): 271–278.

    PubMed  CAS  Google Scholar 

  • Monson, R. R., Peters, J. M., and Johnson, M. N., 1974, Proportional mortality among vinyl-chloride workers, Lancet ii:397–398.

    PubMed  CAS  Google Scholar 

  • Morris, G. E., 1953, Vinyl plastics. Their dermatological and chemical aspects, Arch. Ind. Occup. Med. 3: 535.

    Google Scholar 

  • Morisset, Y., P’an, A., and Jegier, Z., 1979, Effect of styrene and fiber glass on small airways of mice, J. Toxicol. Environ. Health 5: 943–956.

    PubMed  CAS  Google Scholar 

  • Müller, G. Norpoth, K., and Eckard, R., 1976, Identification of two urine metabolites of vinyl chloride by GC-MS investigations. Int. Arch. Occup. Environ. Health 38: 69–75.

    PubMed  Google Scholar 

  • Muller, G., Norpoth, C. K., and Owzarski, W., 1978, In vivo trapping of a vinyl chloride metabolite by means of 3,4-dichlorobenzenethiol, Int. Arch. Occup. Environ. Health 42: 137–139.

    PubMed  CAS  Google Scholar 

  • Muratov, M. M., and Gus’Kova, S. I., 1978, The question of the mutagenic activity of vinyl chloride, Hyg. Sanit. 7: 111–112.

    Google Scholar 

  • Murdoch, I. A., and Hammond, A. R., 1977, A practical method for the measurement of vinyl chloride monomer (VCM) in air, Ann. Occup. Hyg. 20: 55–61.

    PubMed  CAS  Google Scholar 

  • Murray, F. J., Schwetz, B. A., Nitschke, K. D., John, J. A., Norris, J. M., and Gehring, P. J., 1978a, Teratogenicity of acrylonitrile given to rats by gavage or by inhalation, Food Cosmet. Toxicol. 16: 547–551.

    PubMed  CAS  Google Scholar 

  • Murray, F. J., John, J. A., Balmer, M. F., and Schwetz, B. A., 1978b, Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage, Toxicology 11: 335–343.

    PubMed  CAS  Google Scholar 

  • Murray, F. J., Mitschke, K. D., Rampy, L. W., and Schwetz, B. A., 1979, Embryotoxicity of fetotoxicity of inhaled or ingested vinylidene chloride in rats and rabbits, Toxicol. Appl. Pharmacol. 49: 189–202.

    PubMed  CAS  Google Scholar 

  • Murzakaev, F. G., 1967, Action exerted by low hexachlorobutadiene doses on the activity of the central nervous system and morphological changes in animals so poisoned, Gig. Tr. Prof. Zabol. 11:23–28. Abstracted in Chem. Abstr. 67: 3 1040.

    PubMed  CAS  Google Scholar 

  • National Cancer Institute, 1979, Bioassay of styrene for possible carcinogenicity. Technical -report series No. 185, case No. 100-42-5, U.S. Department of Health, Education, and Welfare. Public Health Service, National Institute of Health.

    Google Scholar 

  • National Institute for Occupational Safety and Health, 1977, Criteria for a Recommended Standard—Occupational Exposure to Chloroprene, DHEW (NIOSH) Publ. No. 77 - 210. Washington, D.C., U.S. Government Printing Office.

    Google Scholar 

  • Nerudova, J., Kopecky, J., Hatle, K., 1978, Acrylonitrile biotransformation in microsomes, isolated perfused liver, and in living rats, Int. Congr. Ser. Exc. Med. 440: 121–123.

    CAS  Google Scholar 

  • Nicholson, W. J., Hammond, E. C., Seidman, H., and Selikoff, I. J., 1975, Mortality experience of a cohort of vinyl chloride-polyvinyl chloride workers, Ann. N. Y. Acad. Sci. 246: 225–230.

    PubMed  CAS  Google Scholar 

  • Nilsen, O. G., Toftgard, R., Eneroth, P., 1980, Effects of acrylonitrile on rat liver cytochrome P450, benzo(a)pyrene metabolism and serum hormone levels, Tox. Lett. 6 (6): 399–404.

    CAS  Google Scholar 

  • Noria, D. F., Ritchie, S., and Silver, M. D., 1976, Angiosarcoma of the liver after vinyl chloride exposure: Report of a case and review of the literature (abstract), Lab. Invest. 34: 346.

    Google Scholar 

  • Norpoth, K., Gottschalk, D., Gottschalk, I., Witting, U., Thomas, H., Fichner, D., and Schmidt, E. H., 1980, Influence of vinyl chloride monomer and As2O3 on rat liver cell proliferation after partial hepatectomy, J. Cancer Res. Clin. Oncol. 97: 41–50.

    PubMed  CAS  Google Scholar 

  • Norppa, H., Elovaara, E., Husgafvel-Pursainen, H., Sorsa, M., and Vainio, H., 1979, Effects of styrene oxide on chromosome aberrations, sister chromatid exchanges and hepatic drug biotransformation in Chinese hamsters in vivo, Chem. Biol. Interact. 26: 305–315.

    PubMed  CAS  Google Scholar 

  • Norppa, H., Sorsa, M., and Vainio, H., 1980a, Chromosomal aberrations in bone marrow of Chinese hamsters exposed to styrene and ethanol, Tox. Lett. 5: 241–244.

    CAS  Google Scholar 

  • Norppa, H., Sorsa, M., Pfäffli, P., and Vainio, H., 1980b, Styrene and styrene oxide induce SCEs and are metabolized in human lymphocytes cultures, Carcinogenesis 1: 357–361.

    PubMed  CAS  Google Scholar 

  • Oesch, F., Jerina, D. M., and Daly, J. W., 1971, A radiometric assay for hepatic epoxide hydrase activity with (7-1H) styrene oxide, Biochim. Biophys. Acta. 227: 685–691.

    PubMed  CAS  Google Scholar 

  • Ogata, M., and Sugishara, R., 1978, H PLC procedure for quantitative determination of urinary phenyl glyoxylic, mandelic, and hippuric acids as indices of styrene exposure, Int. Arch. Occup. Environ. Health. 42: 11–19.

    PubMed  CAS  Google Scholar 

  • Ohtsuji, H., and Ikeda, M., 1971, The metabolism of styrene in the rat and the stimulatory effect of phenobarbital, Toxicol. Appl. Pharmacol. 18: 321–328.

    CAS  Google Scholar 

  • O’Mara, M. M., Crider, L. B., and Daniel, R. L., 1971, Combustion products from vinyl chloride monomer, An. Ind. Hvg. Assoc. J. 32: 153–156.

    Google Scholar 

  • Ott, M. G., Langner, R. R., and Holder, B. B., 1975, Vinyl chloride exposure in a controlled industrial environment. A long-term mortality experience in 594 employees, Arch. Environ. Health 30: 333–339.

    PubMed  CAS  Google Scholar 

  • Ott, M. G., Fishbeck, W. A., Townsend, J. C., and Schneider, E. J., 1976, A health study of employees exposed to vinylidene chloride, J. Occup. Med. 18: 735–738.

    PubMed  CAS  Google Scholar 

  • Pagano, G., Esposito, A., Giordano, G., and Hagstrom, B. E., 1978, Embryotoxic and teratogenic effects of styrene derivatives on sea urchin development, Scand. J. Work Environ. Health 4 (suppl. 2): 136–141.

    CAS  Google Scholar 

  • Pagé, M., Theriault, L., and Delorme, F., 1976, Elevated CEA levels in polyvinyl chloride workers, Biomedicine 25: 279.

    PubMed  Google Scholar 

  • Pantarotto, C., Fanelli, R., Bidoli, F., Morazzoni, P., Salmona, M., and Szczawinska, K., 1978, Arene oxide in styrene metabolism: A new perspective in styrene toxicity? Scand. J. Work. Environm. Health 4 (suppl. 2): 67–77.

    CAS  Google Scholar 

  • Parent, R. A., and Casto, B. C., 1979, Effect of acrylonitrile on primary Syrian golden hamster embryo cells in culture: transformation and DNA fragmentation, J. Nat. Cane. Inst. 62:4, 1025–1029.

    CAS  Google Scholar 

  • Parkki, M. G., Marniemi, J., and Vainio, H., 1976, Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo, Toxicol. Appl. Pharmacol. 38: 59–70.

    PubMed  CAS  Google Scholar 

  • Parkki, M. G., Marniemi, J., Ekfors, T., Louhivuori, A., and Aitio, A., 1979, Hepatotoxic changes of hamsters by styrene, in Proceedings of the Industrial Toxicology Meeting, Prague 1977, p. 74.

    Google Scholar 

  • Paulet, G., and Desnos, J., 1961, Acrylonitrile. Toxicity—mechanism of therapeutic action, Arch. Int. Pharmacodvn. 131: 54–83.

    CAS  Google Scholar 

  • Patty, F. R., 1963, Industrial Hygiene and Toxicology, Interscience Publishers, New York, vol. II, pp. 1319–1321.

    Google Scholar 

  • Pell, S., 1978, Mortality of workers exposed to chloroprene, J. Occup. Med. 20: 21–29.

    PubMed  CAS  Google Scholar 

  • Penttilä, M., Sorsa, M., and Vainio, H., 1980, Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster, Tox. Lett. 6: 119–123.

    Google Scholar 

  • Peter, S., and Ungvary, G., 1980, Lack of mutagenic effects of vinyl chloride monomer in the mammalian spot test, Mutat. Res. 77: 193–196.

    PubMed  CAS  Google Scholar 

  • Pessayre, D., Wandscheer, J. C., Descatoire, V., Artigou, J. Y., and Benhamou, J. P., 1979, Formation and inactivation of a chemically reactive metabolite of vinyl chloride, Toxicol. Appl. Pharmacol. 49: 505–515.

    PubMed  CAS  Google Scholar 

  • Philippe, R., Lauwerijs, R., Buchet, J. P., and Roels, H., 1971, Evalution de l’exposition des travailleurs au styrène par le dosage de ses métabolites urinaires: Les acides mandélique et phénylglyoxylique. II: Application aux travailleurs fabriquants des polyesters, Arch. Mai. Prof. Med. Trav. Sec-Soc. 35 (6): 631–640.

    Google Scholar 

  • Picciano, D. J., Flake, R. E., Gay, P. C., and Kilian, D. J., 1977, Vinyl chloride cytogenetics, J. Occup. Med. 19: 527–530.

    PubMed  CAS  Google Scholar 

  • Plotnick, H. B., and Weigel, W. W., 1979, Tissue distribution and excretion of 14C styrene in male and female rats, Res. Comm. Chem. Pathol. Pharmacol. 24 (3): 515–524.

    CAS  Google Scholar 

  • Plugge, H., and Safe, S., 1977, Vinyl chloride metabolism. A review, Chemosphere 6: 309–325.

    CAS  Google Scholar 

  • Plugge, H., and Jaeger, R. J., 1979, Acute inhalation toxicity of 2-chloro-l,3-butadiene (chloroprene): Effects on liver and lung, Toxicol. Appl. Pharmacol. 50: 565–572.

    PubMed  CAS  Google Scholar 

  • Pollock, J. R. A., and Stevens, R. (eds.), 1965, Dictionary of Organic Compounds, 4th ed., Vol. 2, New York, Oxford University Press, p. 681.

    Google Scholar 

  • Ponomarkov, V., and Tomatis, L., 1978, Effects of long term oral administration of styrene to mice and rats, Scand. J. Work. Environ. Health 4 (suppl. 2): 127–135.

    PubMed  CAS  Google Scholar 

  • Ponomarkov, V., and Tomatis, L., 1980, Long-term testing of vinylidene chloride and chloroprene for carcinogenicity in rats, Oncology 37: 136–141.

    PubMed  CAS  Google Scholar 

  • Popper, H., and Thomas, L. B., 1975, Alterations of liver and spleen among workers exposed to vinyl chloride, Ann. N. Y. Acad. Sci. 246: 172–194.

    PubMed  CAS  Google Scholar 

  • Popper, H., 1979, Hepatic cancers in man: quantitative perspective, Environm. Res. 19: 482–494.

    CAS  Google Scholar 

  • Poteryaeva, G. E., 1966, Effect of hexachlorobutadiene on the offspring of albino rats, Gigiena i, Sanit 31–33. Abstracted in Chem. Abs. 65:1281f.

    Google Scholar 

  • Prodan, L., Suciu, I., Pislaru, V., Ilea, E., and Pascu, L., 1975, Experimental acute toxicity of vinyl chloride (monochlorethylene), Ann. N. Y. Acad. Sci. 246: 154–158.

    PubMed  CAS  Google Scholar 

  • Purchase, I. F. H., Richardson, C. R., Anderson, D., Paddle, G. M., and Adams, W. G. F., 1978, Chromosomal analyses in vinyl chloride-exposed workers, Mutat. Res. 57: 325–334.

    PubMed  CAS  Google Scholar 

  • Purchase, I. F. H., Richardson, C. R., and Anderson, D., 1975, Chromosomal and dominant lethal effects of vinyl chloride, Lancet ii:410–411.

    Google Scholar 

  • Rabello-Gay, H. N., and Ahmed, E. A., 1980, Acrylonitrile: In vivo cytogenetic studies in mice and rats, Mut. Res. 79: 249–255.

    CAS  Google Scholar 

  • Radike, M. J., Stemmer, K. L., Brown, P. G., Larson, E., and Bingham, E., 1977, Effect of ethanol and vinyl chloride on the induction of liver tumours: preliminary report, Environ. Health Perspect. 21: 153–155.

    PubMed  CAS  Google Scholar 

  • Radwan, Z., and Henschler, D., 1977, Uptake and rate of metabolism of vinyl chloride by the isolated perfused rat liver preparation, Int. Arch. Occup. Environm. Health 40: 101–110.

    CAS  Google Scholar 

  • Ragule, N., 1974, Embryotoxic action of styrene, Gig. i. Sanit. 11: 85–86.

    Google Scholar 

  • Ramsey, J. C., and Young, J. D., 1978, Pharmacokinetics of inhaled styrene in rats and humans, Scand. J. Work Environm. Health 4 (suppl. 2): 84–94.

    CAS  Google Scholar 

  • Ramsey, J. C., Young, J. D., Karbowski, R. J., Chenoweth, M. B., McCarty, L. P., and Braun, W. H., 1980, Pharmakokinetic of styrene in human volunteers, Toxicol. Appl. Pharmacol. 53: 54–63.

    PubMed  CAS  Google Scholar 

  • Rannug, U., Johansson, A., Ramel, C, and Wachtmeister, C. A., 1974, The mutagenicity of vinyl chloride after metabolic activation, Ambio 3: 194–197.

    CAS  Google Scholar 

  • Rannug, U., Gothe, R., and Wachtmeister, C. A., 1976, The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol, and chloroacetic acid, conceivable metabolites of vinyl chloride, Chem. Biol. Interact. 12: 251–263.

    PubMed  CAS  Google Scholar 

  • Ravier, E., Diter, J. M.,and Pialat, J., 1975, A case of hepatic angiosarcoma in a worker exposed to vinyl chloride monomer (Fr.), Arch. Mai. Prof., Med. Trav. Sec. Soc. 36: 171–177.

    Google Scholar 

  • Reichert, D., Werner, H. W., and Hanschler, D., 1978, Role of liver glutathione in 1,1- dichloroethylene metabolism and hepatotoxicity in intact rats and isolated perfused rat liver, Arch. Toxicol. 41: 169–178.

    PubMed  Google Scholar 

  • von Reinl, W., Weber, H., and Greiser, E., 1977, Epidemiological study on mortality of VC- exposed workers in the Federal Republic of Germany (Ger.), Medichem (September): pp. 2–8.

    Google Scholar 

  • Reitz, R. H., Watanabe, P. G., McKenna, M. J., Quast, J. F., and Gehring, P. J., 1980, Effects of vinylidene chloride on DN A synthesis and DNA repair in the rat and mouse. A comparative study with dimethylnitrosamine, Toxicol. Appl. Pharmacol. 52: 357–370.

    PubMed  CAS  Google Scholar 

  • Reynolds, E. S., Moslen, M. T., Szabo, S., and Jaeger, R. J., 1975a, Vinyl chloride induced deactivation of cytochrome P4so and other components of the liver mixed function oxidase system: an in vivo study, Res. Commun. Chem. Pathol. Pharmacol. 12: 685–694.

    PubMed  CAS  Google Scholar 

  • Reynolds, E. S., Moslen, M. T., Szabo, S., Jaeger, R. J., and Murphy, S. D., 1975b, Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene, Am. J. Pathol. 81: 219–236.

    PubMed  CAS  Google Scholar 

  • Reynolds, E. S., Jaeger, R. J., and Murphy, S. D., 1975c, Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats, Environ. Health Perspect. 11: 227–233.

    PubMed  CAS  Google Scholar 

  • Roche, J., Fournet, J., Hostein, J., Panh, M., and Bonnet-Eymard, J., 1978, Hepatic angiosarcoma due to vinyl chloride. Report of 4 cases (Fr.), Gastroenterol. Clin. Biol. 2: 669–678.

    PubMed  CAS  Google Scholar 

  • Ryan, A. J., James, M. O., BenZvi, Z., Law, F. L. P., and Bend, J. R., 1975, Hepatic and extrahepatic metabolism of 14C styrene oxide, Environ. Health Perspect. 17: 135–144.

    Google Scholar 

  • Salmon, A. G., 1976, Cytochrome P450 and the metabolism of vinyl chloride, Cancer Lett. 2: 109–114.

    PubMed  CAS  Google Scholar 

  • Salnikova, L. S., and Fomenko, V. N., 1973, Experimental investigation of the influence of chloroprene on embryogenesis, Gig. Tr. Prof. Zabol. 8: 23–26.

    Google Scholar 

  • Sandberg, E. Ch., and Slanina, P., 1980, Distribution of 1-14C acrylonitrile in rat and monkey, Tox. Lett. 6: 187–191.

    CAS  Google Scholar 

  • Sandell, J., Parkki, M. G., Marniemi, J., and Aitio, A., 1978, Effects of inhalation and cutaneous exposure to styrene on drug metabolizing enzymes in the rat, Res. Comm. Chem. Pathol. Pharmacol. 19 (1): 109–118.

    CAS  Google Scholar 

  • Sanotskii, I. V., 1976, Aspects of the toxicology of chloroprene: Immediate and long-term effects, Environ. Health Perspect. 17: 85–93.

    PubMed  CAS  Google Scholar 

  • Saric, M., Kulcar, Z., Zorica, M., and Gelic, I., 1976, Malignant tumours of the liver and lungs in an area with a PVC industry, Environ. Health Perspect. 17: 394–398.

    Google Scholar 

  • Sassu, G. M., Zilio-Grandi, F., and Conte, A., 1968, Gas chromatographic determinations of impurities in vinyl chloride, J. Chromatogr. 34: 394–398.

    CAS  Google Scholar 

  • Savolainen, H., and Vainio, H., 1977, Organ distribution and nervous system binding of styrene and styrene oxide, Toxicology 8: 135–141.

    PubMed  CAS  Google Scholar 

  • Savolainen, H., and Pfaffli, P., 1977, Effects of chronic styrene inhalation on rat brain protein metabolism, Acta Neuropath. 40: 237–241.

    PubMed  CAS  Google Scholar 

  • Savolainen, H., and Pfaffli, P., 1978, Accumulation of styrene monomer and neurochemical effects of long term inhalation exposure in rats, Scand. J. Work. Environ. Health 4 (suppl. 2): 78–84.

    PubMed  CAS  Google Scholar 

  • Sax, N. I., 1968, Dangerous Properties of Industrial Materials, Third Edition. Van Nostrand Reinhold, New York, p. 576.

    Google Scholar 

  • Schwetz, B. A., Smith, F. A., Humiston, C. G., Quast, J. F., and Kociba, R. J., 1977, Results of a reproduction study in rats fed diets containing hexachlorobutadiene, Toxicol. Appl. Pharmacol. 42: 387–398.

    PubMed  CAS  Google Scholar 

  • Seppäläinen, A. M., and Harkonen, H., 1976, Neurophysiological findings among workers occupationally exposed to styrene, Scand. J. Work Environ. Health 2: 140–146.

    PubMed  Google Scholar 

  • Seppäläinen, A. M., 1978, Neurotoxicity of styrene in occupational and experimental exposure, Scand. J. Work. Environ, and Health 4 (suppl 2): 181–183.

    Google Scholar 

  • Seutter-Berlage, F., Delbressine, L. P. C., Smeets, F. L. M., and Ketelaars, H. C. J., 1978, Identification of three sulfur containing urinary metabolites of styrene in the rat, Xenobiotica 8 (7): 413–418.

    PubMed  CAS  Google Scholar 

  • Shahin, M. J., 1976, The nonmutagenicity and recombinogenicity of vinyl chloride in the absence of metabolic activation, Mutat. Res. 40: 269–272.

    PubMed  CAS  Google Scholar 

  • Shimkin, M. B., Weisburger, J. H., Weisburger, E. K., Gubareff, N., and Sumtzeff, V., 1966, Bioassay of 29 alkylating chemicals by the pulmonary-tumour response in strain A mice, J. Natl. Cancer Inst. 36: 915–935.

    CAS  Google Scholar 

  • Short, R. D., Winston, J. M., Minor, J. L., Hong, C. B., Seifter, J., and Lee, C. C., 1977a, Toxicity of vinylidene chloride in mice and rats and its alteration by various treatments, J. Toxicol. Env. Health 3: 913–921.

    CAS  Google Scholar 

  • Short, R. D., Minor, J. L., Winston, J. M., and Lee, C. C., 1977b, A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride, J. Toxicol. Env. Health 3: 965–968.

    CAS  Google Scholar 

  • Shugaev, B. B., 1969, Concentrations of hydrocarbons in tissues as a measure of toxicity, Arch. Environ. Health 18: 878–882.

    CAS  Google Scholar 

  • Siegers, C. P., Younes, M., and Schmitt, G., 1979, Effects of dithiocarb and (+)-cyanidanol-3 on the hepatotoxicity and metabolism of vinylidene chloride in rats, Toxicology 15: 55–64.

    PubMed  CAS  Google Scholar 

  • Simmon, V., 1977, Mutagenic halogenated hydrocarbons. Presented at Meeting of Structural Parameters Associated with Carcinogenesis, Annapolis, Maryland, Aug. 31-Sept. 2.

    Google Scholar 

  • Smith, P. M., Williams, D. M. J., and Evans, D. M. D., 1976, Hepatic angiosarcoma in a vinyl chloride worker, Bull. N. Y. Acad. Med. 52: 447–452.

    PubMed  CAS  Google Scholar 

  • Sollenberg, J., and Baldesten, A., 1977, Isotachophoretic analysis of mandelic acid, phenyl- glyoxylic acid, hippuric acid and methylhippuric acid in urine after occupational exposure to styrene, toluene and/or xylene, J. Chromatogr. 132: 469–476.

    PubMed  CAS  Google Scholar 

  • Spencer, H. C., Irish, D. D., Adams, E. M., and Rowe, V. K., 1942, The response of Laboratory animals to monomeric styrene, J. Ind. Hyg. Toxicol. 24: 295–301.

    CAS  Google Scholar 

  • Spirtas, R., and Kaminski, R., 1978, Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers. 1977 Update of the NIOSH Register, J. Occup. Med. 20: 427–429.

    PubMed  CAS  Google Scholar 

  • Stoltz, D. R., and Withey, R. J., 1977, Mutagenicity testing of styrene and styrene epoxide in Salmonella tvphimurium, Bull. Environm. Contam. Toxicol. 17: 737–742.

    Google Scholar 

  • Suciu, I., Drejman, I., and Valaskai, M., 1963, Investigation of the disease produced by vinyl chloride, Med. Interna 15: 967.

    CAS  Google Scholar 

  • Suzuki, Y., 1978, Pulmonary tumours induced in mice by vinyl chloride monomer, Environm. Res. 16: 285–301.

    CAS  Google Scholar 

  • Szabo, S., and Selye, H., 1972, Effect of phenobarbital and steroids on the adrenal apoplexy produced by acrylonitrile in rats, Endocrinol. Exp. 6: 141–146.

    PubMed  CAS  Google Scholar 

  • Szabo, S., Reynolds, E. S., and Kovacs, K., 1976, Animal model of human disease, American J. Pathol. 82: 653–656.

    CAS  Google Scholar 

  • Szabo, S., Bailey, K. A., Boor, P. J., and Jaeger, R. J., 1977a, Acrylonitrile and tissue glutathione: differential effect of acute and chronic interactions, Biochem. Biophys. Res. Comm. 79:1, 32–37.

    CAS  Google Scholar 

  • Szabo, S., Jaeger, R. J., Moslen, M. T., and Reynolds, E. S., 1977b, Modification of 1,1- dichloroethylene hepatotoxicity by hypothyroidism, Toxicol. Appl. Pharmacol. 42: 367–376.

    PubMed  CAS  Google Scholar 

  • Szentesi, I., Hornyak, E., Ungvary, G., Czeizel, A., Bognar, Z., and Timar, M., 1976, High rate of chromosomal aberration in PVC workers, Mutat. Res. 37: 313–316.

    PubMed  CAS  Google Scholar 

  • Tabershaw, I. R., and Gaffey, W. R., 1974, Mortality study of workers in the manufacture of vinyl chloride and its polymers, J. Occup. Med. 16: 509–518.

    PubMed  CAS  Google Scholar 

  • Thiess, A. M.,and Fleig, I., 1978a, Analysis of chromosomes of workers exposed to acrylonitrile, Arch. Toxicol. 41: 149–152.

    CAS  Google Scholar 

  • Thiess, A. M., and Fleig, I., 1978b, Chromosome investigations on workers exposed to styrene/polystyrene, J. Occup. Med. 20: 747–749.

    PubMed  CAS  Google Scholar 

  • Thiess, A. M., and Friedheim, M., 1978, Morbidity among persons employed in styrene production, polymerization and processing plants, Scand. J. Work. Environ. Health. 4 (suppl. 2): 203–214.

    PubMed  CAS  Google Scholar 

  • Thomas, L. B., and Popper, H., 1975, Pathology of angiosarcoma of the liver among vinyl chloride-polyvinyl chloride workers, Ann. N. Y. Acad. Sci. 246: 268–277.

    PubMed  CAS  Google Scholar 

  • Ungvary, G., Hudak, A., Tatrai, E., Lorincz, M., and Fally, G., 1978, Effects of vinyl chloride exposure alone and in combination with trypan blue—applied systematically during all thirds of pregnancy on the foetuses of CFY rats, Toxicology 11: 45–54.

    PubMed  CAS  Google Scholar 

  • U.S. Consumer Product Safety Commission, 1978. Assessment of acrylonitrile contained in consumer products, Final report, contract No. CPSC-C-77-0009, Task No. 1014K. H.I.A./Economic Analysis, Washington, D.C.

    Google Scholar 

  • U.S. Department of Labor, 1978, Occupational exposure to acrylonitrile (vinyl cyanide). Proposed standard and notice of hearing, Fed. Regist. 43: 2586–2621.

    Google Scholar 

  • U.S. Food and Drug Administration, 1975, Vinyl chloride polymers in contact with food. Notice of proposed rulemaking. Fed. Regist. 40:40, 529 - 40, 537.

    Google Scholar 

  • U.S. Environmental Protection Agency, 1975a, Preliminary assessment of suspected carcinogens in drinking water, Washington, D.C., p. II–3.

    Google Scholar 

  • U.S. Environmental Protection Agency, 1975b, Preliminary assessment of suspected carcinogens in drinking water, Report to Congress, Washington, D.C., pp. II - 7.

    Google Scholar 

  • U.S. Environmental Protection Agency, 1975c, Scientific and technical assessment report on vinyl chloride and polyvinyl chloride. EPA-600/6-75-004, Springfield, Va., National Technical Information Service, pp. 7–42.

    Google Scholar 

  • Vainio, H., Pääkkönen, R., Rönnholm, K., Raunio, V., and Pelkonen, O., 1976, A study on the mutagenic activity of styrene and styrene oxide, Scand. J. Work. Environ. Health 3: 147–151.

    Google Scholar 

  • Vainio, H., and Mäkinen, A., 1977, Styrene and acrylonitrile induced depression of hepatic nonsulfhydryl content in various rodent species, Res. Comm. Pathol. Pharmacol. 17 (1): 115–124.

    CAS  Google Scholar 

  • Vainio, H., Hemminki, K.,and Elovaara, E., 1977, Toxicity of styrene and styrene oxide on chick embryos, Toxicology 8: 319–325.

    PubMed  CAS  Google Scholar 

  • Vainio, H., and Elovaara, E., 1979, The interaction of styrene oxide with hepatic cytochrome P450 in vitro and effects of styrene oxide inhalation on xenobiotic biotransformation in mouse liver and kidney, Biochem. Pharmacol. 28: 2001–2004.

    PubMed  CAS  Google Scholar 

  • Vainio, H., Jarvisalo, J., and Taskinen, E., 1979, Adaptive changes caused by intermittent styrene inhalation on xenobiotic biotransformation, Toxicol. Appl. Pharmacol. 49: 7–14.

    PubMed  CAS  Google Scholar 

  • Van Bladeren, P. J., Delbressine, L. P. C., Hoogeterp, J. J., Beaumont, A. H. G. M., Breiner, D. D., Seutter-Berlage, F., and Van der Gen, A., Formation of mercapturic acids from acrylonitrile, crotononitrile and cinnamonitrile by direct conjugation and via an intermediate oxidation process,...in “The Dual Role of Glutathione Conjugation in the Biotransformation of Xenobiotics,” P. J. Van Bladeren, Academic dissertation 8th April 1981, Klokke, Netherlands.

    Google Scholar 

  • Van Duuren, B. L., Nelson, N., Orris, L., Palmes, E. D., and Schmitt, F. L., 1963, Carcinogenicity of epoxides, lactones and peroxy compounds, J. Natl. Cancer Inst. 31: 41–55.

    Google Scholar 

  • Van Duuren, B. L., Langseth, L., Orris, L., Teebor, G., Nelson, N., and Kuschner, M., 1966, Carcinogenicity of epoxides, lactones and peroxy compounds. IV. Tumour response in epithelial and connective tissue in mice and rats, J. Natl. Cancer Inst. 37: 825–834.

    PubMed  Google Scholar 

  • Van Duuren, 1975, On the mechanism of carcinogenic action of vinyl chloride, Ann. N. Y. Acad. Sci. 246: 258–267.

    PubMed  Google Scholar 

  • Venitt, S., Bushell, C. T., and Osborne, M., 1977, Mutagenicity of acrylonitrile (cyanoethylene) in Escherichia coli, Mutat. Comm. Res. 45: 283–288.

    CAS  Google Scholar 

  • Venitt, S., 1978, Mutagenic studies with acrylonitrile. Reply to author’s comments, Mutat. Res. 57 (1): 113.

    CAS  Google Scholar 

  • Verburgt, F. G., and Vogel, E., 1977, Vinyl chloride mutagenesis in Drosophila melanogaster, Mutat. Res. 48: 327–336.

    PubMed  CAS  Google Scholar 

  • Viola, P. L., Bigotti, A., and Caputo, A., 1971, Oncogenic response of rat skin, lung and bone to vinyl chloride, Cancer Res. 31: 516–522.

    PubMed  CAS  Google Scholar 

  • Viola, P. L., and Caputo, A., 1977, Carcinogenicity studies on vinylidene chloride, Environ. Health Persp. 81: 45–47.

    Google Scholar 

  • Vogel, E., 1979, Mutagenicity of chloroprene, l-chloro-l,3-trans-butadiene, 1,4-dichlorobutene- 2 and l,4-dichloro-2,3-epoxybutane in Drosophila Melanogaster, Mutat. Res. 67: 377–381.

    PubMed  CAS  Google Scholar 

  • Von Oettingen, W. F., Hueper, W. C., Deichmann-Grubler, W., and Wiley, F. H., 1936, 2-chloro-butadiene (chloroprene): Its toxicity and pathology and the mechanism of its action, J. Ind. Hyg. Toxicol. 18: 240–270.

    Google Scholar 

  • Wagoner, J. K., 1978, Vinyl chloride and pulmonary cancer, J. Environ. Pathol. Toxicol. 1: 361–362.

    PubMed  CAS  Google Scholar 

  • Ward, A. M., Udnoon, S., Watkins, J., Walker, A. E., and Darke, C. S., 1976, Immunological mechanisms in the pathogenesis of vinyl chloride disease, Brit. Med. J. 1: 936–938.

    PubMed  CAS  Google Scholar 

  • Watanabe, P. G., Hefner, R. E., Jr., and Gehring, P. J., 1976, Vinyl chloride-induced depression of hepatic non-protein sulfhydryl content and effects on bromosulfophtalein (BSP) clearance in rats, Toxicology 6: 1–8.

    PubMed  CAS  Google Scholar 

  • Watabe, T., Isobe, M., Yoshikawa, K., and Takabatake, E., 1978a, Studies on metabolism and toxicity of styrene to styrene glycol via styrene oxide by rat liver microsomes, J. Pharm. Dyn. 1: 98–104.

    CAS  Google Scholar 

  • Watabe, T., Isobe, M., Sawahata, T., Yoshikawa, K., Yamada, S., and Takabatake, E., 1978b, Metabolism and mutagenicity of styrene, Scand. J. Work Environ. Health 4 (suppl. 2): 142–155.

    CAS  Google Scholar 

  • Watabe, T., Isobe, M., Yoshikawa, K., and Takabatake, E., 1978c, Studies on metabolism and toxicity of styrene II. Mutagenesis in Salmonella typhimurium by metabolic activation of styrene with 3-methylcholanthrene pretreated rat liver, J. Pharm. Dyn. 1: 301–309.

    CAS  Google Scholar 

  • Watson, W. A. F., 1972, Studies on a recombination-deficient mutation of Drosophila. II. Response to X rays and alkylating agents, Mutat. Res. 14: 299–307.

    CAS  Google Scholar 

  • Waxweiler, R. J., Stringer, W., Wagoner, J. K., Jones, J., Falk, H., and Carter, C., 1976, Neoplastic risk among workers exposed to vinyl chloride, Ann. N. Y. Acad. Sci. 271: 40–48.

    PubMed  CAS  Google Scholar 

  • Williams, D. T., and Miles, W. F., 1975, Gas-liquid chromatographic determination of vinyl chloride in alcoholic beverages, vegetable oils, and vinegars, J. Assoc. Off. Anal. Chem. 58: 272–275.

    PubMed  CAS  Google Scholar 

  • Wilson, R. H., Hough, G. V.,and McCormick, W. E., 1948, Medical problems encountered in the manufacture of American-made rubber, Ind. Med. 17: 199–207.

    CAS  Google Scholar 

  • Wilson, R. H., and McCormich, W. E., 1954, Toxicity of plastics and rubber. Plastomers and monomers, Ind. Med. Surg. 23: 479.

    PubMed  CAS  Google Scholar 

  • Windholz, M., (ed.) 1976, The Merck Index, 9th ed., Rahway, N. Y., Merck & Co., pp. 986, 1283.

    Google Scholar 

  • Winell, M., Holmberg, B., and Kromevi, T., 1976, Biological effects of vinyl chloride: An experimental study, Environ. Health Perspect. 17: 211–216.

    PubMed  CAS  Google Scholar 

  • Withey, J. R., 1976, Quantitative analysis of styrene monomer in polystyrene and foods including some preliminary studies of the uptake and pharmacodynamics of the monomer in rats, Environ. Health Perspect. 17: 125–133.

    PubMed  CAS  Google Scholar 

  • Withey, J. R., and Collins, P. G., 1977, Pharmacokinetics and distribution of styrene monomer in rats after intravenous administration, J. Toxicol. Environ. Health 3: 1011–1020.

    PubMed  CAS  Google Scholar 

  • Withey, J. R., and Collins, P. G., 1978, Styrene monomer in foods. A limited Canadian survey, Bull. Environ. Contam. Toxicol. 19: 86–94.

    PubMed  CAS  Google Scholar 

  • Withey, J. R., and Collins, P. G., 1979, The distribution and pharmacokinetics of styrene monomer in rats by the pulmonary route, J. Environ. Pathol. Toxicol. 2: 1329–1342.

    PubMed  CAS  Google Scholar 

  • Wolf, M. A., Rowe, V. K., Collister, D. D., Hollingsworth, R. L., and Oyen, F., 1956, Toxicological studies of certain alkylated benzenes and benzene, Arch. Ind. Health 14: 381–398.

    Google Scholar 

  • Wolff, M. S., 1976, Evidence for existence in human tissues of monomer for plastics and rubber manufacture, Environ. Health Perspect. 17: 183–187.

    PubMed  CAS  Google Scholar 

  • Wolff, M. S., Lorimer, W. V., Lilis, R., and Selikoff, I. J., 1978, Blood styrene and urinary metabolites in styrene polymerisation, Brit. J. Ind. Med. 35: 318–329.

    CAS  Google Scholar 

  • Yagen, B., Hernandez, O., Bend, J. R., and Cox, R. H., 1981, Synthesis and relative stereochemistry of the four mercapturic acids derived from styrene oxide and V-acetyl cysteine, Chem. Biol. Interact. 34: 57–87.

    PubMed  CAS  Google Scholar 

  • Yllner, S., 1971, Metabolism of chloroacetate-l-uC in the mouse, Acta Pharmacol. Toxicol. 30: 69–80.

    CAS  Google Scholar 

  • Yoshikawa, K., Isobe, M., Watabe, T., and Takabatake, E., 1980, Studies on met abolism and toxicity of styrene. III. The effects of metabolic inactivation by rat liver S9 on the mutagenicity of phenyloxirane towards Salmonella typhimurium, Mutat. Res. 78: 219–226.

    PubMed  CAS  Google Scholar 

  • Zajdela, F., Croisy, A., Barbin, A., Malaveille, C., Tomatis, L., and Bartsch, H., 1980, Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride and bis (chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice, Cancer Res. 40: 352–356.

    PubMed  CAS  Google Scholar 

  • Zil’Fyan, V. N., Fichidzhyan, B. S., Garibyan, D. K., and Pogosova, A. M., 1977, Experimental study of chiproprene for carcinogenicity, Vop. Onkol. 23: 61–65.

    Google Scholar 

  • Zimmermann, F. K.,and Vig. B. K., 1975, Mutagen specificity in the induction of mitotic crossing over in Saccharomyces cerevisiae, Mol. Gen. Genet. 139: 255–268.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Poncelet, F., Bogaert, M.Dv., Lambotte-Vandepaer, M., de Meester, C. (1984). Mutagenicity, Carcinogenicity, and Teratogenicity of Industrially Important Monomers. In: Kirsch-Volders, M. (eds) Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2643-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2643-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9649-2

  • Online ISBN: 978-1-4613-2643-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics