Abstract
Owing to their widespread use and occurrence in the environment, and their toxicological hazards, the group vinyl chloride (VCM), vinylidene chloride (VDC), acrylonitrile (ACN), styrene (STY), butadiene (BUT), and chlorobutadiene (CBD) form an important category of industrial chemicals. These so-called monomers are extensively used in the production of homo- and copolymeric materials utilized in the manufacture of many and various products, such as food packaging (VCM, VDC, STY), synthetic textile fibers (ACN, VDC), synthetic rubber goods (CBD, BUT), resins, and elastomers (VCM, VDC, BUT, etc.) and, according to published reports, world annual production varies from 7000 million kg for STY to 300 million kg for chlorobutadiene. All of them are gaseous or volatile and are generally poorly soluble in water.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abreu, M. E., and Ahmed, A. E., 1980, Metabolism of acrylonitrile to cyanide, Drug Met. and Disp. 8: 3762–379.
Agakhanyan, A. G., Fridenshtein, A. Y., Allverdyan, A. G., 1973, Immunomorphology of chloroprene toxicosis, Zh. Eksp. Klin. Med.: 13: 3–7.
American Conference of Governmental Industrial Hygienists, 1976, TLVsR, Threshold limit values for chemical substances in workroom air adopted by ACGIH for 1976, Cincinnati, Ohio, p. 30.
Andersen, M. E., Jones, R. A. and Jenkins, L., 1978, The acute toxicity of vinyle, oral doses of 1,1 -dichloroethylene in the fasted, male rat: Effect of induction and inhibition of microsomal enzyme activities on mortality, Toxicol. Appl. Pharmacol. 46: 227–234.
Andersen, M. E., Gargas, M. L., Jones, R. A. and Jenkins, L. J., 1979a, The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism, Toxicol. Appl. Pharmacol. 47: 395–409.
Andersen, M. E., French, J. E., Gargas, M. L., Jones, R. A., and Jenkins, L. J., 1979b, Saturable metabolism and acute toxicity of 1,1-dichloroethylene, Toxicol. Appl. Pharmacol. 47: 385–393.
Andersen, M. E., Thomas, O. E., Gargas, M. L., Jones, R. A. and Jenkins, L. J., 1980, The significance of multiple detoxification pathways for reactive metabolites in the toxicity of 1,1-dichloroethylene, Toxicol. Appl. Pharmacol. 52: 422–432.
Anderson, D., Hodge, M. C. E. and Purchase, I. F. H., 1977, Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-I mice, Environ. Health Persp. 21: 71–78.
Anderson, D., Hodge, M. C. E. & Purchase, I. F. H., 1976, Vinyl chloride: Dominant lethal studies in male CD-I mice, Mutat. Res. 40: 359–370.
Andrews, A. W., Zawistowski, E. S., and Valentine, C. R., 1976, A comparison of the mutagenic properties of vinyl chloride and methyl chloride, Mutat. Res. 40: 273–276.
Anonymous, 1980, ACN testing shows tumors at all levels, Food and Drug Packaging, March 20, 1980, 43–44.
Antweiler, H., 1976, Studies on the metabolism of vinyl chloride, Environ. Health Perspect. 17: 217–219.
Baggett, M. S., Morie, G. P., Simmons, M. W. and Lewis, J. S., 1974, Quantitative determination of semivolatile compounds in cigarette smoke, J. Chromatogr. 97: 79–82.
Bakke, O. N., and Sheline, R. R., 1970, Hydroxylation of aromatic hydrocarbons in the rat, Toxicol. Appl. Pharmacol. 16: 691–700.
Barbin, A., Bresil, H., Croisy, A., Jacquignon, P., Malaveille, C., Montesano, R., and Bartsch, H., 1975, Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride, Biochem. Biophys. Res. Commun., 67: 596–603.
Bardodej, Z., and Bardodejova, E., 1970, Biotransformation of ethylbenzene, styrene, and alpha-methylstyrene in man, Am. Ind. Hyg. Assoc. J. 31: 206–209.
Barrio, J. R., Secrist, J. A., and Leonard, N. J., 1972, Fluorescent adenosine and cytidine derivatives, Biochem. Biophys. Res. Commun. 46: 597–604.
Bartsch, H., and Montesano, R., 1975, Mutagenic and carcinogenic effects of vinyl chloride, Mutat. Res. 32: 93–114.
Bartsch, H., Malaveille, C., Montesano, R., 1975a, Human rat and mouse liver-mediated mutagenicity of vinyl chloride in S. tvphimurium strains, Int..J. Cancer 15: 429–437.
Bartsch, H., Malaveille, C., Montesano, R. and Tomatis, L., 1975b ), Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella tvphimurium, Nature 255: 641–643.
Bartsch, H., Malaveille, C., Barbin, A., Bresil, H., Tomatis, L., and Montesano, R., 1976, Mutagenicity and metabolism of vinyl chloride and related compounds, Environ. Health Perspect. 17: 193–198.
Bartsch, H., Malaveille, C., Barbin, A. and Planche, G., 1979, Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono- oxygenases, Arch. Toxicol. 41: 249–277.
Basler, A., and Rohrborn, G., 1980, Vinyl chloride: An example for evaluating mutagenic effects in mammals in vivo after exposure to inhalation, Arch. Toxicol. 45: 1–7.
Bauer, C., Leporini, C., Bronzetti, G., Corsi, C., Nieri, R., Del Carratore, R., Tonarelli, S., 1980, The problem of negative results for styrene in the in vitro mutagenesis test with metabolic activation, Boll. Soc. It. Biol. Sper. 56: 203–207.
Baxter, P. J., Anthony, P. P., McSween, R. N. M., and Scheuer, P. J., 1977, Angiosarcoma of the liver in Great Britain, 1963–1973. Brit. Med. J.: 919–921.
Belvedere, G., Cantoni, L., Tacchinetti, T., and Salmona, M., 1977, Kinetic behaviour of microsomal styrene monooxygenase and styrene epoxide hydratase in different animal species, Experientia 33: 708–709.
Biersack, H. J., Sanluis, T. Jr., Lange, C. E., Thelen, M., Veltman, G., Winkler, C., 1977, Scintigraphy of liver and spleen in vinyl chloride workers, Acta Hepato-Gastroenterol. 24: 357–361.
Binns, C. H. B., 1979, Vinyl chloride: a review, J. Soc. Occup. Med. 29: 134–141.
Block, J. B., 1974, Angiosarcoma of the liver following vinyl chloride exposure, J. Am. Med. Assoc. 229: 53–54.
Bolt, H. M., Kappus, H., Buchter, A., and Bolt, W., 1976, Disposition of (1,2-14C) vinyl chloride in the rat, Arch. Toxicol., 35: 153–162.
Bolt, H. M., and Filser, J. G., 1977, Irreversible binding of chlorinated ethylenes to macromolecules, Environ. Health Perspect. 21: 107–112.
Bonatti, S., Abbondandolo, A., Corti, G., Fiorio, R., and Mazzaccaro, A., 1978, The expression curve of mutants induced by styrene oxide at the HGPRT locus in V 79 cells, Mutation Res. 52: 295–300.
Border, E. A., and Webster, I., 1977, The effect of vinyl chloride monomer, chloroethylene oxide and chloroacetaldehyde on DNA synthesis in regenerating rat liver, Chem. Biol. Interact. 17: 239–247.
Bos, R., Guicherit, R. and Hoogeveen, A., 1977, Distribution of some hydrocarbons in ambient air near Delft and the influence of the formation of secondary air pollutants, Sci. Total Environ. 7: 269–281.
Boyland, E., and Williams, K., 1965, An enzyme catalysing the conjugation of epoxides with glutathione, Biochem. J. 94: 190–197.
Brady, J, Liberatore, F., Harper, Ph., Greenwald, P., Burnett, W., Davies, J. N. P., Bishop, M., Polan, A., and Vianna, N., 1977, Angiosarcoma of the liver: an epidemiologic study,J Nat’l Cancer Inst. 59: 1383–1385.
Brand, K. G., Buoen, L. C., and Brand, I., 1975, Foreign-body tumorigenesis by vinyl chloride vinyl acetate copolymer: No evidence for chemical cocarcinogenesis, J. Nat’l Cancer Inst. 54: 1259–1262.
Buffler, P. A., Wood, S., Eifler, C., Suarez, L., Kilian, D. J., 1979, Mortality experience of workers in a vinyl chloride monomer production plant, J. Occup. Medicine 21: 195–203.
Busk, L., 1979, Mutagenic effects of styrene and styrene oxide, Mutat. Res. 67: 201–208.
Byrén, D., and Holmberg, B., 1975, Two possible cases of angiosarcoma of the liver in a group of Swedish vinyl chloride-polyvinyl chloride workers, Ann. N. Y. Acad. Sci. 246: 249–250.
Byrén, D., Engholm, G., Englund, A., and Westerholm, P., 1976, Mortality and cancer morbidity in a group of Swedish VCM and PVC production workers, Environ. Health Perspect. 17: 167–170.
Cantoni, L., Salmona, M. Facchinetti, T., Pantarotto, C., and Belvedere, G., 1978, Hepatic and extrahepatic formation and hydration of styrene oxide in vitro, in animals of different species and sexes, Tox. Letters 2: 179–186.
Caperos, J. R., Humbert, B. and Droz, P. O., 1979, Exposition au Styrène. II. Bilan de l’absorption, de l’excrétion et du métabolisme sur des sujets humains, Int. Arch. Occup. Environ. Health 42: 223–230.
Caputo, A., Viola, P. L., and Bigotti, A., 1974, Oncogenicity of vinyl chloride at low concentrations in rats and rabbits, Int. Res. Commun. 2: 1582.
Chiazze, L., Jr., Nichols, W. E., and Wong, O., 1977, Mortality among employees of PVC fibricators, J. Occup. Med. 19: 623–628.
Chmielewski, J., and Renke, W., 1976, Clinical and experimental research into the pathogenesis of toxic effect of styrene, Bull. Inst. Mar. Trop. Med. Gdynia 27: 63–68.
Chmielewski, J., and Hac, E., 1976, Clinical and experimental research into the pathogenesis of toxic effects of styrene. IV. Estimation of liver functions in persons exposed to the action of styrene during their work, Bull. Inst. Mar. Trop. Med. Gdynia 27: 69–74.
Chmielewski, J., 1976, Clinical and experimental research into the pathogenesis of toxic effects of styrene. V. Impact of styrene on carbohydrate balance in people in the course of their work, Bull. Inst. Mar. Trop. Med. Gdynia 27: 177–184.
Clarke, C. H., and Loprieno, N., 1965, The influence of genetic background on the induction of methionine reversions by diepoxybutane in Schizosaccharomyces pombe, Microb. Genet. Bull. 22: 11–12.
Clary, J. J., Feron, V. J., and Reuzel, P. G. J., 1978, Toxicity of β-chloroprene (2- chlorobutadiene-1,3): Acute and subacute toxicity, Toxicol. Appl. Pharmacol. 46: 375–384.
Conner, M. K., Alarie, Y. and Dombroske, R. L., 1979, Sister chromatid exchange in regenerating liver and bone marrow cells of mice exposed to styrene, Toxicol. Appl. Pharmacol. 50: 365–367.
Conner, M. K., Alarie, Y., and Dombroske, R. L., 1980, Sister chromatid exchange in murine alveolar macrophages, bone marrow and regenerating liver cells induced by styrene inhalation, Toxicol. Appl. Pharmacol. 55: 37–42.
Conolly, R. B., Jaeger, R. J., and Szabo, S., 1978, Acute hepatotoxicity of ethylene, vinyl fluoride, vinyl chloride and vinyl bromide after Aroclor 1254 pretreatment, Exper. Molec. Pathol. 28: 25–33.
Conolly, R. B., and Jaeger, R. J., 1979, Acute hepatotoxicity of vinyl chloride and ethylene: Modification by trichfloropropene oxide, diethylmaleate, and cysteine, Toxicol. Appl. Pharmacol. 50: 523–531.
Couderc, P., Panh, M.-H., Pasquier, B., Pasquier, D., N’Golet, A., and Faure, H., 1976, Angiosarcoma of the bone indicating a hepatic tumor in a worker exposed to vinyl chloride (Fr.), Semin. Hop. Paris 52: 1721–1722.
Creech, J. L., Jr., and Johnson, M. N., 1974, Angiosarcoma of liver in the manufacture of polyvinyl chloride, J. occup. Med. 16: 150–151.
Crouch, C. N., Pullinger, D. H., and Gaunt, J. F., 1979, Inhalation toxicity studies with l,3-butadiene-2. 3 month toxicity study in rats, Am. Ind. Hvg. Assoc. J. 40: 796–802.
Culik, R., Kelly, D. P., and Clary, J. J., 1978, Inhalation studies to evaluate the teratogenic and embryotoxic potential of /3-chloroprene(2-chlorobutadiene-1,3), Toxicol. Appl. Pharmacol. 44: 81–88.
Danishefsky, I., and Willhite, M., 1954, The metabolism of styrene in the rat, J. Biol. Chem. 211: 549–553.
Delorme, F., and I heriault, G., 1978, Ten cases of angiosarcoma of the liver in Shawinigan, Quebec, J. Occup. Med. 20: 338–340.
Delorme, F., 1978, Association d’un angiosarcome du foie et d’un hepatome chez un ouvrier du chlorure de vinyle, Ann. Anat. Pathol. 23: 105–114.
de Meester, C., Poncelet, F., Roberfroid, M., Rondelet, J., and Mercier, M., 1977, Mutagenicity of styrene and styrene oxide, Mutat. Res. 56: 147–152.
de Meester, C., Poncelet, F., Roberfroid, M., Mercier, M., 1978a, Mutagenicity of acrylonitrile, Toxicology 11 (1): 19–27.
de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1978b, Etude de Tactivite mutagene du butadiene, de l’acrylonitrile de du styrene. Presented at the National Congres of the Belgian Society for Pharmaceutical Science. Liege, Belgium, March 16-17, Abst., p. 47.
de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1978c, Impact of microsomal enzymes on the mutagenicity of acrylonitrile, butadiene and styrene. Presented at the Eighth Annual Meeting of the European Environmental Mutagen Society. Dublin, July 11-13, Abst. p. 63.
de Meester, C., Poncelet, F., Roberfroid, M.,and Mercier, M., 1978d. Mutagenicity of butadiene and butadiene monoxide, Biochem. Biophys. Res. Commun. 80: 298–305.
de Meester, C., Duverger-van Bogaert, M., Lambotte-Vandepaer, M., Roberfroid M., Poncelet, F., Mercier, M., 1979a, Liver extract mediated mutagenicity of acrylonitrile, Toxicology 13 (1): 7–15.
de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1979b, Mutagenic activity of butadiene and related compounds. Presented at the Ninth Annual Meeting of the European Environmental Mutagen Society. Makarska, September 30-0ctober 5, 1979, Abst. p. 94.
de Meester, C., Duverger-van Bogaert, M., Lambotte-Vandepar, M., Roberfroid, M., Poncelet, F., and Mercier, M., 1980a, Mutagenicity of vinyl chloride in the Ames test: Possible artifacts related to experimental conditions, Mutat. Res. 77: 175–179.
de Meester, C., Poncelet, F., Roberfroid, M., and Mercier, M., 1980b, The mutagenicity of buradiene towards Salmonella typhimurium. Tox. Letters 6: 125–130.
de Meester, C., Duverger-van Bogaert, M., Lombotte-Vandepaer, M., Mercier, M., and Poncelet, F., 1981, Mutagenicity of styrene in the Salmonella typhimurium test system, Mutat. Res., 90: 443–450.
de Meester, C., Mercier, M., and Poncelet, F., Mutagenic activity of butadiene, hexachlorobutadiene, and isoprene (to be published)
de Raat, W. K., 1978, Induction of sister chromatic exchanges by styrene and its presumed metabolite styrene oxide in the presence of rat liver homogenate, Chem.-biol. Interact. 20: 163–170.
Dinu, V., 1975, Activity of GSH peroxidase and catalase and the concentration of lipid peroxides in acute intoxication with Acrylonitrile, Rev. Roum. Biochim. 12(1): 11–14.
Dinu, V., and Klein, R., 1976, Activite catalasique et concentration de glutathion et d’acide lactique dans l’intoxication aigue par l’acrylonitrile chez le rat, J. Pharmacol. (Paris) 7: 2, 223–226.
Dmitrienko, V. D., and Vasilos, A. F., 1972, Kidney damage during the experimental acute poisoning with hexachlorobutadiene, Zdravookhranenie (Kishinev) 15:11–12. Abstracted in Chem. Abstr. 77, 44061.
Dolmierski, R., Kwaiktowski, S. R., and Nitka, J., 1976, Clinical and experimental research into the pathogenesis of toxic effects of styrene: VII. Appraisal of the nervous system in the workers exposed to styrene. Bull. Inst. Mar. Trop. Med. Gdynia 27: 193–196.
Donner, M., Sorsa, M., and Vainio, H., 1979, Recessive lethals induced by styrene and styrene oxide in Drosophila melanogaster. Mutat. Res. 67: 373–376.
Drevon, C., and Kuroki, T., 1979, Mutagenicity of vinyl chloride, vinylidene chloride, and chloroprene in V 79 Chinese hamster cells, Mutat. Res. 67: 173–182.
Drew, R. T., Harper, C., Gupta, B. N., Talley, F. A., 1975, Effects of vinyl chloride exposures to rats pretreated with phenobarbital. Environ. Health Persp. 11: 235–242.
Drozdowicz, B. Z., and Huang, P. C., 1977, Lack of mutagenicity of vinyl chloride in two strains of Neurospora crassa, Mutat. Res. 48: 43–50.
Du, J. T., Sandoz, J. P., Tseng, M. T., and Tamburro, C. H., 1979, Biochemical alterations in livers of rats exposed to vinyl chloride, J. Toxicol. Environm. Health 5: 1119–1132.
Ducatman, A., Hirschhorn, K., and Selikoff, I. J., 1975, Vinyl chloride exposure and human chromsome aberrations, Mutat. Res. 31: 163–168.
Duck, B. W., and Carter, J. T., 1976, Vinyl chloride and mortality? Lancet ii:195.
Duprat, P., and Gradiski, O., 1978, Percutaneous toxicity of hexachlorobutadiene, Acta Pharmacol. Toxicol. 43: 346–353.
Duverger-van Bogaert, M., Lambotte-Vandepaer, M., Noel, G., Roberfroid, M., and Mercier, M., 1978a, Biochemical effects of acrylonitrile on the rat liver, as influenced by various pretreatments of the animals, Biochem. Biophvs. Res. Commun. 83: 3, 1117–1124.
Duverger-van Bogaert, M., Noel, G., Rollmann, B., Cumps, J., Roberfroid, M., and Mercier, M., 1978b, Determination of oxide synthetase and hydratase activities by a new highly sensitive gas chromatographic method using styrene and styrene oxide as substrates, Biochim. Biophvs. Acta 526: 77–84.
Duverger-van Bogaert, M., Noel, G., Rollmann, B., Cumps, J., Roberfroid, M., and Mercier, M., 1978b, Determination of oxide synthetase and hydratase activities by a new highly sensitive gas chromatographic method using styrene and styrene oxide as substrates, Biochim. Biophvs. Acta 526: 77–84.
Duverger-van Bogaert, M., Lambotte-Vandepaer, M., de Meester, C., Rollmann, b., Poncelet, F., and Mercier, M., 1981b, Effect of several factors on the liver extract mediated mutagenicity of acrylonitrile and identification of four new in vitro metabolites. Tox. Lett. 7: 311–318.
Edmonds, L. D., Anderson, C. E., Flynt, J. W., Jr., and James, L. M., 1978, Congenital central nervous system malformations and vinyl chloride monomer exposure: A community study, Teratology 17: 137–142.
El Masri, A. M., Smith, J. N., and Williams, R. T., 1958, Studies in detoxications 73. The metabolism of alkylbenzenes: phenyl acetylene and phenylethylene, Biochem. J. 68: 199–204.
Elmore, J. D., Wong, J. L., Laumback, A. D., and Streips, U. N., 1976, Vinyl chloride mutagenicity via the metabolites chlorooxirane and chloroacetaldehyde monomer hydrate, Biochim. Biophvs. Acta 442: 405–419.
Engström, J., Bjurström, R., Astrand, I., and Övrum, B., 1978, Uptake, distribution and elimination of styrene in man, Scand. J. Work. Environ. Health 4: 315–323.
Eurocop-Cost, 1976, A comprehensive list of polluting substances which have been identified in various fresh waters, effluent discharges, aquatic animals and plants, and bottom sediments, EUCO/MDU 73 76, XII 476 76. 2nd ed., Luxembourg, Commission of the European Communities, p. 19.
Fabry, L., Leonard, A. and Roberfroid, M., 1978, Mutagenicity tests with styrene oxide in mammals, Mutat. Res. 51: 377–381.
Falk, H., Creech, J. L., Jr., Heath, C. W., Jr., Johnson, M. N., & Key, M. M., 1974, Hepatic disease among workers at a vinyl chloride polymerization plant, J. Am. Med. Assoc. 230: 59–63.
Fasset, D. W., 1963, Cyanides and nitriles, in Industrial Hygiene and Toxicology (edited by F. A. Patty) 2nd Revised edition, New York, Interscience, Vol. II, pp. 2009 - 2012.
Feron, V. J., Kruysse, A., and Til, H. P., 1979a, One-year time sequence inhalation toxicity study of vinyl chloride in rats. I. Growth, mortality, haematology, clinical chemistry and organ weights. Toxicology 13: 25–28.
Feron, V. J., Spit, B. J., Immel, H. R., and Kross, R., 1979b, One year time sequence inhalation toxicity study of vinyl chloride in rats. III. Morphological changes in the liver. Toxicology 13: 143–154.
Filatova, V. S., and Gronsberg, E. S., 1957, Sanitary-hygienic conditions of work in the production of polychlorvinylic tar and measures of improvement (Russ.) Gig. i Sanit. 22: 38–42.
Fishbein, L., 1979, Potential Industrial Carcinogens and Mutagens, Elsevier, Amsterdam, pp. 165, 178, 189, 193-194, 495.
Fleig, L, and Thiess, A. M., 1978, Mutagenicity of vinyl chloride. External chromosome studies on persons with and without illness and on VC exposed animals. J. Occup. Med. 20: 557–560.
Fox, A. J., and Collier, P. F., 1976, Low mortality rates in industrial cohort studies due to selection for work and survival in the industry, Br. J. Prev. Soc. Med. 30: 225–230.
Fox, A. J., and Collier, P. F., 1977, Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain, Br. J. Ind. Med. 34: 1–10.
Fuchs, G., Gawell, B. M., Albanus, L., and Slorach, S., 1975, Vinyl chloride monomer levels in edible fats (Swed.), Var Foeda 27:134–145. Chem. Abstr. 83:14587Og.
Funes-Cravioto, F., Lambert, B., Lindsten, J., Ehrenberg, L., Natarajan, A. L, and Osterman- Golkar, S., 1975, Chromsome aberrations in workers exposed to vinyl chloride, Lancet i:459.
Gadzhiev, F. M., and Aliev, T. V., 1974, New method of studying free amino acids and their metabolism in brain tissues under the prolonged effects of gasoline and styrene vapors, Izv. Akad. Nauk. Az. SSR Ser. Biol. Nauk. 4: 112–118.
Garro, A. J., Guttenplan, J. B., and Milvy, P., 1976, Vinyl chloride dependent mutagenesis: Effects of liver extracts and free radicals, Mutat. Res. 38: 81–88.
Gazzotti, G., Garatti, E., and Salmona, M., 1980, Nuclear metabolism. I. Determination of styrene monooxygenase activity in rat liver nuclei, Chem.-Biol. Interact. 29: 189–195.
Gehring, P. J., Watanabe, P. G., and Park, C. N., 1978, Resolution of dose-response toxicity data for chemicals requiring metabolic activation: example—Vinyl chloride, Toxicol. Appl. Pharmacol. 44: 581–591.
Glover, S. W., 1956, A comparative study of induced reversions in Escherichia coli, in Genetic studies with bacteria, Carnegie Institution of Washington, Publication GI2, Washington D.C., p. 121–136.
Gotell, P., Axelson, O., and Lindelof, B., 1972, Field studies on human styrene exposure, Work Environ. Health 9: 76–83.
Göthe, R., Calleman, C. J., Ehrenberg, L., and Wachtmeister, C. A., 1974, Trapping with 3,4-dichlorobenzenethiol of reactive metabolites formed in vitro from the carcinogen vinyl chloride, Ambio 3: 234–236.
Gradiski, D., Duprat, P., Magadur, J. L., Fayein, E., 1975, Etude toxicologique experimental de Thexachlorobutadiène, Eur. J. Toxicol. 8: 180–187.
Green, T., and Hathway, D. E., 1975, The biological fate in rats of vinyl chloride in relation to its oncogenicity, Chem. Biol. Interact. 11: 545–562.
Green, T., and Hathway, D. E., 1977, The chemistry and biogenesis of the S-containing metabolites of vinyl chloride in rats, Chem. Biol. Interact. 17: 137–150.
Green, T., and Hathway, D. E., 1978, Interactions of vinyl chloride with rat liver DNA in vivo, Chem. Biol. Interact. 22: 211–224.
Greim, H., Bonse, G., Radwan, Z., Reichert, D., and Henschler, D., 1975, Mutagenicity w vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation, Biochem. Pharmacol. 24: 2013–2017.
Grigorescu, I., and Toba, G., 1966, Chlorura di vino. Aspects de toxicologic industrielle, Rev. Chim. Rom. 17: 499–501.
Gross, H., and Freiberg, J. 1969, Ziir existenz von chloroathylenoxid, J. Prak. Chem. 311: 506–510.
Gudumak, V. S., 1968, The change in activity of the oxidative enzymes in the organs of white rats given hexachlorobutadiene in acute experiments, Zdravookvr (Kishinev) 3:47–50. Abstracted in Ref. Zh. Old. Vyp. Farmakol. Khimioter. Sredstva. Toksikol. 4. 54. 828 (1969).
Guengerich, F. P., Grawford, W. M., Watanabe, P. G., Jr., 1979, Activation of vinyl chloride to covalently bound metabolites: Roles of 2-chloroethylene oxide and 2-chloroacetaldehyde, Biochemistry 18: 5177–5182.
Guerin, M. R., Olerich, G., and Horton, A. D., 1974, Routine gas chromatographic component profiling of cigarette smoke for the identification of biologically significant constituents, J. Chromatogr. Sci. 12: 385–391.
Guillemin, M. P., and Bauer, D., 1979, Human exposure to styrene. Elimination kinetic of urinary mandelic and phenylglyoxylic acids after single experimental exposures, Int. Arch. Occup. Environ. Health 44: 249–263.
Gut, I., Nerudova, J., Kopecky, J., and Holecek, V., 1975, Acrylonitrile biotransformation in rats, mice and Chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol or thiosulfate, Arch. Toxico. 33: 151–161.
Gut, I., Kopecky, J., and Filip, J., 1981, Acrylonitrile 14C metabolism in rats: Effect of the route of administration on the elimination of thiocyanate and other radioactive metabolites in urine and faeces, J. Hvg. Epid. Microbiol, and Immunol. 25: 12–16.
Haley, T. J., 1975a, Vinyl chloride: How many unknown problems, J. Toxicol. Environm. Health 1: 47–73.
Haley, T. J., 1975b, Vinylidene chloride: A review of the literature, Clin. Toxicol. 8: 633–643.
Haley, T. J., 1978, Chloroprene (2-chloro-l,3-butadiene). What is the evidence for its carcinogenicity? Clin. Toxicol. 13: 153–170.
Hansteen, I. L., Hillestad, L., Thiis-Evensen, E., and Heldaas, S. S., 1978, Effects of vinyl chloride in man, a cytogenetic follow up study, Mutat. Res. 51: 271–278.
Harleman, J. H., and Seinen, W., 1979, Short-term toxicity and reproduction studies in rats with hexachloro-(l,3)-butadiene, Toxicol. Appl. Pharmacol. 47: 1–14.
Härkönen, H., 1978, Styrene: Its experimental and clinical toxicology, Scand. J. Work Environ. Health 4 (2): 104–113.
Härkönen, H., Lindstrom, H., Sepalainen, A. M., Asp. S., and Hernberg, S., 1978, Exposure relationship between styrene exposure and central nervous functions, Scand. J. Work. Environ. Health 4 (2): 53–59.
Hashimoto, K., and Kanai, R., 1965, Studies on the toxicology of acrylonitrile. Metabolism, mode of action and therapy, Ind. Health 3: 30–46.
Hashimoto, K., and Kanai, R., 1972, Effect of acrylonitrile on sulfhydryls and pyruvate metabolism in tissues, Biochem. Pharmacol. 21: 635–640.
Hathway, D. E., 1977, Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential, Environ. Health Persp. 21: 55–59.
Hawley, G. G., Ed., 1971, The Condensed Chemical Dictionary, 8th ed., Van Nostrand- Reinhold, New York, p. 206.
Heath, C. W., Jr., Dumont, C. R., Gamble, J., and Waxweiler, R. J., 1977, Chromosomal damage in men occupationally exposed to vinyl chloride monomer and other chemicals, Environ. Res. 14: 68–72.
Hedley, W. H., Cheng, J. T., McCormick, R. J., and Lewis, W. A., 1976, Sampling of automobile interiors for vinyl chloride monomer, EPA-600/2-76-124, Springfield, Va., National Technical Information Service.
Hefner, R. E., Jr., Watanabe, P. G., and Gehring, P. J., 1975, Preliminary studies on the fate of inhaled vinyl chloride monomer (VCM) in rats, Environ. Health Perspect. 11: 85–95.
Heineman, B., and Howard, A. J., 1964, Induction of lambda-bacteriophage in Escherichia coli as a screening test for potential antitumor agents, Appl. Microbiol. 12: 234–239.
Hoffmann, D., Patrianakos, C., Brunnemann, K. D., and Gori, G. B., 1976, Chromatographic determination of vinyl chloride in tobacco smoke, Anal. Chem. 48: 47–50.
Holmberg, B., Kronevi, T., and Winell, M., 1976, The pathology of vinyl chloride exposed mice, Acta Vet. Scand. 17: 328–342.
Holmberg, P. C., 1977, Central nervous defects in two children of mothers exposed to chemicals in the reinforced plastic industry: Chance or a causal relation? Scand. J. Work Environ. Health 3: 212–214.
Hopkins, J., 1980, Vinyl chloride. V. Mutagenicity in man, Food Cosmet. Toxicol. 18: 200–201.
Huberman, E., Bartsch, H., and Sachs, L., 1975, Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde, Int. J. Cancer 16: 639–644.
Hushon, J., and Kornreich, M., 1976, Air pollution assessment of vinylidene chloride, Springfield, Va., U.S. National Technical Information Service, PB 256, 738, p. 40.
IARC, 1979, IARC monographs on the evaluation of the carcinogenic risk of chemicals to human, 19, some monomers, plastics and synthetic elastomers and acrolein, pp. 73–86; pp. 131–156; pp. 231–244; pp. 377–401; pp. 439–459.
Ikeda, M., Ohtsuji, H., and Imamura, I., 1972, In vivo suppression of benzene and styrene oxidation by co-administration of toluene in rats and effects of phenobarbital, Xenobiotica 2: 101–106.
Infante, P. F., Wagoner, J. K., and Waxweiller, R. J., 1976, Carcinogenic, mutagenic and teratogenic risks associated with vinyl chloride, Mutat. Res. 41: 131–142.
Infante, P. F., Wagoner, J. K., and Young, R. J., 1977, Chloroprene: Observations of carcinogenesis and mutagenesis, in Origins of Human Cancer, Book A, (edited by H. H. Hiatt, J. D. Watson, and J. A. Winsten ), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 205 - 217.
Ivanov, V. V., Kutznetsova, G. P., Archakov, A. I., 1978, Stimulation of lipid peroxidation by acrylonitrile in rat liver tissue, Vopr. Med. Khim. 24 (6): 816–818.
Ivanetich, K.M., Aronson, I., and Katz, I. D., 1977, The interaction of vinyl chloride with rat hepatic microsomal cytochrome P450 in vitro, Biochem. Biophys. Res. Comm. 74: 1411–1418.
Jacobs, A., Blangetti, M., and Hellmond, F., 1974, Accumulation of noxious chlorinated substances from Rhine River water in the fatty tissue of rats, Vom. Wasser 43:259–274, Abstracted in Chem. Abstr. 82: 165547.
Jaeger, R. J., Trabulus, M. J., and Murphy, S. D., 1973a, The interaction of adrenalectomy partial adrenal replacement therapy, and starvation with hepatotoxicity and lethality of 1,1-dichloroethylene intoxication, Toxicol. Appl. Pharmacol. 25: 491.
Jaeger, R. J., Trabulus, M. J., and Murphy, S. D., 1973b, Biochemical effects of 1,1- dichloroethylene in rats: Dissociation of its hepatotoxicity from a lipoperoxidative mechanism, Toxicol. Appl. Pharmacol. 24: 457–467.
Jaeger, R. J., Reynolds, E. S., Conolly, R. B., Moslen, M. T., Szabo, S., and Murphy, S. D., 1974, Acute hepatic injury by vinyl chloride in rats pretreated with phenobarbital, Nature 252: 724–725.
Jaeger, R. J., Conolly, R. B., Reynolds, E. S., and Murphy, S. D., 1975a, Biochemical toxicology of unsaturated halogenated monomers, Environ. Health Persp. 11: 121–128.
Jaeger, R. J., Conolly, R. B., and Murphy, S. D., 1975b, Short-term inhalation toxicity of halogenated hydrocarbons, Arch. Environm. Health. 30: 26–31.
Jaeger, R. J., 1975, Vinyl chloride monomer: Comments on its hepatotoxicity and interaction with 1,1-dichloroethylene, Ann. N.Y. Acad. Sci. 246: 150–151.
Jaeger, R. J., Murphy, S. D., Reynolds, E. S., Szabo, S., and Moslen, M. T., 1977, Chemical modification of acute hepatotoxicity of vinyl chloride monomer in rats, Toxicol. Appl. Pharmacol. 41: 597–607.
James, S. P., and White, D. A., 1967, The metabolism of phenethyl bromide, styrene, and styrene oxide in the rabbit and rat, Biochem. J. 104: 914–921.
James, M. O., Fouts, J. R., and Bend, J. R., 1975, Hepatic and extrahepatic metabolism in vitro of an epoxide (8-14C styrene oxide) in the rabbit, Biochem. Pharmacol. 25: 187–193.
John, J. A., Smith, F. A., Leong, B. K. J., and Schwetz, B. A., 1977, The effects of maternally inhaled vinyl chloride on embryonal and foetal development in mice, rats and rabbits, Toxicol. Appl. Pharmacol. 39: 497–513.
Jones, B. K., and Hathway, D. E., 1978a, Differences in metabolism of vinylidene chloride between mice and rats, Br. J. Cancer 37: 411–417.
Jones, B. K., and Hathway, D. E., 1978b, The biological fate of vinylidene chloride in rats, Chem. Biol. Interact. 20: 27–41.
Jones, B. K., and Hathway, D. E., 1978c, Tissue-mediated mutagenicity of vinylidene chloride in Salmonella tvphimurium TA 1535. Cancer Lett. 5: 1–6.
Kankaanpää, J., Elovaara, E., Hemminki, K., and Vainio, H., 1979a, Embryotoxicity of acrolein, acrylonitrile and acrylamide, in developing chick embryos, Tox. Lett. 4: 93–96.
Kankaanpää, J. T., Hemminki, K., and Vainio, H., 1979b, Embryotoxicity and teratogenicity of styrene and styrene oxide on chick embryos enhanced by trichloropropene oxide, Acta Pharmacol. Toxicol. 45: 399–402.
Kankaanpää, J. T., Elovaara, E., Hemminki, K., and Vainio, H., 1980, The effects of maternally inhaled styrene on embryonal and foetal development in mice and Chinese hamsters, Acta Pharmacol. Toxicol. 47: 127–129.
Kappus, H., Bolt, H. M., Buchter, A., and Bolt, W., 1976, Liver microsomal uptake of 14C vinyl chloride and transformation to protein alkylating metabolites in vitro, Toxicol. Appl. Pharmacol. 37: 461–471.
Keplinger, M. L., Goode, J. W., Gordon, D. E., and Calandra, J. C., 1975, Interim results of exposure of rats, hamsters, and mice to vinyl chloride, Ann. N. Y. Acad. Sci. 246: 219–224.
Khachatryan, E. A., 1972, The occurrence of lung cancer among people working with chloroprene, Probl. Oncol. 18: 85.
Klimkova-Deutschova, E., Jandova, D., Salcmanova, Z., Schwartzova, K., and Titman, O., 1973, Recent advances concerning the clinical picture of professional styrene exposure (Czech.), Cesk. Neurol. Neurochir. 36: 20–25.
Kociba, R. J., Keyes, D. G., Jersey, G. C., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, C. E., Humiston, C. G., and Schwetz, B. A., 1977, Results of a two year chronic toxicity study with hexachlorobutadiene in rats, Ann. Ind. Hyg. Assoc. J. 38: 589–602.
Kølmark, G., and Westergaard, M.,1953, Further studies on chemically induced reversions at the adenine locus of Neurospora Hereditas 39: 209–224.
Kopecky, J., Gut, I., Nerudova, J., Zachardova, D., Holecek, V., Filip, J., 1980, Acrylonitrile metabolism in the rat, Arch. Toxicol. Suppl. 4: 322–324.
Kopecky, J., Gut, I., Nerudova, J., Zachardova, D., Holecek, V. 1980a, Two routes of acrylonitrile metabolism, J. Hvg. Epid. Microbiol. Immunol. 24: 356–362.
Kramer, C. G., and Mutchler, J. E., 1972, The correlation of clinical and environmental measurements for workers exposed to vinyl chloride, Am. Ind. Hyg. Assoc. J. 33: 19–30.
Krasmyuk, E. P., Zaritskaya, L. A., Bioko, V. G., Viotenko, G. A., and Matokhmyuk, L. A., 1969, Health of vineyard workers having contact with the fumigants hexachlorobutadiene and polychlorobutane, 80, Vrach. Delo. 7: 111–115.
Kucerova, M., Polivkova, Z., and Batora, J., 1979, Comparative evaluations of the frequency of chromosomal aberrations and the SCE numbers in peripheral lymphocytes of workers occupationally exposed to vinyl chloride monomer, Mutat. Res. 67: 97–100.
Laib, R. J., and Bolt, H. M., 1978, Formation of 3, N4-ethenocytidine moietis in RNA by vinyl chloride metabolites in vitro and in vivo, Arch. Toxicol. 39: 235–240.
Lambotte-Vandepaer, M., Duverger-van Bogaert, M., de’Meester, C., Noel, G., Poncelet, F., Roberfroid, M., and Mercier, M., 1979, Styrene induced modification of some rat liver enzymes involved in the activation and inactivation of xenobiotics, Biochem. Pharmacol. 28: 1653–1659.
Lambotte-Vandepaer, M., Duverger-van Bogaert, M., de Meester, C., Poncelet, F., and Mercier, M., 1980, Mutagenicity of urine from rats and mice treated with Acrylonitrile, Toxiciology 16: 67–71.
Lambotte-Vandepaer, M., Duverger-van Bogaert, M., de Meester, C., Rollmann, B., Poncelet, F., and Mercier, M., 1981, Identification of two urinary metabolites of rats treated with acrylonitrile: Influence of several inhibitors on the mutagenicity of those urine, Tox. Lett. 7: 321–328.
Lange, C. E., Juhe, S., Stein, G., and Veltman, G. 1975, Further results in polyvinyl chloride production workers, Ann. N. Y. Acad. Sci. 246: 18–21.
Langvardt, P. W., Putzig, C. L., Braun, W. H., and Young, J. D., 1980, Identification of the major urinary metabolites of acrylonitrile in the rat, J. Toxicol. Environ. Health 6: 273–282.
Laska, A. L., Bartell, C. K., Condie, D. B., Brown, J. W., Evans, R. L., and Laseter, J. L., 1978, Acute and chronic effects of hexachlorobenzene and hexachlorobutadiene in red swamp crayfish (Procambarus clarki) and selected fish species, Toxicol. Appl. Pharmacol. 43: 1–12.
Lee, F. I., and Harry, D. S., 1974, Angiosarcoma of the liver in a vinyl chloride worker, Lancet. i:1316–1318.
Lee, C. C., Bhandari, J. C., Winston, J. M., House, W. B., Peters, P. J., Dixon, R. L., and Woods, J. S., 1977, Inhalation toxicity of vinyl chloride and vinylidene chloride, Environ. Health Perspect. 21: 25–32.
Lee, C. C., Bhandari, J. C., Winston, J. M., House, W. B., Dixon, R. L., and Woods, J. S., 1978, Carcinogenicity of vinyl chloride and vinylidene chloride, J. Toxicol. Environ. Health 4: 15–30.
Leibman, K. C., and Ortiz, E., 1969, Oxidation of styrene in liver microsome, Biochem. Pharmacol. 18: 552–554.
Leibman, K. C., 1975, Metabolism and toxicity of styrene, Environ. Health Perspect. 11: 115–119.
Léonard, A., Decat, G., Leonard, E. D., Lefevre, M. J., Decuyper, I. I., and Nicaise, C., 1977, Cytogenetic investigations on lymphocytes from workers exposed to vinyl chloride, J. Toxicol. Environ. Health 2: 1135–1141.
Léonard, A., Garny, V., Poncelet, F., and Mercier, M., 1981, Mutagenicity of acrylonitrile in mouse, Tox. Lett. 7: 329–334.
Lilis, R., and Nicholson, W. J., 1976, Cancer experience among workers in a chemical plant producing styrene monomers, in Proceedings of NIOSH Styrene-Butadiene briefing, Covington, Kentucky, 1976, (edited by L. Ede), HEW Publ. No. (NIOSH) 77-129, Cincinnati, Ohio, U.S. Department of Health, Education, and Welfare, pp. 22 - 27.
Lilis, R., Lorimer, W. V., Diamond, S., and Selikoff, I. J., 1978, Neurotoxicity of styrene in production and polymerization workers, Environ. Res. 15: 133–138.
Lindström, K., Härkönen, H., and Hernberg, S., 1976, Disturbances in psychological functions of workers occupationally exposed to styrene, Scand. J. Work. Environ. Health 3: 129–139.
Lingeman, C. H., 1976, The vinyl chloride story, The Bulletin of SPEP IV: 9–15.
Linnainmaa, K., Meretoja, T., Sorsa, M., and Vainio, H., 1978, Cytogenetic effects of styrene and styrene oxide on human lymphocytes and “Allium Cepa.” Scand. J. Work. Environ. Health 4 (2): 156–162.
Lloyd, J. W., 1975, Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers, J. Occup. Med. 17: 333–334.
Lloyd, J. W., Decoufle, P., Moore, R. M., 1975, Background information on chloroprene, J. Occup. Med. 17: 263–264.
Lock, E. A., and Ishmael, J., 1979, The acute toxic effects of hexachloro-1,3-butadiene on the rat kidney, Arch. Toxicol. 43: 47–57.
Locker, G. Y., Doroshow, J. H., Zwelling, L. A., and Chabner, B. A., 1979, The clinical features of hepatic angiosarcomas. A report of four cases and a review of the English literature, Medicine 58: 48–64.
Loprieno, N., Barale, R., Baroncelli, S., Bauer, C., Bronzetti, G., Cammellini, A., Cercignani, G., Corsi, C., Gervasi, G., Leporini, C., Nieri, R., Rossi, A. M., Stretti, G., and Turchi. G., 1976a, Evaluation of the genetic effects induced by vinyl chloride monomer (VCM) under mammalian metabolic activation: Studies in vitro and in vivo, Mutat. Res. 40: 85–96.
Loprieno, N., Abbondandolo, A., Barale, R., Baroncelli, S., Bonatti, S., Bronzetti, G., Cammellini, A., Corsi, C, Corti, G., Frezza, D., Leporini, C., Mazzaccaro, A., Nieri, R., Rosellini, D., and Rossi, A. M., 1976b, Mutagenicity of industrial compounds; Styrene and its possible metabolite styrene oxide, Mutat. Res. 40: 317–324.
Loprieno, N., Barale, R., Baroncelli, S., Bartsch, H., Bronzetti, G., Cammellini, A., Corsi, C., Frozza, D., Nieri, R., Leporini, C., Rosellini, D., and Rossi, A. M., 1977, Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast, Cancer Res. 36: 253–257.
Loprieno, N., Presciuttini, S., Sbrana, I., Stretti, G., Zaccaro, L., Abbondandolo, A., Bonatti, S., Fiorio, R., and Mazzaccaro, A., 1978, Mutagenicity of industrial compounds VII: Styrene and styrene oxide. II. Point mutations, chromosome aberrations and DNA repair induction analyses, Scand. J. Work. Environ. Health. 4: (suppl. 2): 169–178.
Lorimer, W. V., Lilis, R., Nicholson, W. J., Anderson, H., Fischbein, A., Daum, S., Rom, W., Rice, C., and Selikoff, I. J., 1976, Clinical studies of styrene workers: Initial findings, Environ. Health Perspect. 17: 171–181.
Lukoshkima, L. P., and Alekperov, I. I., 1973, Lipid protein metabolism in workers handling divinylbenzene and styrene, Gig. Tr. Prof. Zahol. 17: 42–44.
Magnusson, J., and Ramel, C., 1978, Mutagenic effect of vinyl chloride on Drosophila melanogaster with and without pretreatment with sodium phenobarbitone, Mutat. Res. 57: 307–312.
Magnusson, J., Hallstrom, I., and Ramel, C., 1979, Studies on metabolic activation of vinyl chloride in Drosophila melanogaster after pretreatment with phenobarbital and poly- chlorinated biphenyls, Chem. Biol. Interact. 24: 287–298.
Magos, L., 1962, A study of acrylonitrile poisoning in relation to methaemoglobin-CN complex formation, Brit. J. Ind. Med. 19: 283–286.
Makk, L., Creech, J. L., Whelan, J. G., Jr., and Johnson, M. N., 1974, Liver damage and angiosarcoma in vinyl chloride workers. A systematic detection program, J. Am. Med. Assoc. 230: 64–68.
Malaveille, C., Bartsch, H., Barbin, A., Camus, A. M., Montesano, R., Croisy, A., and Jacquignon, P., 1975, Mutagenicity of vinyl chloride, chloroethyleneoxide, chloro- acetaldehyde, and chloroethanol, Biochem. Biophys. Res. Commun. 63: 363–370.
Malaveille, C., Planche, G., and Bartsch, H., 1977, Factors for efficiency of the Salmonella I microsome mutagenicity assay, Chem. Biol. Interact. 17: 129–136.
Maltoni, C., 1974, Angiosarcoma of the liver in workers exposed to vinyl chloride. First two cases found in Italy (Ital.), Med. Lav. 65: 445–450.
Maltoni, C., Lefemine, G., Chicco, P., and Carreti, D., 1974, Vinyl chloride carcinogenesis: Current results and perspectives, Med. Lav. 65: 421–444.
Maltoni, C., 1976a, Vinyl chloride pathology, Med. Biol. Environ. 4: 267–278.
Maltoni, C., 1976b, Occupational chemical carcinogenesis New facts, priorities and perspectives, Colloq. Inst. Natl. Scint. Rech. Med. 52: 127–150.
Maltoni, C., 1977a, Vinyl chloride carcinogenecity: An experimental model for carcinogenesis studies, in Origins of Human Cancer, (edited by H. H. Hiatt, J. D. Watson, and J. A. Winsten ), Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp. 119–146.
Maltoni, C., Ciliberti, A., and DiMaio, V., 1977b, Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion, Med. Lav. 68: 401–411.
Maltoni, C., Cotti, G., Morisi, L., and Chieco, P. 1977c, Carcinogenicity bioassays of vinylidene chloride, Research plan and early results, Med. Lav. 68: 241–262.
Maltoni, C., Failla, G., and Kassapidis, G., 1979, First experimental demonstration of the carcinogenic effects of styrene oxide, Med. Lav. 5: 358–362.
Malvoisin, E., Lhoest, G., Poncelet, F., Roberfroid, M., and Mercier, M., 1979, Identification and quantitation of l,2-epoxybutene-3 as the primary metabolite of 1,3-butadiene. J. Chrom. 178: 419–425.
Maricq, H. R., Johnson, M. N., Whetstone, C. L., and Carwille, E., 1976, Capillary abnormalities in polyvinyl chloride production workers. Examination by in vivo microscopy, Jama 236: 1368–1371.
Marniemi, J., Suolinna, E. M., Kaartinen, N., and Vainio, H., 1976, Covalent binding of styrene oxide to rat liver macromolecules in vivo and in vitro. Hoppe Seyler’s, Z. Physiol. Chem. 357: 140.
Martynenko, D. N., 1973, Hygienic characteristics of working conditions during production of articles from polymeric materials used in machine construction (Russ.), Cig. Tr. 9:57–61. Chem. Abstr. 85:14832If.
Mattern, I. E., Van der Zwaan, W. B., and Willems, M. J., 1977, Mutagenicity testing of urine from vinyl chloride treated rats using the Salmonella test system, Mutat. Res. 46: 230–231.
McCann, J., Simmon, V., Streitwieser, D., and Ames, B. N., 1975a, Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide, Proc. Natl. Acad. Sci. (Wash.) 72: 3190–3193.
McCann, J., Choi, E., Yamasaki, E., and Ames, B. N., 1975b, Detection of carcinogens as mutagens in the Salmonella I microsome test: Assay of 300 chemicals, Proc. Natl. Acad. Sci. U.S.A. 72: 5135–5139.
McKenna, M. J., Watanabe, P. G., and Gehring, P. J., 1977, Pharmacokinetics of vinylidene chloride in the rat, Environm. Health Perspect. 21: 99–105.
McKenna, M. J., Zempel, J. A., Madrid, E. O., Braun, W. H., and Gehring, P. J., 1978a, Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration, Toxicol. Appl. Pharmacol. 45: 821–835.
McKenna, M. J., Zempel, J. A., Madrid, E. O., and Gehring, P. J., 1978b, The pharmacokinetics of 14C vinylidene chloride in rats following inhalation exposure, Toxicol. Appl. Pharmacol. 45: 599–610.
McLaughlin, J., Jr., Marliac, J.-P., Verrett, M. J., Mutchler, M. K., and Fitzhugh, O. G., 1964, Toxicity of fourteen volatile chemicals as measured by the chick embryo method, Am. Ind. Hyg. Assoc. J. 25: 282–284.
Menezes, S., Papadopoulo, D., Levry, S., and Markovits, P., 1979, Transformation in vitro de cellules de poumons de jeunes hamsters par le chloro-2-butadiene, C. R. Acad. Sci. Paris 288: 923–926.
Meretoja, T., Vainio, H., Sorsa, M., and Härkönen, H., 1977, Occupational styrene exposure and chromosomal aberrations, Mutat. Res. 56: 193–197.
Meretoja, T., Vainio, H., and Jarventaus, H., 1978, Clastogenic effects of styrene exposure on bone marrow cells of rats, Tox. Lett. 1: 315–318.
Miller, A., Teirstein, A. S., Chuang, M., and Selikoff, I. J., 1975, Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride, Ann. N. Y. Acad. Sci. 246: 42–52.
Milvy, P., and Garro, A. J., 1976, Mutagenic activity of styrene oxide (1,2-epoxyethylbenzene), a presumed styrene metabolite, Mutat. Res. 40: 15–18.
Milvy, P., and Wolff, M., 1977, Mutagenic studies with acrylonitrile, Mutat. Res. 48 (3-4): 271–278.
Monson, R. R., Peters, J. M., and Johnson, M. N., 1974, Proportional mortality among vinyl-chloride workers, Lancet ii:397–398.
Morris, G. E., 1953, Vinyl plastics. Their dermatological and chemical aspects, Arch. Ind. Occup. Med. 3: 535.
Morisset, Y., P’an, A., and Jegier, Z., 1979, Effect of styrene and fiber glass on small airways of mice, J. Toxicol. Environ. Health 5: 943–956.
Müller, G. Norpoth, K., and Eckard, R., 1976, Identification of two urine metabolites of vinyl chloride by GC-MS investigations. Int. Arch. Occup. Environ. Health 38: 69–75.
Muller, G., Norpoth, C. K., and Owzarski, W., 1978, In vivo trapping of a vinyl chloride metabolite by means of 3,4-dichlorobenzenethiol, Int. Arch. Occup. Environ. Health 42: 137–139.
Muratov, M. M., and Gus’Kova, S. I., 1978, The question of the mutagenic activity of vinyl chloride, Hyg. Sanit. 7: 111–112.
Murdoch, I. A., and Hammond, A. R., 1977, A practical method for the measurement of vinyl chloride monomer (VCM) in air, Ann. Occup. Hyg. 20: 55–61.
Murray, F. J., Schwetz, B. A., Nitschke, K. D., John, J. A., Norris, J. M., and Gehring, P. J., 1978a, Teratogenicity of acrylonitrile given to rats by gavage or by inhalation, Food Cosmet. Toxicol. 16: 547–551.
Murray, F. J., John, J. A., Balmer, M. F., and Schwetz, B. A., 1978b, Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage, Toxicology 11: 335–343.
Murray, F. J., Mitschke, K. D., Rampy, L. W., and Schwetz, B. A., 1979, Embryotoxicity of fetotoxicity of inhaled or ingested vinylidene chloride in rats and rabbits, Toxicol. Appl. Pharmacol. 49: 189–202.
Murzakaev, F. G., 1967, Action exerted by low hexachlorobutadiene doses on the activity of the central nervous system and morphological changes in animals so poisoned, Gig. Tr. Prof. Zabol. 11:23–28. Abstracted in Chem. Abstr. 67: 3 1040.
National Cancer Institute, 1979, Bioassay of styrene for possible carcinogenicity. Technical -report series No. 185, case No. 100-42-5, U.S. Department of Health, Education, and Welfare. Public Health Service, National Institute of Health.
National Institute for Occupational Safety and Health, 1977, Criteria for a Recommended Standard—Occupational Exposure to Chloroprene, DHEW (NIOSH) Publ. No. 77 - 210. Washington, D.C., U.S. Government Printing Office.
Nerudova, J., Kopecky, J., Hatle, K., 1978, Acrylonitrile biotransformation in microsomes, isolated perfused liver, and in living rats, Int. Congr. Ser. Exc. Med. 440: 121–123.
Nicholson, W. J., Hammond, E. C., Seidman, H., and Selikoff, I. J., 1975, Mortality experience of a cohort of vinyl chloride-polyvinyl chloride workers, Ann. N. Y. Acad. Sci. 246: 225–230.
Nilsen, O. G., Toftgard, R., Eneroth, P., 1980, Effects of acrylonitrile on rat liver cytochrome P450, benzo(a)pyrene metabolism and serum hormone levels, Tox. Lett. 6 (6): 399–404.
Noria, D. F., Ritchie, S., and Silver, M. D., 1976, Angiosarcoma of the liver after vinyl chloride exposure: Report of a case and review of the literature (abstract), Lab. Invest. 34: 346.
Norpoth, K., Gottschalk, D., Gottschalk, I., Witting, U., Thomas, H., Fichner, D., and Schmidt, E. H., 1980, Influence of vinyl chloride monomer and As2O3 on rat liver cell proliferation after partial hepatectomy, J. Cancer Res. Clin. Oncol. 97: 41–50.
Norppa, H., Elovaara, E., Husgafvel-Pursainen, H., Sorsa, M., and Vainio, H., 1979, Effects of styrene oxide on chromosome aberrations, sister chromatid exchanges and hepatic drug biotransformation in Chinese hamsters in vivo, Chem. Biol. Interact. 26: 305–315.
Norppa, H., Sorsa, M., and Vainio, H., 1980a, Chromosomal aberrations in bone marrow of Chinese hamsters exposed to styrene and ethanol, Tox. Lett. 5: 241–244.
Norppa, H., Sorsa, M., Pfäffli, P., and Vainio, H., 1980b, Styrene and styrene oxide induce SCEs and are metabolized in human lymphocytes cultures, Carcinogenesis 1: 357–361.
Oesch, F., Jerina, D. M., and Daly, J. W., 1971, A radiometric assay for hepatic epoxide hydrase activity with (7-1H) styrene oxide, Biochim. Biophys. Acta. 227: 685–691.
Ogata, M., and Sugishara, R., 1978, H PLC procedure for quantitative determination of urinary phenyl glyoxylic, mandelic, and hippuric acids as indices of styrene exposure, Int. Arch. Occup. Environ. Health. 42: 11–19.
Ohtsuji, H., and Ikeda, M., 1971, The metabolism of styrene in the rat and the stimulatory effect of phenobarbital, Toxicol. Appl. Pharmacol. 18: 321–328.
O’Mara, M. M., Crider, L. B., and Daniel, R. L., 1971, Combustion products from vinyl chloride monomer, An. Ind. Hvg. Assoc. J. 32: 153–156.
Ott, M. G., Langner, R. R., and Holder, B. B., 1975, Vinyl chloride exposure in a controlled industrial environment. A long-term mortality experience in 594 employees, Arch. Environ. Health 30: 333–339.
Ott, M. G., Fishbeck, W. A., Townsend, J. C., and Schneider, E. J., 1976, A health study of employees exposed to vinylidene chloride, J. Occup. Med. 18: 735–738.
Pagano, G., Esposito, A., Giordano, G., and Hagstrom, B. E., 1978, Embryotoxic and teratogenic effects of styrene derivatives on sea urchin development, Scand. J. Work Environ. Health 4 (suppl. 2): 136–141.
Pagé, M., Theriault, L., and Delorme, F., 1976, Elevated CEA levels in polyvinyl chloride workers, Biomedicine 25: 279.
Pantarotto, C., Fanelli, R., Bidoli, F., Morazzoni, P., Salmona, M., and Szczawinska, K., 1978, Arene oxide in styrene metabolism: A new perspective in styrene toxicity? Scand. J. Work. Environm. Health 4 (suppl. 2): 67–77.
Parent, R. A., and Casto, B. C., 1979, Effect of acrylonitrile on primary Syrian golden hamster embryo cells in culture: transformation and DNA fragmentation, J. Nat. Cane. Inst. 62:4, 1025–1029.
Parkki, M. G., Marniemi, J., and Vainio, H., 1976, Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo, Toxicol. Appl. Pharmacol. 38: 59–70.
Parkki, M. G., Marniemi, J., Ekfors, T., Louhivuori, A., and Aitio, A., 1979, Hepatotoxic changes of hamsters by styrene, in Proceedings of the Industrial Toxicology Meeting, Prague 1977, p. 74.
Paulet, G., and Desnos, J., 1961, Acrylonitrile. Toxicity—mechanism of therapeutic action, Arch. Int. Pharmacodvn. 131: 54–83.
Patty, F. R., 1963, Industrial Hygiene and Toxicology, Interscience Publishers, New York, vol. II, pp. 1319–1321.
Pell, S., 1978, Mortality of workers exposed to chloroprene, J. Occup. Med. 20: 21–29.
Penttilä, M., Sorsa, M., and Vainio, H., 1980, Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster, Tox. Lett. 6: 119–123.
Peter, S., and Ungvary, G., 1980, Lack of mutagenic effects of vinyl chloride monomer in the mammalian spot test, Mutat. Res. 77: 193–196.
Pessayre, D., Wandscheer, J. C., Descatoire, V., Artigou, J. Y., and Benhamou, J. P., 1979, Formation and inactivation of a chemically reactive metabolite of vinyl chloride, Toxicol. Appl. Pharmacol. 49: 505–515.
Philippe, R., Lauwerijs, R., Buchet, J. P., and Roels, H., 1971, Evalution de l’exposition des travailleurs au styrène par le dosage de ses métabolites urinaires: Les acides mandélique et phénylglyoxylique. II: Application aux travailleurs fabriquants des polyesters, Arch. Mai. Prof. Med. Trav. Sec-Soc. 35 (6): 631–640.
Picciano, D. J., Flake, R. E., Gay, P. C., and Kilian, D. J., 1977, Vinyl chloride cytogenetics, J. Occup. Med. 19: 527–530.
Plotnick, H. B., and Weigel, W. W., 1979, Tissue distribution and excretion of 14C styrene in male and female rats, Res. Comm. Chem. Pathol. Pharmacol. 24 (3): 515–524.
Plugge, H., and Safe, S., 1977, Vinyl chloride metabolism. A review, Chemosphere 6: 309–325.
Plugge, H., and Jaeger, R. J., 1979, Acute inhalation toxicity of 2-chloro-l,3-butadiene (chloroprene): Effects on liver and lung, Toxicol. Appl. Pharmacol. 50: 565–572.
Pollock, J. R. A., and Stevens, R. (eds.), 1965, Dictionary of Organic Compounds, 4th ed., Vol. 2, New York, Oxford University Press, p. 681.
Ponomarkov, V., and Tomatis, L., 1978, Effects of long term oral administration of styrene to mice and rats, Scand. J. Work. Environ. Health 4 (suppl. 2): 127–135.
Ponomarkov, V., and Tomatis, L., 1980, Long-term testing of vinylidene chloride and chloroprene for carcinogenicity in rats, Oncology 37: 136–141.
Popper, H., and Thomas, L. B., 1975, Alterations of liver and spleen among workers exposed to vinyl chloride, Ann. N. Y. Acad. Sci. 246: 172–194.
Popper, H., 1979, Hepatic cancers in man: quantitative perspective, Environm. Res. 19: 482–494.
Poteryaeva, G. E., 1966, Effect of hexachlorobutadiene on the offspring of albino rats, Gigiena i, Sanit 31–33. Abstracted in Chem. Abs. 65:1281f.
Prodan, L., Suciu, I., Pislaru, V., Ilea, E., and Pascu, L., 1975, Experimental acute toxicity of vinyl chloride (monochlorethylene), Ann. N. Y. Acad. Sci. 246: 154–158.
Purchase, I. F. H., Richardson, C. R., Anderson, D., Paddle, G. M., and Adams, W. G. F., 1978, Chromosomal analyses in vinyl chloride-exposed workers, Mutat. Res. 57: 325–334.
Purchase, I. F. H., Richardson, C. R., and Anderson, D., 1975, Chromosomal and dominant lethal effects of vinyl chloride, Lancet ii:410–411.
Rabello-Gay, H. N., and Ahmed, E. A., 1980, Acrylonitrile: In vivo cytogenetic studies in mice and rats, Mut. Res. 79: 249–255.
Radike, M. J., Stemmer, K. L., Brown, P. G., Larson, E., and Bingham, E., 1977, Effect of ethanol and vinyl chloride on the induction of liver tumours: preliminary report, Environ. Health Perspect. 21: 153–155.
Radwan, Z., and Henschler, D., 1977, Uptake and rate of metabolism of vinyl chloride by the isolated perfused rat liver preparation, Int. Arch. Occup. Environm. Health 40: 101–110.
Ragule, N., 1974, Embryotoxic action of styrene, Gig. i. Sanit. 11: 85–86.
Ramsey, J. C., and Young, J. D., 1978, Pharmacokinetics of inhaled styrene in rats and humans, Scand. J. Work Environm. Health 4 (suppl. 2): 84–94.
Ramsey, J. C., Young, J. D., Karbowski, R. J., Chenoweth, M. B., McCarty, L. P., and Braun, W. H., 1980, Pharmakokinetic of styrene in human volunteers, Toxicol. Appl. Pharmacol. 53: 54–63.
Rannug, U., Johansson, A., Ramel, C, and Wachtmeister, C. A., 1974, The mutagenicity of vinyl chloride after metabolic activation, Ambio 3: 194–197.
Rannug, U., Gothe, R., and Wachtmeister, C. A., 1976, The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol, and chloroacetic acid, conceivable metabolites of vinyl chloride, Chem. Biol. Interact. 12: 251–263.
Ravier, E., Diter, J. M.,and Pialat, J., 1975, A case of hepatic angiosarcoma in a worker exposed to vinyl chloride monomer (Fr.), Arch. Mai. Prof., Med. Trav. Sec. Soc. 36: 171–177.
Reichert, D., Werner, H. W., and Hanschler, D., 1978, Role of liver glutathione in 1,1- dichloroethylene metabolism and hepatotoxicity in intact rats and isolated perfused rat liver, Arch. Toxicol. 41: 169–178.
von Reinl, W., Weber, H., and Greiser, E., 1977, Epidemiological study on mortality of VC- exposed workers in the Federal Republic of Germany (Ger.), Medichem (September): pp. 2–8.
Reitz, R. H., Watanabe, P. G., McKenna, M. J., Quast, J. F., and Gehring, P. J., 1980, Effects of vinylidene chloride on DN A synthesis and DNA repair in the rat and mouse. A comparative study with dimethylnitrosamine, Toxicol. Appl. Pharmacol. 52: 357–370.
Reynolds, E. S., Moslen, M. T., Szabo, S., and Jaeger, R. J., 1975a, Vinyl chloride induced deactivation of cytochrome P4so and other components of the liver mixed function oxidase system: an in vivo study, Res. Commun. Chem. Pathol. Pharmacol. 12: 685–694.
Reynolds, E. S., Moslen, M. T., Szabo, S., Jaeger, R. J., and Murphy, S. D., 1975b, Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene, Am. J. Pathol. 81: 219–236.
Reynolds, E. S., Jaeger, R. J., and Murphy, S. D., 1975c, Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats, Environ. Health Perspect. 11: 227–233.
Roche, J., Fournet, J., Hostein, J., Panh, M., and Bonnet-Eymard, J., 1978, Hepatic angiosarcoma due to vinyl chloride. Report of 4 cases (Fr.), Gastroenterol. Clin. Biol. 2: 669–678.
Ryan, A. J., James, M. O., BenZvi, Z., Law, F. L. P., and Bend, J. R., 1975, Hepatic and extrahepatic metabolism of 14C styrene oxide, Environ. Health Perspect. 17: 135–144.
Salmon, A. G., 1976, Cytochrome P450 and the metabolism of vinyl chloride, Cancer Lett. 2: 109–114.
Salnikova, L. S., and Fomenko, V. N., 1973, Experimental investigation of the influence of chloroprene on embryogenesis, Gig. Tr. Prof. Zabol. 8: 23–26.
Sandberg, E. Ch., and Slanina, P., 1980, Distribution of 1-14C acrylonitrile in rat and monkey, Tox. Lett. 6: 187–191.
Sandell, J., Parkki, M. G., Marniemi, J., and Aitio, A., 1978, Effects of inhalation and cutaneous exposure to styrene on drug metabolizing enzymes in the rat, Res. Comm. Chem. Pathol. Pharmacol. 19 (1): 109–118.
Sanotskii, I. V., 1976, Aspects of the toxicology of chloroprene: Immediate and long-term effects, Environ. Health Perspect. 17: 85–93.
Saric, M., Kulcar, Z., Zorica, M., and Gelic, I., 1976, Malignant tumours of the liver and lungs in an area with a PVC industry, Environ. Health Perspect. 17: 394–398.
Sassu, G. M., Zilio-Grandi, F., and Conte, A., 1968, Gas chromatographic determinations of impurities in vinyl chloride, J. Chromatogr. 34: 394–398.
Savolainen, H., and Vainio, H., 1977, Organ distribution and nervous system binding of styrene and styrene oxide, Toxicology 8: 135–141.
Savolainen, H., and Pfaffli, P., 1977, Effects of chronic styrene inhalation on rat brain protein metabolism, Acta Neuropath. 40: 237–241.
Savolainen, H., and Pfaffli, P., 1978, Accumulation of styrene monomer and neurochemical effects of long term inhalation exposure in rats, Scand. J. Work. Environ. Health 4 (suppl. 2): 78–84.
Sax, N. I., 1968, Dangerous Properties of Industrial Materials, Third Edition. Van Nostrand Reinhold, New York, p. 576.
Schwetz, B. A., Smith, F. A., Humiston, C. G., Quast, J. F., and Kociba, R. J., 1977, Results of a reproduction study in rats fed diets containing hexachlorobutadiene, Toxicol. Appl. Pharmacol. 42: 387–398.
Seppäläinen, A. M., and Harkonen, H., 1976, Neurophysiological findings among workers occupationally exposed to styrene, Scand. J. Work Environ. Health 2: 140–146.
Seppäläinen, A. M., 1978, Neurotoxicity of styrene in occupational and experimental exposure, Scand. J. Work. Environ, and Health 4 (suppl 2): 181–183.
Seutter-Berlage, F., Delbressine, L. P. C., Smeets, F. L. M., and Ketelaars, H. C. J., 1978, Identification of three sulfur containing urinary metabolites of styrene in the rat, Xenobiotica 8 (7): 413–418.
Shahin, M. J., 1976, The nonmutagenicity and recombinogenicity of vinyl chloride in the absence of metabolic activation, Mutat. Res. 40: 269–272.
Shimkin, M. B., Weisburger, J. H., Weisburger, E. K., Gubareff, N., and Sumtzeff, V., 1966, Bioassay of 29 alkylating chemicals by the pulmonary-tumour response in strain A mice, J. Natl. Cancer Inst. 36: 915–935.
Short, R. D., Winston, J. M., Minor, J. L., Hong, C. B., Seifter, J., and Lee, C. C., 1977a, Toxicity of vinylidene chloride in mice and rats and its alteration by various treatments, J. Toxicol. Env. Health 3: 913–921.
Short, R. D., Minor, J. L., Winston, J. M., and Lee, C. C., 1977b, A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride, J. Toxicol. Env. Health 3: 965–968.
Shugaev, B. B., 1969, Concentrations of hydrocarbons in tissues as a measure of toxicity, Arch. Environ. Health 18: 878–882.
Siegers, C. P., Younes, M., and Schmitt, G., 1979, Effects of dithiocarb and (+)-cyanidanol-3 on the hepatotoxicity and metabolism of vinylidene chloride in rats, Toxicology 15: 55–64.
Simmon, V., 1977, Mutagenic halogenated hydrocarbons. Presented at Meeting of Structural Parameters Associated with Carcinogenesis, Annapolis, Maryland, Aug. 31-Sept. 2.
Smith, P. M., Williams, D. M. J., and Evans, D. M. D., 1976, Hepatic angiosarcoma in a vinyl chloride worker, Bull. N. Y. Acad. Med. 52: 447–452.
Sollenberg, J., and Baldesten, A., 1977, Isotachophoretic analysis of mandelic acid, phenyl- glyoxylic acid, hippuric acid and methylhippuric acid in urine after occupational exposure to styrene, toluene and/or xylene, J. Chromatogr. 132: 469–476.
Spencer, H. C., Irish, D. D., Adams, E. M., and Rowe, V. K., 1942, The response of Laboratory animals to monomeric styrene, J. Ind. Hyg. Toxicol. 24: 295–301.
Spirtas, R., and Kaminski, R., 1978, Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers. 1977 Update of the NIOSH Register, J. Occup. Med. 20: 427–429.
Stoltz, D. R., and Withey, R. J., 1977, Mutagenicity testing of styrene and styrene epoxide in Salmonella tvphimurium, Bull. Environm. Contam. Toxicol. 17: 737–742.
Suciu, I., Drejman, I., and Valaskai, M., 1963, Investigation of the disease produced by vinyl chloride, Med. Interna 15: 967.
Suzuki, Y., 1978, Pulmonary tumours induced in mice by vinyl chloride monomer, Environm. Res. 16: 285–301.
Szabo, S., and Selye, H., 1972, Effect of phenobarbital and steroids on the adrenal apoplexy produced by acrylonitrile in rats, Endocrinol. Exp. 6: 141–146.
Szabo, S., Reynolds, E. S., and Kovacs, K., 1976, Animal model of human disease, American J. Pathol. 82: 653–656.
Szabo, S., Bailey, K. A., Boor, P. J., and Jaeger, R. J., 1977a, Acrylonitrile and tissue glutathione: differential effect of acute and chronic interactions, Biochem. Biophys. Res. Comm. 79:1, 32–37.
Szabo, S., Jaeger, R. J., Moslen, M. T., and Reynolds, E. S., 1977b, Modification of 1,1- dichloroethylene hepatotoxicity by hypothyroidism, Toxicol. Appl. Pharmacol. 42: 367–376.
Szentesi, I., Hornyak, E., Ungvary, G., Czeizel, A., Bognar, Z., and Timar, M., 1976, High rate of chromosomal aberration in PVC workers, Mutat. Res. 37: 313–316.
Tabershaw, I. R., and Gaffey, W. R., 1974, Mortality study of workers in the manufacture of vinyl chloride and its polymers, J. Occup. Med. 16: 509–518.
Thiess, A. M.,and Fleig, I., 1978a, Analysis of chromosomes of workers exposed to acrylonitrile, Arch. Toxicol. 41: 149–152.
Thiess, A. M., and Fleig, I., 1978b, Chromosome investigations on workers exposed to styrene/polystyrene, J. Occup. Med. 20: 747–749.
Thiess, A. M., and Friedheim, M., 1978, Morbidity among persons employed in styrene production, polymerization and processing plants, Scand. J. Work. Environ. Health. 4 (suppl. 2): 203–214.
Thomas, L. B., and Popper, H., 1975, Pathology of angiosarcoma of the liver among vinyl chloride-polyvinyl chloride workers, Ann. N. Y. Acad. Sci. 246: 268–277.
Ungvary, G., Hudak, A., Tatrai, E., Lorincz, M., and Fally, G., 1978, Effects of vinyl chloride exposure alone and in combination with trypan blue—applied systematically during all thirds of pregnancy on the foetuses of CFY rats, Toxicology 11: 45–54.
U.S. Consumer Product Safety Commission, 1978. Assessment of acrylonitrile contained in consumer products, Final report, contract No. CPSC-C-77-0009, Task No. 1014K. H.I.A./Economic Analysis, Washington, D.C.
U.S. Department of Labor, 1978, Occupational exposure to acrylonitrile (vinyl cyanide). Proposed standard and notice of hearing, Fed. Regist. 43: 2586–2621.
U.S. Food and Drug Administration, 1975, Vinyl chloride polymers in contact with food. Notice of proposed rulemaking. Fed. Regist. 40:40, 529 - 40, 537.
U.S. Environmental Protection Agency, 1975a, Preliminary assessment of suspected carcinogens in drinking water, Washington, D.C., p. II–3.
U.S. Environmental Protection Agency, 1975b, Preliminary assessment of suspected carcinogens in drinking water, Report to Congress, Washington, D.C., pp. II - 7.
U.S. Environmental Protection Agency, 1975c, Scientific and technical assessment report on vinyl chloride and polyvinyl chloride. EPA-600/6-75-004, Springfield, Va., National Technical Information Service, pp. 7–42.
Vainio, H., Pääkkönen, R., Rönnholm, K., Raunio, V., and Pelkonen, O., 1976, A study on the mutagenic activity of styrene and styrene oxide, Scand. J. Work. Environ. Health 3: 147–151.
Vainio, H., and Mäkinen, A., 1977, Styrene and acrylonitrile induced depression of hepatic nonsulfhydryl content in various rodent species, Res. Comm. Pathol. Pharmacol. 17 (1): 115–124.
Vainio, H., Hemminki, K.,and Elovaara, E., 1977, Toxicity of styrene and styrene oxide on chick embryos, Toxicology 8: 319–325.
Vainio, H., and Elovaara, E., 1979, The interaction of styrene oxide with hepatic cytochrome P450 in vitro and effects of styrene oxide inhalation on xenobiotic biotransformation in mouse liver and kidney, Biochem. Pharmacol. 28: 2001–2004.
Vainio, H., Jarvisalo, J., and Taskinen, E., 1979, Adaptive changes caused by intermittent styrene inhalation on xenobiotic biotransformation, Toxicol. Appl. Pharmacol. 49: 7–14.
Van Bladeren, P. J., Delbressine, L. P. C., Hoogeterp, J. J., Beaumont, A. H. G. M., Breiner, D. D., Seutter-Berlage, F., and Van der Gen, A., Formation of mercapturic acids from acrylonitrile, crotononitrile and cinnamonitrile by direct conjugation and via an intermediate oxidation process,...in “The Dual Role of Glutathione Conjugation in the Biotransformation of Xenobiotics,” P. J. Van Bladeren, Academic dissertation 8th April 1981, Klokke, Netherlands.
Van Duuren, B. L., Nelson, N., Orris, L., Palmes, E. D., and Schmitt, F. L., 1963, Carcinogenicity of epoxides, lactones and peroxy compounds, J. Natl. Cancer Inst. 31: 41–55.
Van Duuren, B. L., Langseth, L., Orris, L., Teebor, G., Nelson, N., and Kuschner, M., 1966, Carcinogenicity of epoxides, lactones and peroxy compounds. IV. Tumour response in epithelial and connective tissue in mice and rats, J. Natl. Cancer Inst. 37: 825–834.
Van Duuren, 1975, On the mechanism of carcinogenic action of vinyl chloride, Ann. N. Y. Acad. Sci. 246: 258–267.
Venitt, S., Bushell, C. T., and Osborne, M., 1977, Mutagenicity of acrylonitrile (cyanoethylene) in Escherichia coli, Mutat. Comm. Res. 45: 283–288.
Venitt, S., 1978, Mutagenic studies with acrylonitrile. Reply to author’s comments, Mutat. Res. 57 (1): 113.
Verburgt, F. G., and Vogel, E., 1977, Vinyl chloride mutagenesis in Drosophila melanogaster, Mutat. Res. 48: 327–336.
Viola, P. L., Bigotti, A., and Caputo, A., 1971, Oncogenic response of rat skin, lung and bone to vinyl chloride, Cancer Res. 31: 516–522.
Viola, P. L., and Caputo, A., 1977, Carcinogenicity studies on vinylidene chloride, Environ. Health Persp. 81: 45–47.
Vogel, E., 1979, Mutagenicity of chloroprene, l-chloro-l,3-trans-butadiene, 1,4-dichlorobutene- 2 and l,4-dichloro-2,3-epoxybutane in Drosophila Melanogaster, Mutat. Res. 67: 377–381.
Von Oettingen, W. F., Hueper, W. C., Deichmann-Grubler, W., and Wiley, F. H., 1936, 2-chloro-butadiene (chloroprene): Its toxicity and pathology and the mechanism of its action, J. Ind. Hyg. Toxicol. 18: 240–270.
Wagoner, J. K., 1978, Vinyl chloride and pulmonary cancer, J. Environ. Pathol. Toxicol. 1: 361–362.
Ward, A. M., Udnoon, S., Watkins, J., Walker, A. E., and Darke, C. S., 1976, Immunological mechanisms in the pathogenesis of vinyl chloride disease, Brit. Med. J. 1: 936–938.
Watanabe, P. G., Hefner, R. E., Jr., and Gehring, P. J., 1976, Vinyl chloride-induced depression of hepatic non-protein sulfhydryl content and effects on bromosulfophtalein (BSP) clearance in rats, Toxicology 6: 1–8.
Watabe, T., Isobe, M., Yoshikawa, K., and Takabatake, E., 1978a, Studies on metabolism and toxicity of styrene to styrene glycol via styrene oxide by rat liver microsomes, J. Pharm. Dyn. 1: 98–104.
Watabe, T., Isobe, M., Sawahata, T., Yoshikawa, K., Yamada, S., and Takabatake, E., 1978b, Metabolism and mutagenicity of styrene, Scand. J. Work Environ. Health 4 (suppl. 2): 142–155.
Watabe, T., Isobe, M., Yoshikawa, K., and Takabatake, E., 1978c, Studies on metabolism and toxicity of styrene II. Mutagenesis in Salmonella typhimurium by metabolic activation of styrene with 3-methylcholanthrene pretreated rat liver, J. Pharm. Dyn. 1: 301–309.
Watson, W. A. F., 1972, Studies on a recombination-deficient mutation of Drosophila. II. Response to X rays and alkylating agents, Mutat. Res. 14: 299–307.
Waxweiler, R. J., Stringer, W., Wagoner, J. K., Jones, J., Falk, H., and Carter, C., 1976, Neoplastic risk among workers exposed to vinyl chloride, Ann. N. Y. Acad. Sci. 271: 40–48.
Williams, D. T., and Miles, W. F., 1975, Gas-liquid chromatographic determination of vinyl chloride in alcoholic beverages, vegetable oils, and vinegars, J. Assoc. Off. Anal. Chem. 58: 272–275.
Wilson, R. H., Hough, G. V.,and McCormick, W. E., 1948, Medical problems encountered in the manufacture of American-made rubber, Ind. Med. 17: 199–207.
Wilson, R. H., and McCormich, W. E., 1954, Toxicity of plastics and rubber. Plastomers and monomers, Ind. Med. Surg. 23: 479.
Windholz, M., (ed.) 1976, The Merck Index, 9th ed., Rahway, N. Y., Merck & Co., pp. 986, 1283.
Winell, M., Holmberg, B., and Kromevi, T., 1976, Biological effects of vinyl chloride: An experimental study, Environ. Health Perspect. 17: 211–216.
Withey, J. R., 1976, Quantitative analysis of styrene monomer in polystyrene and foods including some preliminary studies of the uptake and pharmacodynamics of the monomer in rats, Environ. Health Perspect. 17: 125–133.
Withey, J. R., and Collins, P. G., 1977, Pharmacokinetics and distribution of styrene monomer in rats after intravenous administration, J. Toxicol. Environ. Health 3: 1011–1020.
Withey, J. R., and Collins, P. G., 1978, Styrene monomer in foods. A limited Canadian survey, Bull. Environ. Contam. Toxicol. 19: 86–94.
Withey, J. R., and Collins, P. G., 1979, The distribution and pharmacokinetics of styrene monomer in rats by the pulmonary route, J. Environ. Pathol. Toxicol. 2: 1329–1342.
Wolf, M. A., Rowe, V. K., Collister, D. D., Hollingsworth, R. L., and Oyen, F., 1956, Toxicological studies of certain alkylated benzenes and benzene, Arch. Ind. Health 14: 381–398.
Wolff, M. S., 1976, Evidence for existence in human tissues of monomer for plastics and rubber manufacture, Environ. Health Perspect. 17: 183–187.
Wolff, M. S., Lorimer, W. V., Lilis, R., and Selikoff, I. J., 1978, Blood styrene and urinary metabolites in styrene polymerisation, Brit. J. Ind. Med. 35: 318–329.
Yagen, B., Hernandez, O., Bend, J. R., and Cox, R. H., 1981, Synthesis and relative stereochemistry of the four mercapturic acids derived from styrene oxide and V-acetyl cysteine, Chem. Biol. Interact. 34: 57–87.
Yllner, S., 1971, Metabolism of chloroacetate-l-uC in the mouse, Acta Pharmacol. Toxicol. 30: 69–80.
Yoshikawa, K., Isobe, M., Watabe, T., and Takabatake, E., 1980, Studies on met abolism and toxicity of styrene. III. The effects of metabolic inactivation by rat liver S9 on the mutagenicity of phenyloxirane towards Salmonella typhimurium, Mutat. Res. 78: 219–226.
Zajdela, F., Croisy, A., Barbin, A., Malaveille, C., Tomatis, L., and Bartsch, H., 1980, Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride and bis (chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice, Cancer Res. 40: 352–356.
Zil’Fyan, V. N., Fichidzhyan, B. S., Garibyan, D. K., and Pogosova, A. M., 1977, Experimental study of chiproprene for carcinogenicity, Vop. Onkol. 23: 61–65.
Zimmermann, F. K.,and Vig. B. K., 1975, Mutagen specificity in the induction of mitotic crossing over in Saccharomyces cerevisiae, Mol. Gen. Genet. 139: 255–268.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Poncelet, F., Bogaert, M.Dv., Lambotte-Vandepaer, M., de Meester, C. (1984). Mutagenicity, Carcinogenicity, and Teratogenicity of Industrially Important Monomers. In: Kirsch-Volders, M. (eds) Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2643-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2643-4_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9649-2
Online ISBN: 978-1-4613-2643-4
eBook Packages: Springer Book Archive