Prevention of Transmission of Virus Infections by Blood Transfusions and Removal of Virus Infectivity from Clotting Factor Concentrates
Virus infections are serious complications following blood transfusions or intravenous therapy with clotting factor concentrates. Hepatitis A virus (HAV) is rarely transmitted by blood and never by plasma derivatives. Hepatitis A is characterized by a short viremia which most often coincides with clinical illness. In addition neutralizing antibodies to HAV are present in all plasma pools from which clotting factor concentrates are manufactured (1). Chronic Hepatitis B and non-A non-B hepatitis commonly follow acute infections (5 to 10% for hepatitis B, more than 40% and perhaps close to 100% for non-A non-B hepatitis). Chronic infections with hepatitis B virus (HBV) are characterized by serum levels of infectious virus up to 108/ml (infectious units) while levels of infectious non-A non-B virus are generally in the range of 102/ml (2,3). Little has been published concerning levels of HTLV III in blood or plasma.
KeywordsClotting Factor Plasma Protein Fraction Plasma Derivative Normal Human Serum Albumin Clotting Factor Concentrate
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