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Cancer Immunology: Innovative Approaches to Therapy pp 1–28Cite as

Immunology of human T-cell leukemia/lymphoma (lymphotropic) viruses (the HTLV ‘family’)

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 27))

Abstract

The human T-lymphotropic viruses (HTLV) comprise a family of type-C retroviruses which infect and interact with human T-cells. Because of their T-cell tropism, they influence the immune functioning of these cells and are, in turn, to some extent influenced by the same biologic control mechanisms which regulate the growth, differentiation, and functioning of uninfected human T cells. It is our intent to explore this interaction in the following pages. Under the broad scope provided by the title ‘immunology of HTLV’, we will review the fairly extensive knowledge which has been acquired concerning these human retroviruses in the short time since their discovery. Our main focus will concern what is known about the viral T-cell tropism, the biologic effects of HTLV on T cells, and the regulatory mechanisms which may influence viral infection and effects. We will indicate, where applicable, areas in which immunologic approaches have been especially useful in elucidating the nature of the virus and its interaction with environmental hosts. Areas in which immunotherapy may prove to be advantageous in the future will also be discussed.

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Authors
  1. Marjorie Robert-Guroff
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  2. Robert C. Gallo
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  1. Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Ronald B. Herberman M.D. (Director) (Director)

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© 1986 Martinus Nijhoff Publishers, Boston

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Robert-Guroff, M., Gallo, R.C. (1986). Immunology of human T-cell leukemia/lymphoma (lymphotropic) viruses (the HTLV ‘family’). In: Herberman, R.B. (eds) Cancer Immunology: Innovative Approaches to Therapy. Cancer Treatment and Research, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2629-8_1

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