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Hepatoblastoma and Hepatocellular Carcinoma

  • Daniel M. Green
Part of the Developments in Oncology book series (DION, volume 37)

Abstract

Hepatoblastoma and hepatocellular carcinoma are the two most common primary malignant tumors of the liver in childhood. The incidence rate of hepatoblastoma was 0.7 cases per million U.S. white children less than 15 years of age per year. The corresponding figure for U.S. black children was 0.9 248. The highest incidence rate was 1.4, among U.S. white boys and the lowest rate was 0.2 among girls in Manchester, England (Table 1) 24,25,63,220,247,249,. The incidence rate of hepatocellular carcinoma was 0.7 cases per million U.S. white children less than 15 years of age per year. The corresponding figure forU.S. black children was 0.0 248. The highest rate was 0.9 among U.S. white girls and the lowest rate was 0.0 among both U.S. black boys and girls(Table) 24, 25,63,220,247,249.

Keywords

Biliary Atresia Hepatic Tumor Precocious Puberty Primary Hepatocellular Carcinoma Hepatic Lobectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adamson RH, Correa P and Dalgard DW: Occurrence of a primary liver carcinoma in a rhesus monkey fed aflatoxin B1. J Nat Cancer Inst 50: 549–553, 1973.PubMedGoogle Scholar
  2. 2.
    Agnew LRC and Gardner WU: The incidence of spontaneous hepatomas in C3H, C3H (low milk factor) and CBA mice and the effect of estrogen and androgen on the occurrence of these tumors in C3H mice. Cancer Res 12: 757–761, 1952.PubMedGoogle Scholar
  3. 3.
    Akoojee SB and Coovadia YM: Hepatoblastoma. South Afr Med J 54: 450–452, 1978.Google Scholar
  4. 4.
    Alexandrov VA: Blastomogenic effect of dimethylnitrosamine on pregnant rats and their offspring. Nature 218: 280–281, 1968.PubMedGoogle Scholar
  5. 5.
    Almersjo O, Bengmark S, Hafstrom LO and Olsson R: Enzyme and function changes after extensive liver resection in man. Ann Surg 169: 111–119, 1969.PubMedGoogle Scholar
  6. 6.
    Alpert E, Hershberg R, Schur PH and Isselbacher KJ: Alpha-fetoprotein in human hepatoma: Improved detection in serum, and quantitative studies using a new sensitive technique. Gastroenterology 61: 137–143, 1971.PubMedGoogle Scholar
  7. 7.
    Alpert ME, Hutt MSR, Wogan GN and Davidson CS: Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 28: 253–260, 1971.PubMedGoogle Scholar
  8. 8.
    Al-sarraf M, Go TS, Kithier K and Vaitkevicius VK: Primary liver cancer. Cancer 33: 574–582, 1974.PubMedGoogle Scholar
  9. 9.
    Andrassy RJ, Brennan LP, Siegel MM, Weitzman JJ, Siegel SE, Stanley P and Mahour GH: Preoperative chemotherapy for hepatoblastoma in children: Report of six cases. J Pediatr Surg 15: 517–522, 1980.PubMedGoogle Scholar
  10. 10.
    Ansfield FJ, Ramirez G, Davis HL Jr, Wirtanen GW, Johnson RO, Bryan GT, Manalo FB, Borden EC, Davis TE and Esmaili M: Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil. Cancer 36: 2413–2417, 1975.PubMedGoogle Scholar
  11. 11.
    Aronsen KF, Ericsson B and Pihl B: Metabolic changes following major hepatic resection. Ann Surg 169: 102–110, 1969.PubMedGoogle Scholar
  12. 12.
    Arshad RR, Woo SY, Abbassi V, Hoy GR and Sinks LF: Virilizing hepatoblastoma: Precocious sexual development and partial response of pulmonary metastases to cis-platinum. Cancer 32: 293–300, 1982.Google Scholar
  13. 13.
    Baum ES, Gaynon P, Greenberg L, Krivit W and Hammond D: Phase II trial of cisplatin in refractory childhood cancer: Children’s cancer study group report. Cancer Treat Rep 65: 815–822, 1981.PubMedGoogle Scholar
  14. 14.
    Beasley RP, Hwang L-Y, Lin C-C and Chien C-S: Hepatocellular carcinoma and hepatitis B virus. Lancet 2: 1129–1133, 1981.PubMedGoogle Scholar
  15. 15.
    Beasley RP, Shiao I-S, Wu T-C and Hwang L-Y: Hepatoma in an HBsAg carrier–seven years after perinatal infection. J Pediatr 101: 83–84, 1982.PubMedGoogle Scholar
  16. 16.
    Beaumont C, Simon M, Fauchet R, Hespel J-P, Brissot P, Genetet B and Bourel M: Serum ferritin as a possible marker of the hemochromatosis allele. New Engl J Med 301: 169–174, 1979.PubMedGoogle Scholar
  17. 17.
    Beck AR: Unusual problems in surgery. Mount Sinai J Med 43: 312–315, 1976.Google Scholar
  18. 18.
    Bedikian AY, Chen TT, Malahy M-A, Patt YZ and Bodey GP: Prognostic factors influencing survival of patients with advanced colorectal cancer: Hepatic-artery infusion versus systemic intravenous chemotherapy for liver metastases. J Clin Oncol 2: 174–180, 1984.PubMedGoogle Scholar
  19. 19.
    Behrle FC, Mantz FA Jr, Olson RL and Trombold JC: Virilization accompanying hepatoblastoma. Pediatrics 32: 265–271, 1963.PubMedGoogle Scholar
  20. 20.
    Bellina PV, Lang EK, Pisco JM and Hanemann M: Multidisciplinary approach to the diagnosis of hepatoblastoma: Ultrasound, nuclear medicine and angiography. South Med J 73: 1085–1087, 1980.PubMedGoogle Scholar
  21. 21.
    Berger PE and Kuhn JP: Computed tomography of the hepatobiliary system in infancy and childhood. Radiol Clin NA 19: 431–444, 1981.Google Scholar
  22. 22.
    Bern MM, McDermott W Jr, Cady B, Oberfield RA, Trey C, Clouse ME, Tullis JL and Parker LM: Intraarterial hepatic infusion and intravenous adriamycin for treatment of hepatocellular carcinoma. Cancer 42: 399–405, 1978.PubMedGoogle Scholar
  23. 23.
    Berry CL, Keeling J and Hilton C: Coincidence of congenital malformation and embryonic tumours of childhood. Arch Dis Child 45: 229–231, 1970.PubMedGoogle Scholar
  24. 24.
    Birch JM: Personal communication.Google Scholar
  25. 25.
    Birch JM, Marsden HB and Swindell R: Incidence of malignant disease in childhood: A 24-year review of the Manchester children’s tumour registry data. Br J Cancer 42: 215–223, 1980.PubMedGoogle Scholar
  26. 26.
    Bradham RR, Paul JR, Thrower WB and McIver FA: Malignant hepatoma in a child: Survival following right hepatic lobectomy, right pneumonectomy and resection of diaphragm and parietal recurrence. Surgery 57: 767–773, 1965.PubMedGoogle Scholar
  27. 27.
    Braunstein GD, Bridson WE, Glass A, Hull EW and McIntire KR: In vivo and in vitro production of human chorionic gonadotropin and alpha-fetoprotein by a virilizing hepatoblastoma. J Clin Endocrinol Metab 35: 857–862, 1972.PubMedGoogle Scholar
  28. 28.
    Burdette WJ: The clinical problem of primary hepatoma. IN. Primary Hepatoma WJ Burdette (ed), University of Utah Press, Salt Lake City, 1965, pp 3–30.Google Scholar
  29. 29.
    Butenandt O, Knorr D, Hecker WC and Lohrs U: Precocious puberty in a boy with HCG-producing hepatoma. Helm Paediatr Acta 35: 155–163, 1980.Google Scholar
  30. 30.
    Cady B and Oberfield RA: Arterial infusion chemotherapy of hepatoma. Surg Gynecol Obstet 138: 381–384, 1974.PubMedGoogle Scholar
  31. 31.
    Cady B and Oberfield RA: Regional infusion chemotherapy of hepatic metastases from carcinoma of the colon. Am J Surg 127: 220–227, 1974.PubMedGoogle Scholar
  32. 32.
    Cameron HM and Warwick GP: Primary cancer of the liver in Kenyan children. Br J Cancer 36: 793–803, 1977.PubMedGoogle Scholar
  33. 33.
    Cariappa A, Thomas JA and Sri Murthy KR: Hepatoblastoma. Ind J Cancer 18: 6973, 1981.Google Scholar
  34. 34.
    Carnaghan RBA: Hepatic tumours and other chronic liver changes in rats following a single oral administration of aflatoxin. Br J Cancer 21: 811–814, 1967.PubMedGoogle Scholar
  35. 35.
    Carnaghan RBA: Hepatic tumors in ducks fed a low level of toxic groundnut meal. Nature 208: 308, 1965.PubMedGoogle Scholar
  36. 36.
    Cartwright GE, Edwards CQ, Kravitz K, Skolnick M, Amos DB, Johnson A and Buskjaer L: Hereditary hemochromatosis. New Engl J Med 301: 175–179, 1979.PubMedGoogle Scholar
  37. 37.
    Chang M-H, Hsu H-C, Lee C-Y, Chen D-S, Lee C-H and Lin K-S: Fraternal hepatocellular carcinoma in young children in two families. Cancer 53: 1807–1810, 1984.PubMedGoogle Scholar
  38. 38.
    Chard RL Jr, Krivit W, Bleyer WA and Hammond D: Phase II study of VP-16–213 in childhood malignant disease: A children’s cancer study group report. Cancer Treat Rep 63: 1755–1759, 1979.PubMedGoogle Scholar
  39. 39.
    Chernozemski IN and Warwick GP: Liver regeneration and induction of hepatomas in B6AF1 mice by urethan. Cancer Res 30: 2685–2690, 1970.PubMedGoogle Scholar
  40. 40.
    Clatworthy HW and Boles ET Jr: Right lobectomy of the liver in children. Surgery 39: 850–859, 1956.PubMedGoogle Scholar
  41. 41.
    Clatworthy HW, Boles ET Jr and Kottmeier PK: Liver tumors in infancy and childhood. Ann Surg 154: 475–484, 1961.PubMedGoogle Scholar
  42. 42.
    Craddock VM: Induction of liver tumours in rats by a single treatment with nitroso compounds given after partial hepatectomy. Nature 245: 386–388, 1973.PubMedGoogle Scholar
  43. 43.
    Craddock VM: Liver carcinomas induced in rats by single administration of dimethylnitrosamine after partial hepatectomy. J Nat Cancer Inst 47: 889–907, 1971.Google Scholar
  44. 44.
    Craig JR, Peters RL, Edmondson JA and Omata M: Fibrolamellar carcinoma of the liver: A tumor of adolescents and young adults with distinctive clinicopathologic features. Cancer 46: 372–379, 1980.PubMedGoogle Scholar
  45. 45.
    Dahms BB: Hepatoma in familial cholestatic cirrhosis of childhood. Arch Pathol Lab Med 103: 30–33, 1979.PubMedGoogle Scholar
  46. 46.
    Deoras MP and Dicus W: Hepatocarcinoma associated with biliary cirrhosis. Arch Pathol 86: 338–341, 1968.PubMedGoogle Scholar
  47. 47.
    Draper GJ, Heaf MM and Kinnier Wilson LM: Occurrence of childhood cancers among sibs and estimation of familial risks. J Med Genet 14: 81–90, 1977.PubMedGoogle Scholar
  48. 48.
    Druekrey H, Preussmann R and Ivankovic S: N-nitroso compounds in organotropic and transplacental carcinogenesis. Ann New York Acad Sci 163: 676–695, 1969.Google Scholar
  49. 49.
    Edmonds AM, Hennigar GR and Crooks R: Galactosemia. Report of case with autopsy. Pediatrics 10: 40–47, 1952.PubMedGoogle Scholar
  50. 50.
    Ein SH, Shandling B, Williams WG and Trusler G: Major hepatic tumor resection using profound hypothermia and circulation arrest. J Pediatr Surg 16: 339–342, 1981.PubMedGoogle Scholar
  51. 51.
    Endres W and Wuttge B: Occurrence of secondary cystathionuria in children with inherited metabolic disorders, liver diseases, neoplasms, cystic fibrosis and celiac disease. Eur J Pediatr 129: 29–35, 1978.PubMedGoogle Scholar
  52. 52.
    Ettinger LJ and Freeman AI: Hepatoma in a child with neurofibromatosis. Am J Dis Child 133: 528–531, 1979.PubMedGoogle Scholar
  53. 53.
    Evans AE, Land VJ, Newton WA, Randolph JG, Sather HN and Tefft M: Combination chemotherapy (vincristine, adriamycin, cyclophosphamide and 5-fluorouracil) in the treatment of children with malignant hepatoma. Cancer 50: 821–826, 1982.PubMedGoogle Scholar
  54. 54.
    Exelby PR, Filler RM and Grosfeld JL: Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American academy of pediatrics surgical section survey–1974. J Pediatr Surg 10: 329–337, 1975.PubMedGoogle Scholar
  55. 55.
    Fajers C-M, Falkmer S, Frisell E and Pehrson M: Primary carcinoma of the liver and giant-cell hepatitis in infancy. Acta Paediatr 49: 96–110, 1960.PubMedGoogle Scholar
  56. 56.
    Farber E: On the pathogenesis of experimental hepatocellular carcinoma. IN. Hepatocellular Carcinoma. K Okuda and RL Peters (eds), John Wiley and Sons, New York, 1976, pp 3–22.Google Scholar
  57. 57.
    Farber E: Carcinoma of the liver in rats fed ethionine. Arch Pathol 62: 445–453, 1956.Google Scholar
  58. 58.
    Farber E and Ichinose H: The prevention of ethionine-induced carcinoma of the liver in rats by methionine. Cancer Res 18: 1209–1213, 1958.PubMedGoogle Scholar
  59. 59.
    Farhi DC, Shikes RH, Murari PJ and Silverberg SG: Hepatocellular carcinoma in young people. Cancer 52: 1516–1525, 1983.PubMedGoogle Scholar
  60. 60.
    Filler RM, Tefft M, Vawter GF, Maddock C and Mitus A: Hepatic lobectomy in childhood: Effects of x-ray and chemotherapy. J Pediatr Surg 4: 31–41, 1969.PubMedGoogle Scholar
  61. 61.
    Finklestein JZ, Albo V, Ertel I and Hammond D: 5-(3,3-dimethyl-1- triazeno)imidazole-4-carboxamide (NSC-45388) in the treatment of solid tumors in children. Cancer Chemo Rep 59: 351–357, 1975.Google Scholar
  62. 62.
    Finklestein JZ, Ekert H, Isaacs H Jr and Higgins G: Bone marrow metastases in children with solid tumors. Am J Dis Child 119: 49–52, 1970.PubMedGoogle Scholar
  63. 63.
    Finnish Cancer Registry: Cancer in Finland 1980. Cancer Society of Finland Publication No. 32, Finnish Cancer Registry, Helsinki, 1983, p 26.Google Scholar
  64. 64.
    Fisch RO, McCabe ERB, Doeden D, Koep LJ, Kohlhoff JG, Silverman A and Starzl TE: Homotransplantation of the liver in a patient with hepatoma and hereditary tyrosinemia. J Pediatr 93: 592–596, 1978.PubMedGoogle Scholar
  65. 65.
    Fish JC and McCary RG: Primary cancer of the liver in childhood. Arch Surg 93: 355–359, 1966.PubMedGoogle Scholar
  66. 66.
    Flores F, Solano A, Rebeil R, Osuna JA, Lopez M, Romero CA and Garcia E: Isosexual precocious puberty in a male infant with hepatoblastoma. Rev Invest Clin (Mex) 31: 251–255, 1979.Google Scholar
  67. 67.
    Fraumeni JF Jr, Rosen PJ, Hull EW, Barth RF, Shapiro SR and O’Connor JF: Hepatoblastoma in infant sisters. Cancer 224: 1086–1090, 1969.Google Scholar
  68. 68.
    Fraumeni JF Jr, Miller RW and Hill JA: Primary carcinoma of the liver in childhood: An epidemiologic study. J Nat Cancer Inst 40: 1087–1099, 1968.PubMedGoogle Scholar
  69. 69.
    Fredens M: Angiography in primary hepatic tumours in children. Acta Radiol (Diag) 8: 193–200, 1969.Google Scholar
  70. 70.
    Gandhi RK, Deshmukh SS and Bhalerao Ra: Hepatoblastoma in children. Ind Pediatr 10: 259–262, 1973.Google Scholar
  71. 71.
    Garnick MB, Ensminger WD and Israel M: A clinical-pharmacological evaluation of hepatic arterial infusion of adriamycin. Cancer Res 39: 4105–4110, 1979.PubMedGoogle Scholar
  72. 72.
    Gasser RW, Judmaier G, Nedden DZ, Aufschnaiter M and Hofstaedter F: Primary hepatocellular carcinoma with hepatitis B virus infection in a 16-year-old noncirrhotic patient. Am J Gastroenterol 78: 305–308, 1983.PubMedGoogle Scholar
  73. 73.
    Gates GF, Miller JH and Stanley P: Scintiangiography of hepatic masses in childhood. JAMA 239: 2667–2670, 1978.PubMedGoogle Scholar
  74. 74.
    Gaynon PS, Baum ES, Krivit W and Hammond D: Phase II trial of prednimustine in children with recurrent cancer: A children’s cancer study group report. Cancer Treat Rep 66: 1583, 1982.PubMedGoogle Scholar
  75. 75.
    Geiser CF, Baez A, Schindler AM and Shih VE: Epithelial hepatoblastoma associated with congenital hemihypertrophy and cystathionuria: Presentation of a case. Pediatrics 46: 66–73, 1970.PubMedGoogle Scholar
  76. 76.
    Geiser CF and Shih VE: Cystathionuria and its origin in children with hepatoblastoma. J Pediatr 96: 72–75, 1980.PubMedGoogle Scholar
  77. 77.
    Gentz J, Heinrich J, Lindblad B, Lindstedt S and Zetterstrom R: Enzymatic studies in a case of hereditary tyrosinemia with hepatoma. Acta Paediatr Scand 58: 393396, 1969.Google Scholar
  78. 78.
    Gjessing LR and Mauritzen K: Cystathionuria in hepatoblastoma. Scand J Clin Lab Invest 17: 513–514, 1965.PubMedGoogle Scholar
  79. 79.
    Gonzalez-Crussi F, Upton MP and Maurer HS: Hepatoblastoma. Am J Surg Pathol 6: 599–612, 1982.Google Scholar
  80. 80.
    Grage TB, Vassilopoulos PP, Shingleton WW, Jubert AV, Elias EG, Aust JB and Moss SE: Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases from colorectal cancer. A central oncology group study. Surgery 86: 550–555, 1979.PubMedGoogle Scholar
  81. 81.
    Grice HC, Moodie CA and Smith DC: The carcinogenic potential of aflatoxin or its metabolites in rats from dams fed aflatoxin pre-and post-partum. Cancer Res 33: 262–268, 1973.PubMedGoogle Scholar
  82. 82.
    Grundy GW, Creagan ET and Fraumeni JF Jr: Non-Hodgkin’s lymphoma in childhood: Epidemiologic features. J Nat Cancer Inst 51: 767–776, 1973.PubMedGoogle Scholar
  83. 83.
    Hagstrom RM and Baker TD: Primary hepatocellular carcinoma in three male siblings. Cancer 22: 142–150, 1968.PubMedGoogle Scholar
  84. 84.
    Hann H-W, Kim CY, London WT, Whitford P and Blumberg BS: Hepatitis B virus and primary hepatocellular carcinoma: Family studies in Korea. Int J Cancer 30: 47–51, 1982.PubMedGoogle Scholar
  85. 85.
    Heinrich UE, Bolkenius M, Daum R, Oppermann HC, Mehls 0 and Brandeis WE: Virilizing hepatoblastoma - Significance of alpha-1-fetoprotein and human chorionic gonadotropin as tumor markers in diagnosis and follow-up. Eur J Pediatr 135: 313317, 1981.Google Scholar
  86. 86.
    Helson L, Peterson RHF and Schwartz MK: Cystathionine excess in children with hepatic cancer. Cancer Res 33: 1570–1573, 1973.PubMedGoogle Scholar
  87. 87.
    Henderson JT, Richmond J and Sumerling MD: Androgenic-anabolic steroid therapy and hepatocellular carcinoma. Lancet 1:934, 1973 (Letter).Google Scholar
  88. 88.
    Hermann RE and Lonsdale D: Chemotherapy, radiotherapy and hepatic lobectomy for hepatoblastoma in an infant: Report of a survival. Surgery 68: 383–388, 1970.PubMedGoogle Scholar
  89. 89.
    Heyward WL, Bender TR, Lanier AP, Francis DP, McMahon BJ and Maynard JE: Serological markers of hepatitis B virus and alpha-fetoprotein levels preceeding primary hepatocellular carcinoma in Alaskan Eskimos. Lancet 2: 889–891, 1982.PubMedGoogle Scholar
  90. 90.
    Hino O, Kitagawa T, Hirama T and Yokoyama S: Hepatitis B virus DNA integration in hepatoblastoma. Lancet’ 2:462–463, 1984 (Letter).Google Scholar
  91. 91.
    Holder LE, Gnarra DJ, Lampkin BC, Nishiyama H and Perkins P: Hepatoma associated with anabolic steroid therapy. Am J Roentgenol 124: 638–642, 1975.Google Scholar
  92. 92.
    Hollander CF and Bentvelzen P: Enhancement of urethan induction of hepatomas by prior partial hepatectomy. J Nat Cancer Inst 41: 1303–1306, 1968.PubMedGoogle Scholar
  93. 93.
    Holton CP, Burrington JD and Hatch EI: A multiple chemotherapeutic approach to the management of hepatoblastoma. Cancer 35: 1083–1087, 1975.PubMedGoogle Scholar
  94. 94.
    Ronan RP and Haqqani MT: Mixed hepatoblastoma in the adult: Case report and review of the literature. J Clin Pathol 33: 1058–1063, 1980.Google Scholar
  95. 95.
    Hung W, Blizzard RM, Migeon CJ, Camacho AM and Nyhan WL: Precocious puberty in a boy with hepatoma and circulating gonadotropin. J Pediatr 63: 895–903, 1963.PubMedGoogle Scholar
  96. 96.
    Ikeda K, Suita S, Nakagawara A and Takabayashi K: Preoperative chemotherapy for initially unresectable hepatoblastoma in children. Arch Surg 114: 203–207, 1979.PubMedGoogle Scholar
  97. 97.
    Ikeda K, Kimura N, Suita S, Hayashida Y, Nakagawara A and Kawaoi A: Pre and postoperative changes of alpha-fetoprotein and human chorionic gonadotropin in hepatoma of children. Z Kinderchir 34: 42–55, 1981.PubMedGoogle Scholar
  98. 98.
    Ishak KG and Glunz PR: Hepatoblastoma and hepatocarcinoma in infancy and childhood. Cancer 20: 396–422, 1967.PubMedGoogle Scholar
  99. 99.
    Ito J and Johnson WW: Hepatoblastoma and hepatoma in infancy and childhood. Arch Pathol 87: 259–266, 1969.PubMedGoogle Scholar
  100. 100.
    Iwatsuki S and Starzl TE: Hepatectomy in children. IN. International Advances in Surgical Oncology. Vol 5, GP Murphy (ed), Alan R Liss Inc, New York, 1982, pp 163–171.Google Scholar
  101. 101.
    Johnson FL, Feagler JR, Lerner KG, Majerus PW, Siegel M, Hartmann JR and Thomas ED: Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet 2: 1273–1276, 1972.PubMedGoogle Scholar
  102. 102.
    Jurgelski W Jr, Hudson PM, Dunn RL and Falk HL: A new animal model for the direct induction of neoplasms during embryonic and fetal development. IN. Prevention and Detection of Cancer. Part 1. Prevention. Vol 1. Etiology. Marcel Dekker Inc., New York, 1977, pp 1033–1059.Google Scholar
  103. 103.
    Jurgelski W Jr, Hudson P and Falk HL: Tissue differentiation and susceptibility to embryonal tumor induction by ethylnitrosourea in the opposum. Nat Cancer Inst Mono 51: 123–158, 1979.Google Scholar
  104. 104.
    Kasai M and Watanabe I: Histologic classification of liver-cell carcinoma in infancy and childhood and its clinical evaluation. Cancer 25: 551–563, 1970.PubMedGoogle Scholar
  105. 105.
    Kaude JV, Felman AH and Hawkins IF Jr: Ultrasonography in primary hepatic tumors in early childhood. Pediatr Radiol 9: 77–83, 1980.PubMedGoogle Scholar
  106. 106.
    Keeling JW: Liver tumors in infancy and childhood. J Pathol 103: 69–85, 1970.Google Scholar
  107. 107.
    Kemeny N, Daly J, Oderman P, Shike M, Chun H, Petroni G and Geller N: Hepatic artery pump infusion: Toxicity and results in patients with metastatic colorectal carcinoma. J Clin Oncol 2: 595–600, 1984.PubMedGoogle Scholar
  108. 108.
    Kew MC, Hodkinson J, Paterson AC and Song E: Hepatitis-B virus infection in black children with hepatocellular carcinoma. J Med Virol 9: 201–207, 1982.PubMedGoogle Scholar
  109. 109.
    Khan A, Bader JL, Hoy GR and Sinks LF: Hepatoblastoma in a child with fetal alcohol syndrome. Lancet 1:1403–1404, 1979 (Letter).PubMedGoogle Scholar
  110. 110.
    Kingston JE, Herbert A, Draper GJ and Mann JR: Association between hepatoblastoma and polyposis coli. Arch Dis Child 58: 959–962, 1983.PubMedGoogle Scholar
  111. 111.
    Koompirochana C, Chinda K and Pongpipat D: Hepatocellular carcinoma in infant: Report of one case. J Med Assoc Thailand 64: 90–95, 1981.Google Scholar
  112. 112.
    Korobkin M, Kirks DR, Sullivan DC, Mills SR and Bowie JD: Computed tomography of primary liver tumors in children. Radiology 139: 431–435, 1981.PubMedGoogle Scholar
  113. 113.
    Kumar EV, Kumar L, Pathak IC, Dash RJ and Joshi VV: Clinical, hormonal and ultrastructure studies of a virilizing hepatoblastoma. Acta Paediatr Scand 67: 389392, 1978.Google Scholar
  114. 114.
    Lack EE, Neve C and Vawter GF: Hepatocellular carcinoma. Review of 32 cases in childhood and adolescence. Cancer 52: 1510–1515, 1983.PubMedGoogle Scholar
  115. 115.
    Lack EE, Neave C and Vawter GF: Hepatoblastoma. A clinical and pathologic study of 54 cases. Am J Surg Pathol 6: 693–705, 1982.PubMedGoogle Scholar
  116. 116.
    Landing BH: Tumors of the liver in childhood. IN. Hepatocellular Carcinoma. K Okuda and PL Peters (eds), John Wiley and Sons, New York, 1976, pp 205–226.Google Scholar
  117. 117.
    Lane M, Liebelt A, Calvert J and Liebelt RA: Effect of partial hepatectomy on tumor incidence in BALB/e mice treated with urethan. Cancer Res 30: 1812–1816, 1970.PubMedGoogle Scholar
  118. 118.
    Lapis K and Johannessen JV: Pathology of primary liver cancer. IN. Liver Carcinogenesis. Hemisphere Publishing Corp, Washington, 1979, pp 145–185.Google Scholar
  119. 119.
    Laquer GL, Michelsen O, Whiting MG and Kurland LT: Carcinogenic properties of nuts from Cycas circinalis L indigenous to Guam. J Nat Cancer Inst 31: 919–951, 1963.Google Scholar
  120. 120.
    Levine G, Mireau G and Favara BE: Hepatic glycogenosis, renal glomerular cysts and hepatocarcinoma. Am J Pathol 82: 16a, 1976 (Abstract).Google Scholar
  121. 121.
    Liebelt RA, Liebelt AG and Lane M: Hormonal influences on urethan carcinogenesis in C3G/f mice. Cancer Res 24: 1869–1879, 1964.PubMedGoogle Scholar
  122. 122.
    Lieberman J, Silton RM, Agliozzo CM and McMahon J: Hepatocellular carcinoma and intermediate alpha-l-antitrypsin deficiency (MZ phenotype). Am J Clin Pathol 64: 304–310, 1975.PubMedGoogle Scholar
  123. 123.
    Lin JJ, Liu C, Svoboda DJ: Long term effects of aflatoxin B1 and viral hepatitis on marmoset liver. A preliminary report. Lab Invest 30: 267–278, 1974.PubMedGoogle Scholar
  124. 124.
    Lin T-Y, Chen C-C and Liu W-P: Primary carcinoma of the liver in infancy and childhood: Report of 21 cases with resection in 6 cases. Surgery 60: 1275–1281, 1966.PubMedGoogle Scholar
  125. 125.
    London WT: Primary hepatocellular carcinoma–Etiology, pathogenesis and prevention. Human Pathol 12: 1085–1097, 1981.Google Scholar
  126. 126.
    Longmire WP Jr: Hepatic surgery. Trauma, tumors and cysts. Ann Surg 161: 114, 1965.Google Scholar
  127. 127.
    Longmire WP Jr and Marable SA: Clinical experiences with major hepatic resections. Ann Surg 154: 460–474, 1961.PubMedGoogle Scholar
  128. 128.
    Macpherson RI, Saldana JA, Cone RM and Mewborne EB: Primary liver masses in infants. J Can Assoc Radiol 32: 81–87, 1981.PubMedGoogle Scholar
  129. 129.
    Magee PN and Barnes JM: The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. Br J Cancer 10: 114–122, 1956.PubMedGoogle Scholar
  130. 130.
    Marsden HB and Steward JK (eds), Tumours in Children. Second Revised Edition. Springer Verlag, Berlin, 1976, pp 408–412.Google Scholar
  131. 131.
    Martin LW and Woodman KS: Hepatic lobectomy for hepatoblastoma in infants and children. Arch Surg 98: 1–7, 1969.PubMedGoogle Scholar
  132. 132.
    Mason HH and Andersen DH: Glycogen storage disease of the liver (von Gierke’s disease) with hepatoma. Pediatrics 16: 785–799, 1955.PubMedGoogle Scholar
  133. 133.
    McArthur JW, Toll GD, Russfield AB, Reiss AM, Quinby WC and Baker WH: Sexual precocity attributable to ectopic gonadotropin secretion by hepatoblastoma. Am J Med 54: 390–403, 1973.PubMedGoogle Scholar
  134. 134.
    McDermott WV Jr, Greenberger VJ, Isselbacher KJ and Weber AL: Major hepatic resection: Diagnostic techniques and metabolic problems. Surgery 54: 56–64, 1963.Google Scholar
  135. 135.
    McDonald P: Hepatic tumors in childhood. Clin Radiol 18: 74–82, 1967.PubMedGoogle Scholar
  136. 136.
    Melamed I, Bujanover Y, Hammer J and Spirer Z: Hepatoblastoma in an infant born to a mother after hormonal treatment for sterility. New Engl J Med 307:820, 1982 (Letter).Google Scholar
  137. 137.
    Meradji M: The radiological investigation of primary hepatic tumours in infancy and childhood. J Belge Radiol 65: 1–8, 1982.PubMedGoogle Scholar
  138. 138.
    Miller JH, Gates GF and Stanley P: The radiologie investigation of hepatic tumors in childhood. Radiology 124: 451–458, 1977.PubMedGoogle Scholar
  139. 139.
    Milman DH and Grayzel DM: Mixed tumor of the liver. Am J Dis Child 81: 408420, 1951.Google Scholar
  140. 140.
    Misugi K, Okajima H, Misugi N and Newton WA Jr: Classification of primary malignant tumors of liver in infancy and childhood. Cancer 20: 1760–1771, 1967.PubMedGoogle Scholar
  141. 141.
    Moazam F, Talbert JL and Rodgers BM: Primary tumors of the liver in infancy and childhood. J Fla Med Assoc 69: 991–996, 1982.PubMedGoogle Scholar
  142. 142.
    Mohr U, Reznik-Schuller H, Reznik G and Hilfrich J: Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy. J Nat Cancer Inst 55: 681–683, 1975.PubMedGoogle Scholar
  143. 143.
    Mokrohisky ST, Ambruso DR and Hathaway WE: Fulminant hepatic neoplasia after androgen therapy. New Engl J Med 296:1411–1412, 1977 (Letter).PubMedGoogle Scholar
  144. 144.
    Morita K, Okabe I, Uchino J, Watanabe I, Iwabuchi M, Matsuyama S, Takahashi H, Nakajo T, Hirai Y, Tsuchida Y, Katsumata K, Hasegawa H, Nishi T, Okamoto E and Ikeda K: The proposed TNM classification of primary liver carcinoma in infants and children. Jap J Clin Oncol 13: 361–370, 1983.Google Scholar
  145. 145.
    Moss AA, Clark RE, Palubinskas AJ and de Lorimier AA: Angiographie appearance of benign and malignant hepatic tumors in infants and children. Am J Roentgenol 113: 61–69, 1971.Google Scholar
  146. 146.
    Moulton JE: Tumors in Domestic Animals. University of California Press, Berkley, 1961, pp 139–141.Google Scholar
  147. 147.
    Murthy ASK, Vawter GF, Lee ABH, Jockin H and Filler RM: Hormonal bioassay of gonadotropin-producing hepatoblastoma. Arch Pathol Lab Med 104: 513–517, 1980.PubMedGoogle Scholar
  148. 148.
    Nakagawara A, Ikeda K, Hayashida Y, Tsuneyoshi M, Enjoji M and Kawaoi A: Immunocytochemical identification of human chorionic gonadotropin-and alphafetoprotein-producing cells of hepatoblastoma associated with precocious puberty. Virch Arch (Pathol Anat) 398: 45–51, 1982.Google Scholar
  149. 149.
    Napoli VM and Campbell WG Jr: Hepatoblastoma in infant sister and brother. Cancer 39: 2647–2650, 1977.PubMedGoogle Scholar
  150. 150.
    Newburne PM, Harrington DH and Wogan GN: Effects of cirrhosis and other liver insults on induction of liver tumors by aflatoxin in rats. Lab Invest 15: 962–969, 1966.Google Scholar
  151. 151.
    Newburne PM and Wogan GN: Sequential morphologic changes in aflatoxin B1 carcinogenesis in the rat. Cancer Res 28: 770–781, 1968.Google Scholar
  152. 152.
    Nikaidoh H, Boggs J and Swenson O: Liver tumors in infants and children. Arch Surg 101: 245–257, 1970.Google Scholar
  153. 153.
    Nixon H11: Hepatic tumors in childhood and their treatment by major hepatic resection. Arch Dis Child 40: 169–172, 1965.Google Scholar
  154. 154.
    Novy S, Wallace S, Medellin H and McBride C: Angiographie evaluation of primary malignant hepatocellular tumors in children. Am J Roentgenol 120: 353–360, 1974.Google Scholar
  155. 155.
    Ohaki Y, Misugi K, Sasaki Y and Tsunoda A: Hepatitis B surface antigen positive hepatocellular carcinoma in children. Cancer 51: 822–828, 1983.PubMedGoogle Scholar
  156. 156.
    Ohbayashi A, Okochi K and Mayumi M: Familial clustering of asymptomatic carriers of Australia antigen and patients with chronic liver disease or primary liver cancer. Gastroenterology 62: 618–625, 1972.Google Scholar
  157. 157.
    Okuyama K: Primary liver cell carcinoma associated with biliary cirrhosis due to congenital bile duct atresia. J Pediatr 67: 89–93, 1965.PubMedGoogle Scholar
  158. 158.
    Ong GB and Chan PKW: Primary carcinoma of the liver. Surg Gynecol Obstet 143: 31–38, 1976.PubMedGoogle Scholar
  159. 159.
    O’Sullivan WD: Hepatoma in five year old child treated with excision. Am J Surg 82: 295–298, 1951.PubMedGoogle Scholar
  160. 160.
    Otten J, Smets R, de Jager R, Gerard A and Maurus R: Heptoblastoma in an infant after contraceptive intake during pregnancy. New Engl J Med 297:222, 1977 (Letter).PubMedGoogle Scholar
  161. 161.
    Otten J and Maurus R: Clinical trial of peptichemio in solid tumors of childhood. Cancer Treat Rep 61: 1015–1019, 1978.Google Scholar
  162. 162.
    Pack GT and Molander DW: Metabolism before and after hepatic lobectomy for cancer. Arch Surg 80: 685–692, 1960.PubMedGoogle Scholar
  163. 163.
    Peers FG and Linsell CA: Dietary aflatoxins and liver cancer–A population based study in Kenya. Br J Cancer 27: 473–484, 1973.PubMedGoogle Scholar
  164. 164.
    Penchansky L: Bone marrow biopsy in the metastatic work-up of solid tumors in children. Cancer 54: 1447–1448, 1984.PubMedGoogle Scholar
  165. 165.
    Peterson RD, Varco RL and Good RA: A 5-year survival of an infant after surgical excision of an embryonal hepatoma. Pediatrics 27: 474–476, 1961.PubMedGoogle Scholar
  166. 166.
    Police L: Primary hepatic tumors in infancy and childhood. Am J Clin Pathol 60: 512–521, 1973.Google Scholar
  167. 167.
    Pongipat D, Suvatte V, Talalak P and Pacharee P: Hepatoma in childhood. Report of 10 cases with emphasis on the significance of alpha-1-fetoprotein. J Med Assoc Thailand 60: 418–423, 1977.Google Scholar
  168. 168.
    Porter CA, Mowat AP, Cook PJL, Haynes DWG, Shilkin KB and Williams R: Alpha1-antitrypsin deficiency and neonatal hepatitis. Br Med J 3: 435–439, 1972.PubMedGoogle Scholar
  169. 169.
    Pratt CB and Shanks EC: Doxorubicin in treatment of malignant solid tumors in children. Am J Dis Child 127: 534–536, 1974.PubMedGoogle Scholar
  170. 170.
    Price JB Jr, Schullinger JN and Santulli TV: Major hepatic resections for neoplasia in children. Arch Surg 117: 1139–1141, 1982.PubMedGoogle Scholar
  171. 171.
    Primack A, Vogel CL, Kyalwazi SK, Ziegler JL, Simon R and Anthony PP: A staging system for hepatocellular carcinoma: Prognostic factors in Ugandan patients. Cancer 35: 1357–1364, 1975.PubMedGoogle Scholar
  172. 172.
    Pritchard J, da Cunha A, Cornbleet MA and Carter CJ: Alpha feto (AFP) monitoring of response to adriamycin in hepatoblastoma. J Pediatr Surg 17: 429–430, 1982.PubMedGoogle Scholar
  173. 173.
    Purtilo DT and Gottlieb LS: Cirrhosis and hepatoma occurring at Boston city hospital (1917–1968). Cancer 32: 458–462, 1973.PubMedGoogle Scholar
  174. 174.
    Purves LR, Bersohn I and Geddes EW: Serum alpha-fetoprotein and primary cancer of the liver in man. Cancer 25: 1261–1270, 1970.PubMedGoogle Scholar
  175. 175.
    Quinn J, Altman A, Garcia L, Robinson T, Foster S, Cooke R and Hight D: Adriamycin (ADRIA) and cis-platinum (DDP) for unresectable hepatoblastoma. Proc Am Assoc Clin Oncol 3: 77, 1984 (Abstract).Google Scholar
  176. 176.
    Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM Jr and George S: Adriamycin in the treatment of childhood solid tumors. Cancer 36: 1567–1571, 1975.PubMedGoogle Scholar
  177. 177.
    Randolph J and Altman RP: Tumors of the liver. IN. Pediatric Surgery Third Edition, MM Ravitch, KJ Welch, CD Benson, E Aberdeen and JG Randolph (eds), Year Book Medical Publishers, Inc, Chicago, 1979, pp 839–847.Google Scholar
  178. 178.
    Randolph JG, Altman RP, Arensman RM, Matlak ME and Leikin SL: Liver resection in children with hepatic neoplasms. Ann Surg 187: 599–604, 1978.PubMedGoogle Scholar
  179. 179.
    Reed ML, Vaitkevicius VK, Al-sarraf M, Vaughn CB, Singhakowinta A, Sexon-Porte M, Isbicki R, Baker L and Straatsma GW: The practicality of chronic hepatic artery infusion therapy of primary and metastatic hepatic malignancies: Ten-year results of 124 patients in a prospective protocol. Cancer 47: 402–409, 1981.PubMedGoogle Scholar
  180. 180.
    Reeves RL, Tesluk H and Harrison CE: Precocious puberty associated with hepatoma. J Clin Endocrinol 19: 1651–1660, 1959.Google Scholar
  181. 181.
    Reuber MD: Influence of hormones on N-2-fluorenyldiacetamide-induced hyperplastic hepatic nodules in rats. J Nat Cancer Inst 43: 445–452, 1969.PubMedGoogle Scholar
  182. 182.
    Reuber MD and Lee CW: Effect of age and sex on hepatic lesions in Buffalo strain rats ingesting diethylnitrosamine. J Nat Cancer Inst 41: 1133–1140, 1968.PubMedGoogle Scholar
  183. 183.
    Rice JM: Transplacental carcinogenesis in mice by 1-ethyl-l-nitrosourea. 163: 813826, 1969.Google Scholar
  184. 184.
    Rivera G, Avery T and Pratt C: 4’–demethylepipodophyllotoxin 9–(4,6–0–2–thenylidene–beta–D–glucopyranoside)(NSC–122819; VM–26) and 4’–demethylepipodophyllotoxin 9–(4,6–0–ethylidene–beta–D–glucopyranoside) (NSC141540; VP–16–213) in childhood cancer: Preliminary observations. Cancer Chemo Rep 59: 743 – 749, 1975.Google Scholar
  185. 185.
    Roe TF, Kogut MD, Buckingham BA, Miller JH, Gates GF and Landing BH: Hepatic tumors in glycogen storage disease (GSD) type I. J Pediatr Res 13: 481, 1979 (Abstract).Google Scholar
  186. 186.
    Root AW, Bongiovanni AM and Eberlein WR: A testicular-interstitial-cell- stimulating gonadotropin in a child with hepatoblastoma and sexual precocity. J Clin Endocrinol 28: 1317–1322, 1968.Google Scholar
  187. 187.
    Rosch J, Mayer BS, Campbell JR and Neerhout RC: Angiography in the diagnosis of liver disease in children. Radiol Clin 46: 321–339, 1977.Google Scholar
  188. 188.
    Roth D and Duncan PA: Primary carcinoma of the liver after giant-cell hepatitis of infancy. Cancer 8: 986–991, 1955.PubMedGoogle Scholar
  189. 189.
    Ruymann FB, Mosijczuk AD and Sayers RJ: Hepatoma in a child with methotrexateinduced hepatic fibrosis. JAMA 238: 2631–2633, 1977.PubMedGoogle Scholar
  190. 190.
    Schumaker RC, Robertson KA, Hsu IC and Allen JR: Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine. J Nat Cancer Inst 56: 787–790, 1976.Google Scholar
  191. 191.
    Seifert P, Baker LH, Reed ML and Vaiekevicius VK: Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma. Cancer 36: 123–128, 1975.PubMedGoogle Scholar
  192. 192.
    Selawry OS, Holland JF and Wolman II: Effect of vincristine (NSC-67574) on malignant solid tumors in children. Cancer Chemo Rep 52: 497–500, 1968.Google Scholar
  193. 193.
    Senzer NN, Terrell W and Pratt CB: Evaluation of a chemotherapeutic regimen for primary liver cancer in children. Cancer Treat Rep 62:1403–1404, 1976 (Letter).Google Scholar
  194. 194.
    Shafer AD and Selinkoff PM: Preoperative irradiation and chemotherapy for initially unresectable hepatoblastoma. J Pediatr Surg 12: 1001–1006, 1977.PubMedGoogle Scholar
  195. 195.
    Shah P, Baker LH and Vaiekevicius VK: Preliminary experiences with intra-arterial adriamycin. Cancer Treat Rep 61: 1565–1567, 1977.PubMedGoogle Scholar
  196. 196.
    Shanser JD, Glicksman MG and Palubinskas AJ: Pitfalls in the arteriographic differentiation of intrahepatic and extrahepatic masses. Am J Roentgenol 121: 420429, 1974.Google Scholar
  197. 197.
    Shapiro P, Ikeda RM, Ruebner BH, Connors MH, Halsted CC and Abildgaard DF: Multiple hepatic tumors and peliosis hepatis in Fanconi’s anemia treated with androgens. Am J Dis Child 131: 1104–1106, 1977.PubMedGoogle Scholar
  198. 198.
    Shimoda T, Uchida T, Miyata H, Abe K, Ariga H, Shikata T and Fujii Y: A 6-year old boy having hepatocellular carcinoma associated with hepatitis B surface antigenemia. Am J Clin Pathol 74: 827–831, 1980.PubMedGoogle Scholar
  199. 199.
    Shiodt T: Hepatoblastoma and hepatocarcinoma in infancy and childhood. Acta Pathol Suppl 212: 181–192, 1970.Google Scholar
  200. 200.
    Shorter RG, Baggenstoss AH, Logan GB and Hallenbeck GA: Primary carcinoma of the liver in infancy and childhood. Pediatrics 25: 191–203, 1960.PubMedGoogle Scholar
  201. 201.
    Siegel MM, Siegel SE, Isaacs J Jr, Weitzman JJ, Hanson BE, Higgins GR and Shore NA: Primary chemotherapeutic management of unresectable and metastatic hepatoblastoma in children: Report of four cases. Med Pediatr Oncol 4: 297–304, 1978.PubMedGoogle Scholar
  202. 202.
    Silen W, Mawdsley D, Jensen P and Gardner RE: Hepatic lobectomy in the treatment of tumors of the liver in children. Ann Surg 150: 1065–1070, 1959.PubMedGoogle Scholar
  203. 203.
    Simone JV, Cassady JR and Filler RM: Cancers of childhood. IN. Cancer, Principles and Practice of Oncology. VT DeVita Jr, S Hellman and SA Rosenberg (eds). JB Lippincott Company, Philadelphia, 1982, pp 1304–1308.Google Scholar
  204. 204.
    Singh BP, Pandit K, Singh AK and Ram SP: Primary carcinoma of liver–hepatoblastoma. Ind J Pediatr 45: 242–245, 1978.Google Scholar
  205. 205.
    Sinnhuber RO and Wales JH: Aflatoxin B1 hepatocarcinogenicity in rainbow trout embryos. Fed Proc 33: 247, 1974 (Abstract).Google Scholar
  206. 206.
    Sinnhuber RO, Lee DJ, Wales JH and Ayres JL: Dietary factors and hepatoma in rainbow trout (Salmo gairdnerii) II. Cocarcinogenesis by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer. J Nat Cancer Inst 41: 1293–1299, 1968.PubMedGoogle Scholar
  207. 207.
    Sinniah D, Campbell PE and Colebatch JH: Primary hepatic cancer in infancy and childhood. A survey of twenty cases. Prog Pediatr Surg 7: 141–170, 1974.Google Scholar
  208. 208.
    Sinniah D, Sumithran E, Lin HP, Chan LL and Toh CK: Primary liver cancer in Malaysian children. Med J Malays 34: 265–268, 1980.Google Scholar
  209. 209.
    Slovis TL, Phillippart AI, Cushing B, Das L, Perlmutter AD, Reed JO, Wilner HI, Kroovand RL and Farooki ZQ: Evaluation of the inferior vena cava by sonography and venography in children with renal and hepatic tumors. Radiology 140: 767772, 1981.Google Scholar
  210. 210.
    Sotelo-Avila C, Gonzalez-Crussi F and Fowler JW: Complete and incomplete forms of Beckwith-Wiedemann syndrome: Their oncogenic potential. J Pediatr 96: 4750, 1980.Google Scholar
  211. 211.
    Spatz M and Laquer GL: Transplacental induction of tumors in Sprague-Dawley rats with crude cycad material. J Nat Cancer Inst 38: 233–245, 1967.PubMedGoogle Scholar
  212. 212.
    Stahl WM: Radical right hepatic lobectomy for hepatoblastoma in infancy. New York State J Med 72: 2083–2085, 1972.Google Scholar
  213. 213.
    Starzl TE, Koep LJ, Schroeter GPJ, Halgrimson CG, Porter KA and Weil R III: Liver replacement for pediatric patients. Pediatrics 63: 825–829, 1979.PubMedGoogle Scholar
  214. 214.
    Sugarman GI, Heuser ET and Reed WB: A case of cerebral gigantism and hepatocarcinoma. Am J Dis Child 131: 631–633, 1977.PubMedGoogle Scholar
  215. 215.
    Sutow WW, Wilbur JR, Vietti TJ, Vuthibhagdee P, Fujimoto T and Watanabe A: Evaluation of dosage schedules of mitomycin C (NSC-26980) in children. Cancer Chemo Rep 55: 285–289, 1971.Google Scholar
  216. 216.
    Svoboda D, Grady H and Higginson J: Aflatoxin B1 injury in rat and monkey liver. Am J Pathol 49: 1023–1051, 1966.PubMedGoogle Scholar
  217. 217.
    Tamm J, Apostolakis M and Voigt KD: The effects of ACTH and HCG on the urinary excretion of testosterone in male patients with various endocrine disorders. Acta Endocrinol 53: 61–72, 1966.PubMedGoogle Scholar
  218. 218.
    Tan C, Rosen G, Ghavimi F, Haghbin M, Helson L, Wollner N and Murphy ML: Adriamycin (NSC-123127) in pediatric malignancies. Cancer Chemo Rep Part 3 6: 259–266, 1975.Google Scholar
  219. 219.
    Taylor PH, Filler RM, Nebesar RA and Tefft M: Experience with hepatic resection in childhood. Am J Surg 117: 435–441, 1969.PubMedGoogle Scholar
  220. 220.
    Teppo L: Personal communication.Google Scholar
  221. 221.
    Thamdrup E: Precocious puberty in a boy with hepatoma. Acta Endocrinol Suppl 101: 23, 1965 (Abstract).Google Scholar
  222. 222.
    Theilen GH and Madewell BR: Veterinary Cancer Medicine. Lea and Febiger, Philadelphia, 1979, pp 325–327.Google Scholar
  223. 223.
    Tong MJ, Thursby MW, Lin J-H, Weissman JY and McPeak CM: Studies on the maternal-infant transmission of the heptitis B virus and HBV infection within families. IN Hepatitis B Virus and Primary Hepatocellular Carcinoma. P Maupas and JL Melnick (eds), S Karger, Basel, 1981, pp 137–147.Google Scholar
  224. 224.
    Toth B, Magee PN and Shubik P: Carcinogenesis study with dimethylnitrosamine administered orally to adult and subcutaneously to newborn BALB/c mice. Cancer Res 24: 1712–1721, 1964.PubMedGoogle Scholar
  225. 225.
    Ugarte N and Gonzalez-Crussi F: Hepatoma in siblings with progressive familial cholestatic cirrhosis of childhood. Am J Clin Pathol 76: 172–177, 1981.PubMedGoogle Scholar
  226. 226.
    Van Vaerenberg P, Thijs L, Delbeke M and Craen M: A case of malignant hepatoma with precocious puberty. Acta Paediatr Belg 26: 78–87, 1972.Google Scholar
  227. 227.
    Van Wyck J, Halgrimson CG, Giles G, Lilly J, Martineau G and Starzl TE: Liver transplantation in biliary atresia with concomitant hepatoma. South Afr Med J 46: 885–889, 1972.Google Scholar
  228. 228.
    Vesselinovitch SD and Mihailovich N: The effect of gonadectomy on the development of hepatomas induced by urethan. Cancer Res 27: 1788–1791, 1967.PubMedGoogle Scholar
  229. 229.
    Vesselinovitch SD, Mihailovich N, Wogan GN, Lombard LS and Rao KVN: Aflatoxin Bi, a hepatocarcinogen in the infant mouse. Cancer Res 32: 2289–2291, 1972.PubMedGoogle Scholar
  230. 230.
    Vileisis RA, Sorensen K, Gonzalez-Crussi F and Hunt CE: Liver malignancy after parenteral nutrition. J Pediatr 100: 88–90, 1982.PubMedGoogle Scholar
  231. 231.
    Voute PA Jr and Wadman SK: Cystathionuria in hepatoblastoma. Clin Chim Acta 22: 373–378, 1968.PubMedGoogle Scholar
  232. 232.
    Wachstein M and Meisel E: Enzymatic histochemistry of ethionine induced liver cirrhosis and hepatomas. J Histo Cyto 7: 189–201, 1959.Google Scholar
  233. 233.
    Wales JH and Sinnhuber RO: Hepatomas induced by aflatoxin in the sockeye salmon. (Oncorhynchus nerka). J Nat Cancer Inst 48: 1529–1530, 1972.PubMedGoogle Scholar
  234. 234.
    Wang JJ, Holland JF and Sinks LF: Phase II study of adriamycin (NSC-123127) in childhood solid tumors. Cancer Chemo Rep Part 3 6: 267–270, 1975.Google Scholar
  235. 235.
    Ward CF, Arkin DB and Benumof JL: The use of profound hypothermia and circulatory arrest for hepatic lobectomy in infancy. Anesthesiology 47: 473–474, 1977.PubMedGoogle Scholar
  236. 236.
    Warren S and Drake WL Jr: Primary carcinoma of the liver in hemochromatosis. Am J Pathol 27: 573–609, 1951.PubMedGoogle Scholar
  237. 237.
    Watkins GL: Primary carcinoma of the liver in an infant: Right lobectomy with six-year survival. Ann Surg 162: 264–266, 1965.PubMedGoogle Scholar
  238. 238.
    Weinberg AG and Finegold MJ: Primary hepatic tumors of childhood. Human Pathol 14: 512–537, 1983.Google Scholar
  239. 239.
    Weinberg AG, Mize CE and Worthen HG: The occurrence of hepatoma in the chronic form of hereditary tyrosinemia. J Pediatr 88: 434–438, 1976.PubMedGoogle Scholar
  240. 240.
    Weinblatt ME, Siegel SE, Siegel MM, Stanley P and Weitzman JJ: Preoperative chemotherapy for unresectable primary hepatic malignancies in children. Cancer 50: 1061–1064, 1982.PubMedGoogle Scholar
  241. 241.
    Weiss GR, Garnick MB, Osteen RT, Steele GD Jr, Wilson RE, Schade D, Kaplan WD, Boxt LM, Kandarpa K, Mayer RJ and Frei E III: Long-term hepatic arterial infusion of 5-fluorodeoxyuridine for liver metastases using an implantable infusion pump. J Clin Oncol 1: 337–344, 1983.PubMedGoogle Scholar
  242. 242.
    Willis RA: Pathology of Tumours. CV Mosby Company, St. Louis, 1948, pp 932–935.Google Scholar
  243. 243.
    Willis RA; Pathology of Tumours. Third edition, Butterworths, Washington, 1960, pp 936–943.Google Scholar
  244. 244.
    Wilson H and Wolf RY: Hepatic lobectomy: Indications, technique and results. Surgery 59: 472–482, 1966.PubMedGoogle Scholar
  245. 245.
    Wogan GN and Newburne PM: Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat. Cancer Res 27: 2370–2376, 1967.PubMedGoogle Scholar
  246. 246.
    Yang SS, Brough AJ and Bernstein J: Tumors of the liver in early infancy: Hepatoblastoma. Mich Med 71: 539–543, 1972.PubMedGoogle Scholar
  247. 247.
    Young JL Jr: Personal communication.Google Scholar
  248. 248.
    Young JL Jr, Heise HW, Silverberg E and Myers MH: Cancer incidence, survival and mortality for children under 15 years of age. American Cancer Society, New York, 1978, p 8.Google Scholar
  249. 249.
    Young JL Jr and Miller RW: Incidence of malignant tumors in U S children. J Pediatr 86: 254–258, 1975.PubMedGoogle Scholar
  250. 250.
    Zangeneh F, Limbeck GA, Brown BI, Emch JR, Arcasoy MM, Goldenberg VE and Kelley VC: Hepatorenal glycogenosis (type I glycogenosis) and carcinoma of the liver. J Pediatr 74: 73–83, 1969.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Daniel M. Green
    • 1
    • 2
  1. 1.School of MedicineState University of New York at BuffaloUSA
  2. 2.Roswell Park Memorial InstituteBuffaloUSA

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