Abstract
Osteosarcoma is the most common primary bone tumor in pediatric patients. The incidence rate was 3.1 cases per million U.S. white children less than 15 years of age per year. The corresponding figure for U.S. black children was 2.5 361. The highest rate was 5.2 among U.S. black boys and the lowest rate was 0.5 among boys in Queensland, Australia 16,17,77,99,209,210,237,332,360,362.
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References
Abramson DG, Ronner HJ and Ellsworth RM: Second tumors in non-irradiated bilateral retinoblastoma. Am J Ophthalmol 87: 624–627, 1979.
Adamson U, Brostrom L-A, Efendic S and Hall K: Glucose tolerance, growth hormone and somatomedin levels in osteosarcoma patients. Acta Endocrinol 94: 517–522, 1980.
Allen CV and Stevens KR: Preoperative irradiation for osteogenic sarcoma. Cancer 31: 1364–1366, 1973.
Ayala AG and Zornosa J: Primary bone tumors: Percutaneous needle biopsy. Radiology 149: 675–679, 1983.
Bacci G, Picci P, Calderoni P, Figus E and Borghi A: Full-lung tomograms and bone scanning in the initial work-up of patients with osteogenic sarcoma. A review of 126 cases. Eur J Cancer Clin Oncol 18: 967–971, 1982.
Bailey RW and Levin PD: The clinical significance of the localization of tetracycline in certain tumors of bone. J Surg Res 3: 146–151, 1963.
Banks WC, Morris E, Herron MR and Green RW: Osteogenic sarcoma associated with internal fracture fixation in two dogs. J Am Vet Med Assoc 167: 166–167, 1976.
Barnes DWH, Carr TEF, Evans EP and Loutit JF: 90Sr-induced osteosarcomas in radiation chimaeras. Int J Rad Biol 18: 531–537, 1970.
Barnes JM and Denz FA: Beryllium bone sarcomata in rabbits. Br J Cancer 4: 212–222, 1950.
Barrows G and Kmetz DR: Treatment of lobar pulmonary metastasis in childhood cancer. J Kentucky Med Assoc 73: 367–370, 1975.
Baum ES, Gaynon P, Greenberg L, Krivit W and Hammond D: Phase II trial of cisplatin in refractory childhood cancer: Children’s cancer study group report. Cancer Treat Rep 65: 815–822, 1981.
Beattie EJ Jr, Martini N and Rosen G: The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy. Cancer 35: 618–621, 1975.
Beck JC, Wara WM, Bovill EG Jr and Phillips TL: The role of radiation therapy in the treatment of osteosarcoma. Radiology 120: 163–165, 1976.
Berg NO, Hakansson C-H, Lovdahl R and Persson BM: Radiotherapy and surgery in 50 cases of osteosarcoma treated without adjuvant chemotherapy. Acta Ortho Scand 48: 580–585, 1977.
Berger PE and Kuhn JP: Computed tomography of tumors of the musculoskeletal system in children. Radiology 127: 171–175, 1978.
Birch JM: Personal communication.
Birch JM, Marsden HB and Swindell R: Incidence of malignant disease in childhood: A 24-year review of the Manchester children’s tumour registry data. Br J Cancer 42: 215–223, 1980.
Bleyer WA, Haas JE, Feigl P, Greenlee TK, Schaller RT Jr, Morgan A, Pendergrass TW, Johnson FL, Bernstein ID, Chard RL Jr and Hartman JR: Improved three-year disease-free survival in osteogenic sarcoma. J Bone Joint Surg 64–8: 233–238, 1982.
Bleyer WA, Krivit W, Chard RL Jr and Hammond D: Phase II study of VM-26 in acute leukemia, neuroblastoma and other refractory childhood malignancies: A report from the children’s cancer study group. Cancer Treat Rep 63: 977–981, 1979.
Bonadonna G, Beretta G, Tancini G, Brambilla C, Bajetta E, De Palo GM, De Lena M, Fossati Bellani F, Gasparini M, Valagussa P and Veronesi U: Adriamycin (NSC123127) studies at the Istituto Nazionale Tumori, Milan. Cancer Chemo Rep Part 3, 6: 231–245, 1975.
Breithaupt H and Kuenzlen E: High-dose methotrexate for osteosarcoma: Toxicity and clinical results. Oncology 40: 85–89, 1983.
Breur K, Cohen P, Schweisguth O and Hart AMM: Irradiation of the lungs as an adjuvant therapy in the treatment of osteosarcoma of the limbs. Eur J Cancer 14: 461–471, 1978.
Brodeur GM, Caces J, Williams DL, Look AT and Pratt CB: Osteosarcoma, fibrous dysplasia and a chromosomal abnormality in a 3-year old child. Cancer 46: 1197–1201, 1980.
Brodey RS: The use of naturally occurring cancer in domestic animals for research into human cancer: General considerations and a review of canine skeletal osteosarcoma. Yale J Biol Med 52: 345–361, 1979.
Brodey RS and Abt DA: Results of surgical treatment in 65 dogs with osteosarcoma. J Am Vet Med Assoc 168: 1032–1035, 1976.
Brodey RS and Riser WH: Canine osteosarcoma–a clinicopathologic study of 194 cases. Clin Ortho 62: 54–64, 1969.
Brostrom L-A, Aparisi T, Ingimarsson S, Lagergren C, Nilsonne U, Stander H and Soderberg G: Can historical controls be used in current clinical trials in osteosarcoma? Metastases and survival in a historical and a concurrent group. Int J Rad Oncol Biol Phys 6: 1717–1721, 1980.
Brostrom L-A, Aparisi T, Ingimarsson C, Nilsonne U, Stander H and Soderberg G: Can historical controls be used in current clinical trials in osteosarcoma? Analysis of prognostic factors. Int J Rad Oncol Biol Phy 6: 1711–1715, 1980.
Brostom L-A and Nilsonne U: Bone tumors. IN. Interferon and Cancer. K Sikora (ed), Plenum Publishing Company, 1983, pp 141–152.
Brown ML: Significance of the solitary lesion in pediatric bone scanning: Concise communication. J Nucl Med 24: 114–115, 1983.
Brunschwig A and Bissell AD: Production of osteosarcoma in a mouse by the intramedullary injection of 1,2-benzpyrene. Arch Surg 36: 53–60, 1938.
Burgers JMV: EORTC/SIOP clinical trial on osteosarcoma 03. IN. Pediatric Oncology. C Raybaud, R Clement, G Lebreuil and JL Bernard (eds). Excerpta Medica, Amsterdam, 1982 pp 301–308.
Burgers JMV, Breur K, van Dobbenburgh OA, Hazebroek F, Vos A and Voute PA: Role of metastatectomy without chemotherapy in the management of osteosarcoma in children. Cancer 45: 1664–1668, 1980.
Byers VS, Le Cam L, Levin AS, Johnston JO and Hackett AJ: Immunotherapy of osteogenic sarcoma with transfer factor. Cancer Immunol Immunother 6: 243–253, 1979.
Caceres E and Moran ME: Actinomycin D in the treatment of metastatic osteogenic sarcoma. Cancer Treat Rep 61:498–499, 1977 (Letter).
Caceres E and Zaharia M: Massive preoperative radiation therapy in the treatment of osteogenic sarcoma. Cancer 30: 634–638, 1972.
Caceres E, Zaharia M, Moran M and Tejada F: Adjuvant whole-lung radiation with or without adriamycin treatment in osteogenic sarcoma. Cancer Treat Rep 62: 297–299, 1978.
Caceres E, Zaharia M, Valdivia S, Misad O, de la Flor J, Tejada F and Zubrod G: Local control of osteogenic sarcoma by radiation and chemotherapy. Int J Rad Oncol Biol Phys 10: 35–39, 1984.
Cade S: Osteogenic sarcoma: A study based on 133 patients. J Royal Coll Surg Edinb 1: 79–111, 1955.
Cade S: Sarcoma of bone. Ann Royal Coll Surg Engl 9: 211–223, 1951.
Campanacci M, Bacci G, Bertoni F, Picci P, Minutillo A and Franceschi C: The treatment of osteosarcoma of the extremities: Twenty years experience at the Istituto Ortopedico Rizzoli. Cancer 48: 1569–1581, 1981.
Campanacci M, Bacci G, Pagani P and Giunti A: Multiple-drug chemotherapy for the primary treatment of osteosarcoma of the extremities. J Bone Joint Surg 62B: 93–101, 1980.
Campanacci M and Laus M: Local recurrence after amputation for osteosarcoma. J Bone Joint Surg 62-B: 201–207, 1980.
Chard RL Jr, Krivit W, Bleyer WA, and Hammond D: Phase II study of VP-16–213 in childhood malignant disease: A children’s cancer study group report. Cancer Treat Rep 63: 1755–1759, 1979.
Chew FS and Hudson TM: Radionuclide bone scanning of osteosarcoma: Falsely extended uptake patterns. Am J Roentgenol 139: 49–54, 1982.
Christensen FC: Bone tumors. Am Surg 81: 1074–1092, 1925.
Cliffton EE and Pool JL: Treatment of lung metastases in children with combined therapy. J Thorac Cardiovasc Surg 54: 403–420, 1967.
Cobb LM: Radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man. Br J Cancer 24: 294–299, 1970.
Codman EA: The nomenclature used by the registry of bone sarcoma. Am J Roentgenol 13: 105–126, 1925.
Codman EA: The registry of cases of bone sarcoma. Surg Gynecol Obstet 34: 335–343, 1922.
Cohen AM, Ketcham AS and Morton DL: Specific inhibition of sarcoma-specific cellular immunity by sera from patients with growing sarcomas. Int J Cancer 11: 273–279, 1973.
Cohen M, Provisor A, Smith WL and Weetman R: Efficacy of whole lung tomography in diagnosing metastases from solid tumors in children. Radiology 141: 375–378, 1981.
Cohen P: Osteosarcoma of the long bones. Eur J Cancer 14: 995–1004, 1978.
Coley BL: Primary bone tumors in children. Am J Surg 38: 334–341, 1938.
Corallini A, Altavilla G, Cecchetti MG, Fabris G, Grossi MP, Balboni PG, Lanza G and Barbanti-Brodano G: Ependymomas, malignant tumors of pancreatic islets and osteosarcomas induced by BK virus a human papovavirus. J Nat Cancer Inst 61: 875–883, 1978.
Cortes EP, Holland JF and Glidewell O: Amputation and adriamycin in primary osteosarcoma: A five-year report. Cancer Treat Rep 62: 271–277, 1978.
Cortes EP, Holland JF, Wang JJ, Sinks LF, Bloom J, Senn H, Bank A and Glidewell O: Amputation and adriamycin in primary osteosarcoma. New Engl J Med 291: 998–1000, 1974.
Coventry MB and Dahlin DC: Osteogenic sarcoma. A critical analysis of 430 cases. J Bone Joint Surg 39-A: 741–758, 1957.
Culbert S, Cangir A, Jaffe N, Sullivan MP and Dicke K: Therapeutic potential of high dose phenylalanine mustard (HDP) in pediatric solid tumors. Proc Am Assoc Cancer Res 22: 400, 1981 (Abstract).
Dahlin DC: Bone Tumors. Third Edition, Charles C Thomas Publishers, Springfield, 1978, pp 226–260.
Dahlin DC and Coventry MB: Osteogenic sarcoma. A study of six hundred cases. J Bone Joint Surg 49-A: 101–110, 1967.
Delgado ER: Sarcoma following a surgically treated fractured tibia. Clin Ortho 12: 315–318, 1958.
de Santos LA, Bernardino ME and Murray JA: Computed tomography in the evaluation of osteosarcoma: Experience with 25 cases. Am J Roentgenol 132: 535–540, 1979.
de Santos LA, Murray JA and Ayala AG: The value of percutaneous needle biopsy in the management of primary bone tumors. Cancer 43: 735–744, 1979.
Diamandopoulos GT: Induction of lymphocytic leukemia, lymphosarcoma, reticulum cell sarcoma and osteogenic sarcoma in the Syrian golden hamster by oncogenic DNA simian virus 40. J Nat Cancer Inst 50: 1347–1365, 1973.
Dwinnell LA, Dahlin DC and Ghormley RK: Parosteal (juxtacortical) osteogenic sarcoma. J Bone Joint Surg 36-A: 732–744, 1954.
Edmonson JH, Green SJ, Ivins JC, Gilchrist GS, Creagan ET, Pritchard DJ, Smithson WA, Dahlin DC and Taylor WF: A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2: 152–156, 1984.
Eilber FR and Eckardt J: Adjuvant therapy for osteosarcoma: A randomized prospective trial. Proc Am Soc Clin Oncol 4: 144, 1985 (Abstract).
Eilber FR, Mirra J, Grant TT, Weisenburger T and Morton DL: Is amputation necessary for extremity sarcomas? A seven-year experience with limb salvage. Ann Surg 192: 431–437, 1980.
Eilber FR and Morton DL: Sarcoma-specific antigen: Detection by complement fixation with serum from sarcoma patients. J Nat Cancer Inst 44: 651–656, 1970.
Eilber FR, Morton DL, Eckardt J, Grant T and Weisenburger T: Limb salvage for skeletal and soft tissue sarcomas. Cancer 53: 2579–2584, 1984.
Eilber FR, Townsend C and Morton DL: Osteosarcoma. Clin Ortho 111: 94–100, 1975.
Enneking WF and Kagan A: “Skip” metastases in osteosarcoma. Cancer 36:2192–2205, 1975.
Enneking WE and Shirley PD: Resection-arthrodesis for malignant and potentially malignant lesions about the knee using an intramedullary rod and local bone grafts. J Bone Joint Surg 59-A: 223–236, 1977.
Enneking WF, Spanier SS and Malawer MM: The effect of anatomic setting on the results of surgical procedures for soft parts sarcoma of the thigh. Cancer 47: 1005–1022, 1981.
Epstein LI, Bixler D and Bennett JE: An incident of familial cancer. Cancer 25: 889–891, 1970.
Ericsson J L-E, Karnstrom L and Mattsson B: Childhood cancer in Sweden, 19581974. Acta Paediatr Seand 67: 425–432, 1978.
Etcubanas E and Wilbur JR: Adjuvant chemotherapy for osteogenic sarcoma. Cancer Treat Rep 62: 283–287, 1978.
Ettinger LJ, Douglass HO Jr, Higby DJ, Mindell ER, Nime F, Ghoorah J and Freeman AI: Adjuvant adriamycin and cis-diamminedichloroplatinum (cis-platinum) in primary osteosarcoma. Cancer 47: 248–254, 1981.
Evans AE: Mitomycin C. Cancer Chemo Rep 14: 1–9, 1961.
Evans AE, Baehner RL, Chard RL, Jr, Leikin SL, Pang EM and Pierce M: Comparison of daunorubicin (NSC-83142) with adriamycin (NSC-123127) in the treatment of late-stage childhood solid tumors. Cancer Chemo Rep 58: 671–676, 1974.
Evans AE, Heyn RM, Nesbit ME and Hartmann JR: Evaluation of mitomycin C (NSC-26980) in the treatment of metastatic osteogenic sarcoma. Cancer Chemo Rep 53: 297–298, 1969.
Ewing J: A review of the classification of bone tumors. Surg Gynecol Obstet 68: 971–976, 1939.
Ewing J: Neoplastic Diseases. A Treatise on Tumors. WB Saunders Company, Philadelphia, 1940, pp 293–316.
Farr GH and Huvos AG: Juxtacortical osteogenic sarcoma: An analysis of fourteen cases. J Bone Joint Surg 54-A: 1205–1216, 1972.
Farr GH, Huvos AG, Marcove RC, Higinbotham NL and Foote FW Jr: Telangiectatic osteogenic sarcoma. Cancer 34: 1150–1158, 1974.
Ferguson AB: Treatment of osteogenic sarcoma. J Bone Joint Surg 22: 92–96, 1940.
Ferguson AB: Treatment of osteogenic sarcoma. J Bone Joint Surg 22: 916–922, 1940.
Ferguson RJ and Yunis EJ: The ultrastructure of human osteosarcoma. A study of nine cases. Clin Ortho 131: 234–246, 1978.
Fine G and Stout AP: Osteogenic sarcoma of the extraskeletal soft tissues. Cancer 9: 1027–1043, 1956.
Finkel MP, Biskis BO and Farrell C: Nonmalignant and malignant changes in hamsters innoculated with extracts of human osteosarcomas. Radiology 92: 1546–1552, 1969.
Finkel MP, Biskis BO and Farrell C: Osteosarcomas appearing in Syrian hamsters after treatment with extracts of human osteosarcomas. Proc Nat Acad Sci 60: 1223–1230, 1968.
Finkel MP, Biskis BO and Farrell C: Pathogenic effects of extracts of human osteosarcomas. Arch Pathol 84: 425–428, 1967.
Finkel MP, Biskis BO and Jinkins PB: Virus induction of osteosarcomas in mice. Science 151: 698–701, 1966.
Finkel MP, Jinkins PB, Tolle J and Biskis BO: Serial radiography of virus-induced osteosarcomas in mice. Radiology 87: 333–339, 1966.
Finkel MP, Reilly CA Jr and Biskis BO: Pathogenesis of radiation and virus-induced bone tumors. IN. Malignant Bone Tumors. E. Grundmann (ed), Springer-Verlag, Berlin, 1976, pp 92–103.
Finklestein JZ, Albo V, Ertel I and Hammond D: 5-(3,3-dimethyl-l- triazeno)imidazole-4-carboxamide (NSC-45388) in the treatment of solid tumors in children. Cancer Chemo Rep 59: 351–357, 1975.
Finklestein JZ, Hittle RE and Hammond GD: Evaluation of a high dose cyclophosphamide regimen in childhood tumors. Cancer 23: 1239–1242, 1969.
Finnish Cancer Registry: Cancer in Finland 1980. Cancer Society of Finland Publication No 32, Finnish Cancer Registry, Helsinki, 1983, p 29.
Fossati-Bellani F, Gasparini M, and Bonadonna G: Adriamycin in the adjuvant treatment of operable osteosarcoma. IN. Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II. G Bonadonna, G Mathe and SE Salmon (eds), Springer-Verlag, Berlin, 1979, pp 25–27.
Fossati-Bellani F, Gasparini M, Gennari L, Fontanillas L and Bonadonna G: Adjuvant treatment with adriamycin in primary operable osteosarcoma. Cancer Treat Rep 62: 279–281, 1978.
Francis KC, Phillips R, Nickson JJ, Woodard HQ, Higinbotham NL and Coley BL: Massive preoperative irradiation in the treatment of osteogenic sarcoma in children. Am J Roentgenol 72: 813–818, 1954.
Francis KC and Worcester JN: Radical resection for tumors of the shoulder with preservation of a functional extremity. J Bone Joint Surg 44-A: 1423–1430, 1962.
Fraumeni JF Jr: Stature and malignant tumors of bone in childhood and adolescence. Cancer 20: 967–973, 1967.
Freeman CR, Gledhill R, Chevalier LM, Whitehead VM and Esseltine DL: Osteogenic sarcoma following treatment with megavoltage radiation and chemotherapy for bone tumors in children. Med Pediatr Oncol 8: 375–382, 1980.
Frei E III, Blum R and Jaffe N: Sarcoma: Natural history and treatment. IN. Immunotherapy of Cancer: Present Status of Trials in Man. WD Terry and D Windhorst (eds), Raven Press, New York, 1978, pp 245–255.
Friedlaender GE and Mitchell MS: A laboratory model for the study of the immunobiology of osteosarcoma. Cancer 36: 1631–1639, 1975.
Gaitan-Yanguas M: A study of the response of osteogenic sarcoma and adjacent normal tissues to radiation. Int J Rad Oncol Biol Phys 7: 593–595, 1981.
Gehan EA, Sutow WW, Uribe-Botero G, Romsdahl M and Smith TL: Osteosarcoma: The M D Anderson experience, 1950–1974. IN. Immunotherapy of Cancer: Present Status of Trials in Man. WD Terry and D Windhorst (ed). Raven Press, New York 1978, pp 271–282.
Geschickter CF and Copeland MM: Parosteal osteoma of bone. A new entity. Ann Surg 133: 790–807, 1951.
Geschickter CF and Copeland MM: Tumors of Bone. JB Lippincott Company, Philadelphia, 1949, pp 181–212.
Ibid. pp 213–245.
Gilchrist GS,Ivins JC, Ritts RE Jr, Pritchard DJ, Taylor WF and Edmonson JM: Adjuvant therapy for nonmetastatic osteogenic sarcoma: An evaluation of transfer factor versus combination chemotherapy. Cancer Treat Rep 62:289–294, 1978.
Giritsky AS, Etcubanas E and Mark JBD: Pulmonary resection in children with metastatic osteogenic sarcoma. J Thorac Cardiovase Surg 75: 354–362, 1978.
Gliedman ML, Horowitz S and Lewis FJ: Lung resection for metastatic cancer. Surgery 42: 521–532, 1957.
Goidanich IF, Battaglia L, Lenzi L and Silva E: Osteogenic sarcoma. Analysis of factors influencing prognosis in 100 cases. Clin Ortho 48: 209–222, 1966.
Goldman A and Malpas JS: Phase I and II study of AMSA in childhood tumours. Cancer Chemo Pharmacol 9: 53–56, 1982.
Goldman AB, Becker MH, Braunstein P, Francis KC, Genieser NB and Firooznia H: Bone scanning–osteogenic sarcoma. Am J Roentgenol 124: 83–90, 1975.
Goldstein H, McNeil BJ, Zufall E, Jaffe N and Treves S: Changing indications for bone scintigraphy in patients with osteosarcoma. Radiology 135: 177–180, 1980.
Goodman MA, McMaster JH, Drash AL, Diamond PE, Kappakas GS and Scranton PE Jr: Metabolic and endocrine alterations in osteosarcoma patients. Cancer 42: 603–610, 1978.
Goorin A, Delorey M, Jaffe N, Link M, Price K, Gelber R, Emans J, Watts H and Abelson HT: Adjuvant chemotherapy using weekly (W) vincristine (V)/high-dose methotrexate (HDMTX)/leukovorin rescue (LV) and adriamycin (A) after ablative (AMP) or limb sparing (R) surgery (Study III) for patients with osteogenic sarcoma. Proc Am Soc Clin Oncol 2: 236, 1983 (Abstract).
Goorin AM, Delorey MJ, Lack EE, Gelber RD, Price K, Cassady JR, Levey R, Tapper D, Jaffe N, Link M and Abelson HT: Prognostic significance of complete surgical resection of pulmonary metastases in patients with osteogenic sarcoma: Analysis of 32 patients. J Clin Oncol 2: 425–431, 1984.
Gross SW: Sarcoma of the long bones; based upon a study of one hundred and sixty-five cases. Am J Med Sci 78: 17–57, 1879.
Grundmann E, Roesser A, Immenkamp M: Tumor cell types in osteosarcoma as revealed by electron microscopy. Virch Arch (Cell Pathol) 36: 257–273, 1981.
Gutierrez ML, Evans AE, Rohrbaugh T, Belasco J, Lee FH and Crooke ST: Phase II evaluation of mitomycin C (MMC) in children with refractory solid tumors using the single high-intermittent-dose schedule. Med Pediatr Oncol 9: 405–407, 1981.
Haggard ME, Cangir A, Ragab AH, Komp D, Falletta J and Humphrey GB: 5fluorouracII in childhood solid tumors. Cancer Treat Rep 61: 69–71, 1977.
Hajdu SI and Melamed MR: Needle biopsy of primary malignant bone tumors. Surg Gynecol Obstet 133: 829–832, 1971.
Han M-T, Telander RL, Pairolero PC, Payne WS, Gilchrist GS, Sim FH and Pritchard DJ: Aggressive thoracotomy for pulmonary metastatic osteogenic sarcoma in children and young adolescents. J Pediatr Surg 16: 928–933, 1981.
Harmon TP and Morton KS: Osteogenic sarcoma in four siblings. J Bone Joint Surg 48-B: 493–498, 1966.
Harvei S and Solheim 0: The prognosis in osteosarcoma: Norwegian national data. Cancer 48: 1719–1723, 1981.
Hayles AB, Dahlin-DC and Coventry MB: Osteogenic sarcoma in children. JAMA 174: 1174–1177, 1960.
Henness AM, Theilen GH, Park RD and Buhles WC: Combination therapy for canine osteosarcoma. J Am Vet Med Assoc 170: 1076–1081, 1977.
Hill P: Local recurrence in primary osteosarcoma of the femur. Br J Surg 60: 4041, 1973.
Hoover HC Jr, Ketcham AS, Millar RC and Gralnick HR: Osteosarcoma. Improved survival with anticoagulation and amputation. Cancer 41: 2475–2480, 1978.
Huebert HT: Osteosarcoma in Manitoba: Review of 95 patients. Can J Surg 22: 564–572, 1979.
Hutter RVP, Foote FW Jr, Francis KC and Sherman RS: Primitive multipotential primary sarcoma of bone. Cancer 19: 1–25, 1966.
Huvos AG, Rosen G, Bretsky SS and Butler AL Telangiectatic osteogenic sarcoma: A clinicopathologic study of 124 patients. Cancer 49: 1679–1689, 1982.
Huvos AG, Higinbotham NL and Miller TR: Bone sarcomas arising in fibrous dysplasia. J Bone Joint Surg 54-A: 1047–1056, 1972.
Ikemoto K and Yamamoto T: Induction of rat osteosarcoma by innoculation of murine sarcoma virus into bone marrow. Gann 63: 141, 1972.
Ito H, Murakami K, Yanagawa T, Ban S, Sawamura H, Sakakida K, Matsuo A, Imanishi J and Kishida T: Effect of human leukocyte interferon on the metastatic lung tumor of osteosarcoma. Cancer 46: 1562–1565, 1980.
Jacobson SA: Polyhistioma. Cancer 40: 2116–2130, 1977.
Jaffe HL: Tumors and Tumorous Conditions of the Bones and Joints. Lea and Febiger, Philadelphia, 1958, pp 256–278.
Jaffe N: Recent advances in the chemotherapy of metastatic osteogenic sarcoma. Cancer 30: 1627–1631, 1972.
Jaffe N, Frei E III, Traggis D and Bishop Y: Adjuvant methotrexate and citrovorumfactor treatment of osteogenic sarcoma. New Engl J Med 291: 994–997, 1974.
Jaffe N, Frei E III, Traggis D and Watts H: Weekly high-dose methotrexatecitrovorum factor in osteogenic sarcoma. Cancer 39: 45–50, 1977.
Jaffe N, Knapp J, Chuang VP, Wallace S, Ayala A, Murray J, Cangir A, Wang A and Benjamin RS: Osteosarcoma: Intra-arterial treatment of the primary tumor with cis-diammine-dichloroplatinum II (CDP). Cancer 51: 402–407, 1983.
Jaffe N, Prudich J, Knapp J, Wang Y-M, Bowman R, Cangir A, Ayala A, Chuang V and Wallace S: Treatment of primary osteosarcoma with intraarterial and intravenous high-dose methotrexate. J Clin Oncol 1: 428–431, 1983.
Jaffe N, Robertson R, Takaue Y, Cangir A, Wallace S, Carrasco H, Ayala A and Wang YM: Osteosarcoma: Prolonged control of the primary tumor with chemotherapy. Proc Am Soc Clin Oncol 3: 77, 1984 (Abstract).
Jaffe N, Traggis D, Cassady JR, Filler RM, Watts H and Frei E III: The role of high-dose methotrexate with citrovorum factor “rescue” in the treatment of osteogenic sarcoma. Int J Rad Oncol Biol Phys 2: 261–266, 1977.
Jaffe N, Watts H, Fellows KE and Vawter G: Local en bloc resection for limb preservation. Cancer Treat Rep 62: 217–223, 1978.
James DH Jr and George P: Vincristine in children with malignant solid tumors. J Pediatr 64: 534–541, 1964.
Janecki CJ and Nelson CL: En bloc resection of the shoulder girdle: Technique and indications. J Bone Joint Surg 54-A: 1754–1758, 1972.
Janes JM: The influence of splenectomy on the induction of osteogenic sarcoma in rabbits. J Bone Joint Surg 51-A: 1432, 1969.
Janes JM, Herrick JF and Higgins GM: The influence of splenectomy on the induction of osteogenic sarcoma in rabbits. Mayo Clin Proc 34: 47–49, 1959.
Janes JM, Higgins GM and Herrick JF: Beryllium-induced osteogenic sarcoma in rabbits. J Bone Joint Surg 36-B: 543–552, 1954.
Janes JM, Higgins GM and Herrick JF: The influence of splenectomy on the induction of osteogenic sarcoma in rabbits. J Bone Joint Surg 38-A: 809–816, 1956.
Jenkin RDT, Allt WEC and Fitzpatrick PF: Osteosarcoma. Cancer 30: 393–400, 1972.
Jensik RJ and Van Hazel W: The surgical treatment of metastatic pulmonary lesions. Surgery 43: 1002–1020, 1958.
Kalenak A and Rogers CC: A comparison of the therapeutic effect of amputation and roentgen radiation on C3H/HES osteogenic sarcoma. J Surg Res 13: 289–294, 1973.
Katenkamp D, Stiller D and Waldmann G: Ultrastructural cytology of human osteosarcoma cells. Virch Arch (Pathol Anat) 381: 49–61, 1978.
Kauffman SL and Stout AP: Extraskeletal osteogenic sarcoma and chondrosarcomas in children. Cancer 16: 432–439, 1963.
Kelly PJ, Janes JM and Peterson LFA: The effect of beryllium on bone. J Bone Joint Surg 43-A: 829–844, 1961.
Kilman JW, Kronberg MW, O’Neill JA and Klassen KP: Surgical resection for pulmonary metastases in children. Arch Surg 99: 158–165, 1969.
King CR, Lemmer J, Campbell JR and Atkins AR: Osteosarcoma in a patient with Hutchinson-Gilford progeria. J Med Genet 15: 481–484, 1978.
Kitchin FD: Genetics of retinoblastoma. IN. Tumors of the Eye. Third Edition, AB Reese (ed), Harper and Row Publishers Inc, Hagerstown, 1976, pp 125–131.
Klenerman L, Ockenden BG and Townsend AC: Osteosarcoma occurring in osteogenesis imperfecta. J Bone Joint Surg 49-B: 314–323, 1967.
Koletsky S, Bonte FJ and Friedell HL: Production of malignant tumors in rats with radioactive phosphorous. Cancer Res 10: 129–138, 1950.
Komp DM, Land VJ, Nitschke R, Cangir A and Dyment P: 5-(3,3-bis(2-chloroethyl)1-triazeno)imidazole-4-carboxamide (NSC-82196) in the treatment of childhood malignancy. Cancer Chemo Rep 59: 371–376, 1975.
Kotz R and Salzer M: Rotation-plasty for childhood osteosarcoma of the distal part of the femur. J Bone Joint Surg 64-A: 959–969, 1982.
Kozlowski K, Scougall JS and Oates RK: Osteosarcoma in a boy with Rothmund-Thomson syndrome. Pediatr Radiol 10: 42–45, 1980.
Kumar APM, Wrenn EL Jr, Fleming ID and Pratt CB: Transmedullary amputation and resection of metastases in combined therapy of osteosarcoma. J Pediatr Surg 12: 427–435, 1977.
Lange B, Kramer S, Gregg JR, Toledano S, Wimmer R and Evans AE: High-dose methotrexate and adriamycin in osteogenic sarcoma. Am J Clin Oncol 5: 3–8, 1982.
Larsson S-E, Lorentzon R, Wedren H and Boquist L: Osteosarcoma. Acta Ortho Scand 49: 571–581, 1978.
Laster WR Jr: Ridgeway osteogenic sarcoma–A promising laboratory model for special therapeutic trials against an advanced-staged, drug-sensitive animal tumor system. Cancer Chemo Rep Part 2, 5: 151–168, 1975.
Lee ES: Osteosarcoma: A reconaissance. Clin Radiol 26: 5–25, 1975.
Lee ES and Mackenzie DH: Osteosarcoma. A study of the value of preoperative megavoltage radiotherapy. Br J Surg 51: 252–274, 1964.
Levine E, Lee KR, Neff JR, Maklad NF, Robinson RG and Preston DF: Comparison of computed tomography and other imaging modalities in the evaluation of musculoskeletal tumors. Radiology 131: 431–437, 1979.
Levy JA, Hartley JW, Rowe WP and Huebner RJ: Studies of FBJ osteosarcoma virus in tissue culture. I. Biologic characteristics of the “C”-type viruses. J Nat Cancer Inst 51: 525–539, 1973.
Lewis RJ and Lotz MJ: Medullary extension of osteosarcoma. Cancer 33: 37 1375, 1974.
Li FP, Tucker MA and Fraumeni JF Jr: Childhood cancer in sibs. J Pediatr 88: 419–423, 1976.
Lichtenstein L: Bone Tumors. The CV Mosby Company, St. Louis, 1965, pp 202–228.
Linberg BE: Interscapulo-thoracic resection for malignant tumors of the ‘Shoulder joint region. J Bone Joint Surg 10: 344–349, 1928.
Link M, Goorin A, Miser A, Green A, Pratt C, Belasco J, Pritchard J, Baker A, Kirkpatrick J, Ayala A, Shuster S, Abelson H, Simone J and Vietti T: The role of adjuvant chemotherapy in the treatment of osteosarcoma (OS) of the extremity: Prelminary results of the multi-institutional osteosarcoma study (MIOS). Proc Am Soc Clin Oncol 4: 237, 1985 (Abstract).
Lisco H, Finkel MP and Brues AM: Carcinogenic properties of radioactive fission products and of plutonium. Radiology 49: 361–363, 1947.
Liu SK, Dorfman HD and Patnaik AK: Primary and secondary bone tumors in the cat. J Small Anim Pract 15: 141–156, 1974.
Mac Donald I and Budd JW: Osteogenic sarcoma. I. A modified nomenclature and a review of 118 five year cures. Surg Gynecol Obstet 77: 413–421, 1943.
Madewell BR, Leighton RL and Theilen GH: Amputation and doxorubicin for treatment of canine and feline osteogenic sarcoma. Eur J Cancer 14: 287–293, 1978.
Madewell BR, Pool RR and Leighton RL: Osteogenic sarcoma at the site of a chronic nonunion fracture and internal fixation device in a dog. J Am Vet Med Assoc 171: 187–189, 1977.
Malawer MM and Dunham WK: Skip metastases in osteosarcoma: Recent experience. J Surg Oncol 22: 236–245, 1983.
Mankin HJ, Fogelson FS, Thrasher AZ and Jaffer F: Massive resection and allograft transplantation in the treatment of malignant bone tumors. New Engl J Med 294: 1247–1255, 1976.
Marcove RC: The Surgery of Tumors of Bone and Cartilage. Grune and Stratton, New York, 1981, pp 53–58.
Ibid. p 147–148.
Ibid. pp 149.
Marcove RC, Lewis MM and Huvos AG: En bloc upper humeral interscapulothoracic resection. Clin Ortho 124: 219–228, 1977.
Marcove RC, Lewis MM, Rosen G and Huvos AG: Total femur replacement. Comp Ther 3: 13–19, 1977.
Marcove RC, Mike V, Hajek JV, Levin AG and Hutter RVP: Osteogenic sarcoma in childhood. New York State J Med 71: 855–859, 1971.
Marcove RC and Rosen G: En bloc resections for osteogenic sarcoma. Cancer 45: 3040–3044, 1980.
Martin SE, Dwyer A, Kissane JM and Costa J: Small-cell osteosarcoma. Cancer 50: 990–996, 1982.
Martinez-Tello FJ and Navas-Palacios JJ: The ultrastructure of conventional, parosteal and periosteal osteosarcomas. Cancer 50: 949–961, 1982.
Martini N, Huvos AG, Mike V, Marcove RC and Beattie EJ Jr: Multiple pulmonary resections in the treatment of osteogenic sarcoma. Ann Thorac Surg 12: 271–280, 1971.
Matsuno T, Unni KK, Mc Leod RA and Dahlin DC: Telangiectatic osteogenic sarcoma. Cancer 38: 2538–2547, 1976.
Mavligit GM, Benjamin R, Patt YZ, Jaffe N, Chuang V, Wallace S, Murray J, Ayala A, Johnston S, Hersh EM and Calvo DB III: Intraarterial cis-platinum for patients with inoperable skeletal tumors. Cancer 48: 1–4, 1981.
Mays CW, Dougherty TF, Taylor GN, Lloyd RD, Stover BJ, Jee WSS, Dougherty JH and Atherton DR: Radiation-induced bone cancer in beagles. IN. Delayed Effects of Bone-,Seeking Radionuclides. CW Mays, WSS Jee, RD Lloyd, BJ Stover, JH Dougherty and GN Taylor (eds). University of Utah Press, Salt Lake City, 1969, pp 387–408.
Mc Allister RM, Gardner MB, Greene AE, Bradt C, Nichols WW and Landing BH: Cultivation in vitro of cells derived from a human osteosarcoma. Cancer 27: 397–402, 1971.
Mc Kenna RJ, Schwinn CP, Soong KY and Higinbotham NL: Sarcomata of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma and sarcomata arising in abnormal bone). An analysis of 552 cases. J Bone Joint Surg 48-A: 1–26, 1966.
Mc Killop JH, Etcubanas E and Goris ML: The indications for and limitations of bone scintigraphy in osteogenic sarcoma: A review of 55 patients. Cancer 48: 1133–1138, 1981.
Mc Leay JF and Walske BR: Tetracycline fluorescence in bone lesions. J Bone Joint Surg 42-A: 940–944, 1960.
Mc Neil BJ, Cassady JR, Geiser CF, Jaffe N, Traggis D and Treves S: Fluorine-18 bone scintigraphy in children with osteosarcoma or Ewing’s sarcoma. Radiology 109: 627–631, 1973.
Mc Whirter WR: Personal communication.
Mc Whirter WR and Bacon JE: Incidence of childhood tumours in Queensland. Br J Cancer 44: 637–642, 1981.
Meadows AT, Strong LC, Li FP, D’Angio GJ, Schweisguth O, Freeman AI, Jenkin RDT, Morris-Jones P and Nesbit ME: Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predisposition. Cancer 46: 2603–2606, 1980.
Meyerding HW: Sarcoma of the long bones. Surg Gynecol Obstet 34: 321–332, 1922.
Miller CW and Mc Laughlin RE: Osteosarcoma in siblings. J Bone Joint Surg 59-A: 261–262, 1977.
Miller RW: Deaths from childhood cancer in sibs. New Engl J Med 279: 122–126, 1968.
Moore GE, Gerner RE and Brugarolas A: Osteogenic sarcoma. Surg Gynecol Obstet 136: 359–366, 1973.
Morton DL and Malmgren RA: Human osteosarcomas: Immunologic evidence suggesting an associated infectious agent. Science 162: 1279–1281, 1968.
Morton DL, Malmgren RA, Hall WT and Schidlovsky G: Immunologic and virus studies with human sarcomas. Surgery 66: 152–161, 1969.
Mosende C, Gutierrez M, Caparros B and Rosen G: Combination chemotherapy with bleomycin, cyclophosphamide and dactinomycin for the treatment of osteogenic sarcoma. Cancer 40: 2779–2786, 1977.
Muhm JR and Pritchard DJ: Computer tomography for the detection of pulmonary metastases in patients with osteogenic sarcoma. Proc Am Assoc Cancer Res 21: 148, 1980 (Abstract).
Mulvihill JJ, Gralnick HR, Wheng-Peng J and Leventhal BG: Multiple childhood osteosarcomas in an American Indian family with erythroid macrocytosis and skeletal anomalies. Cancer 40: 3115–3122, 1977.
Newton KA and Barrett A: Prophylactic lung irradiation in the treatment of osteogenic sarcoma. Clin Radiol 29: 493–496, 1978.
Nielson SW: Comparative pathology of bone tumors in animals, with particular emphasis on the dog. IN. Malignant Bone Tumors. E Grundmann (ed), Springer-Verlag, Berlin, 1976, pp 3–16.
Nitschke R, Fagundo R, Berry DH and Falletta JM: Weekly administration of cisdichlorodiammineplatinum (II) in childhood solid tumors: A southwest oncology group study. Cancer Treat Rep 63: 497–499, 1979.
Noss G, Stauch G, Mehraein P and Georghi A: Oncogenic activity of the BK type of human papova virus in newborn Wistar rats. Arch Virol 69: 239–251, 1981.
Ochs JJ, Freeman AI, Douglass HO Jr, Higby DS, Minden ER and Sinks LF: Cisdichlorodiammineplatinum (II) in advanced osteogenic sarcoma. Cancer Treat Rep 62: 239–245, 1978.
Ohno T, Abe M, Tateishi A, Kako K, Miki H, Sekine K, Ueyama H, Hasegawa O and Lbara K: Osteogenic sarcoma. J Bone Joint Surg 57-A: 397–304, 1975.
Olson HM and Capen CC: Moloney sarcoma virus (MSV)-induced osteosarcoma in the rat: Ultrastructural and histopathologic studies. Lab Invest 34: 328–329, 1976 (Abstract).
Otten J and Maurus R: Clinical trial of peptichemio in solid tumors of childhood. Cancer Treat Rep 62:1015–1019, 1978.
Ottolenghi CE: Diagnosis of orthopaedic lesions by aspiration biopsy. J Bone Joint Surg 37-A: 443–464, 1955.
Owen LN and Bostock DE: Effects of intravenous BCG in normal dogs and in dogs with spontaneous osteosarcoma. Eur J Cancer 10: 775–780, 1974.
Owen LN and Bostock DE: Prophylactic X-irradiation of the lung in canine tumors, with particular reference to osteosarcoma. Eur J Cancer 9: 747–752, 1973.
Pack GT and Baldwin JC: The Tikhor-Linberg resection of shoulder girdle. Surgery 38: 753–757, 1955.
Pack GT, Mc Neer G and Coley BL: Interscapulothoracic amputation for malignant tumors of the upper extremity. Surg Gynecol Obstet 74: 161–175, 1942.
Papanicolaou N, Kozakewich H, Treves S, Goorin A and Emans J: Comparison of the extent of osteosarcoma between surgical pathology and skeletal scintigraphy. J Nucl Med 23p: 7, 1982, (Abstract).
Parrish FF: Allograft replacement of all or part of the end of a long bone following excision of a tumor. J Bone Joint Surg 55-A: 1–22, 1973.
Paschall HA and Paschall MM: Electron microscopic observations of 20 human osteosarcomas. Clin Ortho 111: 42–56, 1975.
Pastore G, Magnani C, Zanetti R and Terracini B: Incidence of cancer in children in the province of Torino (Italy) 1967–1978. Eur J Cancer 17: 1337–1341, 1981.
Phelan JT and Cabrera A: Osteosarcoma of bone. Surg Gynecol Obstet 118: 330–336, 1964.
Phillips TL and Sheline GE: Radiation therapy of malignant bone tumors. Radiology 92: 1537–1545, 1969.
Pinkel D: Cyclophosphamide in children with cancer. Cancer 15: 42–49, 1962.
Pohle EA, Stovall WD and Boyer HN: Concurrence of osteogenic sarcoma in two sisters. Radiology 27: 545–548, 1936.
Pool RR: Tumors of bone and cartilage. IN. Tumors in Domestic Animals. Second Edition, JE Moulton (ed). University of California, Berkeley, 1978, pp 67–71.
Poppe E, Liverud K and Efskind J: Osteosarcoma. Acta Chir Scand 134: 549–556, 1968.
Pratt CB: Outcome of patients failing adjuvant chemotherapy for osteosarcoma. Cancer Bull 34: 100–103, 1982.
Pratt CB, Etcubanas E, Thompson E, Hayes FA, Champion JE and Crom DB: Mitoxantrone (dihydroxy anthracenedione, DHAD) - Phase II study in pediatric patients. Proc Am Assoc Cancer Res 23:122, 1982 (Abtract).
Pratt CB, Hayes A, Green AA, Evans WE, Senzer N, Howarth CB, Ransom JL and Crom W: Pharmacokinetic evaluation of cisplatin in children with malignant solid tumors: A phase II study. Cancer Treat Rep 65: 1021–1026, 1981.
Pratt CB, Howarth C, Ransom JL, Bowles D, Green AA, Kumar APM, Rivera G and Evans WE: High-dose methotrexate used alone and in combination for measurable primary or metastatic osteosarcoma. Cancer Treat Rep 64: 11–20, 1980.
Pratt CB and Shanks EC: Doxorubicin in treatment of malignant solid tumors in children. Am J Dis Child 127: 534–536, 1974.
Pratt C, Shanks E, Hustu O, Rivera G, Smith J and Kumar APM: Adjuvant multiple drug chemotherapy for osteosarcoma of the extremity. Cancer 39: 51–57, 1977.
Pratt CB and Wang JJ: Acetylenic carbamate in childhood cancer. Cancer 27: 1094–1098, 1971.
Price CHG: The grading of osteogenic sarcoma. Br J Cancer 6: 46–68, 1952.
Price CHG, Zhuber K, Salzer-Kuntschik M, Salzer M, Willert HG, Immunkamp M, Groh P, Matejovsky Z and Keyl W: Osteosarcoma in children. J Bone Joint Surg 57-B: 341–345, 1975.
Pritchard DJ, Finkel MP and Reilly CA Jr: The etiology of osteosarcoma. Clin Ortho 111: 14–22, 1975.
Pritchard DJ, Reilly CA Jr and Finkel MP: Evidence for a human osteosarcoma virus. Nature New Biol 234: 126–127, 1971.
Putnam JB Jr, Roth JA, Wesley MN, Johnston MR and Rosenberg SA: Survival following aggressive resection of pulmonary metastases from osteogenic sarcoma: Analysis of prognostic factors. Ann Thorac Surg 36: 516–523, 1983.
Rab GT, Ivins JC, Childs DS Jr, Cupps RE and Pritchard DJ: Elective whole lung irradiation in the treatment of osteogenic sarcoma. Cancer 38: 939–942, 1976.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM Jr and George S: Adriamycin in the treatment of childhood solid tumors. Cancer 36: 1567–1571, 1975.
Reddick RL, Michelitch HJ, Levine AM and Triche TJ: Osteogenic sarcoma. A study of ultrastructure. Cancer 45: 64–72, 1980.
Regal A-M, Reese P, Antkowiak J, Hart T and Takita H: Median sternotomy for metastatic lung lesions in 131 patients. Cancer 55: 1334–1339, 1985.
Reilly CA Jr, Pritchard DJ, Biskis BO and Finkel MP: Immunologic evidence suggesting a viral etiology of human osteosarcoma. Cancer 30: 603–609, 1972.
Ringus JC and Riddell RH: Small cell osteosarcoma: Ultrastructural description and differentiation from atypical Ewing’s sarcoma. Lab Invest 44: 55A, 1981 (Abstract).
Rivera G, Avery T and Pratt C: 4’–demethylepipodophyllotoxin 0–(4,6–0–2–thenylidene–beta–D–glucopyranoside) (NSC–122819; VM–26) and 4’–demethylepipodophyllotoxin 9–(4,6–0–ethylidene–beta–D–glucopyranoside) (NSC141540; VP–16–213) in childhood cancer: Preliminary observations. Cancer Chemo Rep 59: 743 – 749, 1975.
Robbins R: Familial osteosarcoma - fifth reported occurrence. JAMA 202:1055, 1967 (Letter).
Roberts CW and Roberts CP: Concurrent osteogenic sarcoma in brother and sisters. JAMA 105: 181–185, 1935.
Rodgers BM, Talbert JL and Alexander JA: Pulmonary metastases in childhood sarcoma. Ann Thorac Surg 29: 410–414, 1980.
Rosen G: Spindle cell sarcoma–osteogenic sarcoma. IN. Clinical Pediatric Oncology. Third Edition. WW Sutow, DJ Fernbach, TJ Vietti (eds). CV Mosby Company, St. Louis, 1984, pp 684–709.
Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove RC, Lane JM, Mehta B and Urban C: Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49: 1221–1230, 1982.
Rosen G, Huvos AG, Mosende C, Beattie EJ Jr, Exelby PR, Caparros B and Marcove RC: Chemotherapy and thoracotomy for metastatic osteogenic sarcoma. Cancer 41: 841–849, 1978.
Rosen G, Marcove RC, Caparros B, Nirenberg A, Kosloff C and Huvos AG: Primary osteogenic sarcoma. Cancer 43: 2163–2177, 1979.
Rosen G, Murphy ML, Huvos AG, Gutierrez M and Marcove RC: Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer 37: 1–11, 1976.
Rosen G, Nirenberg A, Caparros B, Juergens H, Kosloff C, Mehta BM, Marcove RC and Huvos AG: Osteogenic sarcoma: Eighty-percent three-year, disease-free survival with combination chemotherapy (T-7). Nat Cancer Inst Mono 56: 213–220, 1981.
Rosen G and Nirenberg A: Chemotherapy for osteogenic sarcoma: An investigative method, not a recipe. Cancer Treat Rep 66: 1687–1697, 1982.
Rosen G, Nirenberg A, Juergens H and Tan C: Phase II trial of cis-platinum in osteogenic sarcoma. Proc Am Assoc Cancer Res 20: 363, 1979 (Abstract).
Rosen G, Suwansirikul S, Kwon C, Tan C, Wu SJ, Beattie EJ Jr and Murphy ML: High-dose methotrexate with citrovorum factor rescue and adriamycin in childhood osteogenic sarcoma. Cancer 35: 1151–1163, 1974.
Rosen G, Tan C, Sanmaneechai A, Beattie EJ Jr, Marcove R and Murphy ML: The rationale for multiple drug chemotherapy in the treatment of osteogenic sarcoma. Cancer 35: 936–945, 1975.
Rosen G, Tefft M, Martinez A, Cham W and Murphy ML: Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma. Cancer 35: 622–630, 1975.
Rosenberg SA, Chabner BA, Young RC, Seipp CA, Levine AS, Costa J, Hanson TA, Head GC and Simon RM: Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation. Cancer Treat Rep 63: 739–751, 1979.
Rosenberg SA, Flye MW, Conkle D, Seipp CA, Levine AS and Simon RM: Treatment of osteogenic sarcoma. II. Aggressive resection of pulmonary metastases. Cancer Treat Rep 63: 753–756, 1979.
Ross JM: The carcinogenic action of radium in the rabbit: The effect of prolonged irradiation with screened radium. J Pathol Bacteriol 43: 267–276, 1936.
Rous P, Murphy JB and Tytler WH: A filtrable agent the cause of a second chicken tumor. An osteo-chondrosarcoma. JAMA 59: 1793–1794, 1912.
Royster RL, King ER, Ebersole J, De Giorgi LS and Levitt SH: High dose, preoperative supervoltage irradiation for osteogenic sarcoma. Am J Roentgenol 114: 536–543, 1972.
Rumel WR, Cutler PR and Halliday WR: Bilateral pulmonary resection for metastatic osteogenic sarcoma: Case report of a seven-year “cure”. Dis Chest 35: 106–109, 1959.
Rutkowski R, Resnick P and Mc Master JH: Osteosarcoma occurring in osteogenesis imperfecta. J Bone Joint Surg 61-A: 606–608, 1979.
Sabin FR, Doan CA and Forkner CE: The production of osteogenic sarcomata and the effects on lymph nodes and bone marrow of intravenous injections of radium chloride and mesothorium in rabbits. J Exp Med 56: 267–289, 1932.
Scaglietti O and Calandriello B: Ossifying parosteal sarcoma: parosteal osteoma or juxtacortical osteogenic sarcoma. J Bone Joint Surg 44-A: 635–647, 1962.
Schajowicz F: Aspiration biopsy in bone lesions. J Bone Joint Surg 37-A: 465–471, 1955.
Schajowicz F and Derqui JC: Puncture biopsy in lesions of the locomotor system. Cancer 21: 531–548, 1968.
Schajowicz F and Hokama J: Aspiration (puncture or needle) biopsy in bone lesions. IN. Malignant Bone Tumors. E Grundmann (ed), Springer-Verlag, Berlin, 1976, pp 139–144.
Schaller RT Jr, Haas J, Schaller J, Morgan A and Bleyer A: Improved survival in children with osteosarcoma following resection of pulmonary metastases. J Pediatr Surg 17: 546–550, 1982.
Schimke RN, Lowman JT and Cowan GAB: Retinoblastoma and osteogenic sarcoma in siblings. Cancer 34: 2077–2079, 1974.
Schuman SH and Burton WE: A new osteosarcoma/malformation syndrome. Clin Genet 15:462–463, 1979 (Letter).
Schwartz DT and Alpert M: The malignant transformation of fibrous dysplasia. Am J Med Sci 247: 1–20, 1964.
Scranton PE, De Cicco FA, Totten RS and Yunis EJ: Prognostic factors in osteosarcoma. Cancer 36: 2179–2191, 1975.
Selawry OS, Holland JF and Wolman IJ: Effect of vincristine (NSC-67574) on malignant solid tumors in children. Cancer Chemo Rep 52: 497–500, 1968.
Shaeffer J, El-Mandi AM and Constable WC: Treatment of metastatic osteosarcoma by cyclophosphamide and radiotherapy. Radiology 111: 467–469, 1974.
Shah A, Exelby PR, Rao B, Marcove R, Rosen G and Beattie EJ Jr: Thoracotomy as adjuvant to chemotherapy in metastatic osteogenic sarcoma. J Pediatr Surg 12: 983–990, 1977.
Shepp M, Necheles TF, Banks HH, Oh WH and Zimbler S: Adjuvant treatment of osteosarcoma with high-dose cyclophosphamide. Cancer Treat Rep 62: 295–296, 1978.
Siddiqui AR and Ellis JH: ‘Cold spot’ on bone scan at the site of primary osteosarcoma. Eur J Nucl Med 7:480–481, 1982.
Sim FH, Ivins JC and Pritchard DJ: Surgical treatment of osteogenic sarcoma at the Mayo Clinic. Cancer Treat Rep 62: 205–211, 1978.
Sim FH, Unni KK, Beabout JW and Dahlin DC: Osteosarcoma with small cells simulating Ewing’s sarcoma. J Bone Joint Surg 61-A: 207–215, 1979.
Singh I, Tsang KY and Blakemore WS: Immunologic studies on contacts of osteosarcoma in humans and animals. Nature 265: 541–542, 1977.
Sinibaldi K, Rosen H, Liu S-K and De Angelis M: Tumors associated with metallic implants in animals. Clin Ortho 118: 257–266, 1976.
Skipper HR: Response of Ridgeway osteogenic sarcoma (ROS) at different stages to a variety of drugs given according to different schedules. Southern Research Institute, Birmingham, 1977.
Skipper HR: Ridgeway osteogenic sarcoma: Response at different stages to surgery, single drugs, combinations of drugs and surgery followed by chemotherapy. Southern Reserch Institute, Birmingham, 1979.
Skrovina B, Cervenansky J, Kossey P and Brozmanova E: Primary osteosarcoma. A clinical evaluation of 73 cases. Neoplasma 18: 377–393, 1971.
Smith AG, Coonrad RW, Boyer DW and Bugg EI: Unusual case of multiple abnormalities of bone with malignant degeneration. J Bone Joint Surg 42-A: 1329–1338, 1960.
Soehner RL, Fujinaga S and Dmochowski L: Neoplastic bone lesions induced in rats and hamsters by Moloney and Harvey murine sarcoma viruses. IN. Comparative Leukemia Research 1969. RM Dutcher (ed), Karger, Basel, 1970, pp 593–599.
Spanos PK, Payne WS, Ivins JC and Pritchard DJ: Pulmonary resection for metastatic osteogenic sarcoma. J Bone Joint Surg 58-A: 624–628, 1976.
Srinivasan U, Reaman GH, Poplack DG, Glaubiger DL and Levine AS: Phase II study of 5-azacytidine in sarcomas of bone. Am J Clin Oncol 5: 411–415, 1982.
Stander H, Adamson U, Aparisi T, Brostrom LA, Cantell K, Einhorn S, Hall K, Ingimarsson S, Nilsonne U and Soderberg G: Adjuvant interferon treatment of human osteosarcoma. IN. Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II. G Bonadonna, G Mathe and SE Salmon (eds), Springer-Verlag, Berlin, 1979, pp 40–44.
Stein JJ: Osteogenic sarcoma (osteosarcoma): Results of therapy. Am J Roentgenol 123: 607–613, 1975.
Strauss HK and Jackson M: Osteogenic sarcoma arising in traumatic hemothorax and hematoma of the thoracic wall. Surgery 29: 917–928, 1951.
Suit H and Lindberg R: Radiation therapy administered under conditions of tourniquet-induced local tissue hypoxia. Am J Roentgenol 102: 27–37, 1968.
Sullivan MP, Sutow WW and Taylor G: L-phenylalanine mustard as a treatment for metastatic osteogenic sarcoma in children. J Pediatr 63: 227–237, 1963.
Sutow WW, Gehan EA, Dyment PG, Vietti T and Miale T: Multidrug adjuvant chemotherapy for osteosarcoma: Interim report of the southwest oncology group studies. Cancer Treat Rep 62: 265–269, 1978.
Sutow WW, Sullivan MP, Fernbach DJ, Cangir A and George SL: Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. Cancer 36: 1598–1602, 1975.
Sutow WW, Sullivan MP, Wilbur JRand Cangir A: Study of adjuvant chemotherapy in osteogenic sarcoma. J Clin Pharmacol 15: 530–533, 1975.
Sutow WW, Sullivan MP, Wilbur JR, Vietti TJ, Kaizer H and Nagamoto A: Lphenylalanine mustard (NSC-8806) administration in osteogenic sarcoma: An evaluation of dosage schedules. Cancer Chemo Rep 55: 151–157, 1971.
Sutow WW, Vietti TJ, Fernbach DJ, Lane DM, Donaldson MH and Lonsdale D: Evaluation of chemotherapy in children with metastatic Ewing’s sarcoma and osteogenic sarcoma. Cancer Chemo Rep 55: 67–78, 1971.
Sutow WW, Wilbur JR, Vietti TJ, Vuthibhagdee P, Fujimoto T and Watanabe A: Evaluation of dosage schedules of mitomycin C (NSC-26980) in children. Cancer Chemo Rep 55: 285–289, 1971.
Swaney JJ: Familial osteogenic sarcoma. Clin Ortho 97: 64–68, 1973.
Sweetnam R: Amputation in osteosarcoma. J Bone Joint Surg 55-B: 189–192, 1973.
Sweetnam R: Osteosarcoma. Ann Royal Coll Surg 44: 38–58, 1969.
Sweetnam R, Knowelden J and Seddon H: Bone sarcoma: Treatment by irradiation, amputation or a combination of the two. Br Med J 2: 363–367, 1971.
Sweetnam R and Ross K: Surgical treatment of pulmonary metastases from primary tumors of bone. J Bone Joint Surg 49-B: 74–79, 1967.
Tan C, Rosen G, Ghavimi F, Haghbin M, Nelson L, Wollner N and Murphy ML: Adriamycin (NSC-123127) in pediatric malignancies. Cancer Chemo Rep Part 3 6: 259–266, 1975.
Tan CTC, Hancock CH, Mondora A and Hoffman NW: Phase I study of aziridinylbenzoquinone (AZQ, NSC-182986) in children with cancer. Cancer Res 44: 831–835, 1984.
Taylor DM and Bensted JPM: Long-term biological damage from plutonium-239 and americium-241 in rats. IN. Delayed Effects of Bone Seeking Radionuclides. CW Mays, WSS Jee, RD Lloyd, BJ Stover, JH Dougherty and N Taylor (eds). University of Utah Press, Salt Lake City, 1969, pp 357–370.
Taylor WF, Ivins JC, Dahlin DC, Edmonson JH and Pritchard DJ: Trends and variability in survival from osteosarcoma. Mayo Clinic Proc 53: 695–700, 1978.
Taylor WF, Ivins JC, Pritchard DJ, Dahlin DC, Gilchrist GS and Edmonson JH: Trends and variability in survival from osteosarcoma: A seven year update. Mayo Clinic Proc 60: 91–104, 1985.
Telander RL, Pairolero PC, Pritchard DJ, Sim FH and Gilchrist GS: Resection of pulmonary metastatic osteogenic sarcoma in children. Surgery 84: 335–341, 1978.
Teppo L: Personal communication.
Teppo L, Saxen E, Tervo T, Partio E, von Bonsdorff H, Salmela J, Avikainen V, Isomaki LM and Krees R: Thalidomide-type malformations and subsequent osteosarcoma. Lancet 2:405,1977 (Letter).
Thorpe WP and Rosenberg SA: Serologic analysis of human tumor antigens. I. Antisarcoma antibodies in the sera of patients with osteogenic sarcomas. J Nat Cancer Inst 62: 1143–1150, 1979.
Thurman GB, Mays CW, Taylor GN, Christensen WR, Rehfeld CE and Dougherty TF: Growth dynamics of beagle osteosarcomas. Growth 35: 119–125, 1971.
Thurman GB, Mays CW, Taylor GN, Keane AT and Sissons HA: Skeletal location of radiation-induced and naturally occurring osteosarcomas in man and dog. Cancer Res 33: 1604–1607, 1973.
Tjalma RA: Canine bone sarcoma: Estimation of relative risk as a function of body size. J Nat Cancer Inst 36: 1137–1150, 1966.
Tsang KY, Singh I and Blakemore WS: Circulating immune complexes in human osteosarcoma. J Nat Cancer Inst 62: 743–748, 1979.
Tudway RC: The place of external irradiation in the treatment of osteogenic sarcoma. J Bone Joint Surg 35-B: 9–21, 1953.
Tytler WH: A transplantable new growth of the fowl, producing cartilage and bone. J Exp Med 17: 466–481, 1913.
Unni KK, Dahlin DC and Beabout JW: Parosteal osteogenic sarcoma. Cancer 3 7: 2466–2475. 1976.
Unni KK, Dahlin DC and Beabout JW: Periosteal osteogenic sarcoma. Cancer 37: 2476–2485, 1976.
Upshaw JE, McDonald JR and Ghormley RK: Extension of primary neoplasms of bone to bone marrow. Surg Gynecol Obstet 89: 704–714, 1949.
Urtasun RC and Mc Connachie PR: Disappearance of osteogenic sarcoma after irradiation: Immunologic observations. J Can Assoc Radiol 27: 80–83, 1976.
Valderrama E, Kahn LB and Wind E: Extraskeletal osteosarcoma arising in an ectopie hamartomatous thymus. Cancer 51: 1132–1137, 1983.
van den Brenk HAS, Kerr RC, Madigan JP, Cass NM and Richter W: Results from tourniquet anoxia and hyperbaric oxygen techniques combined with megavoltage treatment of sarcomas of bone and soft tissues. Am J Roentgenol 96: 760–776, 1966.
van der Heul RO and von Ronnen JR: Juxtacortical osteosarcoma. J Bone Joint Surg 49-A: 415–439, 1967.
Van Nes CP: Rotation-plasty for congenital defects of the femur. J Bone Joint Surg 32-B: 12–16, 1950.
Varela-Duran J and Dehner LP: Postirradiation osteosarcoma in childhood. Am J Pediatr Hematol/Oncol 2: 263–271, 1980.
Wang JJ, Holland JF and Sinks LF: Phase II study of adriamycin (NSC-123127) in childhood solid tumors Cancer Chemo Rep Part 3 6: 267–270, 1975.
Watts HG: Surgical management of malignant bone tumors in children. IN. Bone Tumors in Children. N Jaffe (ed), PSG Publishing Company, Littleton, 1979, pp 131–142.
Weichselbaum RR, Cassady JR, Jaffe N and Filler RM: Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma. Cancer 40: 78–83, 1977.
Weichselbaum R, Epstein J and Little JB: A technique for developing established cell lines from human osteosarcomas. In Vitro 12:833–836, 1976.
Weiss AB, Adams G, Brackin B, Pritchett P and Moreno H: Osteosarcoma: A review of 50 patients treated at the University of Alabama in Birmingham Medical Center between 1944 and 1975. Clin Ortho 135: 137–147, 1978.
Williams AH, Schwin CP and Parker JW: The ultrastructure of osteosarcoma. A review of twenty cases. Cancer 37: 1293–1301, 1967.
Winkler K, Beron G, Kotz R, Salzer-Kuntschik M, Beck J, Beck W, Brandeis W, Ebell W, Erttmann R, Gobel U, Havers W, Henze G, Hinderfeld L, Hocker P, Jobke A, Jurgens H, Kabisch H, Preusser P and Landbeck G: Neoadjuvant chemotherapy for osteogenic sarcoma: Results of a cooperative German/Austrian study. J Clin Oncol 2: 617–624, 1984.
Wood WC and Morton DL: Host immune response to a common cell-surface antigen in human sarcomas. New Engl J Med 284: 569–572, 1971.
Wood WC and Morton DL: Microcytotoxicity test: Detection in sarcoma patients of antibody cytotoxic to human sarcoma cells. Science 170: 1318–1320, 1970.
Woodard HQ and Coley BL: The correlation of tissue dose and clinical response in irradiation of bone tumors and of normal bone. Am J Roentgenol 57: 464–471, 1947.
Young JL Jr: Personal communication.
Young JL Jr, Heise HW, Silverberg E and Myers MH: Cancer incidence, survival and mortality for children under 15 years of age. American Cancer Society, New York, 1978, p 8.
Young JL Jr and Miller EW: Incidence of malignant tumors in US children. J Pediatr 86: 254–258, 1975.
Yu A, Watts H, Jaffe N and Parkman R: Concomitant presence of tumor specific cytotoxic and inhibitor lymphocytes in patients with osteogenic sarcoma. New Engl J Med 297: 121–127, 1977.
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© 1985 Martinus Nijhoff Publishing, Boston
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Green, D.M. (1985). Osteosarcoma. In: Diagnosis and Management of Malignant Solid Tumors in Infants and Children. Developments in Oncology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2623-6_7
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