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Load Regulation of Cardiac Muscle

  • G. Cooper
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 49)

Abstract

The intent of this review is to discuss briefly the recent work, both in my laboratory and in the laboratories of my colleagues, which tends to suggest a primary role of hemodynamic load in the regulation of the structure, composition and function of adult mammalian myocardium. Taken as a whole, this body of work supports the concept that the initiation of normal cardiac growth and development, the maintenance of normal cardiac properties in the adult, and the transition from normal to abnormal heart muscle during sustained hemodynamic alterations are each directly related to the environment of systolic and diastolic stress and strain to which the cardiocytes comprising ventricular myocardium are exposed.

Keywords

Papillary Muscle Pressure Overload Active Tension Hypertrophied Myocardium Pulmonary Artery Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cooper, G. and Marcus, M.L. Clin. Res. 27: 160A, 1979.Google Scholar
  2. 2.
    Williams, J.F. and Potter, R.D. J. Clin Invest. 54: 1266–1272, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    Bishop, S.P. and Melsen, L.R. Circ. Res. 39: 238–245, 1976.PubMedGoogle Scholar
  4. 4.
    Cooper, G., Tomanek, R.J., Ehrhardt, J.C. and Marcus, M.L. Circ. Res. 48: 488–497, 1981.PubMedGoogle Scholar
  5. 5.
    Wisenbaugh, T., Allen, P., Cooper, G., O’Connor, W.N., Mezaros, L., Streter, F., Bahinski, A., Houser, S. and Spann, J.F. Am. J. Physiol. 247: H146 - H154, 1984.Google Scholar
  6. 6.
    Cooper, G. and Marino, T.A. Circ. Res. 54: 323–331, 1984.PubMedGoogle Scholar
  7. 7.
    Cooper, G. and Tomasek, R.J. Clin. Res. 27: 160A, 1979.Google Scholar
  8. 8.
    Cooper, G. and Tomanek, R.J. Circ. Res. 50: 788–798, 1982.PubMedGoogle Scholar
  9. 9.
    Tomanek, R.J. and Cooper, G. Anat. Rec. 200: 271–280, 1981.PubMedCrossRefGoogle Scholar
  10. 10.
    Thompson, E.W., Marino, T.A., Uboh, C.E., Kent, R.L. and Cooper, G. Circ. Res. 54: 367–377, 1984.PubMedGoogle Scholar
  11. 11.
    Kent, R.L., Uboh, C.E., Thompson, E.W., Gordon, S.S., Marino, T.A., Hoober, J.K. and Cooper, G. J. Mol. Cell. Cardiol, in press, 1984.Google Scholar
  12. 12.
    Nag, A.C., Cheng, M., Fischman, D.A. and Zak, R. J. Mol. Cell. Cardiol. 15: 301–317, 1983.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • G. Cooper
    • 1
    • 2
  1. 1.Cardiology Section of the Department of MedicineTemple University School of MedicinePhiladelphiaUSA
  2. 2.Department of PhysiologyTemple University School of MedicinePhiladelphiaUSA

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