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Myocardial Arachidonate Metabolism during ATP Depletion

  • K. R. Chien
  • L. M. Buja
  • J. T. Willerson
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 49)

Abstract

Myocardial ischemia is a major cause of morbidity and mortality in human disease. Previous studies have demonstrated that the prognosis following acute myocardial infarction is directly related to the amount of myocardium which has been irreversibly injured. Recent attempts to limit infarct size during acute myocardial ischemia have focused on either increasing myocardial oxygen supply or decreasing oxygen demand (1). A more precise understanding of the biochemical mechanisms responsible for the development of irreversible myocardial injury is required to develop specific agents to protect ischemic myocardium from the consequences of oxygen deprivation.

Keywords

Membrane Phospholipid Myocardial Cell Extracellular Medium High Energy Phosphate Calcium Permeability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • K. R. Chien
    • 1
    • 2
  • L. M. Buja
    • 1
    • 2
  • J. T. Willerson
    • 1
    • 2
  1. 1.Departments of Internal Medicine and CardiologyUniversity of Texas Health Science Center at DallasDallasUSA
  2. 2.Departments of Internal Medicine and PathologyUniversity of Texas Health Science Center at DallasDallasUSA

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