Alterations of Ionic Permeability during Ischemia
The viability of cells depends critically upon the finely modulated distribution of ions across the cell membrane and between a number of intracellular sites and compartments. This is particularly important in myocardial cells which must maintain a coordinated sequence of electrical activation, modify contractile behavior to meet changing physiological conditions, and perform the cellular metabolic functions to provide energy and support anabolism and catabolism. Alterations in ionic movements occur almost instantaneously upon the production of anoxia or ischemia in myocardium. These changes are closely associated temporally with alterations of electrical and mechanical events and of metabolism. However, the precise mechanisms by which all of these phenomena are connected remain matters of speculation.
KeywordsAction Potential Duration Rabbit Heart Extracellular Potassium Perfuse Rabbit Potassium Loss
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