Alterations of Ionic Permeability during Ischemia

  • K. I. Shine
  • J. Weiss
  • M. Bersohn
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 49)


The viability of cells depends critically upon the finely modulated distribution of ions across the cell membrane and between a number of intracellular sites and compartments. This is particularly important in myocardial cells which must maintain a coordinated sequence of electrical activation, modify contractile behavior to meet changing physiological conditions, and perform the cellular metabolic functions to provide energy and support anabolism and catabolism. Alterations in ionic movements occur almost instantaneously upon the production of anoxia or ischemia in myocardium. These changes are closely associated temporally with alterations of electrical and mechanical events and of metabolism. However, the precise mechanisms by which all of these phenomena are connected remain matters of speculation.


Action Potential Duration Rabbit Heart Extracellular Potassium Perfuse Rabbit Potassium Loss 
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  1. 1.
    Rau, E.E., Shine, K.I. and Langer, G.A. Am. J. Physiol. 232:H85–H94, 1977.PubMedGoogle Scholar
  2. 2.
    Conrad, G.L., Rau, E.E. and Shine, K.I. J. Clin. Invest. 64:155–161, 1979.CrossRefGoogle Scholar
  3. 3.
    Rau, E.E. and Langer, G.A. Am. J. Physiol. 235:H537–H543, 1978.PubMedGoogle Scholar
  4. 4.
    Vleugels, A., Vereecke, J. and Carmeliet, E. Circ. Res. 47:501–508, 1980.PubMedGoogle Scholar
  5. 5.
    Weiss, J. and Shine, K.I. Am. J. Physiol. 243:H318–H327, 1982.PubMedGoogle Scholar
  6. 6.
    Hill, J.L. and Gettes, L.S. Circulation 61:768–778, 1980.PubMedGoogle Scholar
  7. 7..
    Weiss, J. and Shine, K.I. Am. J. Physiol. 242:H619–H628, 1982A.Google Scholar
  8. 8.
    Kleber, A.G. Circ. Res. 52:442, 1983.PubMedGoogle Scholar
  9. 9.
    Kleber, A.G. J. Mol. Cell. Cardiol. 16:389–393, 1984.PubMedCrossRefGoogle Scholar
  10. 10.
    Weiss, J. and Shine, K.I. J. Mol. Cell. Cardiol. 13:699–704, 1981.PubMedCrossRefGoogle Scholar
  11. 11.
    Trube, G. and Heschler, I. Naunyn-schmiedebergs archs pharmak. 322:244, 1983.Google Scholar
  12. 12.
    Noma, A. Nature 305:147, 1983.PubMedCrossRefGoogle Scholar
  13. 13.
    Vleugels, A. and Carmeliet, E. Experientia 32:483, 1976.PubMedCrossRefGoogle Scholar
  14. 14.
    Reimer, K.A., Jennings, R.B., Hill, M.L. Circ. Res. 49:901, 1981.PubMedGoogle Scholar
  15. 15.
    Shen, A.C., Jennings, R.B. Am. J. Physiol. 67:417–433, 1972.Google Scholar
  16. 16.
    Jennings, R.B., Hawkins, H.K., Lowe, J.E., Hill, M.C., Klotman, S. and Reimer, K.A. Am. J. Pathol. 72:187–214, 1978.Google Scholar
  17. 17.
    Shine, K.I., Douglas, A.M. and Ricchuiti, N. Am. J. Physiol. 231:1225–1232, 1976.PubMedGoogle Scholar
  18. 18.
    Shine, K.I., Douglas, A.M. and Ricchuiti, N.V. Circ. Res. 43:712–720, 1978.PubMedGoogle Scholar
  19. 19.
    Ferrari, R., Bigoli, C.D., Lisa, F., Roddins, R., Ceconi, C. and Visioli, O. J. Mol. Cell. Cardiol. 15(Suppl 1):328, 1983.Google Scholar
  20. 20.
    Follette, D.M., Fey, K.H., Livesay, J.L., Nelson, R.L., Maloney, J.V., Jr. and Buckberg, G.D. Surg. Forum 27:244–246, 1976.PubMedGoogle Scholar
  21. 21.
    Yamamoto, F., Braimbridge, M.V. and Hearse, D.J. J. Mol. Cell. Cardiol. 15 (Suppl 1):272, 1983.Google Scholar
  22. 22.
    Bersohn, M.M., Shine, K.I. and Sterman, W.D. Am. J. Physiol. 242:H89–H93, 1982A.Google Scholar
  23. 23.
    Shine, K.I. Am. J. Physiol. 237:H413–H423, 1979.PubMedGoogle Scholar
  24. 24.
    Bersohn, M.M., Philipson, K.D. and Fukushima, J.Y. Am. J. Physiol. 242:C288–C295, 1982.PubMedGoogle Scholar
  25. 25.
    Watts, J.A., Koch, C.D. and Lalloue, K.F. Am. J. Physiol. 238:H909–H916, 1980.PubMedGoogle Scholar
  26. 26.
    Bersohn, M.M. and Shine, K.I. J. Mol. Cell. Cardiol. 15:659–671, 1983.PubMedCrossRefGoogle Scholar
  27. 27.
    Boudillon, P.D. and Poole-Wilson, P.A. Circ. Res. 50:360–369, 1982.Google Scholar
  28. 28.
    Weiss, J. and Hiltbrand, B. Circulation 68 (Suppl. III):III-66, 1983.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • K. I. Shine
    • 1
  • J. Weiss
    • 1
  • M. Bersohn
    • 1
  1. 1.Department of Medicine and the Greater Los Angeles Affiliate Cardiovascular LaboratoriesUCLA School of MedicineLos AngelesUSA

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