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Myofilament Protein Phosphorylation and Neural Regulation of Cardiac Contractility

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Pathobiology of Cardiovascular Injury

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 49))

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Abstract

Hearts function reasonably well without nerves, but the close match of cardiac output to metabolic demands across a wide range of work loads involves adjustments of the functional properties of the cells by extrinsic regulation involving the autonomic nervous system. Parasympathetic and sympathetic nerves and their neurotransmitters influence not only the frequency of cell beating but also the dynamics of their contraction and relaxation (1,2). The parasympathetic nerves and their neurotransmitter acetylcholine also influence the extent of effects of a given level of sympathetic nervous stimulation (3). As an example of the effects of the autonomic nervous system on the mechanics of heart muscle contraction, Figure 1 shows a schematic of the well-known changes in the twitch dynamics of papillary muscle in response to adrenergic stimulation. Maximum force is increased and the rates of rise and fall of force are increased. These changes reduce overall cycle time and ensure adequate filling of the ventricle in spite of relatively fast heart rates.

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Author information

Authors and Affiliations

  1. Department of Physiology & Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, 45267-0576, USA

    R. J. Solaro & J. L. Garvey

  2. Department of Pharmacology & Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, 45267-0576, USA

    R. J. Solaro & J. L. Garvey

Authors
  1. R. J. Solaro
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  2. J. L. Garvey
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Editor information

Editors and Affiliations

  1. Health Sciences Center, University of Oklahoma, USA

    H. Lowell Stone

  2. Cardiovascular Research Program, Oklahoma Medical Research Foundation, USA

    William B. Weglicki

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© 1985 Martinus Nijhoff Publishing, Boston

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Solaro, R.J., Garvey, J.L. (1985). Myofilament Protein Phosphorylation and Neural Regulation of Cardiac Contractility. In: Stone, H.L., Weglicki, W.B. (eds) Pathobiology of Cardiovascular Injury. Developments in Cardiovascular Medicine, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2621-2_1

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  • DOI: https://doi.org/10.1007/978-1-4613-2621-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9639-3

  • Online ISBN: 978-1-4613-2621-2

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