Abstract
Many “tumor specific” or “tumor associated” monoclonal antibodies show only a three- to five-fold increase in specific tumor localization in animal models when compared with nonspecific antibodies. We have explored the possible reasons for this relative lack of in vivo specificity using the antibodies B6.2 and B72.3 as well as xenografts of a human breast (Clouser) and a colorectal (LS174T) carcinoma. Several non-immunological factors such as blood flow, vascular permeability, delivery of antibody, and availability of antigen were studied for their effect on the localization of monoclonal antibodies within these tumors. These findings may have implications on the choice of antibody and of radionuclide for radio-immunodiagnosis and radioimmunotherapy of cancer in patients.
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© 1985 Martinus Nijhoff Publishing, Boston
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Sands, H., Shah, S.A., Jones, P.L., Neacy, W., Gallagher, B.M. (1985). Non-Immunological Factors Affecting the Localization of Monoclonal Antibodies in Xenografts of Human Breast and Colon Tumors. In: Ceriani, R.L. (eds) Monoclonal Antibodies and Breast Cancer. Developments in Oncology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2617-5_21
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DOI: https://doi.org/10.1007/978-1-4613-2617-5_21
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