Breast Cancer Antigens Detected with Human Monoclonal Antibodies

  • K. G. Burnett
  • E. Oh
  • J. Hayden
Part of the Developments in Oncology book series (DION, volume 35)


Fusion of mouse myeloma P3/HT to lymph node lymphocytes of breast cancer patients has produced two human monoclonal antibodies which show selective binding to human breast carcinoma. The 41 and 43 Kd antigens recognized by YBB190 are found primarily in the cytosol fraction of breast carcinoma. YBY088 detects a 30 Kd antigen restricted to membranes of breast tumors, but also found in cytosols of several non-malignant tissues. Although not entirely tumor-restricted, the antigens bound by these human anti-breast monoclonal antibodies have distribution patterns that may be of significance in tumor imaging and therapy.


Breast Cancer Breast Carcinoma Cytosol Fraction Human Monoclonal Antibody Benign Tissue 
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  1. 1.
    Cannon, G.B., McCoy, J.L., Connor, R.J., Jerome, L., Keys, L., Dean, J.H., and Herberman, R.B. 1979. J. Natl. Cancer Inst. 60: 969–978.Google Scholar
  2. 2.
    Fossati, G., Canevari, S., Pierotti, M.A., Vezzoni, P., Porta, G.D. and Vaglini, M., 1979. J. Natl. Cancer Inst. 62: 1381–1385.PubMedGoogle Scholar
  3. 3.
    Fritze, D., Schulte-Uentrop, C., and Kaufmann, M. 1979. Eur. J. Cancer 15: 1491–1496.PubMedCrossRefGoogle Scholar
  4. 4.
    Boehm, O.R., Boehm, B.J. and Humphrey, L.J. 1974. Clin. Exp. Immunol. 16: 31–40.Google Scholar
  5. 5.
    Plain, M.J., Whitehead, R.H., and Jose, D.G. 1982. Clin. Immunol. Immunopathol. 23: 392–399.PubMedCrossRefGoogle Scholar
  6. 6.
    Schlom, J., Wunderlich, D. and Teramoto, Y.A. 1980. Proc. Natl. Acad. Sci. 77: 6841–6845.PubMedCrossRefGoogle Scholar
  7. 7.
    Burnett, K.G., Masuho, Y., Hernandez, R., Maeda, T., King, M.P. and Martinis, J. 1984. In: International Conference on Monoclonal Antibodies: Diagnostic and Therapeutic Uses in Tumors and Transplantation (e.d. S.N. Chatterjee) John Wright-PSG Publications, Boston, MA. In press.Google Scholar
  8. 8.
    Imam, A., Laurence, D.J.R, and Neville, M.A., 1982. Biochem. J. 207: 37–42.PubMedGoogle Scholar
  9. 9.
    Kearney, J.F., Radbruch, A., Liesegang, B., and Rajewsky, K. 1979. J. Immunol. 123: 1548–1550.PubMedGoogle Scholar
  10. 10.
    Gerhard, W., 1980. In: Monoclonal Antibodies. (R. Kennett, T.J. McKearn and K.G. Bebtol, ed.) Plenum Press, N.Y., pp. 370–371.Google Scholar
  11. 11.
    Littlefield, J.W., 1964. Science 145: 709–710.PubMedCrossRefGoogle Scholar
  12. 12.
    Tamura, G.S., Dailey, M.O., Gallatin, W.M., McGrath, M.S., Weissman, I.L. and Pillemer, E.A. 1984. Analyt. Biochem. 136: 458–464.PubMedCrossRefGoogle Scholar
  13. 13.
    Hilkens, J., Hilgers, J., Buijs, F., Hageman, P., Schol, D., VanDoornewaard, G., and VanDenTweel, J., 1983. Proc. Protides of the Biological Fluids, 31: 1013–1016.Google Scholar
  14. 14.
    Winman, K., Curman, B., Tragardh, L. and Peterson, P.A. 1979. Eur. J. Immunol. 9: 190–195.CrossRefGoogle Scholar
  15. 15.
    Rainsbury, R.M., Westwood, J.H., Coombes, R.C., Neville, A.M., Ott, R.J., Kalirai, T.S., McCready, V.R., and Gazet, J.C., 1983. Lancet Oct. 22: 934–938.CrossRefGoogle Scholar
  16. 16.
    Epenetos, A.A., Mather, S., Granowska, M., Nimon, C.C., Hawkins, L.R., Britton, K.E., Shepherd, J., Taylor, J., Papadimitriou, Durbin, H., Malpis, J.S., and Bodmer, W.F. 1982. Lancet, Nov. 6: 999–1000.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • K. G. Burnett
    • 1
  • E. Oh
    • 1
  • J. Hayden
    • 1
  1. 1.Hybritech IncorporatedSan DiegoUSA

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