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Immunity

  • Chapter
Marek’s Disease

Part of the book series: Developments in Veterinary Virology ((DVVI,volume 1))

Abstract

Immune responses in Marek’s disease (MD) are complicated by antagonism between immunity on the one hand and immunosuppression on the other. Lymphocytes are responsible for mounting immune responses, some of which may contribute to protection while others may be involved in the pathology of the disease, and it is the same cell type that is the primary target for infection with Marek’s disease virus (MDV). Infection may be lytic, resulting in cell death, or it may lead to malignant transformation; both types of infection appear to be associated with immunosuppression. It is assumed that an efficient host immune response limits the extent and spread of virus replication, and also contributes to the regression and rejection of tumour cells. At the same time virus-induced immunosuppression will be acting to limit the effectiveness of these responses. The outcome of infection therefore depends upon a balance between the immune responses provoked by the virus and tumour antigens and the immunosuppression caused by the replication of the virus in the lymphoid organs. Nevertheless, the importance of the immune system in ensuring that this internecine struggle results in a satisfactory outcome from the chicken’s point of view has been amply demonstrated by the success of a variety of live virus vaccines against MD (1).

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  1. Houghton Poultry Research Station, Houghton, Huntingdon, Cambs., PE17 2DA, UK

    L. N. Payne

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© 1985 Martinus Nijhoff Publishing, Boston

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Powell, P.C. (1985). Immunity. In: Payne, L.N. (eds) Marek’s Disease. Developments in Veterinary Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2613-7_7

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