Clinical Disease and Its Economic Impact

  • H. G. Purchase
Part of the Developments in Veterinary Virology book series (DVVI, volume 1)


Marek’s disease (MD) is the most common clinical neoplastic condition of any animal, including man, on the globe. However, the clinical disease represents the “tip of the iceberg” in that many more birds are infected with the virus than show clinical signs. Clinical signs are also very varied.


Broiler Chicken Agricultural Research Service Young Chicken Total Bird High Condemnation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Marek J: Multiple Nervenenzundung (polyneuritis) bei Hühnern. Dtsch Tieräerztl Wochenschr (15):417–421, 1907.Google Scholar
  2. 2.
    Benton WJ, Cover MS: The increased incidence of visceral lymphomatosis in broiler and replacement birds. Avian Dis (1):320–327, 1957.CrossRefGoogle Scholar
  3. 3.
    Biggs PM, Purchase HG, Bee BR, Dalton PJ: Preliminary report on acute Marek’s disease (fowl paralysis) in Great Britain. Vet Rec (77):1339–1340, 1965.PubMedCrossRefGoogle Scholar
  4. 4.
    Purchase HG: Control of Marek’s disease by vaccination. World’s Poult Sci J (29):238–250, 1973.CrossRefGoogle Scholar
  5. 5.
    Eidson CS, Page RK, Kleven SB: Effectiveness of cell-free or cell-associated turkey herpesvirus vaccine against Marek’s disease in chickens as influenced by maternal antibody, and time of exposure to Marek’s disease virus. Avian Dis (22):583–597, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Witter RL, Sharma JM, Fadly AM: Pathogenicity of variant Marek’s disease isolants in vaccinated and unvaccinated chickens. Avian Dis (24):210–232, 1980.CrossRefGoogle Scholar
  7. 7.
    Schat KA, Calnek BW, Fabricant J: Influence of oncogenicity of Marek’s disease virus on evaluation of genetic resistance. Poult Sci (60):2559–2566, 1981.PubMedGoogle Scholar
  8. 8.
    Biggs PM: The world of poultry disease. Avian Pathol (11):281–300, 1982.Google Scholar
  9. 9.
    FAO-WHO-OIE: Animal Health Yearbook 1979, FAO-WHO-OIE, Geneva/ Rome/Paris, 1980.Google Scholar
  10. 10.
    Lancaster JE: The zoo-sanitary situation in Africa. Avian Dis Rev Sci Tech Off Int Epiz (2):889–892, 1983.Google Scholar
  11. 11.
    Calnek BW, Witter RL: Marek’s disease. In: Hofstad MS, Calnek BW, Helmboldt CF, Reed WM, Yoder HW, Jr (eds). Diseases of Poultry, 7th ed. Iowa State University Press, Ames, Iowa, 1978, pp 385–418.Google Scholar
  12. 12.
    Kenzy SG, Cho BR: Transmission of classical Marek’s disease by affected and carrier birds. Avian Dis (13):211–214, 1969.PubMedCrossRefGoogle Scholar
  13. 13.
    Powell PC, Howes K, Lawn AM, Mustill BM, Payne IN, Rennie M, Thompson MA: Marek’s disease in turkeys: The induction of lesions and the establishment of lymphoid cell lines. Avian Pathol (13):201–214, 1984.PubMedCrossRefGoogle Scholar
  14. 14.
    Witter RL: Vaccines and vaccination against Marek’s disease. In: Proc Int Symp on Marek’s Disease. Ithaca, New York, July 22–26, 1984 (in press).Google Scholar
  15. 15.
    Kenzy SG, Cho BR, Kim Y: Oncogenic Marek’s disease herpes virus in avian encephalitis (temporary paralysis). J Natl Cancer Inst (51):977–982, 1973.PubMedGoogle Scholar
  16. 16.
    Walker D, Grattan KAP: A temporary paralytic syndrome of growing pullets. Vet Rec (82):43–73, 1968.Google Scholar
  17. 17.
    Settnes OP: Marek’s disease: A common naturally herpesvirusinduced lymphoma of the chicken. Nord Vet Med Supp 11, 1982, pp. 132.Google Scholar
  18. 18.
    Fujita K, Uda K, Fukui H, Nishikawa K, Takei K, Okomura T: Outbreak of transient paralysis in broiler chickens. J Jpn Soc Poult Dis (17):167–171, 1981.Google Scholar
  19. 19.
    Purchase HG, Biggs PM: Characterization of five isolates of Marek’s disease. Res Vet Sci (8):440–449, 1967.PubMedGoogle Scholar
  20. 20.
    Eidson CS, King DD, Connell HE, Anderson DP, Kleven SH: Efficacy of turkey herpesvirus vaccine against Marek’s disease in broilers. Poult Sci (52):1482–1491, 1973.PubMedGoogle Scholar
  21. 21.
    Purchase HG: The etiology and control of Marek’s disease of chickens and the economic impact of a successful research program. In: Ranberger JA, Anderson JD, Powell RL (eds). Beltsville Symposia in Agricultural Research. I. Virology in Agriculture. Alanheld, Osmun & Co. Montclair, NJ, 1977, pp 63–81.Google Scholar
  22. 22.
    Honegger KA, McMurray BL, Gledhill RH, Purchase HG: Performance response of leghorn type layer flock to turkey herpesvirus vaccine. Avian Dis (16):78–85, 1972.PubMedCrossRefGoogle Scholar
  23. 23.
    Kilgore RL: Prophylactic efficacy of a Marek’s disease vaccine in broiler and replacement layer chickens. Avian Dis (16):72–77, 1972.PubMedCrossRefGoogle Scholar
  24. 24.
    Purchase HG, Okazaki W, Burmester BR: Long term field trials with the herpesvirus of turkeys vaccine against Marek’s disease. Avian Dis (16):34–44, 1972.Google Scholar
  25. 25.
    Biggs PM, Shilleto RFW, Lawn AM, Cooper DM: Idiopathic poly- neuritis in SPF chickens. Avian Pathol (11):163–178, 1982.PubMedCrossRefGoogle Scholar
  26. 26.
    USDA, Code of Federal Regulations (CFR), Title 9, Chapter III, Subchapter C, part 381.76 and 381.82. 1982.Google Scholar
  27. 27.
    USDA, Food Safety and Inspection Service. Meat and Poultry Inspection, 1982. Report of the Secretary of Agriculture to the USA Congress, March 1, 1983. pp 51.Google Scholar
  28. 28.
    The Poultry Meat (Hygiene) Regulation. Statutory Instruments no. 1289. Food and Drugs, Food Hygiene. Her Majesty’s Stationery Office, London 1976.Google Scholar
  29. 29.
    The animals and animal products (control of export) law, 5717–1957 and the animal diseases ordinance, 1945. Regulations for the control of the manufacture of poultry products for export and their export. Ministry of Agriculture, Veterinary Services and Animal Health, Beit Dagan, Israel.Google Scholar
  30. 30.
    Republic of South Africa, Government Gazette. Regulation Gazette No. 1186. Vol. 52. No. 2540. 9th October 1969. pp. 83.Google Scholar
  31. 31.
    USDA, Agricultural Statistics. 1983. United States Government Printing Office, Washington, DC. 1983. pp 558.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • H. G. Purchase

There are no affiliations available

Personalised recommendations