Metabolism and the “Initiation” of Tumors by Chemicals

  • Charles M. King
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 2)

Abstract

This presentation is based on the idea that genomic alterations by carcinogens are crucial to the production of tumors. The objective is to provide insight as to how investigators may wish to approach the identification and characterization of metabolic activation pathways, as well as the clarification of the role of these pathways in the induction of tumors. It is not intended to be an encyclopedic review, but rather a communication that reflects personal experience in the field of aromatic amines and the external influences of the carcinogenesis community. Hopefully, it will serve both as an introduction to the subsequent chapters of this book and as a framework for the investigation of the mechanisms by which other as yet unstudied compounds cause cancer.

Keywords

Fluorene Macromolecule Pyrene Epoxidation Nucleoside 

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© Martinus Nijhoff Publishing, Boston 1985

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  • Charles M. King

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