Therapeutic use of monoclonal anti-idiotype antibodies against B-cell lymphoma

  • A. Hekman
  • E. M. Rankin
  • R. Somers
  • W. ten Bokkel Huinink
Part of the Developments in Oncology book series (DION, volume 32)


Human malignant B-cell tumors arise from a proliferation of a single clone of cells [1]. The immunoglobulin (Ig) which is expressed by the tumor cells is limited to the expression of one single VH and VL region, and to a single light chain. The unique variable region of the Ig, the idiotype, thus forms a specific tumor marker and a potential target for immunotherapy. Levy and colleagues [2] used a monoclonal anti-idiotype antibody to treat a patient with a nodular poorly-differentiated lymphocytic lymphoma, and achieved a complete remission which has lasted so far for 29 months. This group has treated seven more patients with anti-idiotype antibodies but no complete remissions have been obtained [3]. Polyclonal anti-idiotype antibodies raised in sheep have been given to one patient with promyelocytic leukemia [4] and to three patients with lymphoma [5]. There were transient reductions in the level of circulating lymphocytes, but no long-lasting antitumor effect was seen.


Chronic Lymphocytic Leukaemia Hodgkin Lymphoma Circulate Tumor Cell Ascitic Fluid Netherlands Cancer Institute 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • A. Hekman
    • 1
  • E. M. Rankin
    • 1
  • R. Somers
    • 1
  • W. ten Bokkel Huinink
    • 1
  1. 1.Netherlands Cancer InstituteAntoni van Leeuwenhoek HuisAmsterdamthe Netherlands

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