Bone marrow and blood involvement by non-Hodgkin’s lymphoma: Clinicopathologic features and prognostic significance in relationship to the Working Formulation

  • E. Morra
  • M. Lazzarino
  • E. Orlandi
  • D. Inverardi
  • A. Castello
  • A. Coci
  • U. Magrini
  • C. Bernasconi
Part of the Developments in Oncology book series (DION, volume 32)

Abstract

Bone marrow (BM) biopsy is a valuable staging procedure for patients with malignant non-Hodgkin’s lymphomas (NHL). In cases presenting with nodal involvement, a positive bone marrow finding would allow diagnosis of Stage IV disease without the need for more aggressive procedures. Previous studies have evaluated the frequency and pattern of bone marrow involvement in the various pathologic subtypes of the NHL classified according to the Rappaport [1–5], Lukes and Collins [6, 7], and Kiel [8–11] schemes. Furthermore, the results of Bartl’s study [10] applying the Kiel classification to BM biopsies, indicated the prognostic significance of BM disease in NHL. As concerns peripheral blood involvement by malignant lymphomas, the leukemic phase has been the subject of several studies, all based on the Rappaport [12–14], Lukes and Collins [7], WHO [15, 16] and Kiel systems [17].

Keywords

Lymphoma Leukemia Cyclophosphamide Stein Prednisone 

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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • E. Morra
    • 1
  • M. Lazzarino
    • 1
  • E. Orlandi
    • 1
  • D. Inverardi
    • 1
  • A. Castello
    • 2
  • A. Coci
    • 2
  • U. Magrini
    • 2
  • C. Bernasconi
    • 1
  1. 1.Divisione di EmatologiaOspedale Policlinico San MatteoPaviaItaly
  2. 2.Istituto di Anatomia ed Istologia PatologicaUniversità di PaviaPaviaItaly

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