Hodgkin’s disease: Further information derived from cell lines
Histologically, Hodgkin’s disease (HD) is characterized by a striking cellular pleomorphism with a low percentage of Hodgkin (H) and Sternberg-Reed (SR) cells, which represent the tumor cell population, admixed with nonmalignant cells, e.g., polymorphonuclears, macrophages, B-cells and T-cells. Aneuploidy and clonal development of H and SR cells confirm their neoplastic nature. However, chromosome markers that are specific for HD have not been identified in freshly sampled tumors. The reasons for the presence of non-malignant cells surrounding H- and SR-cells are still unknown. This admixture has been regarded as a type of graft-vs-host reaction.
KeywordsMigration Agar Lymphoma Leukemia Agarose
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- 1.Kaplan HS (1981). On the biology and immunology of Hodgkin’s disease. Hematology and Blood Transfusion 26: 11–23.Google Scholar
- 2.Reed DM (1902). On the pathological changes in Hodgkin’s disease with especial reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 10: 133–196.Google Scholar
- 7.Bieber MM, King DP, Strober S and Kaplan HS (1979). Characterization of an E-rosette inhibitor ( ERI) in the serum of patients with Hodgkin’s disease, as a glycolipid. Clin Res 27: 081A.Google Scholar
- 11.Heit W, Rich IN and Kubanek B (1981). Macrophage-dependent production of erythropoietin and colony-stimulating factor. Hematology and Blood Transfusion 27: 73–78.Google Scholar
- 12.Kortmann C, Burrichter H, Monner D et al. (1984). Interleukin-1-like activity constitutively generated by Hodgkin derived cell lines. L. Measurement in a human lymphocyte co-stimulator assay. Immunobiology 166: 318–333.Google Scholar
- 13.Schaadt M, Diehl V, Kalden JR et al. (1978). Langzeitauswirkungen der Splenektomie auf den immunstatus von Hodgkin-Patienten in Abhängigkeit von der Therapieform. Med Klinik 73: 1381–1386.Google Scholar
- 15.Nelson RD, McCormack RT and Fiegel VD (1978). Chemotaxis of human leucocytes under agarose. In: Gallin JI and Quie PG (Eds.) Leukocyte Chemotaxis, pp 25–42.Google Scholar
- 16.Oppenheim JJ, Stadler BM, Siraganian RP et al. (1982). Lymphokines: Their role in lymphocyte responses. Properties of interleukin 1 Fed Proc 41: 257–262.Google Scholar