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Lymphocyte uroporphyrinogen synthase activity as a diagnostic test in lymphoproliferative disorders — preliminary results

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Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances

Part of the book series: Developments in Oncology ((DION,volume 32))

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Abstract

Uroporphyrinogen synthase (EC 4.3.1.8) (UROS), an enzyme in the heme biosynthetic pathway, converts porphobilinogen to uroporphyrinogen. Lym­phocyte UROS (L-UROS) is an inducible enzyme [1] and its activity is increased in erythroleukemia cells [2]. Recent observations [3, 4] showed the presence of circulating malignant lymphocytes in the blood of patients with lymphoproliferative diseases (LPD) without apparent peripheral in­volvement.

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References

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Author information

Authors and Affiliations

  1. Laboratory of Biochemical Pharmacology, Ramat Aviv, Israel

    M. Lahav, O. Epstein, N. Schoenfeld & A. Atsmon

  2. Department of Internal Medicine B, Ramat Aviv, Israel

    M. Lahav & A. Atsmon

  3. Hematology Unit, Beilinson Medical Center, Petah Tiqva ,The Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

    M. Shaklai

Authors
  1. M. Lahav
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  2. O. Epstein
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  3. N. Schoenfeld
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  4. M. Shaklai
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  5. A. Atsmon
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Editor information

Editors and Affiliations

  1. Division of Oncology, Ospedale San Giovanni, Bellinzona, Switzerland

    Franco Cavalli

  2. Istituto Nazionale, per lo Studio e la Cura dei Tumori, Milano, Italy

    G. Bonadonna

  3. Pharmaceutical Research & Development Division, Bristol-Myers Company, Syracuse, NY, USA

    Marcel Rozencweig

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© 1985 Martinus Nijhoff Publishers, Boston

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Lahav, M., Epstein, O., Schoenfeld, N., Shaklai, M., Atsmon, A. (1985). Lymphocyte uroporphyrinogen synthase activity as a diagnostic test in lymphoproliferative disorders — preliminary results. In: Cavalli, F., Bonadonna, G., Rozencweig, M. (eds) Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Developments in Oncology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2607-6_18

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  • DOI: https://doi.org/10.1007/978-1-4613-2607-6_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9632-4

  • Online ISBN: 978-1-4613-2607-6

  • eBook Packages: Springer Book Archive

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