The importance of prostaglandins, thromboxanes, prostacyclin, hydroperoxy fatty acids and leukotienes in cancer can no longer be considered simply a possibility; work in recent years has clearly indicated such a reality. These compounds are produced by the oxidation of 20 carbon fatty acids such as arachidonic acid (see Figure 1). The level of involvement of these eicosanoids, the term applied to all arachidonate metabolites, in cancer occurs at all levels from carcinogen metabolism to tumor promotion to the rate of proliferation of tumors to the interaction between the tumor and host to the metastatic potential of tumors. This volume, one of a series intended to cover this spectrum of the disease we call cancer, is devoted to one aspect, tumor promotion.
KeywordsArachidonic Acid Benzoyl Peroxide Tumor Promotion Mouse Skin Arachidonic Acid Metabolism
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