What Animal Models are Useful in Selecting New Antiarrhythmic Drugs?
Although many animal models are useful for evaluating new antiarrhythmic agents, it must be admitted that no animal model is ideal, nor can any single animal model alone predict antiarrhythmic efficacy in man. The selection of which animal model(s) to use depends first of all on whether one is “screening” for a new active compound or alternatively, “evaluating” an already identified active antiarrhythmic drug. This paper will deal primarily with models designed to evaluate mechanisms of action and effectiveness of new antiarrhythmic agents.
KeywordsToxicity Depression Ischemia Barium Cardiomyopathy
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