What Animal Models are Useful in Selecting New Antiarrhythmic Drugs?

  • E. Neil Moore
  • Joseph F. Spear
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 47)

Abstract

Although many animal models are useful for evaluating new antiarrhythmic agents, it must be admitted that no animal model is ideal, nor can any single animal model alone predict antiarrhythmic efficacy in man. The selection of which animal model(s) to use depends first of all on whether one is “screening” for a new active compound or alternatively, “evaluating” an already identified active antiarrhythmic drug. This paper will deal primarily with models designed to evaluate mechanisms of action and effectiveness of new antiarrhythmic agents.

Keywords

Toxicity Depression Ischemia Barium Cardiomyopathy 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • E. Neil Moore
  • Joseph F. Spear

There are no affiliations available

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