What Animal Models are Useful in Selecting New Antiarrhythmic Drugs?
Although many animal models are useful for evaluating new antiarrhythmic agents, it must be admitted that no animal model is ideal, nor can any single animal model alone predict antiarrhythmic efficacy in man. The selection of which animal model(s) to use depends first of all on whether one is “screening” for a new active compound or alternatively, “evaluating” an already identified active antiarrhythmic drug. This paper will deal primarily with models designed to evaluate mechanisms of action and effectiveness of new antiarrhythmic agents.
KeywordsLeft Anterior Descend Ventricular Fibrillation Antiarrhythmic Drug Antiarrhythmic Agent Ventricular Tachyarrhythmia
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- 1.Moore EN and Spear JF: Acute animal models for the study of antiarrhythmic drugs for the prevention of sudden coronary death. In: Clinical Pharmacology of Antiarrhythmic Therapy. Ed. Lucchesi, BR, Dingell, JV and Schwarz RP Jr. Raven Press, N.Y. pp. 31–46, 1984.Google Scholar
- Wiggers, CJ, and Wegria R: Ventricular fibrillation due to a single localized induction and condenser shock applied during the vulnerable phase of ventricular systole. Am. J. Physiol. 128: 500–505.Google Scholar
- 5.Greenberg, HM and Dwyer, EM. Eds. Sudden Coronary Death Ann. NY Acad. Sci. 382: 1–484, 1982.Google Scholar
- 6.Kaplinsky, E, Ogawa S, Balke CW and Dreifus LS: Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model. Circ. 60: 397–403, 1979.Google Scholar
- 7.Harris, AS and Rojas, AG: Initiation of ventricular fibrillation due to coronary occlusion. Exp. Med. Surg. 1: 105–122, 1943.Google Scholar