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Liver Cancer pp 143-156 | Cite as

Hepatic Artery Ligation for Liver Cancer

  • Nicholas J. Petrelli
  • Arnold Mittelman
Part of the Developments in Oncology book series (DION, volume 30)

Abstract

This chapter describes techniques for interrupting the blood supply to tumors metastatic to the liver and to primary tumors of the liver, and reviews the results observed with these methods. Generally, regional treatment of hepatic metastases has been limited to tumors that arise from the abdominal gastrointestinal tract. Hepatic-dominated metastases are observed more often in certain types of gastrointestinal tumors. For example, carcinomas of the esophagus rarely metastasize solely to the liver, whereas colorectal, carcinoid tumors of the gastrointestinal tract, islet cell tumors of the pancreas, and leiomyosarcomas of the intestinal tract have a unique predisposition for hepatic-only metastases. Isolated hepatic metastases are common for choroidal or retinal melanomas, but these metastases seldom respond to even the most aggressive regional therapy. Metastases from other nongastrointestinal primary tumors, e.g., lung cancer, are rarely confined to the liver. Relative tumor vascularity would be expected to be an important factor determining tumor responsiveness to blood flow interruption. Primary hepatomas tend to be vascular, and metastastic tumors tend to vary in vascularity (table 7–1). Typically hypervas-cular metastatic tumors are hypernephromas, leiomyosarcomas, carcinoid tumors, islet cell and papillary cell tumors of the pancreas, and transitional cell carcinomas.

Keywords

Hepatic Artery Hepatic Metastasis Carcinoid Tumor Islet Cell Tumor Infusion Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bragg D. Angiography of hepatic metastasis: a review. Int J Radiat Oncol Biol Phys 1:965–971, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Suzuki T, et al. Study of vascularity of tumors of the liver. Surg Gynecol Obstet 134:27–34, 1972.PubMedGoogle Scholar
  3. 3.
    Segall H. An experimental anatomical investigation of the blood and bile channels of the liver. Surg Gynecol Obstet 37:152–178, 1923.Google Scholar
  4. 4.
    Taylor I, Bennett T, Sherriff S. The blood supply of colorectal metastasis. Br J Cancer 39: 749–756, 1979.Google Scholar
  5. 5.
    Markowitz J, Rappaport A, Scott A. Prevention of liver necrosis following ligation of the hepatic artery. Proc Soc Exp Biol Med 70:305, 1949.PubMedGoogle Scholar
  6. 6.
    Wirtanen G, Kaude J. Inferior phrenic artery collateralization in hepatic artery occlusion. Am J Radiol 117:615–619, 1973.Google Scholar
  7. 7.
    Bengmark S, Rosengren K. Angiographic study of the collateral circulation to the liver after ligation of the hepatic artery in man. Am J Surg 119:620–624, 1970.PubMedCrossRefGoogle Scholar
  8. 8.
    Ledesma E, Evans J, Mittelman A, Yoon J, Bruno S. Indications for cholecystectomy in ligation of the hepatic artery. Surg Gynecol Obstet 152:451–452, 1981.PubMedGoogle Scholar
  9. 9.
    Petrelli N, Barcewicz P, Evans J, Ledes AE, Lawrence D, Mittelman A Hepatic artery ligation for liver metastases in colorectal carcinoma. Cancer e 53: 1347–1353, 1984.Google Scholar
  10. 10.
    Nilsson L. Therapeutic hepatic artery ligation in patients with secondary liver tumors. Rev Surg 23:374–376, 1966.PubMedGoogle Scholar
  11. 11.
    Almersjö O, Bengmark S, Rudenstram C, Hafström L, Nilsson L. Evaluation of hepatic dearteri-alization in primary and secondary cancer of the liver. Am J Surg 124:5–9, 1972.PubMedCrossRefGoogle Scholar
  12. 12.
    Larmi T, Karkola P, Klintrup H, Heikkinen E. Treatment of patients with hepatic tumors and jaundice by ligation of the hepatic artery. Arch Surg 108:178–183, 1974.PubMedGoogle Scholar
  13. 13.
    Koudahl, G, Funding J. Hepatic artery ligation in primary and secondary hepatic cancer. Acta Chir Scand 138:289–292, 1972.PubMedGoogle Scholar
  14. 14.
    Former J, Mulcarr R, Solis A, Watson R, Golbey R. Treatment of primary and secondary liver cancer by hepatic artery ligation and infusion chemotherapy. Ann Surg 178:162–172, 1973.CrossRefGoogle Scholar
  15. 15.
    Sparks F, Mosher M, Hallauer W, Silverstein M, Ransel D, Passaro E, Morton D. Hepatic artery ligation and postoperative chemotherapy for hepatic metastasis: clinical and pathophysiological results. Cancer 35:1074–1082, 1975.PubMedCrossRefGoogle Scholar
  16. 16.
    Ramming K, Sparks F, Eilber F, Holmes E, Morton D. Hepatic artery ligation and 5-fluorour-acil infusion for metastatic colon carcinoma and primary hepatoma. Am J Surg 132:236–242, 1976.PubMedCrossRefGoogle Scholar
  17. 17.
    Almersjö O, Bengmark S, Hafström L. Liver resection for cancer. Acta Chir Scand 142:139–144, 1976.PubMedGoogle Scholar
  18. 18.
    McDermott W, et al. Dearterialization of the liver for metastatic cancer. Ann Surg 187:38–46, 1978.PubMedCrossRefGoogle Scholar
  19. 19.
    Mori W, Masuda M, Myanaga T. Hepatic artery ligation and tumor necrosis in the liver. Surgery 59:359:363, 1966.PubMedGoogle Scholar
  20. 20.
    Dahl E, et al. Transient hepatic dearterialization followed by regional intraarterial 5-fluorouracil infusion as treatment for liver tumors. Ann Surg 193:82–88, 1981.PubMedCrossRefGoogle Scholar
  21. 21.
    Joachimsson P, et al. Iatrogenic liver abscesses: a complication of hepatic artery ligation for tumor. Arch Surg 113:141–144, 1978.Google Scholar
  22. 22.
    Berjian R, Douglass H, Nava H, Karakousis C. The role of hepatic artery ligation and dearterialization with infusion chemotherapy in advanced malignancies in the liver. J Surg Oncol 14: 379–387, 1980.PubMedCrossRefGoogle Scholar
  23. 23.
    Clouse M, Lee R, Duszlak E, Lokich J, et al. Peripheral hepatic artery embolization for primary and secondary hepatic neoplasms. Radiology 147:407–411, 1983.PubMedGoogle Scholar
  24. 24.
    Chuang V, Wallace S, Soo C, Charnsangavej C, Bowers T. Therapeutic Ivalon embolization of hepatic tumors. Am J Radiol 138:289–294, 1982.Google Scholar
  25. 25.
    Wallace S, Chuang V. The radiologic diagnosis and management of hepatic metastasis. Radiology 22:56–64, 1982.Google Scholar
  26. 26.
    Aronsen K, Hellekant C, Holmbers J, Rothman U, Teder H. Controlled blocking of hepatic artery flow with enzymatically degradable microspheres combined with oncolytic drugs. Eur Surg Res 11:99–106, 1979.PubMedCrossRefGoogle Scholar
  27. 27.
    Charnsangavej C, Chuang V, Wallace S, Soo C, Bowers T. Angiographic classification of hepatic arterial collaterals. Radiology 144:485–494, 1982.PubMedGoogle Scholar
  28. 28.
    Balasegaram M. Complete hepatic dearterialization for primary carcinoma of the liver: report of twenty-four patients. Am J Surg 124:340–345, 1972.PubMedCrossRefGoogle Scholar
  29. 29.
    Olweny C, Katongole E, Bahendeka S, Otim D, Mugerwa J, Kyalwazi S. Further experience in treating patients with hepatocellular carcinoma in Uganda. Cancer 46:2717–2722, 1980.PubMedCrossRefGoogle Scholar
  30. 30.
    Inokuchi K, Nagasue N, Kanashima R, Kohno H, Kobayashi M. Treatment of hepatocellular carcinoma with associated cirrhosis. Ann Chir Gynaecol 68:94–97, 1979.PubMedGoogle Scholar
  31. 31.
    Lee Y, Irwin L. Hepatic artery ligation and adriamycin infusion chemotherapy for hepatoma. Cancer 41:1249–1255, 1978.PubMedCrossRefGoogle Scholar
  32. 32.
    Kanashima R, Nagasue N, Kobayashi M, Inokuchi K. Tumor embolism in the right atrium after hepatic artery ligation for hepatoma. Jpn J Surg 7:246–252, 1977.PubMedCrossRefGoogle Scholar
  33. 33.
    Kim D, Watson R, Pahnke L, Fortner J. Tumor vascularity as a prognostic factor for hepatic tumors. Ann Surg 185:31–34, 1977.PubMedCrossRefGoogle Scholar
  34. 34.
    Nakamura H, Tanaka T, Hori S, Yoshioka H, Kuroda C, Okamura J, Sakurai M. Transcatheter embolization of hepatocellular carcinoma: assessment of efficacy in cases of resection following embolization. Radiology 147:401–405, 1983.PubMedGoogle Scholar
  35. 35.
    Charnsangavej C, Chuang V, Wallace S, Soo C, Bowers T. Work in progress: transcatheter management of primary carcinoma of the liver. Radiology 147:51–55, 1983.PubMedGoogle Scholar
  36. 36.
    Monna T, Kanno T, Marumo T, Harihara S, Kuroki T, Yamamoto S, Kobayashi N, Sato M, Nakamura K, Nakatsuka H, Onoyama Y, Yamada R. A comparison of transcatheter arterial embolization with one shot therapy for the patients with hepatic cell carcinoma. Gastroenterol. JPN 17:542–549, 1982.PubMedGoogle Scholar
  37. 37.
    Chuang V, Wallace S. Hepatic artery embolization in the treatment of hepatic neoplasms. Radiology 140:51–58, 1981.PubMedGoogle Scholar
  38. 38.
    Sako M, Yokogawa S, Sakomoto K, Adachi S, Hirota S, Okada S, Mura S. Transcatheter microembolization with ferropolysaccharide. A new approach to ferromagnetic embolization of tumors: preliminary report. Invest Radiol 17:573–582, 1982.PubMedCrossRefGoogle Scholar
  39. 39.
    Shermeta D, Golladay E, White R. Preoperative occlusion of the hepatic artery with isobutyl 2-cyanoacrylate for resection of the “Ddunresectable” hepatic tumor. Surgery 83:319–322, 1978.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston/Dordrecht/Lancaster 1985

Authors and Affiliations

  • Nicholas J. Petrelli
  • Arnold Mittelman

There are no affiliations available

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