Skip to main content
SpringerLink
Log in

Thermochemotherapy of Liver Metastases

  • Chapter
Liver Cancer

Part of the book series: Developments in Oncology ((DION,volume 30))

  • 72 Accesses

Abstract

Surgery is the treatment of choice for hepatic metastases. Refinement in surgical technique and postoperative care in the last decade have resulted in satisfactory morbidity and mortality for elective hepatic resections, and surgery remains the only modality with consistent, rewarding two- and five-year cure rates. Unfortunately, because many hepatic metastases impinge on vital structures, or because of multiplicity of lesions, only about 5% to 7% of patients with hepatic metastases are candidates for surgical resection. The results of conventional chemotherapy, particularly in patients with metastases of malignant melanoma or colon cancer, are dismal. Thus a variety of innovative approaches utilizing infusion therapy by a variety of routes and using a variety of devices, often combined with other modalities, has evolved. This report contains our early clinical experience with the treatment of hepatic metastases using hyperthermia and chemotherapy, particularly in metastases of colorectal cancer and malignant melanoma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bender E, Schramm T. Untersuchungen zur thermosensibilitat von tumor und normaizellen in vitro. Acta Biol Med Germ 17:527–543, 1966.

    PubMed  CAS  Google Scholar 

  2. Cavaliere, R, Ciocatto EC, Giovanella BC, et al. Selective heat sensitivity of cancer cells: biochemical and clinical studies. Cancer 20:1251–1381, 1967.

    Article  Google Scholar 

  3. Giovanella BC, Morgan AC, Stehlin JS, et al. Selective lethal effect of supranormal temperatures on mouse sarcoma cells. Cancer Res 33:2568–2578, 1973.

    PubMed  CAS  Google Scholar 

  4. Crile G. Heat as an adjunct to the treatment of cancer. Cleveland Clin Quart 28:75–89, 1961.

    PubMed  Google Scholar 

  5. Muckle DS, Dickson JA. The selective inhibitory effect of hyperthermia on the metabolism and growth of malignant cells. Br J Cancer 15:771–778, 1978.

    Google Scholar 

  6. Overgaard K, Overgaard J. Investigations on the possibility of a thermic tumor therapy. Eur J Cancer 8:65–78, 1982.

    Google Scholar 

  7. Mendecki J, Griedenthal E, Botstein C. Effects of micro-wave induced local hyperthermia on mammary carcinoma in C3H mice. Cancer Res 36:2113–2114, 1976.

    PubMed  CAS  Google Scholar 

  8. Marmor JB, Hahn N, Hahn GM. Tumor cure and cell survival after localized radiofrequency heating. Cancer Res 37:879–883, 1977.

    PubMed  CAS  Google Scholar 

  9. Dickson JA, Suzanger M. In vitro sensitivity screening system for human cancers to drugs and hyperthermia (42°C). Br J Cancer 28:81–85, 1973.

    Article  PubMed  CAS  Google Scholar 

  10. Mondovi B, Strom R, Rotilio G, et al. The biochemical mechanism of selective heat sensitivity of cancer cells. I. Studies on cellular respiration. Eur J Cancer 5:129–136, 1969.

    Article  PubMed  CAS  Google Scholar 

  11. Mondovi B, Finazzi-Agro A, Rotilio G, et al. The biochemical mechanism of selective heat sensitivity of cancer cells. 11. Studies on nucleic acids and protein synthesis. Eur J Cancer 5:137–147, 1969.

    Article  PubMed  CAS  Google Scholar 

  12. Strom R, Santoro AS, Crifo C, et al. The biochemical mechanism of selective heat sensitivity of cancer cells. IV. Inhibition of RNA synthesis. Eur J Cancer 9:103–112, 1973.

    Article  PubMed  CAS  Google Scholar 

  13. Hahn GM. Thermochemotherapy: interactions between hyperthermia and chemotherapeutic agents. In Proceedings of the International Symposium on Cancer Therapy by Hyperthermia and Radiation. Washington, DC: American College of Radiation Press, 1975, pp. 61–65.

    Google Scholar 

  14. Strom P. Ricerche sul meccanismo d’azione del calore sui tumori. Atti Soc Ital Cancer IV Natl Congr 7:49–60, 1970.

    Google Scholar 

  15. Turano CM, Ferraro AM, Strom RM, et al. The biochemical mechanism of selective heat sensitivity of cancer cells. 111. Studies on lysosomes. Eur J Cancer 6:67–72, 1970.

    Article  PubMed  CAS  Google Scholar 

  16. Joines WT, UR, Noell TK, et al. Techniques and results of using microwaves and x-rays for the treatment of tumors in man. In Proceedings of the International Symposium on the Biological Effects of Electromagnetic Waves, Airlie, Virginia, October 1977 (Abstracts 5–7), p. 160.

    Google Scholar 

  17. Kim JH, Hahn EW. Clinical and biological studies of localized hyperthermia. Cancer Res 39:2258–2261, 1979.

    PubMed  CAS  Google Scholar 

  18. Marmor JB, Pounds D, Hahn GM. Clinical studies with ultrasound for the induction of localized hyperthermia. In Proceedings of the Third International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. J Natl Cancer Inst (Monograph) 61:333–337, 1982.

    CAS  Google Scholar 

  19. Storm FK, Morton DL, Kaiser LR, et al. Clinical radiofrequency hyperthermia: a review. In Proceedings of the Third Inernational Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation, J Natl Cancer Inst (Monograph) 61:343–350, 1982.

    CAS  Google Scholar 

  20. Storm FK, Harrison WH, Morton DL, et al. Human hyperthermia therapy: relationship between tumor type and capacity to induce hyperthermia by radiofrequency. Am J Surg 138:170–174, 1979.

    Article  PubMed  CAS  Google Scholar 

  21. Storm FK, Harrison WH, Morton DL, et al. Normal tissue and solid tumor effects of hyperthermia in animal models and clinical trials. Cancer Res 39:2245–2251, 1979.

    PubMed  CAS  Google Scholar 

  22. Storm FK, Elliott RS, Harrison WH, et al. Hyperthermia therapy for human neoplasma: thermal death time. Cancer 46:1849–1854, 1980.

    Article  PubMed  CAS  Google Scholar 

  23. Dickson JA. Hyperthermia and laboratory animal systems: chairman’s address. In Proceedings of the International Symposium on Cancer Therapy by Hyperthermia and Radiation. Washington, DC: Am Coll Rad Press, 1975, pp. 105–106.

    Google Scholar 

  24. Johnson HA, Pavelec M. Thermal enhancement of thiotepa toxicity. J Natl Cancer Inst 50: 903–910, 1973.

    PubMed  CAS  Google Scholar 

  25. Muckle DS, Dickson JA. Hyperthermia (42°C) as an adjuvant to radiotherapy and chemotherapy in the treatment of the allogenic VX2 carcinoma in the rabbit. Br J Cancer 27:307–315, 1973.

    Article  PubMed  CAS  Google Scholar 

  26. Hahn GM, Braun J, Har-Kedar I. Thermochemotherapy Surgery between hyperthermia (42–43°C) and adriamycin (or bleomycin) in mammalian cell inactivation. Proc Natl Acad Sci USA 72:937–940, 1975.

    Article  PubMed  CAS  Google Scholar 

  27. Albert DS, Peng Y-M, Chen GH-S, Moon TE, Cetas TC, Hoeschele JD. Therapeutic synergism of hyperthermia: cis-platin in a mouse tumor model. J Natl Cancer Inst 65:455–461, 1980.

    Google Scholar 

  28. Goss P, Parson PG. The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines. Cancer Res 37:152–156, 1977.

    PubMed  CAS  Google Scholar 

  29. Mann BD, Storm FK, Kern DH, Giuliano A, Morton DL. Predictive value of the clonogenic assay in the treatment of melanoma with DTIC and DTIC plus hyperthermia. Cancer 1389–94, 1983.

    Google Scholar 

  30. Storm FK, Sparks FC, Morton DL. Treatment of melanoma of the lower extremity with intralesional injection of bacille Calmette Guerin and hyperthermic perfusion. Surg Gynecol Obstet 149:17–21, 1979.

    PubMed  CAS  Google Scholar 

  31. Storm FK, Kaiser LR, Goodnight JE, et al. Thermochemotherapy for melanoma metastases in liver. Cancer 49:1243–1248, 1982.

    Article  PubMed  CAS  Google Scholar 

  32. Mann BD, Storm FK, Kern DH, Giuliano A, Morton DL. Predictive value of the clonogenic assay in the treatment of melanoma with DTIC and DTIC + hyperthermia. Proc Am Soc Clin Oncol 17:432, 1981.

    Google Scholar 

  33. Storm FK, Morton DL. Hyperthermia: adjunctive modality for hepatic infusion therapy. Sem Oncol 10:223–227, 1983.

    CAS  Google Scholar 

  34. Elliott RS, Harrison WH, Storm FK. Hyperthermia: electromagnetic heating of deep-seated tumors. IEEE Biomed Trans 29:61–64, 1982.

    Article  CAS  Google Scholar 

  35. Storm FK, Harrison WH, Elliott RS, Morton DL. Thermal distribution of magnetic-loop induction of hyperthermia in phantoms and animals. Intl J Rad Oncol Biol Physics 8:865–871, 1982.

    CAS  Google Scholar 

  36. Ramming KP, Sparks FC, Eilber FR, Morton DL. Management of hepatic metastases. Sem Oncol 4:71–80, 1977.

    CAS  Google Scholar 

  37. Healy JE. Vascular pattern in human metastatic liver tumors. Surg Gynecol Obstet 12:1187–1193, 1965.

    Google Scholar 

  38. Breedis C, Young G. Blood supply of neoplasms in the liver. Am J Path 30:969–986, 1954.

    PubMed  CAS  Google Scholar 

  39. Taylor J. The blood supply of colorectal liver metastases. Brit J Cancer 38:749–756, 1978.

    Article  PubMed  CAS  Google Scholar 

  40. Fortner JG. Current management of tumors in the liver. Surg Clin N Amer 54:469–472, 1977.

    Google Scholar 

  41. Ensminger WD, Gyves VW. Clinical pharmacology of hepatic artery chemotherapy. Sem Oncol 10:176–182, 1983.

    CAS  Google Scholar 

  42. Ensminger WD, Rosowsky A, Raso V, et al. A clinical pharmacological evaluation of hepatic arterial infusion of 5-fluoro-2-deoxouridine and 5-fluorouracil. Cancer Res 38:3784–3792, 1978.

    PubMed  CAS  Google Scholar 

  43. Ramming KP, Haskell CM, Tesler AS. Gastrointestinal tract neoplasm. In Cancer Treatment, Haskell Ch (ed). Philadelphia: WB Saunders, 1980, pp. 331–334.

    Google Scholar 

  44. Balch CM, Urist MM, Soong SJ, et al. A prospective Phase II clinical trial of continuous 5-FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 198:567–573, 1983.

    Article  PubMed  CAS  Google Scholar 

  45. Ensminger WD, Niederhuber J, Gyves J, et al. Effective control of liver metastases from colon cancer with an implantable system for hepatic arterial chemotherapy. Proc ASCO 1:94, 1982.

    Google Scholar 

  46. Adson M.A. Hepatic metastases and prospectives. Am J Radiol 140:696–700, 1983.

    Google Scholar 

  47. Lokich JJ. Hepatic artery infusion: present status and future perspectives. Semin Oncol 10: 249–250, 1983.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Surgical Oncology, UCLA School of Medicine, 9th Floor, Louis Factor Building, Los Angeles, CA, 90024, USA

    Kenneth P. Ramming M.D.

Authors
  1. Kenneth P. Ramming M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Kristian Storm
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Rita and Stanley H. Kaplan Cancer Center, New York University Medical Center, 550 First Avenue, New York, NY, 10016, USA

    Joseph C. Bottino M.D.  & Franco M. Muggia M.D.  & 

  2. Clinical Oncology Program, University of California,Irvine Medical Center, Orange, CA, 92668, USA

    Richard W. Opfell M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishing, Boston/Dordrecht/Lancaster

About this chapter

Cite this chapter

Ramming, K.P., Storm, F.K. (1985). Thermochemotherapy of Liver Metastases. In: Bottino, J.C., Opfell, R.W., Muggia, F.M. (eds) Liver Cancer. Developments in Oncology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2593-2_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2593-2_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9625-6

  • Online ISBN: 978-1-4613-2593-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation