Lipid Analysis of Aortic Tissue from Alloxan-Diabetic Rats

  • David M. Roth
  • Diane K. Reibel
  • Allan M. Lefer
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 46)


Diabetics exhibit a higher risk of developing cardiovascular disease than the normal population (1). Recently, alterations in the cardiovascular actions of the eicosanoids have been implicated in the vascular disorders associated with diabetes mellitus (2). In this regard, we have shown that vascular tissue from diabetic animals exhibits increased reactivity towards endoperoxide analogs (3), platelet produced eicosanoids (4) and leukotrienes (5). We have also shown that vascular tissue from diabetic rats develop altered production of prostacyclin (3) and leukotrienes (6).


Diabetic Group Diabetic Animal Aortic Ring Aortic Tissue Plasma Cholesterol Concentration 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • David M. Roth
  • Diane K. Reibel
  • Allan M. Lefer

There are no affiliations available

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