Abstract
Alterations in the normal electrophysiology of the cardiac cells causes arrythmias, the cellular mechanisms of which have been described in detail (1). Such alterations may result from changes in the extracellular ionic environment or may result from the abnormal alterations in the cardiac muscle cells. Myocardial sarcolemma regulates the ionic conductances, and specific factors affecting membrane systems that are responsible for the well recognised changes in ionic conductances and resulting disturbances of cardiac rhythm have been identified recently in relation to the ischemic myocardium. Sobel, Corr and associates (2,3,4), have emphasized the role of altered membrane phospholipid metabolism in the genesis of ischemia-induced arrythmias. Myocardial ischemia stimulates membrane phospholipid hydrolysis possibly due to theactivation of phospholipase A2. The resultant breakdown products, lysophosphoglycerides, have detergent like properties and exhibit marked effects on membrane integrity, their accumulation may be an important factor in the genesis of ventricular arrythmias.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wit AL, Bigger TJ Jr: Possible electrophysiological mechanisms for lethal arrythmias accompanying myocardial ischemia and infaraction. Circulation (51–52): 111.95–111.115.
Sobel BE, Corr PB, Robinson AK, Goldstein RA, Witkowski FX, Klein MS: Accumulation of lysophosphoglycerides with arrythmogenic properties in ischemic myocardium. J Clin Invest (62): 546–553, 1978.
Corr PB, Snyder DW, Lee BI, Gross RW, Kein R, Sobel RE: Pathophysiological concentrations of lysophosphatides and the slow response. Am J Physiol (243): H187-H195, 1982.
Gross RW, Corr PB, Lee BL, Saffitz JE, Crafford WA Jr, Sobel BE: Incorporation of radiolabeled lysophosphatidyl- choline into canine Purkinje fibers and ventricular muscle. Circ Res (51): 27–36, 1982.
Hoffman BF, Cranefield PF, Lepeschkin E, Surawiz B, Herrlich HC: Comparison of cardiac monophasic action potentials recorded by intracellular and suction electrode. Am J Physiol (196): 1297–1301, 1959.
Downer E, Janse MJ, Durrer D: The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart. Circulation (56): 217–224, 1977.
Russel DC, Oliver MF, Wojtczak J: Combined electrophysiological technique for assessment of the cellular basis of the early ventricular arrythmias. Lancet (1): 686–688, 1977.
Mascher D: Electrical and mechanical responses from ventricular muscle fibers after inactivation of the sodium carrying system. Pfluegers Arch (317): 359–372, 1970.
Kleber AG, Janse MJ, Van Capelle FJL, Durrer D: Mechanism and time-course of S-T and T-Q segment changes during acute regional myocardial ischemia in the pig heart determined by extracellular and intracellular recordings. Circ Res (42): 603–613, 1978.
Katz AM, Messineo FC: Lipid membrane interactions and the pathogenesis of ischemic damage in the myocardium. Circ Res (48): 1–16, 1981.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Juggi, J.S., Braveny, P., Mohan, S. (1985). Effects of Lysophosphatidylcholine on the Electrical and Mechanical Activity of Perfused Rat Heart. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pathogenesis of Stress-Induced Heart Disease. Developments in Cardiovascular Medicine, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2589-5_33
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2589-5_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9623-2
Online ISBN: 978-1-4613-2589-5
eBook Packages: Springer Book Archive