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A Histochemical Study of Long Term Changes in Myocardial Lipid Distribution Induced by Isoproterenol

  • S. R. Bawa
  • P. K. Singal
  • N. K. Relan
  • R. Kaur
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 46)

Abstract

It is now well established that administration of large doses of the synthetic catecholamine, isoproterenol, and the natural catecholamines, epinephrine or norepinephrine, produces myocardial hypertrophy and necrosis (1–3). This as well as myocardial changes due to an increase in sympathetic activity under a variety of conditions have been proposed to involve free radicals which by promoting lipid peroxidation in the hydrophobic region of the membrane (4–6) can lead to the reported intracellular Ca+ overload as well as exhaustion of high energy phosphates (7). Sequential increase and decrease in cAMP have also been suggested to occur during the genesis of catecholamine induced cardiomyopathy (8,9). All these mechanisms put forward to explain the toxic effects of catecholamines may not be mutually exclusive.

Keywords

Lipid Droplet Neutral Lipid Plasma Free Fatty Acid Myocardial Lipid Promote Lipid Peroxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • S. R. Bawa
    • 1
  • P. K. Singal
    • 2
  • N. K. Relan
    • 1
  • R. Kaur
    • 1
  1. 1.Department of BiophysicsPanjab UniversityChandigarhIndia
  2. 2.Department of PhysiologyUniversity of ManitobaWinnipegCanada

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