A Histochemical Study of Long Term Changes in Myocardial Lipid Distribution Induced by Isoproterenol
It is now well established that administration of large doses of the synthetic catecholamine, isoproterenol, and the natural catecholamines, epinephrine or norepinephrine, produces myocardial hypertrophy and necrosis (1–3). This as well as myocardial changes due to an increase in sympathetic activity under a variety of conditions have been proposed to involve free radicals which by promoting lipid peroxidation in the hydrophobic region of the membrane (4–6) can lead to the reported intracellular Ca+ overload as well as exhaustion of high energy phosphates (7). Sequential increase and decrease in cAMP have also been suggested to occur during the genesis of catecholamine induced cardiomyopathy (8,9). All these mechanisms put forward to explain the toxic effects of catecholamines may not be mutually exclusive.
KeywordsLipid Droplet Neutral Lipid Plasma Free Fatty Acid Myocardial Lipid Promote Lipid Peroxidation
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- 6.Singal PK, Kapur N, Beamish RE, Das PK, Dhalla NS: Antioxidant protection against epinephrine-induced arrhythmias. In, Beamish RE, Singal PK, Dhalla NS (eds). Stress and heart disease. Martinus Nijhoff Pub. Boston, USA, 1985 (In Press).Google Scholar
- 7.Fleckenstein A, Janke J, Doering HL, Leder O: Myocardial fiber necrosis due to intracellular Ca-overload: A new principle in cardiac pathophysiology. Recent Adv Stud Card Struct Metab (4) 563–580, 1974.Google Scholar
- 8.Bhagat B, Sullivan JM, Fischer VW, Nadel EM, Dhalla NS: cAMP activity and isoproterenol-induced myocardial injury in rats. Recent Adv Stud Card Struct Metab (12): 465–470, 1978.Google Scholar
- 11.Wartmann WB, Jennings RB, Yokoyama H., Clabaugh GF: Fatty change of the myocardium in early experimental infarction. AMA Arch Path (62): 318–323, 1956.Google Scholar
- 14.Muller E, Rotter W: Uber histologische Veranderungen beim akuten Hohentod. Beitr Path. Anat. (107): 156, 1942.Google Scholar
- 15.Rona G, Chappel CI, Blazs T, Gaudry R: An infaret-like myocardial lesion and other toxic manifestations produced by isoprotenerol in the rat. AMA Arch Path (67): 443–455, 1959.Google Scholar
- 16.Pearse AGE: Histochemistry — Theoratical and Applied Vol. 1. J & A Churchill Ltd. 1972.Google Scholar
- 17.Mallow S: Cold effect in rat: plasma and adipose tissue free fatty acids and adipose lipase. Am J Physiol (204): 157–164, 1962.Google Scholar
- 18.Mueller PS, Horwitz D: Plasma free fatty acid and blood glucose responses to analogues of norepinephrine in man. J Lipid Res (3): 251–255, 1962.Google Scholar
- 19.Regan TJ, Markov A, Khan MI, Jesrani MV, Oldewurtel HA, Ettinger PO: Myocardial ion and lipid changes during ischemia and catecholamine induced necrosis: Relation to regional blood flow. Rec Adv Stud Card Struct Metabol (1): 656–664, 1972.Google Scholar