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Thromboxane A2 and Prostaglandin I2 as Precipitating Factors of Vasospastic and Thrombotic Events in Coronary Artery Disease

  • T. Kuzuya
  • S. Hoshida
  • M. Yamagishi
  • M. Ohmori
  • H. Matsuda
  • M. Tada
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 46)

Abstract

Recent clinical evidence has indicated that during the active phase of coronary artery disease, coronary thrombosis and/or vasospasm could initiate the pathological events associated with angina pectoris and acute myocardial infarction (1). Platelet aggregates within the coronary circulation may exert their effects directly through machanical obstruction to blood flow, resulting in myocardial ischemic injury. In addition they may release thromboxane A2 (TXA2), a potent vasoconstrictor and platelet aggregating agent (2), thereby causing coronary vasospasm and myocardial ischemia. We have already shown that transcardiac TXA2 release is associated with the induction of myocardial ischemia in patients with angina pectoris (3).

Keywords

Angina Pectoris Coronary Sinus Anginal Attack Coronary Vasospasm Variant Angina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • T. Kuzuya
    • 1
  • S. Hoshida
    • 1
  • M. Yamagishi
    • 1
  • M. Ohmori
    • 1
  • H. Matsuda
    • 1
  • M. Tada
    • 1
  1. 1.Division of Cardiology, First Department of MedicineOsaka University School of MedicineOsaka 553Japan

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