Noradrenaline Induced Myocardiopathy in Normal and Hypercholesterolaemic Rhesus Monkeys
Acute stress is known to cause endogenous liberation of catecholamines which appear to produce myocardial injury through biochemical and pathological mechanisms (Friedberg, 1963; Schettler, 1970). To elaborate these changes in the human is not easy and, therefore, recourse to experimental studies on laboratory animals has been taken (Rona et al. 1959; Renaud and Godu, 1969; Bhattacharya et al. 1974; Johnsson et al. 1974; Sood and Chakravarti, 1976; Khuller et al. 1982). The present report describes the effects of noradrenaline infusion into normo or hypercholesterolaemic rhesus monkeys to elucidate the biochemical and pathological basis of the myocardial lesions produced.
KeywordsMyocardial Injury Heart Muscle Saline Infusion Control Monkey Intercalate Disc
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