Hormone-Induced Changes in Response to Drugs Affecting Cardiac Function and Metabolism
The metabolic and inotropic effects of catecholamines on the heart can be modified by several procedures, including altering the hormonal state of the animal or exposing the heart to drugs known to affect the disposition of sympathomimetic agents. Data from various laboratories, including our own, has shown that activation of Phosphorylase by catecholamines in hearts from rats pretreated with thyroid hormone is significantly greater than in hearts from euthyroid animals (1, 2, 3, 4, 5). Supersensitivity to the metabolic effects of catecholamines has also been demonstrated in hearts from diabetic animals. Using epinephrine (6) or isoproterenol (7, 8), several investigators showed an enhanced activation of Phosphorylase in hearts from rats with experimental diabetes.
KeywordsThyroid Hormone Control Diet Diabetic Animal Vagal Stimulation High Carbohydrate Diet
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