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Classification of 358 Cases of Acute Myeloid Leukemia by FAB Criteria: Analysis of Clinical and Morphologic Features

  • Michael Stanley
  • Robert W. McKenna
  • Gary Ellinger
  • Richard D. Brunning
Part of the Cancer Treatment and Research book series (CTAR, volume 26)

Abstract

In 1976, a new morphologic classification for the acute leukemias was proposed by a working committee of French, American, and British hematologists [1,2]. Since its introduction, the FAB classification has been widely accepted internationally because of its underlying logic and relative ease of application. It has served as the basis for classification in several studies evaluating the results of chemotherapy in acute myeloid leukemia (AML) [3–8].

Keywords

Acute Myeloid Leukemia Mitotic Count Serum Lysozyme Absolute Monocyte Count Acute Monocytic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposals for the classification of the acute leukaemias. Br J Haematol 33:451–458, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Gralnick HR, Galton DAG, Bennett JM, Catovsky D, Sultan C, Bennett JM: Classification of acute leukemia. Ann Intern Med 87:740–753, 1977.Google Scholar
  3. 3.
    Bennett JM, Begg CB: The cytochemistry of adult acute myeloid leukemia: correlation of subtypes with response and survival: an Eastern Cooperative Oncology Group Study. Cancer Res 3:271–283, 1981.Google Scholar
  4. 4.
    Bennett JM: The French-American-British Classification of the acute myeloid leukemias: its clinical relevance. In: Bloomfield CD (ed): Adult Leukemias. Boston, Martinus Nijoff Publishers, 1982, pp 109–125.CrossRefGoogle Scholar
  5. 5.
    Foon KA, Naiem F, Yale C, Gale RP: Acute myelogenous leukemia: Morphologic classification and response to therapy. Leuk Res 3:171–173, 1979.PubMedCrossRefGoogle Scholar
  6. 6.
    Mertelsmann R, Tzvi TT, To L, Gee TS, McKenzie S, Schauer P, Friedman A, Arlin Z, Cirrincione C, Clarkson B: Morphologic classification, response to therapy, and survival of 263 adult patients with acute nonlymphoblastic leukemia. Blood 56:773–781, 1980.PubMedGoogle Scholar
  7. 7.
    Passe S, Mike V, Mertelsmann R, Gee T, Clarkson BD: Acute nonlymphoblastic leukemia. Cancer 50:1462–1471, 1982.PubMedCrossRefGoogle Scholar
  8. 8.
    Sultan C, Deregnaucourt J, Ko YW, Imbert M, Ricard D’Agay MF, Gouaulf-Heilmann M, Brun B: Distribution of 250 cases of acute myeloid leukaemia (AML) according to to the FAB classification and response to therapy. Brit J Haematol 47:545–551, 1981.CrossRefGoogle Scholar
  9. 9.
    Kaplow LS: Simplified myeloperoxidase stain using benzidine dihydrochloride. Blood 26:215–219, 1965.PubMedGoogle Scholar
  10. 10.
    Yam LT, Li CY, Crosby WH: Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol 55:283–290, 1971.PubMedGoogle Scholar
  11. 11.
    Brynes RK, McKenna RW, Sundberg RD: Bone marrow aspiration and trephine biopsy. Am J Clin Pathol 70:753–759, 1978.PubMedGoogle Scholar
  12. 12.
    Parkin JL, McKenna RW, Brunning RD: Philadelphia chromosome-positive blastic leukaemia: ultrastructural and ultracytochemical evidence of basophil and mast cell differentiation. Brit J Haematol 52:665–677, 1982.CrossRefGoogle Scholar
  13. 13.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: The French-American-British (FAB) Cooperative Group: Proposals for the classification of the myelodysplastic syndromes. Brit J Haematol 51:189–199, 1982.Google Scholar
  14. 14.
    McKenna RW, Parkin J, Bloomfield CD, Sundberg RD, Brunning RD: Acute promyelocytic leukaemia (APL): A study of 39 cases with identification of a hyperbasophilic microgranular APL variant. Brit J Haematol 50:201–214, 1982.CrossRefGoogle Scholar
  15. 15.
    McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD: Acute monoblastic leukemia: Diagnosis and treatment of ten cases. Blood 45:481–494, 1978.Google Scholar
  16. 16.
    Sultan C, Imbert M, Richard ME, Sebaoun G, Marquet M, Brun B, Forgues L: Pure acute monocytic leukemia. Am J Clin Pathol 68:752–757, 1977.PubMedGoogle Scholar
  17. 17.
    Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau J-L, Schaison G, Boiron M, Bernard J: Acute monoblastic leukemia: A clinical and biological study of 74 cases. Blood 55:71–76, 1980.PubMedGoogle Scholar
  18. 18.
    Bennett JM: Personal communication.Google Scholar
  19. 19.
    Bloomfield CD, Brunning R: Prognostic significance of cytology in the acute leukemias. Human Pathol 5:641–659, 1974.CrossRefGoogle Scholar
  20. 20.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: A variant form of hypergranular promyelocytic leukaemia (M3). Brit J Haematol 44:169–170, 1980.CrossRefGoogle Scholar
  21. 21.
    Golomb HM, Rowley JD, Vardiman JW, Testa JR, Bulter A: ‘Microgranular’ acute promyelocytic leukemia: A distinct clinical, ultrastructural, and cytogenetic entity. Blood 55:253–259, 1980.PubMedGoogle Scholar
  22. 22.
    Arthur D, Bloomfield CD: Partial deletion of the long arm of chromosome 16 and bone marrow eos inophilia in acute nonlymphocytic leukemia: A new association. Blood 61:994–998, 1983.PubMedGoogle Scholar
  23. 23.
    Bitter MA, LeBau M, Larson R, et al: A morphologic and cytochemical study of acute myelomonocytic leukemia with abnormal eosinophils associated with Inv (16) (p13 q22). Am J Clin Pathol 81:733–741, 1984.PubMedGoogle Scholar
  24. 24.
    Dreyfus B: Preleukemic states I. Definition and classification II. Refractory anemia with an excess of myeloblasts in the bone marrow (smoldering acute leukemia). Blood Cells 2:33–43, 1976.Google Scholar
  25. 25.
    Foucar K, Langdon R, Carroll T: Clinicopathologic features of myelodysplastic syndromes. Lab Invest 50:21A, 1984.Google Scholar
  26. 26.
    Bennett JM: Leukemia Morphology and Cytochemistry, in Gunz FW and Henderson ES (eds) Leukemia, 4th ed. Grune & Stratton, NY, 1982, pp 463–474.Google Scholar
  27. 27.
    Peterson L, Dehner LP, Brunning RD: Extramedullar masses as presenting features of acute monoblastic leukemia. Am J Clin Pathol 75:140–148, 1981.PubMedGoogle Scholar
  28. 28.
    Breton-Gorius J, Reyes F, Verant J, Tulliez M, Dreyfus B: Megakaryoblastic acute leukemia: Identification by the ultrastructural demonstration of platelet peroxidase. Blood 51:45–60, 1978.PubMedGoogle Scholar
  29. 29.
    Bain BJ, Catovsky D, O’Brien M, Prentice HG, Lawlor R, Kumaran TO, McCann, SR, Matutes E, Galton DAG: Megakaryoblastic leukemia presenting as acute myelofibrosis — a study of four cases with platelet-peroxidase reaction. Blood 58:206–213, 1981.PubMedGoogle Scholar
  30. 30.
    Wick MR, Li CY, Pierre RV: Acute nonlymphocytic leukemia with basophilic differentiation. Blood 60:38–45, 1982.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • Michael Stanley
  • Robert W. McKenna
  • Gary Ellinger
  • Richard D. Brunning

There are no affiliations available

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