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Supportive therapy in haematology pp 245–256Cite as

Bone marrow transplantation (BMT)

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Abstract

The concept of bone marrow transplantation dates back to the 1950’s when Lorenz and Jacobson first showed that injections of marrow cells into irradiated mice could protect them against the effects of lethal irradiation [1].They have subsequently shown that the protective effect was due to viable bone marrow precursor cells engrafting in the irradiated animal and reconstituting new bone marrow.

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References

  1. Uphoff DE: Egm Lorenz — 30 years ago. In: Experimental Haematology Today, Baum SJ, Ledney GD, Thierfelder S (eds). Karger, Basel, 1982: 17–19.

    Google Scholar 

  2. Thomas ED: Marrow transplantation for patients with leukaemia. In: Experimental Haematology Today, Baum SJ, Ledney GD, Thierfelder S (eds). Karger, Basel, 1982: 137–46.

    Google Scholar 

  3. Hobbs JR: Bone marrow transplantation for inborn errors. Lancet, 1981; 2: 735–36.

    Article  PubMed  CAS  Google Scholar 

  4. Lucarelli G, Fliedner TM, Gale RP: Fetal liver transplantation: Current concepts and future directions. Proceedings of the first international symposium on foetal liver transplantation. Pisero, Italy. September, 1979. Elsevier/Excerpta Medica, Amsterdam, 1980.

    Google Scholar 

  5. de Koning J, v.d. Waay D, Vossen JM, Versprille A, Dooren U: Barrier nursing of an infant in a laminar cross-flow bench. Maandschrift voor Kindergeneeskunde, 1970; 38: 1–13.

    PubMed  Google Scholar 

  6. vd Waay D, Vossen JM, Hartgrinh CA, Nieweg HO: In: New Criteria for Antimicrobial Therapy, vd Waay D, Verhoef J (eds). Amsterdam, Excerpta Medica, 1979.

    Google Scholar 

  7. Camitta BM, Thomas ED, Nathan DG, Santos G, Gordon-Smith EC, Gale RP, Rappaport JM, Storb R: Severe aplastic anaemia prospective study of the effect of early marrow transplantation on acute mortality. Blood, 1976; 48: 63–70.

    PubMed  CAS  Google Scholar 

  8. Gluckman E, Devergie A, Poros A, Degoulet P: Results of immunosuppression in 170 cases of severe aplastic anaemia. Br J Haematol, 1982; 51: 541–50.

    Article  PubMed  CAS  Google Scholar 

  9. Gluckman E, Devergie A, Schaison G, Busse(A, Berger R, Sohier J, Bernard J: Bone marrow transplantation in Fanconi anaemia. Br J Haematol, 1980; 45: 557–64.

    Article  PubMed  CAS  Google Scholar 

  10. Storb R: In: Immunobiology of Bone Marrow Transplantation, Thierfelder S, Rodt H, Kolb HJ (eds). Berlin, Springer Verlag, 1980: 367.

    Google Scholar 

  11. Weiden PL, Sillivan KM, Flournoy N, et al.: Antileukaemic effect of chronic graft versus host disease contribution to improved survival after allogeneic marrow transplantation. N Eng J Med, 1981; 304: 1529–33.

    Article  CAS  Google Scholar 

  12. Clift RA, Hanson JA, Thomas ED, Buckner CD, Saunders JE, Mickelson EM, Storb R, Johnson FL, Singer JW, Goodell BW: Marrow transplantation from donors other than HLA identical siblings. Transplantation, 1979: 28: 235–42.

    Article  PubMed  CAS  Google Scholar 

  13. Powles RL, Morgenstern GR: Allogeneic bone marrow transplantation using mismatched family donors in Cyclosporin A, White D, Powles RL, Masters P (eds). Elsevier, Amsterdam, 1982: 539–44.

    Google Scholar 

  14. Gordon-Smith EC, Fairhead SM, Chipping PM, Howes J, James DCO, Dodi A, Batchelor JR: Bone marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors. Br Med J, 1982: 835–37.

    Google Scholar 

  15. Rodt H, Netzel B, Kolb HJ, Haas RJ, Wilms K, Link H, Bender Gotze C, Niethammer D, Wernet P, Janka G, Thierfelder S: Suppression of graft versus host disease by antisera-clinical results in 20 patients. In: Experimental Haematology Today, Baum SJ, Ledney GD, Thierfelder S (eds). Kager, Basel, 1982: 147–53.

    Google Scholar 

  16. Fillipovitch AH, McGlave PB, Ramsay MK, Goldstein G, Warkentin PL, Kerssy JH: Pretreatment of donor bone marrow with monoclonal antibody OKT3 for prevention of acute graft versus host disease in allogeneic histocompatible bone marrow transplantation. Lancet, 1982; 1: 327–31.

    Google Scholar 

  17. Reisner Y, Kapoor N, Kirkpatrick D, et al.: Transplantation for acute leukaemia with HLA A and B nonidentical parental marrow cells fractionated with soy bean agglutinin and sheep red blood cells. Lancet, 1981; 2: 327–31.

    Article  PubMed  CAS  Google Scholar 

  18. Saunders JE: Effect of cyclophosphamide and total body irradiation on ovarian and testicular function. Exp Haematol, 1982; 10 suppl. 11: 49.

    Google Scholar 

  19. Tutschka PJ, Santos GW, Elfenbein GJ: Marrow transplantation in acute leukaemia following Busulphan and Cyclophosphamide. In Immunobiology of bone marrow transplantation, Thierfelder S, Rodt H, Kolb H (eds). Springer Verlag, Berlin, 1980: 375–80.

    Google Scholar 

  20. U.C.L.A. Bone Marrow Transplantation Group: Bone marrow transplantation with intensive combination chemotherapy radiotherapy (SCARI) in acute leukaemia. An Int Med, 1977; 86: 155–61.

    Google Scholar 

  21. Gluckman E, Devergie A, Dutreix A, Dutreix J, Boiron M, Bernard J: Bone marrow grafting in aplastic anaemia after conditioning with cyclophosphamide and total body irradiation with lung shielding. In: Recent Trends in the Immunobiology of Bone Marrow Transplantation. Bergmann, Munich, 1980: 339–47.

    Google Scholar 

  22. Ramsay MKC, Kim T, Nesbitt ME, Krivit W, Coccia PF, Levitt SH, Woods WG, Kerssy JH: Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anaemia. Blood, 1980; 55: 344–46.

    PubMed  CAS  Google Scholar 

  23. Gale RP, Ho W, Feig S, Champlin R, Tesler A, Arranson E, Cadish S, et al.: Prevention of graft rejection following bone marrow transplantation. Blood, 1981; 57, 49: 165–75.

    Google Scholar 

  24. Powles RL, Clink H, Sloane J, Barrett AJ, Kay HEM, McElwain TJ: Cyclosporin A for the treatment of graft versus host disease in man. Lancet, 1978; 2: 1327–31.

    Article  PubMed  CAS  Google Scholar 

  25. Joss V, Rogers TR, Hugh-Jones K, et al.: A bone marrow transplant for metachromatic leucodystrophy. Exp Haematol Suppl, 1982; 10: 52–53.

    Google Scholar 

  26. Powles RL, Clink HM, Spence D, Barrett AJ, Jameson B, Kay HEM: Cyclosporin A to prevent graft versus host disease in man after allogeneic marrow transplantation. Lancet, 1980; 1: 327–29.

    Article  PubMed  CAS  Google Scholar 

  27. Ramsay MK, Kersey JH, Robson L, McGlave PB, Woods WG, Krivit W, Kim HT, Goldman A, Nesbitt M: A randomised study of the prevention of acute graft versus host disease. N Eng J Med, 1982; 306: 392–97.

    Article  CAS  Google Scholar 

  28. Barrett AJ, Kendra JR, Lucas CL, Joss V, Joshi R, Desai M, Pendharker P, Hugh-Jones K: Cyclosporin A as prophylaxis against graft versus host disease in 36 transplanted patients. Br Med J, 1982; 285: 162–66.

    Article  CAS  Google Scholar 

  29. Howes JM, Palmer S, Want S, Dearden D, Gordon-Smith EC: Serum levels of Cyclosporin A and nephrotoxicity in bone marrow transplant patients. Lancet, 1981; 2: 144–55.

    Google Scholar 

  30. Valman MB: Growth and fat absorption after resection of ileum in childhood. J Pediatr, 1976; 88: 41–45.

    Article  PubMed  CAS  Google Scholar 

  31. Fliedner TM, Gossner W, Patrick G. (eds): Late effects after therapeutic whole body irradiation. Report of the Commission of the European Countries (1982). EUCEP Symposium, August 1981. Munich.

    Google Scholar 

  32. Thomas ED, Buckner CD, Banaji M, et al.: One hundred patients with acute leukaemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation. Blood, 1977; 49: 511–33.

    PubMed  CAS  Google Scholar 

  33. Powles RL, Morgenstern GR, Clink H, et al.: The place of bone marrow transplantation in acute myeloid leukaemia. Lancet, 1980; 1: 1047–50.

    Article  PubMed  CAS  Google Scholar 

  34. Thomas ED, Buckner CD, Clift RA, Fefer A, Johnson FL, Neiman PE, et al.: Marrow transplantation for acute non lymphoblastic leukemia in first remission. N Eng J Med, 1979; 301: 597–99.

    Article  CAS  Google Scholar 

  35. Zwaan FE, Hermans J: For the European Bone Marrow Transplant group leukaemia working party: Allogeneic bone marrow transplantation for leukaemia–European results in 264 cases. Exp Haematol Rev, 1982; 12: 96–106.

    Google Scholar 

  36. Thomas ED, Saunders JE, Flournoy M, Johnson FL, Buckner CD, Clift RA, Fefer L, Goodell BW, Storb R, Weiden PL: Marrow transplantation for patients with acute lymphoblastic leukaemia in remission. Blood, 1979; 54: 465–78.

    Google Scholar 

  37. Barrett AJ, Kendra JR, Lucas CG, Joss DV, Joshi R, Desai M, Hugh-Jones K, Philips R, Rogers TR, Tabara Z,Williamson S, Hobbs JR: Bone marrow transplantation for acute lymphoblastic leukaemia. Br J Haematol, 1982; 52: 181–88.

    Article  PubMed  CAS  Google Scholar 

  38. Goldman JM: Modern approaches to the management of chronic granulocytic leukaemia. Semin Haemato1, 1978; 15: 420–30.

    CAS  Google Scholar 

  39. Clift RA, Buckner CD, Thomas ED, Doney K, Fefer A, Neiman P, Singer J, Saunders J, Stewart P, Sullivan KM, Deeg A, Storb R: Treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation. Lancet, 1982; 2: 612–25.

    Google Scholar 

  40. Goldman JM, Baugham ASJ, McCarthy DM, Worsley AM, Howes JM, Gordon-Smith EC, Catovski D, Batchelor MD, Goulden AWG, Galton DAG: Marrow transplantation for patients in the chronic phase of chronic granulocytic leukemia. Lancet, 1982; 2: 623–25.

    Article  PubMed  CAS  Google Scholar 

  41. Clift RA, Buckner CD, Thomas ED, Doney K, Fefer A, Neiman P, Singer J, Saunders J, Stewart P, Sullivan KM, Deeg A, Storb R: Treatment of chronic granulocytic leukaemia in chronic phase by allogeneic marrow transplantation. Lancet, 1982; 2: 621–22.

    Article  PubMed  CAS  Google Scholar 

  42. Storb R, Thomas ED, Weiden PL, et al.: One hundred patients with aplastic anaemia (AA) treated by marrow transplantation in Seattle. Transplant Proc, 1978; 10: 13540.

    Google Scholar 

  43. Gluckman E, Barrett AJ, Arcese W, Devergie A, Degoulet P: Bone marrow transplantation in severe aplastic anaemia: a survey of the European group for bone marrow transplantation (EG-BMT). Br J Haematol, 1981; 49: 165–73.

    Article  PubMed  CAS  Google Scholar 

  44. Ramsay NKC, Kim TH, McGlave PB, Nesbitt ME, Golman A, Krivit W, Woods WG, Kersey JH: Bone marrow transplantation for severe aplastic anaemia using the conditioning regimen of cyclophosphamide and total lymphoid irradiation. Exp Haematol Rev, 1982; 12: 139–42.

    Google Scholar 

  45. Speck B, Gratwohl A, Nissen C, et al.: Treatment of severe aplastic anaemia with antilymphocyte globulin or bone marrow transplantation. Br Med J, 1981; 282: 860–63.

    Article  CAS  Google Scholar 

  46. Bortin MM, Rimm AA: Severe combined immunodeficiency disease. JAMA, 1977; 238: 591–600.

    Article  PubMed  CAS  Google Scholar 

  47. Touraine JL: Foetal liver transplantation for severe combined immunodeficiency in Europe. Exp Haematol, 1982; 10: 40–45.

    Google Scholar 

  48. Hobbs JR, Hugh-Jones K, Barret AJ, Chambers D, James DCO, Byrom N, Henry K, et al.: Reversal of clinical features of Hurler’s Disease and biochemical improvement after treatment by bone marrow transplantation. Lancet, 1981; 2: 709–12.

    Article  PubMed  CAS  Google Scholar 

  49. Thomas ED, Buckner CD, Saunders J, Papyannopoulou T, Borgna CE, Stefano P, Sullivan KM, Clift RA, Storb R: Marrow transplantation for thalassaemia. Lancet, 1982; 2: 227–29.

    PubMed  CAS  Google Scholar 

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Authors
  1. A. J. Barrett
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  2. J. De Koning
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank, Groningen-Drenthe, The Netherlands

    P. C. Das  & C. Th. Smit Sibinga  & 

  2. Dept. of Haematology, University Hospital, Groningen, The Netherlands

    M. R. Halie

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© 1985 Martinus Nijhoff Publishers. Boston/Dordrecht/Lancaster

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Barrett, A.J., De Koning, J. (1985). Bone marrow transplantation (BMT). In: Das, P.C., Sibinga, C.T.S., Halie, M.R. (eds) Supportive therapy in haematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2577-2_23

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  • DOI: https://doi.org/10.1007/978-1-4613-2577-2_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9617-1

  • Online ISBN: 978-1-4613-2577-2

  • eBook Packages: Springer Book Archive

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