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Supportive therapy in haematology pp 199–208Cite as

Blood transfusion in sickle cell disease

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Abstract

Sickle cell disease is characterised by two basically independent but closely interrelated pathophysiological processes, haemolysis and vaso-occlusion. Polymerisation of deoxygenated sickle haemoglobin molecules leads to cell deformity and secondary membrane change. Such cells have a high internal viscosity and relatively inelastic membranes rendering them less likely to negotiate the small vessels in capillary beds. These processes bring about either destruction of the red cell itself or impairment of flow in a capillary bed with avascular necrosis of the tissue supplied.

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Authors
  1. G. R. Serjeant
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank, Groningen-Drenthe, The Netherlands

    P. C. Das  & C. Th. Smit Sibinga  & 

  2. Dept. of Haematology, University Hospital, Groningen, The Netherlands

    M. R. Halie

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© 1985 Martinus Nijhoff Publishers. Boston/Dordrecht/Lancaster

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Serjeant, G.R. (1985). Blood transfusion in sickle cell disease. In: Das, P.C., Sibinga, C.T.S., Halie, M.R. (eds) Supportive therapy in haematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2577-2_19

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  • DOI: https://doi.org/10.1007/978-1-4613-2577-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9617-1

  • Online ISBN: 978-1-4613-2577-2

  • eBook Packages: Springer Book Archive

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