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Malignant germ cell tumors of the ovary

  • Chapter
Ovarian Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 23))

Abstract

Malignant germ cell tumors of the ovary are those neoplasms derived from the primitive germ cells of the embryonic gonad. As a group they represent less than 5% of all ovarian malignancies [1]. Younger patients with ovarian tumors, however, have a much greater likelihood of having a malignant germ cell tumor [2, 3].

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References

  1. Weiss NS, Homonchuk T, Young JL: Incidence of the histologic type of ovarian cancer: the U.S. third national cancer survey, 1969–1971. Gynecol Oncol 5:161–167, 1977.

    Article  PubMed  CAS  Google Scholar 

  2. Abell MR, Johnson VJ, Holtz F: Ovarian neoplasms in childhood and adolescence I. — Tumors of germ cell origin. Am J Obstet Gynecol 92:1059–1081, 1965.

    PubMed  CAS  Google Scholar 

  3. Norris HJ, Jensen RD: Relative frequency of ovarian neoplasms in children and adolescents. Cancer 30:713–719, 1972.

    Article  PubMed  CAS  Google Scholar 

  4. Teilum G: Classification of endodermal sinus tumour (mesoblastoma vitellinum) and socalled ‘embryonal carcinoma’ of the ovary. Acta Pathol Microbiol cand 64:407–429, 1965.

    CAS  Google Scholar 

  5. Gillman J: The development of the gonads in man with consideration of the role of fetal endocrines and the histogenesis of ovarian tumors. Contrib Embryol 32:83–131, 1948.

    Google Scholar 

  6. Witschi E: Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. Contrib Embryol 32:69–80, 1948.

    Google Scholar 

  7. Teilum G: Homologous tumours in ovary and testis: contribution to classification of gonadal tumours. Acta Obstet Gynecol Scand 24:480–503, 1944.

    Article  Google Scholar 

  8. Teilum G: Gonocytoma: homologous ovarian and testicular tumours: 1: with discussion of ‘mesonephroma ovarii’ (Schiller: Amer J Cancer 1939). Acta Pathol Microbiol Scand 23:242–251, 1946.

    Article  Google Scholar 

  9. Friedman NB, Moore RA: Tumors of the testis. A report of 922 cases. Mil Surgeon 99:573–593, 1946.

    CAS  Google Scholar 

  10. Dixon FJ, Moore RA: Tumors of the Male Sex Organs. Atlas of Tumor Pathology, Sect. VIII, Fasc. 31b and 32. Washington, D.C., Armed Forces Institute of Pathology, 1952.

    Google Scholar 

  11. Serov SF, Scully Re, Sobin LH: Histological typing of ovarian tumors. International histological classification of tumors, No. 9. Geneva, World Health Organization, 1973.

    Google Scholar 

  12. Chenot M: Contribution à l’étude des épithélimoas primitifs de l’ovaire. Thesis, Paris, 1911.

    Google Scholar 

  13. Meyer R: The pathology of some special ovarian tumors and their relation to sex characteristics. Am J Obstet Gynecol 22:697–713, 1931.

    Google Scholar 

  14. Kurman RJ, Norris HJ: Endodermal sinus tumor of the ovary. A clinical and pathologic analysis of 71 cases. Cancer 38:2404–2419, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Kurman RJ, Norris HJ: Malignant germ cell tumors of the ovary. Hum Pathol 8:551–564, 1977.

    Article  PubMed  CAS  Google Scholar 

  16. Schiller W: Mesonephroma ovarii. Am J Cancer 35:1–21, 1939.

    Google Scholar 

  17. Teilum G: Endodermal sinus tumors of the ovary and testis, comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (Yolk-sac-allantoic) structures of the rat’s placenta. Cancer 12:1092–1105, 1959.

    Article  PubMed  CAS  Google Scholar 

  18. Teilum G: The concept of endodermal sinus (yolk sac) tumor. Scand J Immunol 8:75–89 (Suppl), 1978.

    Article  Google Scholar 

  19. Ballas M: Yolk sac carcinoma of ovary with alpha fetoprotein in the serum and ascitic fluid demonstrated by immunoosmophoresis. Am J Clin Pathol 57:511–516, 1972.

    PubMed  CAS  Google Scholar 

  20. Norgaard-Pedersen B, Albrechtesen R, Teilum G: Serum alpha-fetoprotein as a marker for endodermal sinus tumor (yolk sac tumor) or a vitelline component of teratocarcinoma. Acta Pathol microbiol Scand (A) 83:573–589, 1975.

    CAS  Google Scholar 

  21. Itoh T, Shirai T, Naka A, et al.: Yolk tumor and a-fetoprotein. Clinico-pathological study of four cases. Gan 65:215–226, 1974.

    Google Scholar 

  22. Talerman A, Haije WG: Alpha-fetoprotein and germ cell tumors: A possible role of yolk sac tumor in production of alpha-fetoprotein. Cancer 34:1722–1726, 1974.

    Article  PubMed  CAS  Google Scholar 

  23. Tsuchida Y, Saito S, Ishida M, et al.: Yolk sac tumor and alpha-fetoprotein. A report of three cases. Cancer 32:917–921, 1973.

    Article  PubMed  CAS  Google Scholar 

  24. Wilkinson EJ, Friedrich EG, Hosty TA: Alpha-fetoprotein and endodermal sinus tumor of the ovary. Am J Obstet Gynecol 116:711–714, 1973.

    PubMed  CAS  Google Scholar 

  25. Jimerson GK, Woodruff JD: Ovarian extraembryonal teratoma. Am J Obstet Gynecol 127:73–79, 1977.

    PubMed  CAS  Google Scholar 

  26. Gershenson DM, Del Junco G, Herson J, Rutledge FN: Endodermal sinus tumor of the ovary: The M.D. Anderson experience. Obstet Gynecol 61:194–202, 1983.

    PubMed  CAS  Google Scholar 

  27. Neubacker RD, Breen JL: Embryonal carcinoma of the ovary. Cancer 15:546–556, 1962.

    Article  Google Scholar 

  28. Smith JP, Rutledge FN: Advances in chemotherapy for gynecologic cancer. Cancer 36:669–674, 1975.

    Article  PubMed  CAS  Google Scholar 

  29. Kurman RJ, Norris HJ: Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. Cancer 38:2420–2433, 1976.

    Article  PubMed  CAS  Google Scholar 

  30. Kurman RJ, Scardino PT, Mclntire KR, Waldmann TA, Javadpour N, Norris HJ: Cellular localization of AFP and hCG in germ cell tumors of the testis and ovary. Scand J Immunol 8 (Supp 8) 127–130, 1978.

    Article  Google Scholar 

  31. Thurlbeck WM, Scully RE: Solid teratoma of the ovary — a clinicopathological analysis of 9 cases. Cancer 13:801–811, 1960.

    Article  Google Scholar 

  32. Robboy SJ, Scully RE: Ovarian teratoma with glial implants on the peritoneum. Hum Pathol 1:643–653, 1970.

    Article  PubMed  CAS  Google Scholar 

  33. Norris HJ, Zirkin HJ, Benson WL: Immature (malignant) teratoma of the ovary. Cancer 37:2359–2372, 1976.

    Article  PubMed  CAS  Google Scholar 

  34. Kurman RJ, Norris HJ: Malignant mixed germ cell tumors of the ovary. Obstet Gynecol 48:579–589, 1976.

    PubMed  Google Scholar 

  35. Mostofi FK, Price EB, Jr: Tumors of the male genital system. Atlas of Tumor Pathology, Series 2. Fascicle 8. Washington, D.C., Armed Forces Institute of Pathology, 1973.

    Google Scholar 

  36. Pick L: Epithelioma chorionektodermale. Berl Klin Schnschr 41:158–195, 1904.

    Google Scholar 

  37. Fox H, Langley FA: Tumours of the Ovary. London, England, William Heinemann Medical Books, 1976.

    Google Scholar 

  38. Gerbie MV, Brewer JI, Tamimi H: Primary choriocarcinoma of the ovary. Obstet Gynecol 46:720–723, 1975.

    PubMed  CAS  Google Scholar 

  39. Peyron A: Sur la présence des cellules génitales primordiales dans les boutons embryonnaires des embryomes parthénogénètiques chez l’homme. C R Acad Sci (D) (Paris), 206:1680–1683, 1938.

    Google Scholar 

  40. Peyron A: Faits nouveaux relatifs a l’origine et à l’histogenèse des embryomes. Bull Cancer (Paris) 28:658–681, 1939.

    Google Scholar 

  41. Beck JS, Fulmer HF, Lee ST: Solid malignant ovarian teratoma with ‘embryoid bodies’ and trophoblastic differentiation. J Pathol 99:67–73, 1969.

    Article  PubMed  CAS  Google Scholar 

  42. Nicod J-L: Phénomènes de parthénogenèse dans des tumeurs de l’homme. Bull Soc vaud de Sc Nat 62:495–505, 1945.

    Google Scholar 

  43. Simard LC: Tératôme malin de l’ovaire humain, d’origine parthénogénétique vraisemblable. Rev Canad de Biol 9:344–265, 1950.

    CAS  Google Scholar 

  44. Simard LC: Polyembryonic embryoma of the ovary of parthenogenetic origin. Cancer 10:215–223, 1957.

    Article  PubMed  CAS  Google Scholar 

  45. Breen JL, Neubecker RK: Malignant teratoma of the ovary: An analysis of 17 cases. Obstet Gynecol 21:669–681, 1963.

    PubMed  CAS  Google Scholar 

  46. Marin-Padilla M: Origin, nature and significance of the ‘embryoids’ of human teratoma. Virchow’s Arch Pathol Anat Physiol 340:105–121, 1965.

    Article  CAS  Google Scholar 

  47. Takeda A, Ishizuka T, Goto T, et al.: Polyembryoma of ovary producing alpha-fetoprotein and HCG: Immunoperoxidase and electron microscopic study. Cancer 49:1878–1889, 1982.

    Article  PubMed  CAS  Google Scholar 

  48. Scully RE: Gonadoblastoma. A gonadal tumor related to dysgerminoma (seminoma) and capable of sex hromone production. Cancer 6:445–463, 1953.

    Article  Google Scholar 

  49. Andrews J: Streak gonads and the Y chromosome. J Obstet Gynaecol Brit Vommonw 78:448–457, 1971.

    Article  CAS  Google Scholar 

  50. Teter J: Rare gonadal tumors occurring in intersexes and their classification. Int J Gynaecol Obstet 7:183–187, 1969.

    Google Scholar 

  51. Teter J, Bozkowski K: Occurrence of tumors in dysgenetic gonads. Cancer 20:1301–1310, 1967.

    Article  PubMed  CAS  Google Scholar 

  52. Talerman A: Gonadoblastoma associated with embryonal carcinoma. Obstet Gynecol 43:138–142, 1974.

    PubMed  CAS  Google Scholar 

  53. Manuel M, Katayama KP, Jones HW: The age of occurrence of gonadal tumors in intersex patients with a y chromosome. Am J Obstet Gynecol 124:293–300, 1970.

    Google Scholar 

  54. Szokol M, Kondrai G, Papp Z: Gonadal malignancy and 46, XY karyotype in a true hermaphrodite. Obstet Gynecol 49:358–360, 1977.

    PubMed  CAS  Google Scholar 

  55. Hart WR, Burkons DM: Germ cell neoplasms arising in gonadoblastomas. Cancer 43:669–678, 1979.

    Article  PubMed  CAS  Google Scholar 

  56. Schwartz IS, Cohen CJ, Deligdisch L: Dysgerminoma of the ovary associated with true hermaphroditism. Obstet Gynecol 56:102–106, 1980.

    PubMed  CAS  Google Scholar 

  57. Szamborski J, Obrebske T, Starzynska J: Germ cell tumors in monozygous twins with gonadal dysgenesis and 46, XY karyotype Obstet Gynecol 58:120–122, 1981.

    CAS  Google Scholar 

  58. Talerman A, Jarabak J, Amarose AP: Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46, XX karyotype. Am J Obstet Gynecol 140:475–477, 1981.

    PubMed  CAS  Google Scholar 

  59. Luzzato R, Murray JM, Gallagher HS: Gonadoblastoma associated with malignant teratoma. South Med J 72:624–627, 1979.

    Article  Google Scholar 

  60. Schellhas HF, Trujillo JM, Rutledge FN, Cork A: Germ cell tumors associated with XY gonadal dysgenesis. Am J Obstet Gynecol 109:1197–1204, 1971.

    PubMed  CAS  Google Scholar 

  61. van Camperhout J, Lord J, Lanthier A, Berard M: The phenotype and gonadal histology in WO/WY mosaic individuals: report of 2 personal cases. J Obstet Gynaecol Br Commonw 76:631–639, 1969.

    Article  Google Scholar 

  62. Ascheim S, Zondek B: Die schangerschafts diagnose aus dem Hern durch nachweis des Hypophysernvonderslappen — hormons. Klin Wochenschr 7:1404–1414, 1928.

    Article  Google Scholar 

  63. Hobson B, Wide L: The immunological and biological activity of human chorionic gonadotropin in urine. Acta Endocrinol. (Kbh.) 46:632–638, 1964.

    CAS  Google Scholar 

  64. Vaitukaitis JL, Braunstein GD, Ross GT: A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol 113:751–758, 1972.

    PubMed  CAS  Google Scholar 

  65. Bergstrand CG, Czar Bb: Demonstration of a new protein fraction in serum from human fetus. Scand J Lab Invest 8:174–178, 1956.

    Article  CAS  Google Scholar 

  66. Abelev GI, Perova SD, Khramkova NI, Postnikova A, Irlin IS: Production of embryonal alpha-globulin by transplantable mouse hepatomas. Transplant Bull 1:174–180, 1963.

    Article  CAS  Google Scholar 

  67. Tatarinov YS: Detection of embryospecific alpha-globulin in the blood sera of patients with primary liver tumor. Vopr Med Khim 10:90–91, 1964.

    PubMed  CAS  Google Scholar 

  68. Gitlin D, Perricelli A, Gitlin GM: Synthesis of alpha-fetoprotein by liver, Yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 32:979–982, 1972.

    PubMed  CAS  Google Scholar 

  69. Abelev GI: Alpha-fetoprotein as a marker of embryospecific differentiations in normal and tumor tissues. Transplant Rev 20:3–37, 1974.

    PubMed  CAS  Google Scholar 

  70. Gershenson DM, Del Junco G, Copeland LJ, Rutledge FN: Rare Germ cell tumors of the ovary: the M.D. Anderson experience (in press)..

    Google Scholar 

  71. Ueda G, Hamanaka N, Hayakawa K, et al.: Clinical, histochemical, and biochemical studies of an ovarian dysgerminoma with trophoblasts and Leydig cells. Am J Obstet Gynecol 114:748–754, 1972.

    PubMed  Google Scholar 

  72. Case Records of the Massachusetts general Hospital (Case 11–1972). New Engl J Med 286:594–600, 1972.

    Google Scholar 

  73. Bahari CM, Lurio M, Schoenfeld A, et al.: Ovarian teratoma with peritoneal gliomatosis and elevated serum alpha-fetoprotein. Am J Clin Pathol 73:603–607, 1980.

    PubMed  CAS  Google Scholar 

  74. Dizerga G, Acosta A, Kaufman RH, et al.: Solid teratoma of the ovary. Gynecol Oncol 3:93–102, 1975.

    Article  Google Scholar 

  75. Esterhay PJ, Shamiro HM, Sutherland JC, et al.: Serum alpha-fetoprotein concentration and tumor growth disassociation in a patient with ovarian teratocarcinoma. Cancer 31:835–839, 1973.

    Article  PubMed  Google Scholar 

  76. Masopeust J, Kithiei K, Radl J, et al.: Occurrence of fetoprotein in patients with neoplasms and non-neoplastic disease. Int J Cancer 3:364–373, 1968.

    Article  Google Scholar 

  77. Mawas C, Kohen M, Lemerle J, et al.: Serum α fetoprotein (fetuin) In children with malignant ovarian or testicular teratomas. Preliminary results. Int J Cancer 4:76–79, 1969.

    Article  PubMed  CAS  Google Scholar 

  78. Lippert MC, Javadpour N: Lactic dehydrogenase in the monitoring and prognosis of testicular cancer. Cancer 48:2274–2278, 1981.

    Article  PubMed  CAS  Google Scholar 

  79. Liu F, Fritsche HA, Trujillo JM, Samuels ML: Serum lactate dehydrogenase isoenzyme I in patients with advanced testicular cancer, (in press).

    Google Scholar 

  80. Zondag HA: Enzyme activity in dysgerminoma and seminoma. A study of Lactic dehydrogenase isoenzymes in malignant diseases (The 1963 Fiske Essay). Rhode Island Med J 47:273–281, 1964.

    PubMed  CAS  Google Scholar 

  81. Sheiko MC, Hart WRb: Ovarian germinoma (dysgerminoma) with elevated serum lactic dehydrogenase: case report and review of literature. Cancer 549:994–998, 1982.

    Article  Google Scholar 

  82. Awais GM: Dysgerminoma and serum lactic dehydrogenase levels. Obstet Gynecol 62:99–101, 1983.

    Google Scholar 

  83. Asadourian LA, Taylor HB: Dysgerminoma. An analysis of 105 cases. Obstet Gynecol 33:370–379, 1969.

    Article  PubMed  Google Scholar 

  84. Mueller CW, Topkins P, Lapp WA: Dysgerminoma of the ovary. An analysis of 427 cases. Am J Obstet Gynecol 60:153–159, 1950.

    PubMed  CAS  Google Scholar 

  85. Santesson L: Clinical and pathological survey of ovarian tumours treated at the Radiumhemmet. 1. Dysgerminoma. Acta Radiol (Stockholm) 28:643–668, 1947.

    Google Scholar 

  86. De Palo G, Pilotti S, Kenda R, et al.: Natural history of dysgerminoma. Am J Obstet Gynecol 143:799–807, 1982.

    PubMed  Google Scholar 

  87. Lucraft HH: A review of thirty-three cases of ovarian dysgerminoma emphasising the role of radiotherapy. Clin Radiol 30:585–589, 1979.

    Article  PubMed  CAS  Google Scholar 

  88. Gordon A, Lipton D, Woodruff JD: Dysgerminoma: a review of 158 cases from the Emil Novak ovarian tumor registry. Obstet Gynecol 58:497–504, 1981.

    PubMed  CAS  Google Scholar 

  89. Talerman A, Huyzinga WT, Kuipers T: Dysgerminoma clinicopathologic study of 22 cases Obstet Gynecol 41:137–147, 1973.

    PubMed  CAS  Google Scholar 

  90. Felmus LB, Pedowitz P: Clinical malignancy of endocrine tumors of the ovary and dysgerminoma. Obstet Gynecol 29:344–350, 1967.

    PubMed  CAS  Google Scholar 

  91. Brody S: Clinical aspects of dysgerminoma of the ovary. Acta Radiol (Stockholm) 56:209–230, 1961.

    Article  CAS  Google Scholar 

  92. Thoeny RH, Dockerty MB, Hunt AB, CHilds DS Jr: Study of ovarian dysgerminoma with emphasis on the role of radiation therapy. Surg Gynecol Obstet 113:692–698, 1961.

    PubMed  CAS  Google Scholar 

  93. Malkasian GD, Symmonds RE: Treatment of the unilateral encapsulated ovarian disgerminoma. Am J Obstet Gynecol 90:379–382, 1964.

    PubMed  Google Scholar 

  94. Afridi MA, Vongtama V, Tsukada Y, Piver MS: Dysgerminoma of the ovary: radiation therapy for recurrence and metastases. Am J Obstet Gynecol 126:180–194, 1976.

    Google Scholar 

  95. Burkons DM, Hart WR: Ovarian germinomas (dysgerminomas). Obstet Gynecol 51:221–224, 1978.

    PubMed  CAS  Google Scholar 

  96. Krepart G, Smith JP, Rutledge F, Delclos L: The treatment for dysgerminoma of the ovary. Cancer 41:986–990, 1978.

    Article  PubMed  CAS  Google Scholar 

  97. Boyes DA, Pankratz E, Galliford BW, et al.: Experience with dysgerminomas at the cancer control agency of british Columbia. Gynecol Oncol 6:123–129, 1978.

    Article  PubMed  CAS  Google Scholar 

  98. Pedowitz P, Felmus LB, Grayzel DM: Dysgerminoma of the ovary. Prognosis and treatment. Am J Obstet Gynecol 70:1284–1297, 1955.

    PubMed  CAS  Google Scholar 

  99. Freel JH, Cassir JF, Pierce VK, et al.: Dysgerminoma of the ovary. Cancer 43:798–805, 1979.

    Article  PubMed  CAS  Google Scholar 

  100. Delclos L, Dembo AJ: Ovaries. In: Fletcher GH (ed), Textbook of Radiotherapy, 3rd edn, Philadelphia, Lea & Febiger, 1980, pp 834–851.

    Google Scholar 

  101. Creasman WT, Fetter BF, Hammond CB, Parker RT: Germ cell malignancies of the ovary. Obstet Gynecol 53:226–230, 1979.

    PubMed  CAS  Google Scholar 

  102. Cohen SM, Goldsmith MA: Case Report. Prolonged chemotherapeutic remission of metastatic ovarian dysterminoma. Report of a case. Gynec Oncol 5:299–304, 1977.

    Article  CAS  Google Scholar 

  103. Weinblatt ME, Ortega JA: Treatment of children with dysgerminoma of the ovary. Cancer 49:2608–2611, 1982.

    Article  PubMed  CAS  Google Scholar 

  104. Newlands ES, Begent RHJ, Rustin GJS, Bagshawe KD: Potential for cure in metastatic ovarian teratomas and dysgerminomas. Brit J Obstet Gynecol 89:555–560, 1982.

    Article  CAS  Google Scholar 

  105. Einhorn LH: Chemotherapy of metastatic seminoma. In: Testicular Tumors: Management and treatment, New York, Masson Publishers, 1980, pp 151–167.

    Google Scholar 

  106. Simon SD, Srougi M, Goes GM: Treatment of advanced seminoma with vinvlastine (VBL), actinomycin D (AcD), cyclophosphamide (CTX), bleomycin (BLEO) and cis-platinum (CPDD). Proc Am Soc Clin Oncol 2:132, 1983 (C-517).

    Google Scholar 

  107. Samuels ML, Logothetis CJ: Follow-up study of sequential weekly pulse-dose cis-platinum for far-advanced seminoma. Proc Am Soc Clin Oncol 2:137, 1983 (C-535).

    Google Scholar 

  108. Stanton GF, Bosl GJ, Vugrin D, et al.: Treatment of patients (pts) with advanced seminoma with cyclophosphamide, belomycin, actinomycin D, vinblastine, and cisplatin (VAB-6). Proc Am Soc Clin Oncol 2:141, 1983 (C-551).

    Google Scholar 

  109. Dougherty CM, Lund CJ: Solid ovarian tumors complicating pregnancy. Am J Obstet Gynecol 60:261–272, 1950.

    PubMed  CAS  Google Scholar 

  110. Creasman WT, Rutledge F, Smith JP: Carcinoma of the ovary associated with pregnancy. Obstet Gynecol 38:111–116, 1971.

    PubMed  CAS  Google Scholar 

  111. Novak ER, Lambrou CD, Woodruff JD: Ovarian tumors in pregnancy. Obstet Gynecol 46:401–406, 1975.

    PubMed  CAS  Google Scholar 

  112. Karlen JR, Akbari A, Cook WA: Dysgerminoma associated with pregnancy. Obstet Gynecol 53:330–335, 1979.

    PubMed  CAS  Google Scholar 

  113. Gershenson DM, Del Junco G, Copeland LJ, Rutledge FN: Mixed germ germ cell tumors of the ovary: the M.D. Anderson experience (in press).

    Google Scholar 

  114. Gallion H, Van Nagell JR, Jr, Powell DF et al.: Therapy of endodermal sinus tumor of the ovary. Am J Obstet Gynecol 135:447–451, 1979.

    PubMed  CAS  Google Scholar 

  115. Jimerson GK, Woodruff JD: Ovarian extraembryonal teratoma II. Endodermal sinus tumor mixed with other germ cell tumors. Am J Obstet Gynecol 127:302–304, 1977.

    PubMed  CAS  Google Scholar 

  116. Forney JP, DiSaia PJ, Morrow CP: Endodermal sinus tumor. A report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil, and cyclophosphamide. Obstet Gynecol 45:186–189, 1975.

    PubMed  CAS  Google Scholar 

  117. Karlen JR, Kastelic JE: Endodermal sinus tumor of the ovary: an improving prognosis. Gynecol Oncol 10:206–216, 1980.

    Article  PubMed  CAS  Google Scholar 

  118. Wider JA, Marshall JR, Bardin W, et al.: Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma. N Engl J Med 280:1439–1442, 1969.

    Article  PubMed  CAS  Google Scholar 

  119. Goldstein DP, Piro AJ: Combination chemotherapy in the treatment of germ cell tumors containing choriocarcinoma in males and females. Surg Gynecol Obstet 134:61–66, 1972.

    PubMed  CAS  Google Scholar 

  120. Slayton RE, Hreshchyshun MM, Silverberg SG, et al.: Treatment of malignant ovarian germ cell tumors. Response to vincristine, dactinomycin, and cyclophosphamide (preliminary report). Cancer 42:390–398, 1978.

    Article  PubMed  CAS  Google Scholar 

  121. Curry SL, Smith JP, Gallagher HS: Malignant teratoma of the ovary: prognostic factors and treatment. Am J obstet Gynecol 131:845–849, 1978.

    PubMed  CAS  Google Scholar 

  122. Cangir A, Smith J, van Eys J: Improved prognosis in children with ovarian cancers following modified VAC (vincristine sulfate, dactinomycin, and cyclophosphamide) chemotherapy. Cancer 42:1234–1238, 1978.

    Article  PubMed  CAS  Google Scholar 

  123. Samuels ML, Holoye PY, Johnson DE: Bleomycin combination chemotherapy in the management of testicular neoplasia. Cancer 36:318–326, 1975.

    Article  PubMed  CAS  Google Scholar 

  124. Einhorn LH, Donohue J: Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87:293–298, 1977.

    PubMed  CAS  Google Scholar 

  125. Julian CG, Barrett JM, Richardson RL, et al.: Bleomycin, vinblastine, and cis-platinum in the treatment of advanced endodermal sinus tumor. Obstet Gynecol 56:396–401, 1979.

    Google Scholar 

  126. Lokey JL, Baker JJ, Prince NA, et al.: Cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovary. Ann Intern Med 94:56–57, 1981.

    PubMed  CAS  Google Scholar 

  127. Williams S, Slayton R, Silverberg S, et al.: Response of malignant ovarian germ cell tumors to cis-platinum, vinblastine, and bleomycin (PVB). Proc Am Assoc Cancer Res and Am Soc Clin Oncol 22:463, 1981 (C-509).

    Google Scholar 

  128. Jacobs AJ, Harris M, Deppe G, et al.: Treatment of recurrent germ cell tumors with cisplatin, vinblastine, and bleomycin. Obstet Gynecol 59:129–132, 1982.

    PubMed  CAS  Google Scholar 

  129. Wiltshaw E, Stuart-Harris R, Barker GH, et al.: Chemotherapy of endodermal sinus tumour (yolk sac tumor) of the ovary: preliminary communication. J R Soc Med 75:888–892, 1982.

    PubMed  CAS  Google Scholar 

  130. Carlson RW Sikic BI, Turbow A, et al.: Cisplatin, vinblastine, and bleomycin (PVB) therapy for ovarian germ cell cancers. Proc Am Soc Clin Oncol 2:156, 1983 (C-609).

    Google Scholar 

  131. Berkson J, Gage RP: Survival curve for cancer patients following treatment. J Am Stat Assoc 47:501Ê515, 1952.

    Article  Google Scholar 

  132. Samuels ML, Johnson DE, Holoye PY: Continuous intravenous bleomycin therapy with vinblastine in stage III testicular neoplasia. Cancer Chemother Rep 59:563–570, 1975.

    PubMed  CAS  Google Scholar 

  133. DiSaia PH, Saltz A, Kagan AR, Morrow CP: Chemotherapeutic retroconversion of immature teratoma of the ovary. Obstet Gynecol 49:346–350, 1977.

    PubMed  CAS  Google Scholar 

  134. Horning SJ, Hoppe RT, Kaplan HS, et al.: Female reproductive potential after treatment for hodgkin’s disease. N Engl J Med 304:1377–1382, 1981.

    Article  PubMed  CAS  Google Scholar 

  135. Warne GL, Fairley KF, Hobbs JB, Martin FIR: Cyclophosphamide-induced ovarian failure. N Engl J Med 289:1159–1162, 1973.

    Article  PubMed  CAS  Google Scholar 

  136. Sisis ES, Leventhal BG, Vaitukaitis JL: Effects of childhood leukemia and chemotherapy on puberty and reproductive function in girls. N Engl J Med 294:1143–1146, 1976.

    Article  Google Scholar 

  137. Blatt J, Poplack DG, Sherins RJ: Testicular function in boys after chemotherapy for acute lymphoblastic leukemia. N Engl J Med 304:1121–1124, 1981.

    Article  PubMed  CAS  Google Scholar 

  138. Stillman RJ, Schinfeld JS, Schiff I, et al.: Ovarian failure in long-term survivors of childhood malignancy. Am J Obstet Gynecol 139:62–66, 1981.

    PubMed  CAS  Google Scholar 

  139. Forney JP: Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. Obstet gynecol 52:360–364, 1978.

    PubMed  CAS  Google Scholar 

  140. Holmes GE, Holmes FF: Pregnancy outcome of patients treated for Hodgkin’s Disease: a controlled study. Cancer 41:1317–1322, 1978.

    Article  PubMed  CAS  Google Scholar 

  141. Javaheri G, Lifschez A, Valle J: Pregnancy following removel of and long-term chemotherapy for ovarian malignant teratoma. Obstet Gynecol 61:85–95, 1983.

    Google Scholar 

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© 1985 Martinus Nijhoff Publishers, Boston

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Gershenson, D.M., Wharton, J.T. (1985). Malignant germ cell tumors of the ovary. In: Alberts, D.S., Surwit, E.A. (eds) Ovarian Cancer. Cancer Treatment and Research, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2561-1_11

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  • DOI: https://doi.org/10.1007/978-1-4613-2561-1_11

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