The Use of Radiolabeled Antibodies for the Localisation of Tumours

  • A. R. Bradwell
Part of the Developments in Oncology book series (DION, volume 21)

Abstract

Tumour diagnosis is becoming increasingly dependent on the use of serum and tissue markers. These are usually proteins produced in excess by malignant cells that may be used to identify malignant tissue. It was soon realised that antibodies against these proteins could specifically identify tumour tissue in histological sections and more recently, with attached radiolabels, could be used for in vivo tumour localisation (known as radioimmunodetection—RAID—or radioimmunolocalisation—RIL). The appeal of the technique is that tumours are localised on the basis of specific biochemical substances rather than on general characteristics such as density (CT scanning, etc.). RAID has been particularly applied to tumours of the gastrointestinal tract and other organs producing carcinoembryonic antigen, germ cell tissues producing alphafetoprotein or chorionic gonadotrophin, and a variety of rarer tumours. Although at present there is no definitive use for RAID, new developments suggest that its sensitivity will improve and its application will become important. This chapter describes the theory and development of the technique, clinical results to date, and future areas of development.

Keywords

Iodine Radionuclide Sarcoma Neurol Macromolecule 

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© Martinus Nijhoff Publishing, Boston/Dordrecht/Lancaster 1985

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  • A. R. Bradwell

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