Autoantibodies to Nonhistone Nuclear Antigens

Their Immunobiology and Clinical Relevance
  • Gordon C. Sharp
  • Margaret A. Alspaugh


In the absence of precise etiologic and pathogenetic information, the diagnosis of the rheumatic diseases is based on a combination of clinical, laboratory, and pathological features. Serologic findings have assumed increasing diagnostic importance since the discovery by Hargraves et al. (1948) of the LE cell, the forerunner of the antinuclear antibodies. Subsequent studies by Holman and Kunkel (1957) showed that the LE cell phenomenon was caused by a circulating autoantibody reacting with autologous nuclear material (DNA-histone). More recently, the widely used indirect immunofluorescent test has served as a sensitive screening test and has revealed the presence of circulating autoantibodies to nuclear antigens (ANA) in systemic rheumatic diseases such as systemic lupus erythematosus (SLE), progressive systemic sclerosis or scleroderma (PSS), mixed connective tissue disease (MCTD), Sjogren’s syndrome, and poly/dermatomyositis.


Systemic Lupus Erythematosus Nuclear Antigen Antinuclear Antibody Progressive Systemic Sclerosis Undifferentiated Connective Tissue Disease 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Gordon C. Sharp
    • 1
  • Margaret A. Alspaugh
    • 1
  1. 1.Department of Medicine and PathologyUniversity of Missouri-Columbia, School of Medicine and Cancer Research CenterColumbiaUSA

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