Macrophages and Dendritic Cells in Rheumatic Diseases

  • Øystein Førre
  • Kristian Waalen
  • Jørn Thoen
  • Torstein Hovig


The normal synovial membrane is lined by a double layer of synovial lining cells, which form a multilayer in the rheumatoid synovial membrane. The synovial lining cells have previously been classified according to electron microscopic criteria as A and C cells, which have macrophage characteristics, and B cells, which have fibroblast characteristics. This classification has recently been confirmed using monoclonal antibodies specific for monocyte/macrophage and fibroblast antigens.


Rheumatoid Arthritis Dendritic Cell Synovial Tissue Synovial Cell Accessory Cell 
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  1. Bach, J. F. (ed.), 1975, The Mode of Action of Immunosuppressive Agents, North-Holland/American Elsevier, New York, pp. 93–225.Google Scholar
  2. Baggiolini, M., 1981, Exportable enzymes of phagocytes, Scand. J. Rheumatol. Suppl. 40:42–45.PubMedGoogle Scholar
  3. Balfour, B. M., Drexhage, H. A., Kamperdick, E. W. A., and Hoefsmith, E. M., 1981, Antigen-presenting cells, including Lagerhans cells, veiled cells and interdigitating cells in microenvironments in haemopoietic and lymphoid differentiation, Ciba Found. Symp. 84:281–301.PubMedGoogle Scholar
  4. Barland, P., Novikoff, A. B., and Hamerman, D., 1962, Electron microscopy of the human synovial membrane, J. Cell. Biol. 14:207–212.PubMedGoogle Scholar
  5. Bergholtz, B. D., Thoreson, A. B., and Thorsby, E., 1980, HLA-D/DR restriction of macrophage dependent antigen activation of immune T lymphocytes:Cross-reacting allogeneic HLA-D/DR may partly substitute for self HLA-D/DR, Scand. J. Immunol. 11:541–548.PubMedGoogle Scholar
  6. Berle, E. J., Braathen, L. R., and Thorsby, E., 1982, HLA-D/DR restriction of Langerhans cell-dependent antigen activation of T lymphocytes. The same D/DR determinants are restriction elements on monocytes and Langerhans cells, Scand. J. Immunol. 16:549–552.PubMedGoogle Scholar
  7. Bomey, R. J., Wightman, P. D., Dahlgren, M. E., Humes, J. L., and Davies, P., 1981, The pathways of biosynthesis for prostaglandins by the stimulus triggered macrophage, Scand. J. Rheumatol. Suppl. 40:53–57.Google Scholar
  8. Braathen, L. R., and Thorsby, E., 1980, Studies on human epidermal Langerhans cells, Scand. J. Immunol. 11:401–408.PubMedGoogle Scholar
  9. Brune, K., 1982, Prostaglandins, inflammation and antiinflammatory drugs, Eur. J. Rheum. Inflam. 5:335–349.Google Scholar
  10. Burmeister, G. R., Dimitriu-Bona, A., Waters, S. J., and Winchester, R. J., 1983a, Identification of three major synovial lining cell populations by monoclonal antibodies directed to la antigens and antigens associated with monocytes/macrophages and fibroblasts, Scand. J. Immunol. 17:69–82.Google Scholar
  11. Burmeister, G. R., Locher, P., Koch, B., Winchester, R. J., Dimitriu-Bona, A., Kalden, J. R., and Mohr, W., 1983b, The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards la and monocyte/macrophage antigens, Rheumatol. Int. 3:173–181.Google Scholar
  12. Bøyum, A., 1983, Isolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium, Scand. J. Immunol. 17:429–431.PubMedGoogle Scholar
  13. Coccia, P. F., Krivit, W., Cervenkea, J., Clomson, C., Kersey, J. H., Kim, T. H., Nesbit, M. E., Ramsay, N. K. C., Warkentin, P. I., and Teitelbaum, S. L., 1980, Successful bone-marrow transplantation for infantile malignant osteopetrosis, N. Engl. J. Med. 302:701–702.PubMedGoogle Scholar
  14. Cupps, T. R., and Fauci, A. S., 1982, Corticosteroid-mediated immunoregulation in man, Immunol. Rev. 65:133–155.PubMedGoogle Scholar
  15. Daha, M. R., vanEs, L. A., Hazevoet, H. M., and Kijlstra, A., 1982, Degradation of soluble immunoglobulin aggregates in vitro by monocytes from normal subjects and from patients with systemic lupus erythematosus, Scand. J. Immunol. 16:117–122.PubMedGoogle Scholar
  16. Dayer, J. M., 1981, gome characteristics and functional aspects of the human monokine, MCF, stimulating collagenase and PGE2 production by rheumatoid synovial cells, Scand. J. Rheumatol. Suppl. 40:88–92.PubMedGoogle Scholar
  17. Duff, G. W., Førre, Ø., Waalen, K., Dickens, E., and Nuki, G., 1985, Rheumatoid arthritis synovial dendritic cells produce interleukin 1. Brit. J. Rheumatol, (in press).Google Scholar
  18. Falkoff, R. J. M., Ping Zhu, L., and Fauci, A., 1982, Separate signals for human B cell proliferation and differentiation in response to Staphylococcus aureus: Evidence for a two-signal model of B cell activation, J. Immunol. 129:97–102.PubMedGoogle Scholar
  19. Famey, J. P., 1982, Free radicals and activated oxygen, Eur. J. Rheum. Inflam. 5:350–359.Google Scholar
  20. Fields, T. R., Gerardi, E. N., Ghebrehiwet, B., Bennet, R. S., Laley, T. J., Hall, R. P., Plotz, P. H., Karsh, J. R., Frank, M. M., and Hamburger, M. I., 1983, Reticuloendothelial system. Fc-receptor function in rheumatoid arthritis, J. Rheumatol. 10:550–557.PubMedGoogle Scholar
  21. Flotte, T. J., Springer, T. A., and Thorbecke, G. J., 1983, Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets, Am. J. Pathol. 111:112–124.PubMedGoogle Scholar
  22. Fontana, A., Hengartner, H., Weber, E., Fehr, K., Grob, P. J., and Cohen, G., 1982, Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis, Rheumatol. Int. 2:49–53.PubMedGoogle Scholar
  23. Førre, Ø, Waalen, K., GlennÅs, A., and Thorsby, E., 1982a, Dendritic cells from the rheumatoid synovial membrane as antigen-presenting cells, Immunobiology 163:2/3/4, 115.Google Scholar
  24. Førre, Ø, Thoen, J., Lea, T., Dobloug, J. H., Mellbye, O. J., Natvig, J. B., Pahle, J., and Solheim, B. G., 1982b, In situ characterization of mononuclear cells in rheumatoid tissues using monoclonal antibodies. No reduction in T8-positive cells or augmentation of T4-positive cells, Scand. J. Immunol. 16:315–319.PubMedGoogle Scholar
  25. Førre, Ø, Thoen, J., Waalen, K., and Natvig, J. B., 1983, Autologous mixed lymphocyte reactions in rheumatoid arthritis. Characterization of stimulator cells and the recognition unit for autoantigens on the responder cells, in:The Autologous Mixed Lymphocyte Reaction: A Basic Immune Regulatory Mechanism, Behring Institute Research Communications, No. 72 ( M. E. Weksler, J. R. Kalden, and N. Talal, eds.), Medizinische Verlagsgesellschaft, Marburg, pp. 188–192.Google Scholar
  26. Goodwin, J. S., and Webb, D., 1980, Regulation of the immune response by prostaglandins, Clin. Immunol. Immunopathol. 15:106–122.PubMedGoogle Scholar
  27. Harris, E. D., Jr., 1981a, Biology of the joint, in:Textbook of Rheumatology ( W. N. Kelley, E. D. Harris, Jr., S. Ruddy, and C. B. Sledge, eds.), W. B. Saunders, Philadelphia, pp. 255–276.Google Scholar
  28. Harris, E. D., Jr., 1981b, Pathogenesis of rheumatoid arthritis in:Textbook of Rheumatology (W. N. Kelley, E. D. Harris, Jr., S. Ruddy, and C. B. Sledge, eds.), W. B. Saunders, Philadelphia, pp. 896–927.Google Scholar
  29. Hart, P. H., Powell, L. W., Cooksley, W. G. E., and Holliday, J. W., 1983, Mononuclear cell factors that inhibit fibroblast collagen synthesis. I. In vitro conditions determining their production and expression, Scand. J. Immunol. 18:41–49.PubMedGoogle Scholar
  30. Harth, M., Keown, P. A., and Orange, J. F., 1983, Monocyte dependent excited oxygen radical generation in rheumatoid arthritis:Inhibition by gold sodium thiomalate, J. Rheumatol. 10:701–707.PubMedGoogle Scholar
  31. Hirschberg, H., Braathen, L. R., and Thorsby, E., 1982, Antigen presentation by vascular endothelial cells and epidermal Langerhans cells:The role of HLA-DR, Immunol. Rev. 66:57–77.PubMedGoogle Scholar
  32. Hume, D. A., Robinson, A. P., MacPherson, G. G., and Gordon, S., 1983, The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells and dendritic cells in lymphoid and hematopoietic organs, J. Exp. Med. 158:1522 - 1536.PubMedGoogle Scholar
  33. Inoba, K., Steinman, R. M., van Voorhis, W. C., and Muramatsu, S., 1983, Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man, Proc. Natl. Acad. Sci. U.S.A. 80:6041–6045.Google Scholar
  34. Janossy, G., Duke, O., Poulter, L. W., Panayi, G., Bofill, M., and Goldstein, G., 1981, Rheumatoid arthritis: A disease of T-lymphocyte/macrophage immunoregulation, Lancet 2:839–842.PubMedGoogle Scholar
  35. Johnson, E., Bøgwald, J., Eskeland, T., and Seljelid, R., 1983, Complement (C3) receptor-mediated attachment of agarose beads to mouse peritoneal macrophages and human monocytes, Scand. J. Immunol. 17:403–410.PubMedGoogle Scholar
  36. Katz, S. I., Tamaki, K., and Sachs, D. H., 1979, Epidermal Langerhans cells are derived from cells originating in bone marrow, Nature 282:324–326.PubMedGoogle Scholar
  37. Klareskog, L., Forsum, U., Malmnaes Tjernlund, U., Kabelitz, D., and Wigren, A., 1981, Appearance of anti-HLA-DR-reactive cells in normal and rheumatoid synovial tissue, Scand. J. Immunol. 14:183–192.PubMedGoogle Scholar
  38. Klareskog, L., Forsum, U., and Wigzell, H., 1982a, Murine synovial intima contains I-A-, I-E/C-positive bone-marrow-derived cells, Scand. J. Immunol. 15:509–514.Google Scholar
  39. Klareskog, L., Forsum, U., Scheynius, A., Kabelitz, D., and Wigzell, H., 1982b, Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis, Proc. Natl. Acad. Sci. U.S.A. 79:3632–3636.PubMedGoogle Scholar
  40. Klareskog, L., Forsum, U., Kabelitz, D., Pløfen, L., Sundstrøm, C., Nilsson, K., Wigren, A., and Wiegzell, H., 1982c, Immune functions of human synovial cells. Phenotypic and T cell regulatory properties of macrophage-like cells that express HLA-DR, Arthritis Rheum. 25:488–501.PubMedGoogle Scholar
  41. Klinkert, W. E., LaBadie, J. H., and Bowers, W. E., 1982, Accessory and stimulating properties of dendritic cells and macrophages isolated from various rat tissues, J. Exp. Med. 156:1–19.PubMedGoogle Scholar
  42. Knight, S. C., Balfour, B. M., O’Brien, J., Buttifant, L., Sumerska, T., and Clarke, J., 1982, Role of veiled cells in lymphocyte activation, Eur. J. Immunol. 12:1057–1060.PubMedGoogle Scholar
  43. Knight, S. C., Mertin, J., Stackpoole, A., and Clark, J., 1983, Induction of immune responses in vivo with small numbers of veiled (dendritic) cells, Proc. Natl. Acad. Sci. U.S.A. 80:6032–6035.PubMedGoogle Scholar
  44. Krane, S. M., Dayer, J. M., and Goldring, S. R., 1982, Consideration of possible cellular events in the destructive synovial lesion of rheumatoid arthritis, in:Advances in Inflammation Research, Vol. 3, Rheumatoid Arthritis ( S. Gorini, M. Ziff, and G. P. Velo, eds.), Raven Press, New York, pp. 1–16.Google Scholar
  45. Kuntz-Crow, M., and Kunkel, H. G., 1982, Human dendritic cells:Major stimulators of the autologous and allogeneic mixed leukocyte reactions, Clin. Exp. Immunol. 49:338–346.Google Scholar
  46. Lachman, L. B., Hacker, M. P., and Handschumacher, R. E., 1977, Partial purification of human lymphocyte- activating factor (LAF) by ultrafiltration and electrophoretic techniques, J. Immunol. 119:2019–2023.PubMedGoogle Scholar
  47. Leijh, P. C. J., and van Furth, R., 1981, Extracellular stimulation of phagocytes by plasma proteins for optimal intracellular killing of micro-organisms, Scand. J. Rheumatol. (Suppl.) 40:62–64.Google Scholar
  48. Librach, C. L., and Burns, G. F., 1983, Spontaneous reverse haemolytic plaque formation. II. The role of T cells and monocytes in regulating immunoglobulin secretion by human peripheral blood B cells, Scand. J. Immunol. 17:171–181.PubMedGoogle Scholar
  49. Lipsky, P. E., and Ziff, M., 1982, The mechanisms of action of gold and D-penicillamine in rheumatoid arthritis, in:Advances in Inflammation Research, Vol. 3, Rheumatoid Arthritis ( S. Gorini, M. Ziff, and G. P. Velo, eds.), Raven Press, New York, pp. 219–235.Google Scholar
  50. Lombardino, J. G., 1983, Mechanism of action of drugs for treating inflammation and arthritis, Eur. J. Rheum. Inflam. 6:24 - 35.Google Scholar
  51. Lunec, J., Halloran, S. P., White, A. G., and Dormandy, T. L., 1981, Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis, J. Rheumatol. 8:234–245.Google Scholar
  52. Matsubara, T., Spycher, M. A., Ruttner, J. R., and Fehr, K., 1983, The ultrastructural localization of fibronectin in the lining layer of rheumatoid arthritis synovium:The synthesis of fibronectin by type B lining cells, Rheumatol. Int. 3:75–79.PubMedGoogle Scholar
  53. Meijer, C. J. L., de Graaf-Reitsma, C. B., Lafeber, G. J. M., and Cats, A., 1983, In situ localization of Lymphocyte subsets in synovial membranes of patients with rheumatoid arthritis with monoclonal antibodies, J. Rheumatol. 9:359–365.Google Scholar
  54. Murphy, G. F., Bhon, A. K., Sato, S., Mihm, M. C., and Harrist, T. J., 1981, A new immunologic marker for human Langerhans cells, N. Engl. J. Med. 304:791–792.PubMedGoogle Scholar
  55. Niederhuber, J. E., 1978, The role of I region gene products in macrophages-T lymphocyte interaction, Immunol. Rev. 40:28–52.PubMedGoogle Scholar
  56. Nussenzweig, M. C., and Steinman, R. M., 1982, The cell surface of mouse lymphoid dendritic cells, Immunol. Today 3:3, 65–68.Google Scholar
  57. Nussenzweig, M. C., Steinman, R. M., Gutchinov, B., and Cohn, Z. A., 1980, Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes, J. Exp. Med. 152:1070–1084.PubMedGoogle Scholar
  58. Nussenzweig, M. C., Steinman, R. M., Witmer, M. D., and Gutchinov, B., 1982, A monoclonal antibody specific for mouse dendritic cells, Proc. Natl. Acad. Sci. U.S.A. 79:161–165.PubMedGoogle Scholar
  59. Panayi, G., 1981, Substrates for phagocytes in joints, Scand. J. Rheumatol. (Suppl.) 40:32–36.Google Scholar
  60. Parnham, M. J., Shoshan, S., Schoenmarker, H., and Bonta, I. L., 1981, Macrophage regulation of collagen deposition in granuloma tissue in vivo and the effect of prostaglandin E2, Scand. J. Rheumatol. (Suppl.) 40:72–74.Google Scholar
  61. Parwaresch, M. R., Radzun, H. J., and Dommes, M., 1981, The homogeneity and monocytic origin of human peritoneal macrophages evidenced by comparison of esterase polymorphism, Am. J. Pathol. 102:209–218.PubMedGoogle Scholar
  62. Parwaresch, M. R., Radzun, H. J., Hausmann, M. L., and Peters, K. P., 1983, Monoclonal antibody Ki-M4 specifically recognizes human dendritic reticulum cells (follicular dendritic cells) and their possible precursor in blood, Blood 62:585–590.PubMedGoogle Scholar
  63. Passwell, J. H., Dayer, J. M., and Merler, E., 1979, Increased prostaglandin production by human monocytes after membrane receptor activation, J. Immunol. 123:115–120.PubMedGoogle Scholar
  64. Pawlowski, N. A., Kaplan, G., Hamill, A. L., Cohn, Z. A., and Scott, W. A., 1983, Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures, J. Exp. Med. 158:393–412.PubMedGoogle Scholar
  65. Pommier, C. G., Inada, S., Fries, L. F., Takahashi, T., Frank, M. M., and Brown, E. J., 1983, Plasma fibronectin enhances phagocytosis of peripheral blood monocytes, J. Exp. Med. 156:1844–1854.Google Scholar
  66. Poulter, L. W., 1983, Antigen presenting cells in situ:Their identification and involvement in immunopathology, Clin. Exp. Immunol. 53:513–520.PubMedGoogle Scholar
  67. Poulter, L. W., and Duke, O., 1983, Dendritic cells of the rhematoid synovial membrane and synovial fluid, in:Quatrième Cours D’Immunopathologie Articulaire ( J. Clot and J. Sany, eds.), Quick Print, Montpellier, pp. 189–199.Google Scholar
  68. Poulter, L. W., Duke, O., Hobbs, S., Janossy, G., Panayi, G., and Seymour, G., 1983, The involvement of interdigitating (antigen-presenting) cells in the pathogenesis of rheumatoid arthritis, Clin. Exp. Immunol. 51:247–257.PubMedGoogle Scholar
  69. Radzun, H. J., Parwaresch, M. R., and Kreipe, H., 1983, Monocytic origin of human alveolar macrophages, J. Histochem. Cytochem. 31:318–324.PubMedGoogle Scholar
  70. Roos, D., 1981, Molecular events during phagocyte stimulation, Scand. J. Rheumatol. (Suppl.) 40:46–52.Google Scholar
  71. Rosenthal, A., 1980, Current concepts:Regulation of the immune response-role of the macrophage, N. Engl. J. Med. 203:1153–1156.Google Scholar
  72. Rowden, G., Lewis, M. G., and Sullivan, A. K., 1977, la antigen expression on human epidermal Langerhans cells, Nature 268:247–248.PubMedGoogle Scholar
  73. Russel, R. G. G., McGuire, M. K. B., Meats, J. E., Ebsworth, N. M., and Beresford, J., 1981, Intercellular messengers in joint tissues in rheumatoid arthritis, Scand. J. Rheumatol. (Suppl.) 40:75–87.Google Scholar
  74. Ryan, P. F. J., and Hughes. G. R. V., 1982, Plasmapheresis and lymphapheresis, in:Advances in Inflammation Research, Vol. 3, Rheumatoid Arthritis ( S. Gorini, M. Ziff, and G. P. Velo, eds.), Raven Press, New York, pp. 271–284.Google Scholar
  75. Scheinberg, M. A., Santos, L. M. B., and Finkelstein, A. E., 1982, The effect of auranofin and sodium aurothiomalate on peripheral blood monocytes, J. Rheumatol. 9:366–369.PubMedGoogle Scholar
  76. Scheinberg, M. A., Rueda, H. O., and Matheus, P. C., 1983, The effect of piroxicam on neutrophil and monocyte-macrophages function, Eur. J. Rheum. Inflam. 6:36–40.Google Scholar
  77. Scheynius, A., Grønvik, K. O., and Andersson, J., 1983, Epidermal Langerhans cells as accessory cells in Con A stimulation of T lymphocytes in the guinea pig, Scand. J. Immunol. 17:283–290.PubMedGoogle Scholar
  78. Selinger, M. J., McAdam, K. P. W. J., Kaplan, M. M., Sipe, J. D., Vogel, S. N., and Rosenstreich, D. L., 1980, Monokine induced synthesis of serum amyloid A protein by hepatocytes, Nature 285:498–500.PubMedGoogle Scholar
  79. Smith, K. A., Lachman, L. B., Oppenheim, J. J., and Fonata, M. F., 1980, The functional relationship of interleukins, J. Exp. Med. 151:1551–1556.PubMedGoogle Scholar
  80. Spalding, D. M., Koopman, W. J., Eldridge, J. H., McGhee, J. R., and Steinman, R. M., 1983, Accessory cells in murine Peyers patch. I. Identification and enrichment of a functional dendritic cell, J. Exp. Med. 157:1646–1659.PubMedGoogle Scholar
  81. Steinman, R. M., 1981, Dendritic cells, Transplantation 31:151–155.PubMedGoogle Scholar
  82. Steinman, R. M., and Cohn, Z. A., 1973, Identification of a novel cell type in peripheral lymphoid organs or mice. I. Morphology, quantitation, tissue distribution, J. Exp. Med. 137:1142–1162.PubMedGoogle Scholar
  83. Steinman, R. M., and Cohn, Z. A., 1974, Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro, J. Exp. Med. 139:380–397.Google Scholar
  84. Steinman, R. M., and Nussenzweig, M. C., 1980, Dendritic cells:Features and functions, Immunol. Rev. 53:127–147.PubMedGoogle Scholar
  85. Steinman, R. M., Kaplan, G., Witmer, M. D., and Cohn, Z. A., 1979, Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro, J. Exp. Med. 149:1–16.Google Scholar
  86. Steinman, R. M., Gutchinov, B., Witmer, M. D., and Nussenzweig, M. C., 1983, Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice, J. Exp. Med. 157:613–627.PubMedGoogle Scholar
  87. Sunshine, G. H., Gold, D. P., Wortis, H. H., Marrack, P., and Kappler, J. W., 1983, Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas, J. Exp. Med. 158:1745–1750.PubMedGoogle Scholar
  88. Teitelbaum, S. L., and Kahn, A. J., 1980, Mononuclear phagocytes, osteoclasts and bone resorption, Min. Electrolyte Metab. 3:2–6.Google Scholar
  89. Theofilopoulos, A. N., Carson, D., Tovassoli, M., Slovin, S. F., Speers, W. C., Jensen, F. B., and Vaughan, J. H., 1980, Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells, Arthritis Rheum. 23:1–9.PubMedGoogle Scholar
  90. Thorsby, E., Berle, E., and Nousiainen, H., 1982, HLA-D region molecules restrict proliferative T cell responses to antigen, Immunol. Rev. 66:39–56.PubMedGoogle Scholar
  91. Trentham, D. E., Dynesius, R. A., Rocklin, R. E., and David, J. R., 1978, Cellular sensitivity to collagen in rheumatoid arthritis, N. Engl. J. Med. 299:327–332.PubMedGoogle Scholar
  92. Unanue, E. R., 1978, The regulation of lymphocyte functions by the macrophage, Immunol. Rev. 40:227–255.PubMedGoogle Scholar
  93. Vaes, G., 1981, Cartilage and bone tissue damage in arthritis:Cellular cooperation and enzymatic mechanisms, Scand. J. Rheumatol. (Suppl.) 40:65–71.Google Scholar
  94. van Furth, R., 1981, The origin of phagocytic cells in the joint and bone, Scand. J. Rheumatol. (Suppl.) 40:13–20.Google Scholar
  95. van Voorhis, W. C., Witmer, M. D., and Steinman, R. M., 1983, The phenotype of dendritic cells and macrophages, Fed. Proc. 42:3114–3118.PubMedGoogle Scholar
  96. Weibart, R. H., Bluestone, R., and Goldberg, L. S., 1975, Cellular immunity to autologous IgG in rheumatoid arthritis and rheumatoid-like disorders, Clin. Exp. Immunol. 20:409 - 417.Google Scholar
  97. Weissmann, G., 1982, The biochemistry of inflammation:Rheumatoid arthritis and anti-inflammatory drugs, Eur. J. Rheum. Inflam. 5:366–381.Google Scholar
  98. Weissmann, G., 1983, Pathways for arachidonate oxidation to prostaglandins and leucotrienes, Semin. Arthritis Rheum. 13 (Suppl. 1):123–129.PubMedGoogle Scholar
  99. Whitten, H. D., Cruse, J. M., and Fudenberg, H. H., 1983, Activation of macrophages by in vitro allostimulated T cells, Scand. J. Immunol. 17:335–343.PubMedGoogle Scholar
  100. Williams, B. D., Russel, B. A., Lockwood, C. M., and Cotton, C., 1979, Defective reticuloendothelial system function in rheumatoid arthritis, Lancet 1:1311–1314.PubMedGoogle Scholar
  101. Winchester, R. J., and Burmeister, G. R., 1981, Demonstration of la antigens on certain dendritic cells and on a novel elongate cell found in human synovial tissue, Scand. J. Immunol. 14:439–444.PubMedGoogle Scholar
  102. Wischer, T. L., 1982, The possible role of cellular interactions in the pathogenesis of rheumatoid joint lesions, in:Advances in Inflammation Research, Vol. 3, Rheumatoid Arthritis ( S. Gorini, M. Ziff, and G. P. Velo, eds.), Raven Press, New York, pp. 55–64.Google Scholar
  103. Wooley, D. E., 1978, Collagenase localization in cultures of rheumatoid synovial cells, Science 200:773–775.Google Scholar
  104. Wood, D. D., Ihrie, E. J., Dinarello, C. A., and Cohen, P. L., 1983, Isolation of aninterleukin 1-like factor from human joint effusions, Arthritis Rheum. 26:975–983.PubMedGoogle Scholar
  105. Ziff, M., 1981, Phagocytes and substrates in the joint, Scand. J. Rheumatol. Suppl. 40:10–12.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Øystein Førre
    • 1
  • Kristian Waalen
    • 2
  • Jørn Thoen
    • 2
  • Torstein Hovig
    • 3
  1. 1.Oslo Sanitetsforenings Rheumatism HospitalOsloNorway
  2. 2.Institute of Immunology and Rheumatology, RikshospitaletThe National HospitalOsloNorway
  3. 3.Institute for Pathology, Electron Microscopic Laboratory, RikshospitaletThe National HospitalOsloNorway

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