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Immune Response to Streptococcal Antigens in Rheumatic Fever

  • Chapter
Immunology of Rheumatic Diseases

Abstract

Acute rheumatic fever still represents the one only of the connective tissue disorders in which a basic causative agent has been clearly identified. We know that rheumatoid arthritis is commonly associated with the production of rheumatoid factors and a positive latex fixation test and that systemic lupus erythematosus represents a generalized often severe disease of connective tissues associated with anti-DNA antibodies, but in neither of the two latter disorders has the original inciting agent been defined. By contrast, it has been firmly established that acute rheumatic fever results from prior pharyngeal infection by (i-hemolytic group A streptococci and that each subsequent attack is set off by throat reinfection with group A streptococci (Anderson et al.,1948; Wannamaker, 1959).

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  1. Department of Medicine, University of New Mexico School of Medicine, 87131, Al-buquerque, New Mexico, USA

    Ralph C. Williams Jr.

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  1. Ralph C. Williams Jr.
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  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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Williams, R.C. (1985). Immune Response to Streptococcal Antigens in Rheumatic Fever. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_13

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  • DOI: https://doi.org/10.1007/978-1-4613-2493-5_13

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