Therapeutic Potential of Monoclonal Antibodies to the Leucocyte Common Antigen
The leucocyte common (LC) antigen is a major glycoprotein family of leucocyte membranes. Monoclonal antibodies against the rat, mouse and human antigens have been described (Sunderland et al., 1979; Trowbridge, 1978; Dalchau et al., 1980). Its cell distribution and molecular weight are very similar in the three species. It is widely distributed on leucocytes, being found on T and B lymphocytes, thymocytes, macrophages and granulocytes, but is absent from other tissues. Its apparent molecular weight by SDS-PAGE is about 200 kilodaltons, but up to four species with slightly different mobilities have been observed according to the cell type studied (Dalchau and Fabre, 1981; Banga et al., 1984).
KeywordsIgG2a Antibody Leukocyte Common Antigen Acute Myeloid Leukaemia Cell Rabbit Complement IgG2b Antibody
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