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Therapeutic Potential of Monoclonal Antibodies to the Leucocyte Common Antigen

  • Carol Bindon
  • Geoff Hale
  • Herman Waldmann

Abstract

The leucocyte common (LC) antigen is a major glycoprotein family of leucocyte membranes. Monoclonal antibodies against the rat, mouse and human antigens have been described (Sunderland et al., 1979; Trowbridge, 1978; Dalchau et al., 1980). Its cell distribution and molecular weight are very similar in the three species. It is widely distributed on leucocytes, being found on T and B lymphocytes, thymocytes, macrophages and granulocytes, but is absent from other tissues. Its apparent molecular weight by SDS-PAGE is about 200 kilodaltons, but up to four species with slightly different mobilities have been observed according to the cell type studied (Dalchau and Fabre, 1981; Banga et al., 1984).

Keywords

IgG2a Antibody Leukocyte Common Antigen Acute Myeloid Leukaemia Cell Rabbit Complement IgG2b Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Carol Bindon
    • 1
  • Geoff Hale
    • 1
  • Herman Waldmann
    • 1
  1. 1.Department of PathologyUniversity of CambridgeCambridgeUK

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