Origin and Turnover of Follicular Dendritic Cells and Marginal Zone Macrophages in the Mouse Spleen

  • John H. Humphrey
  • Vijaya Sundaram


By constructing bone marrow chimaeras between F1 mice and either parent it becomes possible to determine whether any particular accessory cell type subject to renewal is derived from stem cells present in the donor bone marrow (b.m.). Necessary conditions are that the cell type can be identified and clearly distinguished from other cells, and that appropriate reagents are available to distinguish between cells of the F1 donor and parent recipient origin.


Marginal Zone Hydroxyethyl Starch Reticulum Cell Mouse Spleen Follicular Dendritic Cell 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John H. Humphrey
    • 1
  • Vijaya Sundaram
    • 1
  1. 1.Department of MedicineRoyal Postgraduate Medical SchoolLondonUK

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