Ia+T10+ Blast Cells in Acute Lymphoblastic Leukaemia are Precursors of T+ and B+ Cells

  • Ana K. Miljković
  • Katarina Isaković
  • Tatjana Matejić
  • Branka Stojanović

Abstract

Acute lymphoblastic leukaemia (ALL) is a lymphoproliferative disorder characterized by a block of cell maturation at very early stages of development. Immunological studies of ALL provided evidence that there are three types of ALL: T, B and non-T, non-B1,2. Furthermore, it was demonstrated that non-T, non-B ALL blasts are a heterogenous population of cells as concerns of their maturity rate. Those cells differentiate in vitro into T and B lymphocytes3. Therefore in vitro differentiation studies of non-T, non-B ALL blasts, as well as of lymphoid blasts in acute crisis of chronic myelocytic leukaemia (AML) provided a useful model for evaluating early progenitors of haemopoietic cells.4

Keywords

Leukemia FITC Phorbol Strepto Progeni 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Refernces

  1. 1.
    L. Borella, and L. Sen, T cell surface markers on lymphoblasts from acute lymphoblastic leukemia, J.Immunol. 111: 1257 (1973).PubMedGoogle Scholar
  2. 2.
    M. F. Greaves, G. Brown, N. Rapson, and T. A. Lister, Antisera to acute lymphatic leukemia cells, Clin.Immunol. Immunopathol. II:67 (1975).CrossRefGoogle Scholar
  3. 3.
    G. Jager, B. Lau, K. Pachmann, and P. Domer, Acute lymphoblastic leukaemia cells in the diffusion chamber: change of surface phenotype during culture periods, Brit. J. Haematol. 52: 319 (1982).CrossRefGoogle Scholar
  4. 4.
    M. F. Greaves, W. E. Verbi, B. R. Reaves, A. V. Hoffbrand, H. C. Draysdale, L. Jones, L. S. Sacker, and I. Samara- tunga, “Pre-B” phenotypes in blast crisis of Ph1 posi-tive CML: evidence for a pluripotential stem cell “target”, Leukemia Res. 3: 181 (1979).CrossRefGoogle Scholar
  5. 5.
    J. D. Griffin, R. P. Beveridge, and S. F. Schlossman, Isolation of myeloid progenitor cells from peripheral blood of chronic myelogenous leukemia, Blood 60: 30 (1982).PubMedGoogle Scholar
  6. 6.
    T. W. LeBien, F. J. Bollum, G. Yasmineh, and J. H. Kersey,Phorbol ester-induced differentiation of a non-T, non-B leukemic cell line: model for human lymphoid progenitor cell development, J.Immunol. 128: 1316 (1982).PubMedGoogle Scholar
  7. 7.
    K. Agasawa, and T. W. Mak, Phorbol esters induce differentiation in human malignant T lymphoblasts, Proc.Natl. Acad.Sci. 11: 296k (1980).Google Scholar
  8. 8.
    M. P. Bodger, C. A. Izaguirre, H. A. Blocklock, and A. V.Hoffbrand, Surface antigenic determinants on human pluripotent and unipotent hemopoietic progenitor cells, Blood 61:1008 (1983).Google Scholar
  9. 9.
    E. L. Reinherz, P. C. Kung, G. Goldstein, R. H. Levey, and S. F. Schlossman, Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T cell lineage, Proc.Natl.Acad.Sci. 77: 1588 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    P. Hokland, P. Rosenthal, J. D. Griffin, L. M. Nadler, J.Doley, M. Hokland, S. F. Schlossman, and J. Ritz, Purification and characterization of fetal hemopoietic cells that expressed the common acute lymphoblastic leukaemia antigen (CALLA), J.Exp.Med. 157: 114 (1983).PubMedCrossRefGoogle Scholar
  11. 11.
    K. Dorshkind, and R. A. Phillips, Characterization of early B lymphocyte precursors present in long-term bone marrow cultures, J.Immunol. 131: 3340 (1983).Google Scholar
  12. 12.
    G. Janossy, M. Roberts, and M. F. Greaves, Target cell in chronic myeloid leukaemia and its relationship to common ALL, Lancet ii:1058 (1976).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Ana K. Miljković
    • 1
    • 2
  • Katarina Isaković
    • 1
    • 2
  • Tatjana Matejić
    • 1
    • 2
  • Branka Stojanović
    • 1
    • 2
  1. 1.Immunology Research CenterYugoslavia
  2. 2.Institute of PathophysiologyBelgradeYugoslavia

Personalised recommendations