Ia+T10+ Blast Cells in Acute Lymphoblastic Leukaemia are Precursors of T+ and B+ Cells
Acute lymphoblastic leukaemia (ALL) is a lymphoproliferative disorder characterized by a block of cell maturation at very early stages of development. Immunological studies of ALL provided evidence that there are three types of ALL: T, B and non-T, non-B1,2. Furthermore, it was demonstrated that non-T, non-B ALL blasts are a heterogenous population of cells as concerns of their maturity rate. Those cells differentiate in vitro into T and B lymphocytes3. Therefore in vitro differentiation studies of non-T, non-B ALL blasts, as well as of lymphoid blasts in acute crisis of chronic myelocytic leukaemia (AML) provided a useful model for evaluating early progenitors of haemopoietic cells.4
KeywordsAcute Lymphoblastic Leukaemia Bone Marrow Culture Haemopoietic Cell Myelomonocytic Cell Unstimulated Culture
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